Abscess, Retropharyngeal

An accumulation of purulent material in the space between the PHARYNX and the CERVICAL VERTEBRAE. This usually results from SUPPURATION of retropharyngeal LYMPH NODES in patients with UPPER RESPIRATORY TRACT INFECTIONS, perforation of the pharynx, or head and neck injuries.

Synonym
Abscess, Retropharyngeal
Retropharyngeal Abscess

Excerpt	Reference
"Retropharyngeal abscess is reported to be decreasing in frequency in recent years."	( Akita, S; Ito, Y; Kato, M; Kato, N; Miyata, H; Miyazaki, T; Mizuta, K; Watanabe, K, 1998)
"Retropharyngeal abscess is an uncommon entity that can have severe and even fatal complications if it is not identified and treated early."	( Ciftci, O; Dagli, S; Ozbek, C; Ozdem, C; Tuna, EE, 2009)

Excerpt	Reference
"Because of a recent upsurge in retropharyngeal abscess (RPA) cases due to community-associated methicillin-resistant Staphylococcus aureus (MRSA), we reevaluated the microbiology, clinical manifestations and treatment outcome of RPA over the past 6 years (2004 to 2010)."	( Abdel-Haq, N; Asmar, BI; Quezada, M, 2012)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	2 (2.22)	23.3326
1990's	16 (17.78)	12.5806
2000's	34 (37.78)	18.1394
2010's	34 (37.78)	28.8240
2020's	4 (4.44)	9.53

Drug	Relationship Strength	Studies
beta-alanine	low	1
dalteparin	low	1
methanol	low	2
pyrazinamide	low	2
taurine	low	1
acetaminophen	low	1
aspirin	low	4
cefuroxime	low	2
ciprofloxacin	low	1
diclofenac	low	2
fluconazole	low	4
fluorouracil	low	1
gentamicin	low	1
ibuprofen	low	2
indomethacin	low	1
isoniazid	low	2
metronidazole	low	5
apnea	low	2
ofloxacin	low	1
sulfamethazine	low	1
trimethoprim	low	1
prednisolone	low	1
prednisone	low	1
methicillin	low	1
cloxacillin	low	1
oxacillin	low	2
trichloroacetic acid	low	1
methylprednisolone	low	2
penicillanic acid	low	1
cyclohexanol	low	1
nafcillin	low	1
dexamethasone 21-phosphate	low	2
erythromycin	low	1
ethambutol	low	1
durapatite	low	1
vancomycin	low	4
streptomycin	low	1
titanium	low	2
gadolinium	low	1
trolamine salicylate	low	1
taurolidine	low	1
amoxicillin	low	2
amikacin	low	3
piperacillin	low	2
itraconazole	low	2
venlafaxine hydrochloride	low	1
cephalosporin c	low	7
flomoxef	low	1
zoledronic acid	low	1
oxazolidin-2-one	low	1
clarithromycin	low	1
mizoribine	low	1
panipenem-betamipron	low	1
methotrexate	low	1
docetaxel anhydrous	low	1
inositol 3-phosphate	low	1
meropenem	low	1
linezolid	low	1
cocaine	low	1
clindamycin	low	15
amphotericin b	low	2
clavulanic acid	low	1
phenylephrine hydrochloride	low	3
cefotaxime	low	4
amoxicillin-potassium clavulanate combination	low	9
nystatin a1	low	1
jaw	low	1
ro13-9904	low	7
sodium pertechnetate tc 99m	low	1
piperacillin, tazobactam drug combination	low	1
tetracycline	low	1
exudates	low	1
rifampin	low	4
trifazid	low	1

