metronidazole has been researched along with Remission, Spontaneous in 11 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Remission, Spontaneous: A spontaneous diminution or abatement of a disease over time, without formal treatment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We used "high-dose" metronidazole, an "in vitro" and "in vivo" specific radiosensitizer of hypoxic cells, in a controlled trial to evaluate possible enhancement of radiation effect in patients with supratentorial glioblastomas." | 9.04 | Radiation and high-dose metronidazole in supratentorial glioblastomas. ( Band, P; Chapman, JD; Feldstein, ML; Fryer, C; Mielke, B; Urtasun, R, 1976) |
| "We used "high-dose" metronidazole, an "in vitro" and "in vivo" specific radiosensitizer of hypoxic cells, in a controlled trial to evaluate possible enhancement of radiation effect in patients with supratentorial glioblastomas." | 5.04 | Radiation and high-dose metronidazole in supratentorial glioblastomas. ( Band, P; Chapman, JD; Feldstein, ML; Fryer, C; Mielke, B; Urtasun, R, 1976) |
| "Women with asymptomatic bacterial vaginosis on Gram stain were assigned randomly at 16 to 23 weeks of gestation to receive two 2-g doses of metronidazole or placebo 48 hours apart and were re-evaluated for changes in Gram stain score on one occasion > or =2 weeks later." | 2.71 | Time course of the regression of asymptomatic bacterial vaginosis in pregnancy with and without treatment. ( Carey, JC; Dombrowski, MP; Hauth, JC; Heine, RP; Iams, JD; Klebanoff, MA; MacPherson, CA; Miodovnik, M; Moawad, A; Sibai, BM; vanDorsten, JP; Wapner, RJ, 2004) |
| "Guinea worm disease is endemic in West Africa." | 2.64 | Failure of thiabendazole and metronidazole in the treatment and suppression of guinea worm disease. ( Belcher, DW; Ward, WB; Wunapa, FK, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (36.36) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 5 (45.45) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hashimoto, R | 1 |
| Aoki, H | 1 |
| Chonan, A | 1 |
| O'Brien, G | 1 |
| Sarna, JR | 1 |
| Brownell, AK | 1 |
| Furtado, S | 1 |
| Heaney, CJ | 1 |
| Campeau, NG | 1 |
| Lindell, EP | 1 |
| Klebanoff, MA | 2 |
| Hauth, JC | 1 |
| MacPherson, CA | 1 |
| Carey, JC | 2 |
| Heine, RP | 1 |
| Wapner, RJ | 2 |
| Iams, JD | 1 |
| Moawad, A | 2 |
| Miodovnik, M | 2 |
| Sibai, BM | 1 |
| vanDorsten, JP | 1 |
| Dombrowski, MP | 1 |
| Sheffield, JS | 1 |
| Andrews, WW | 1 |
| Macpherson, C | 1 |
| Ernest, JM | 1 |
| Trout, W | 1 |
| Sibai, B | 1 |
| Varner, MW | 1 |
| Caritis, SN | 1 |
| Dombrowski, M | 1 |
| Langer, O | 1 |
| O'Sullivan, MJ | 1 |
| Spiller, RC | 1 |
| Belcher, DW | 1 |
| Wunapa, FK | 1 |
| Ward, WB | 1 |
| Urtasun, R | 1 |
| Band, P | 1 |
| Chapman, JD | 1 |
| Feldstein, ML | 1 |
| Mielke, B | 1 |
| Fryer, C | 1 |
| Fleury, FJ | 1 |
| Van Bergen, WS | 1 |
| Prentice, RL | 1 |
| Russell, JG | 1 |
| Singleton, JA | 1 |
| Standard, JV | 1 |
| Long, PI | 1 |
5 trials available for metronidazole and Remission, Spontaneous
| Article | Year |
|---|---|
Time course of the regression of asymptomatic bacterial vaginosis in pregnancy with and without treatment.
Topics: Adult; Anti-Infective Agents; Female; Humans; Metronidazole; Pregnancy; Pregnancy Complications, Inf | 2004 |
Spontaneous resolution of asymptomatic Chlamydia trachomatis in pregnancy.
Topics: Adult; Anti-Infective Agents; Chlamydia Infections; Chlamydia trachomatis; Double-Blind Method; Fema | 2005 |
Failure of thiabendazole and metronidazole in the treatment and suppression of guinea worm disease.
Topics: Adolescent; Adult; Africa, Western; Aged; Child; Child, Preschool; Clinical Trials as Topic; Dracunc | 1975 |
Radiation and high-dose metronidazole in supratentorial glioblastomas.
Topics: Administration, Oral; Adult; Aged; Brain Neoplasms; Cobalt Radioisotopes; Evaluation Studies as Topi | 1976 |
Single dose of two grams of metronidazole for Trichomonas vaginalis infection.
Topics: Administration, Oral; Clinical Trials as Topic; Dose-Response Relationship, Drug; Female; Humans; Ma | 1977 |
6 other studies available for metronidazole and Remission, Spontaneous
| Article | Year |
|---|---|
Spontaneous Resolution of Pancreatic Cyst After Treatment for Giardiasis.
Topics: Antiprotozoal Agents; Female; Giardia lamblia; Giardiasis; Host-Parasite Interactions; Humans; Metro | 2017 |
Bacterial vaginosis.
Topics: Adult; Anti-Infective Agents; Bacterial Infections; Child; Female; Humans; Metronidazole; Mucous Mem | 2008 |
Cases: Reversible cerebellar syndrome caused by metronidazole.
Topics: Aged; Bronchiectasis; Cerebellar Diseases; Dose-Response Relationship, Drug; Drug Administration Sch | 2009 |
MR imaging and diffusion-weighted imaging changes in metronidazole (Flagyl)-induced cerebellar toxicity.
Topics: Abdominal Abscess; Abdominal Neoplasms; Aged; Amoxicillin; Anti-Infective Agents; Carcinoid Tumor; C | 2003 |
Is there any difference in Helicobacter pylori eradication rates in patients with active peptic ulcer, inactive peptic ulcer and functional dyspepsia?
Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Ulcer Agents; Clarithromycin; Drug Therapy, Combination; Dy | 1999 |
Cutaneous leishmaniasis treated with metronidazole.
Topics: Adult; Evaluation Studies as Topic; Humans; Leishmaniasis; Male; Metronidazole; Remission, Spontaneo | 1973 |