metronidazole has been researched along with Substance Withdrawal Syndrome in 4 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Substance Withdrawal Syndrome: Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kissin, B | 1 |
| Gross, MM | 1 |
| Gelder, MG | 1 |
| Edwards, G | 1 |
| Lal, S | 1 |
| Pazukhanich, EI | 1 |
2 trials available for metronidazole and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Metronidazole in the treatment of alcohol addiction. A controlled trial.
Topics: Alcoholism; Blood Pressure; Clinical Trials as Topic; Humans; Metronidazole; Placebos; Pulse; Semant | 1968 |
Metronidazole in the treatment of alcoholism. A clinical trial and review of the literature.
Topics: Adult; Alcohol Drinking; Alcoholism; Clinical Trials as Topic; Humans; Male; Metronidazole; Middle A | 1969 |
2 other studies available for metronidazole and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Drug therapy in alcoholism.
Topics: Adult; Alcoholic Intoxication; Alcoholism; Antidepressive Agents; Anxiety; Carbamates; Chlordiazepox | 1970 |
[Treatment of chronic alcoholism patients with metronidazole under ambulatory conditions].
Topics: Alcoholism; Ambulatory Care; Humans; Metronidazole; Substance Withdrawal Syndrome | 1971 |