Protein Targets (774)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
RAR-related orphan receptor gamma	13	0	0	13
ATAD5 protein, partial	7	0	0	7
GLS protein	6	0	0	6
Microtubule-associated protein tau	6	0	0	6
Smad3	2	0	0	2
aldehyde dehydrogenase 1 family, member A1	15	0	0	15
thyroid stimulating hormone receptor	9	0	0	9
nuclear receptor subfamily 1, group I, member 3	12	0	0	12
progesterone receptor	9	0	0	9
EWS/FLI fusion protein	14	0	0	14
retinoic acid nuclear receptor alpha variant 1	14	0	0	14
retinoid X nuclear receptor alpha	17	0	0	17
estrogen-related nuclear receptor alpha	19	0	0	19
estrogen nuclear receptor alpha	27	0	0	27
peroxisome proliferator activated receptor gamma	9	0	0	9
aryl hydrocarbon receptor	8	0	0	8
chromobox protein homolog 1	9	0	0	9
thyroid hormone receptor beta isoform 2	13	0	0	13
peripheral myelin protein 22	6	0	0	6
cytochrome P450 3A4 isoform 1	5	0	0	5
Gamma-aminobutyric acid receptor subunit pi	5	2	0	7
ATP-binding cassette sub-family C member 3	0	26	0	26
Multidrug resistance-associated protein 4	0	26	0	28
Solute carrier family 22 member 6	0	6	0	6
Carbonic anhydrase 12	0	2	0	2
UDP-glucuronosyltransferase 1A9	0	1	0	3
Bile salt export pump	0	11	0	11
Voltage-dependent calcium channel gamma-2 subunit	6	0	0	6
Bile salt export pump	0	33	0	33
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	5	0	5
Carbonic anhydrase 2	0	5	1	6
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	0	1	2
Cytochrome P450 1A2	0	4	0	6
Prostaglandin G/H synthase 1	0	7	0	8
Carbonic anhydrase 3	0	1	0	1
Cytochrome P450 3A4	0	10	0	11
Cytochrome P450 2D6	0	4	0	5
Cytochrome P450 2C9	0	12	0	14
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	5	2	0	7
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	5	2	0	7
Gamma-aminobutyric acid receptor subunit gamma-2	5	2	0	7
UDP-glucuronosyltransferase 1-6	0	2	0	3
Glutamate receptor 2	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-5	5	2	0	7
Gamma-aminobutyric acid receptor subunit alpha-3	5	2	0	7
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	2	0	3
Carbonic anhydrase 4	0	1	0	1
Prostaglandin G/H synthase 1	0	7	0	7
Carbonic anhydrase 6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	5	2	0	7
Gamma-aminobutyric acid receptor subunit alpha-2	5	2	0	7
Gamma-aminobutyric acid receptor subunit alpha-4	5	2	0	7
Gamma-aminobutyric acid receptor subunit gamma-3	5	2	0	7
Gamma-aminobutyric acid receptor subunit alpha-6	5	2	0	7
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Prostaglandin G/H synthase 2	0	7	1	9
Carbonic anhydrase 7	0	1	0	1
Nuclear receptor ROR-gamma	5	0	0	5
Cytochrome P450 2J2	0	7	0	7
Gamma-aminobutyric acid receptor subunit alpha-1	5	3	0	8
Gamma-aminobutyric acid receptor subunit beta-3	5	2	0	7
Gamma-aminobutyric acid receptor subunit beta-2	5	2	0	7
Carbonic anhydrase 9	0	3	0	3
GABA theta subunit	5	2	0	7
Canalicular multispecific organic anion transporter 1	0	26	0	26
Carbonic anhydrase 15	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	5	2	0	7
Carbonic anhydrase 14	0	2	0	2
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
toxin B	0	0	0	1
histone acetyltransferase KAT2A isoform 1	5	0	0	5
lamin isoform A-delta10	16	0	0	16
Aminoglycoside 3'-phosphotransferase	0	0	0	1
ATP-dependent phosphofructokinase	6	0	0	6
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	11	0	0	11
Chain A, Beta-lactamase	2	0	0	2
Chain A, 2-oxoglutarate Oxygenase	9	0	0	9
Beta-lactamase	0	1	0	3
Beta-lactamase	0	1	0	4
Beta-lactamase	0	0	0	4
Beta-lactamase	0	1	0	4
AR protein	19	0	0	19
apical membrane antigen 1, AMA1	3	0	0	3
Beta-lactamase	0	0	0	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	4	0	0	4
DNA polymerase eta isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	7	0	0	7
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
DNA polymerase kappa isoform 1	6	0	0	6
Beta-lactamase SHV-1	0	1	0	4
Beta-lactamase SHV-1	0	2	0	6
Beta-lactamase	0	1	0	5
Kappa-type opioid receptor	0	0	0	3
Solute carrier family 15 member 1	0	6	0	6
Solute carrier family 15 member 1	0	1	0	1
B2 metallo-beta-lactamase	0	0	0	3
Solute carrier family 15 member 2	0	4	0	4
Beta-lactamase	0	1	0	4
Beta-lactamase	0	1	0	4
Solute carrier family 15 member 2	0	4	0	4
Beta-lactamase	0	1	0	4
Beta-lactamase	0	0	0	3
Chain A, HADH2 protein	7	0	0	7
Chain B, HADH2 protein	7	0	0	7
Chain A, Cruzipain	5	0	0	5
interleukin 8	7	0	0	7
phosphopantetheinyl transferase	5	0	0	5
glucocorticoid receptor [Homo sapiens]	17	0	0	17
farnesoid X nuclear receptor	7	0	0	7
peroxisome proliferator-activated receptor delta	10	0	0	10
vitamin D (1,25- dihydroxyvitamin D3) receptor	10	0	0	10
tumor necrosis factor	1	0	0	1
vitamin D3 receptor isoform VDRA	8	0	0	8
nuclear factor erythroid 2-related factor 2 isoform 1	17	0	0	17
Cytochrome P450 2C19	0	4	0	5
Potassium voltage-gated channel subfamily H member 2	0	9	0	10
Aurora kinase B	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	3
thioredoxin reductase	8	0	0	8
TDP1 protein	14	0	0	14
arylsulfatase A	7	0	0	7
euchromatic histone-lysine N-methyltransferase 2	17	0	0	17
Bloom syndrome protein isoform 1	7	0	0	7
D(1A) dopamine receptor	1	0	0	1
neuropeptide S receptor isoform A	2	0	0	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	4	0	0	4
Chain A, Phospholipase A2 isoform 3	0	0	1	1
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
hypothetical protein, conserved	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	10	0	0	10
cytochrome P450 2D6	3	0	0	3
glucocerebrosidase	3	0	0	3
Rac1 protein	0	0	1	1
IDH1	7	0	0	7
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	4	0	0	4
muscarinic acetylcholine receptor M1	2	0	0	2
lethal factor (plasmid)	4	0	0	4
Prostaglandin-H2 D-isomerase	0	2	0	2
Prostaglandin G/H synthase 1	0	4	0	5
Prostaglandin G/H synthase 2	0	3	0	4
Epidermal growth factor receptor	0	4	0	4
Fatty acid-binding protein, liver	0	4	0	4
Integrin beta-3	2	1	0	3
Myeloperoxidase	0	2	0	2
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	2	1	0	3
Glutathione hydrolase 1 proenzyme	0	1	0	1
Adenosine receptor A1	0	3	0	3
Adenosine receptor A2a	0	3	0	3
Substance-P receptor	0	3	0	3
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	2	0	2
Ras-related protein Rab-2A	0	0	1	1
Prostaglandin G/H synthase 2	0	6	0	6
Rho-associated protein kinase 2	0	2	0	2
Nicotinate phosphoribosyltransferase	0	2	0	2
Solute carrier family 22 member 20	0	3	0	3
Solute carrier family 22 member 6	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	2	1	3
Sigma non-opioid intracellular receptor 1	0	0	1	1
regulator of G-protein signaling 4	3	0	0	3
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	2	0	2
Proton-coupled amino acid transporter 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	2	0	2
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	2	0	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
Luciferase	7	0	0	7
Solute carrier family 22 member 6	0	5	0	6
Solute carrier family 22 member 8	0	4	0	6
Solute carrier family 22 member 11	0	2	0	4
Solute carrier family 22 member 8	0	2	0	2
Beta-lactamase	0	1	0	2
Beta-lactamase	0	2	0	4
Beta-lactamase	0	2	0	3
Beta-lactamase	0	0	0	3
Metallo-beta-lactamase type 2	0	0	1	4
Metallo-beta-lactamase VIM-11	0	0	0	2
Metallo-beta-lactamase VIM-2	0	0	0	2
Beta-lactamase	0	1	0	2
Metallo-beta-lactamase VIM-19	0	0	0	3
Beta-lactamase	0	1	0	3
Beta-lactamase	0	0	0	3
Metallo-beta-lactamase	0	0	0	2
Beta-lactamase	0	2	0	3
Albumin	0	3	8	11
Beta-lactamase	0	1	0	2
Beta-lactamase	0	1	0	2
Beta-lactamase	0	1	0	2
Metallo-beta-lactamase VIM-13	0	0	0	3
Beta-lactamase	0	0	0	1
Beta-lactamase	0	1	0	3
Metallo-beta-lactamase VIM-2	0	0	0	3
Beta-lactamase	0	0	0	3
Beta-lactamase Toho-1	0	0	0	1
Solute carrier family 22 member 7	0	1	0	2
Metallo-beta-lactamase	0	0	0	2
Beta-lactamase	0	1	0	4
Metallo-b-lactamase	0	0	0	5
BlaVIM-1	0	0	0	3
Beta-lactamase	0	0	0	1
Beta-lactamase	0	1	0	3
Carbapenem-hydrolyzing beta-lactamase KPC	0	2	0	5
Histamine H3 receptor	0	0	0	3
Beta-lactamase class B VIM-2	0	0	1	6
Beta-lactamase VIM-1	0	0	0	3
Solute carrier family 22 member 7	0	1	0	2
cytochrome P450 2C9 precursor	2	0	0	2
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	2
DNA gyrase subunit A	0	4	0	7
DNA gyrase subunit B	0	4	0	7
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	1	0	2
DNA topoisomerase 2-alpha	0	1	0	4
DNA gyrase subunit A	0	1	0	2
Multidrug resistance protein MdtK	0	0	1	1
Histamine H2 receptor	3	0	0	3
DNA gyrase subunit B	0	4	0	5
DNA gyrase subunit A	0	4	0	5
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	2	0	7
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
Integrase	0	2	0	2
GLI family zinc finger 3	19	0	0	19
importin subunit beta-1 isoform 1	3	0	0	3
mitogen-activated protein kinase 1	2	0	0	2
snurportin-1	3	0	0	3
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
geminin	14	0	0	14
streptokinase A precursor	0	0	5	5
ATP-dependent translocase ABCB1	0	5	0	5
Solute carrier organic anion transporter family member 1B3	0	5	0	7
Solute carrier organic anion transporter family member 1B1	0	5	0	6
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	2	0	2
Beta-lactamase	0	1	0	2
Neutrophil elastase	0	1	0	1
Beta-lactamase OXA-1	0	1	0	1
Cytochrome P450 2B6	0	1	1	2
Beta-lactamase TEM	0	3	0	5
Beta-lactamase	0	1	0	1
Class D beta-lactamase	0	1	0	3
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Protein-arginine deiminase type-4	0	6	0	6
Solute carrier family 22 member 8	0	4	0	5
Beta-lactamase OXA-7	0	0	0	3
Efflux transporter	0	1	0	1
Beta-lactamase	0	1	0	1
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Amyloid-beta precursor protein	1	1	0	2
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	0	1
5-hydroxytryptamine receptor 2C	0	3	0	4
Tryptophan 5-hydroxylase 1	0	1	0	1
5-hydroxytryptamine receptor 2A	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
D	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Alpha-2B adrenergic receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Liver carboxylesterase 1	0	0	0	1
Sodium-dependent noradrenaline transporter	0	3	0	3
Sodium-dependent dopamine transporter	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
5-hydroxytryptamine receptor 1B	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 1F	0	1	0	1
5-hydroxytryptamine receptor 2B	0	3	0	3
5-hydroxytryptamine receptor 6	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Sodium-dependent serotonin transporter	0	3	0	3
Sodium-dependent serotonin transporter	0	3	0	4
5-hydroxytryptamine receptor 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Sodium-dependent dopamine transporter	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Leukotriene B4 receptor 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
5-hydroxytryptamine receptor 4	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Leukotriene B4 receptor 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Transporter	0	3	0	3
pregnane X nuclear receptor	16	0	0	16
Aldo-keto reductase family 1 member B10	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Dihydrofolate reductase	0	6	0	7
Cytochrome c oxidase subunit 2	0	2	0	2
Transthyretin	0	0	1	3
Interleukin-8	0	2	0	2
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	0	1
Fatty acid-binding protein, intestinal	0	2	0	2
Aldo-keto reductase family 1 member B1	0	2	0	2
UDP-glucuronosyltransferase 2B7	0	1	0	3
UDP-glucuronosyltransferase 1A4	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
C-X-C chemokine receptor type 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Prostaglandin G/H synthase 2	0	3	0	4
UDP-glucuronosyltransferase 1A3	0	0	0	2
UDP-glucuronosyltransferase 2B10	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	2	0	2
Prostaglandin G/H synthase 2	0	3	0	4
Prostaglandin G/H synthase 1	0	3	0	4
Carbonic anhydrase 4	0	1	0	1
Multidrug and toxin extrusion protein 1	0	3	0	3
P2Y purinoceptor 12	0	2	0	2
UDP-glucuronosyltransferase 1A7	0	1	0	1
UDP-glucuronosyltransferase 1A10	0	1	0	1
PPM1D protein	2	0	0	2
caspase 7, apoptosis-related cysteine protease	1	0	0	1
67.9K protein	7	0	0	7
caspase-3	1	0	0	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	5	0	0	5
thyroid stimulating hormone receptor	3	0	0	3
nuclear receptor subfamily 1, group I, member 2	3	0	0	3
Interferon beta	8	0	0	8
Cellular tumor antigen p53	13	0	0	13
Serum paraoxonase/arylesterase 1	0	2	0	2
Kinesin-like protein KIF11	0	1	0	1
Spike glycoprotein	5	0	0	5
ATPase family AAA domain-containing protein 5	5	0	0	5
Ataxin-2	5	0	0	5
Nucleotide-binding oligomerization domain-containing protein 2	0	1	0	1
Motilin receptor	0	0	1	1
acid sphingomyelinase	2	0	0	2
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
Motilin receptor	0	1	1	2
Rap guanine nucleotide exchange factor 3	2	0	0	2
30S ribosomal protein S6	0	3	1	4
30S ribosomal protein S7	0	3	1	4
50S ribosomal protein L15	0	3	1	4
ATP-dependent translocase ABCB1	0	3	0	3
60 kDa chaperonin	0	1	0	1
50S ribosomal protein L10	0	3	1	4
50S ribosomal protein L11	0	3	1	4
50S ribosomal protein L7/L12	0	3	1	4
50S ribosomal protein L19	0	3	1	4
50S ribosomal protein L1	0	3	1	4
50S ribosomal protein L20	0	3	1	4
50S ribosomal protein L27	0	3	1	4
50S ribosomal protein L28	0	3	1	4
50S ribosomal protein L29	0	3	1	4
50S ribosomal protein L31	0	3	1	4
50S ribosomal protein L31 type B	0	3	1	4
50S ribosomal protein L32	0	3	1	4
50S ribosomal protein L33	0	3	1	4
50S ribosomal protein L34	0	3	1	4
50S ribosomal protein L35	0	3	1	4
50S ribosomal protein L36	0	3	1	4
30S ribosomal protein S10	0	3	1	4
30S ribosomal protein S11	0	3	1	4
30S ribosomal protein S12	0	3	1	4
30S ribosomal protein S13	0	3	1	4
30S ribosomal protein S16	0	3	1	4
30S ribosomal protein S18	0	3	1	4
30S ribosomal protein S19	0	3	1	4
30S ribosomal protein S20	0	3	1	4
30S ribosomal protein S2	0	3	1	4
30S ribosomal protein S3	0	3	1	4
30S ribosomal protein S4	0	3	1	4
30S ribosomal protein S5	0	3	1	4
30S ribosomal protein S8	0	3	1	4
30S ribosomal protein S9	0	3	1	4
50S ribosomal protein L13	0	3	1	4
50S ribosomal protein L14	0	3	1	4
50S ribosomal protein L16	0	3	1	4
50S ribosomal protein L23	0	3	1	4
30S ribosomal protein S15	0	3	1	4
50S ribosomal protein L17	0	3	1	4
50S ribosomal protein L21	0	3	1	4
50S ribosomal protein L30	0	3	1	4
50S ribosomal protein L6	0	3	1	4
30S ribosomal protein S14	0	3	1	4
30S ribosomal protein S17	0	3	1	4
30S ribosomal protein S1	0	3	1	4
50S ribosomal protein L18	0	3	1	4
60 kDa heat shock protein, mitochondrial	0	3	0	3
Chitinase B	0	1	0	1
ATP-dependent translocase ABCB1	0	3	0	3
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
50S ribosomal protein L2	0	3	1	4
50S ribosomal protein L3	0	3	1	4
50S ribosomal protein L24	0	3	1	4
50S ribosomal protein L4	0	3	1	4
50S ribosomal protein L22	0	3	1	4
10 kDa heat shock protein, mitochondrial	0	3	0	3
50S ribosomal protein L5	0	3	1	4
30S ribosomal protein S21	0	3	1	4
50S ribosomal protein L25	0	3	1	4
Cytochrome P450 1B1	0	1	0	1
Thiosulfate sulfurtransferase	0	3	0	3
Lanosterol 14-alpha demethylase	0	5	1	6
50S ribosomal protein L36 2	0	3	1	4
60 kDa chaperonin	0	3	0	3
10 kDa chaperonin	0	3	0	3
Pantothenate synthetase	0	2	0	2
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
acetylcholinesterase	6	0	0	6
G	6	0	0	6
unnamed protein product	0	1	0	1
transcriptional regulator ERG isoform 3	3	0	0	3
heat shock protein HSP 90-alpha isoform 2	0	1	0	2
bcl-2-like protein 11 isoform 1	0	0	1	1
Histone deacetylase 3	0	1	0	1
Chymotrypsinogen A	0	2	0	2
HLA class I histocompatibility antigen, B alpha chain	6	0	0	6
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Heme oxygenase 1	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	1	2
Aromatase	0	2	0	2
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B2, mitochondrial	0	1	0	1
Heme oxygenase 2	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Histone deacetylase 4	0	1	0	1
Cytochrome P450 144	0	0	2	2
Steroid C26-monooxygenase	0	0	2	2
Steroid C26-monooxygenase	0	0	2	2
Mycocyclosin synthase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
TAR DNA-binding protein 43	4	0	0	4
Histone deacetylase 1	0	1	0	1
Sterol 14-alpha demethylase	0	0	1	1
Sterol 14-alpha demethylase	0	1	1	2
Histone deacetylase 7	0	1	0	1
Inositol hexakisphosphate kinase 1	6	0	0	6
Histone deacetylase 2	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
14-alpha sterol demethylase	0	0	1	1
Histone deacetylase 8	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	1	0	1
cytochrome P450 2C9, partial	6	0	0	6
heat shock protein 90, putative	0	0	0	1
likely tRNA 2'-phosphotransferase	0	1	0	1
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
endonuclease IV	2	0	0	2
glp-1 receptor, partial	3	0	0	3
Skn7p	0	0	0	1
pregnane X receptor	3	0	0	3
hypoxia-inducible factor 1 alpha subunit	7	0	0	7
Thrombopoietin	1	0	0	1
estrogen receptor 2 (ER beta)	8	0	0	8
nonstructural protein 1	3	0	0	3
v-jun sarcoma virus 17 oncogene homolog (avian)	5	0	0	5
Histone H2A.x	6	0	0	6
peripheral myelin protein 22 isoform 1	2	0	0	2
hemoglobin subunit beta	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	7	0	0	7
huntingtin isoform 2	2	0	0	2
flap endonuclease 1	3	0	0	3
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
Vpr	3	0	0	3
survival motor neuron protein isoform d	5	0	0	5
muscleblind-like protein 1 isoform 1	5	0	0	5
Thymidylate synthase	0	3	0	3
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
USP1 protein, partial	3	0	0	3
NFKB1 protein, partial	2	0	0	2
Acid-sensing ion channel 3	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	2	0	2
Albumin	0	1	0	1
Albumin	0	0	1	1
Cholinesterase	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	4
Acetylcholinesterase	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Caspase-1	0	2	0	3
Aldo-keto reductase family 1 member C3	0	3	0	3
Caspase-3	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	2	0	2
Caspase-4	0	1	0	1
Caspase-5	0	1	0	1
Caspase-9	0	1	0	1
Acid-sensing ion channel 1	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Fatty-acid amide hydrolase 1	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
SMAD family member 2	1	0	0	1
SMAD family member 3	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	4	0	0	4
Parkin	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	4	0	0	4
cytochrome P450 2D6 isoform 1	2	0	0	2
thyroid hormone receptor beta isoform a	3	0	0	3
heat shock protein beta-1	3	0	0	3
ras-related protein Rab-9A	1	0	0	1
nuclear receptor ROR-gamma isoform 1	4	0	0	4
M-phase phosphoprotein 8	2	0	0	2
Prostaglandin E synthase	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	4	0	4
Phospholipase A2, major isoenzyme	0	1	0	1
Procathepsin L	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	1	0	2
Androgen receptor	0	2	1	3
Neuronal acetylcholine receptor subunit beta-2	1	1	0	2
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member C4	0	1	0	1
Thromboxane-A synthase	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Nitric oxide synthase, inducible	0	1	0	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	2
Bifunctional epoxide hydrolase 2	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	1	1
C-X-C chemokine receptor type 3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Guanine nucleotide-binding protein G	1	0	0	1
Prostaglandin D2 receptor	0	2	0	2
Solute carrier organic anion transporter family member 1A3	0	1	0	2
Lactoylglutathione lyase	0	1	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Cytosolic phospholipase A2 gamma	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
N-glycosylase/DNA lyase	0	1	0	1
Polyphenol oxidase 2	0	3	0	4
Formamidopyrimidine-DNA glycosylase	0	1	0	1
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 2A6	0	1	0	1
Macrophage migration inhibitory factor	0	1	0	1
Endonuclease III-like protein 1	0	1	0	1
Isocitrate lyase	0	1	0	1
Putative FAD-containing monooxygenase MymA	0	1	0	1
Dihydrofolate reductase	0	3	0	3
Endonuclease 8-like 1	0	1	0	1
Fumarate hydratase	3	0	0	3
GALC protein	3	0	0	3
polyprotein	3	0	0	3
activating transcription factor 6	2	0	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	3	0	3
Estrogen receptor	0	0	1	1
Amine oxidase [flavin-containing] B	0	1	0	1
Amine oxidase [flavin-containing] A	0	2	0	2
Amine oxidase [flavin-containing] B	0	1	0	1
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1S	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	4	0	4
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	1	0	1
Estrogen receptor beta	0	0	1	1
Renin	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	1	2
Beta-lactamase IMP-1	0	0	0	1
Beta-lactamase	0	0	0	1
Dopamine beta-hydroxylase	0	2	0	2
Lactoperoxidase	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain A, Ferritin light chain	2	0	0	2
dopamine D1 receptor	3	0	0	3
ClpP	1	0	0	1
15-lipoxygenase, partial	2	0	0	2
Thymidylate synthase	0	1	0	1
alpha-galactosidase	1	0	0	1
Thymidylate synthase	0	1	0	1
cellular tumor antigen p53 isoform a	2	0	0	2
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
DNA polymerase beta	1	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
caspase-1 isoform alpha precursor	1	0	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	3	0	4
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	3	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	4	0	5
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Thymidylate synthase	0	3	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	3	0	3
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	3	0	3
Thymidylate synthase	0	2	0	2
Dihydrofolate reductase	0	4	2	6
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	3	0	3
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	4	0	5
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Caspase-7	1	0	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	3	0	3
Dihydrofolate reductase	0	2	0	3
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Glucocorticoid receptor	0	6	2	13
Glycine receptor subunit alpha-1	0	6	0	6
Androgen receptor	0	3	0	3
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Thioredoxin reductase	0	1	0	1
Flavodoxin	0	0	0	1
lysosomal alpha-glucosidase preproprotein	2	0	0	2
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
STE24	0	0	0	1
CAAX prenyl protease	0	0	0	1
Trypsin	0	0	0	1
MecA	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
beta-2 adrenergic receptor	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Beta-lactamase	0	0	0	1
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
thioredoxin glutathione reductase	3	0	0	3
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
NH(3)-dependent NAD(+) synthetase	0	2	0	2
Arylacetamide deacetylase	0	1	0	2
Alpha-synuclein	0	2	0	2
Solute carrier organic anion transporter family member 1A2	0	1	0	1
Glutathione S-transferase omega-1	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
cytochrome P450 2C19 precursor	2	0	0	2
Sodium- and chloride-dependent taurine transporter	0	1	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
Tetracycline resistance protein, class B	0	0	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
72 kDa type IV collagenase	0	2	0	2
Stromelysin-1	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Alpha-1B adrenergic receptor	0	2	0	2
Neutrophil collagenase	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
Alpha-1A adrenergic receptor	0	2	0	2
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Chain A, Dihydrofolate Reductase	0	0	1	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, dihydrofolate reductase (DHFR)	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase type 1	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase type 1 from Tn4003	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Metabotropic glutamate receptor 5	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Trace amine-associated receptor 5	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
Butyrophilin subfamily 3 member A1	0	0	1	2
Geranylgeranyl pyrophosphate synthase	0	2	0	3
Farnesyl pyrophosphate synthase	0	2	0	2
Matrix metalloproteinase-9	0	1	0	1
Farnesyl diphosphate synthase	0	1	0	1
Matrix metalloproteinase-14	0	1	0	1
Farnesyl pyrophosphate synthase	0	2	0	2
Geranylgeranyl pyrophosphate synthase	0	2	0	2
Farnesyl pyrophosphate synthase	0	1	0	1
H	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(2)

Research Excerpts

Overview

Treatment

Research

Studies (90)

Protein Targets (774)

Abscess, Retropharyngeal

Synonyms(2)

Research Excerpts

Overview

Treatment

Research

Studies (90)

Drugs Studied (80)

Protein Targets (774)