Page last updated: 2024-08-03 04:09:34
big gastrin
Description
big gastrin: isolated from Zollinger-Ellison syndrome gastrinomas & hog antral mucosa; have encountered tetratricontapeptide & nonadecapeptide gastrin; big-big gastrin significantly higher in patients with duodenal ulcers; big gastrin refers gastrin which has a longer peptide chain than the normal heptadecapeptide gastrin [MeSH]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 16132306 |
| MeSH ID | M0061679 |
Synonyms (11)
| Synonym |
|---|
| big gastrin |
| 53988-98-0 |
| gastrin 34 |
| g-34 |
| gastrin 71 |
| pro-gastrin |
| 3bl184galn , |
| gastrin 52 |
| big-big gastrin |
| unii-3bl184galn |
| gastrin (human), big |
Research
Studies (257)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 69 (26.85) | 18.7374 |
| 1990's | 79 (30.74) | 18.2507 |
| 2000's | 68 (26.46) | 29.6817 |
| 2010's | 30 (11.67) | 24.3611 |
| 2020's | 11 (4.28) | 2.80 |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 20 (7.60%) | 6.00% |
| Case Studies | 1 (0.38%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 242 (92.02%) | 84.16% |
| Condition | Indicated | Studies | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|
| Aberrant Crypt Foci | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Achlorhydria | 0 | | 1985 | 2000 | 32.6 | low | 0 | 2 | 3 | 0 | 0 | 0 |
| Addison's Anemia | 0 | | 1984 | 1997 | 35.0 | low | 0 | 2 | 2 | 0 | 0 | 0 |
| Adenocarcinoma | 0 | | 1984 | 2017 | 24.0 | low | 0 | 1 | 3 | 2 | 2 | 0 |
| Adenocarcinoma, Basal Cell | 0 | | 1984 | 2017 | 24.0 | low | 0 | 1 | 3 | 2 | 2 | 0 |
| Adenoma | 0 | | 1986 | 2013 | 25.4 | low | 0 | 2 | 1 | 1 | 1 | 0 |
| Adenoma, Basal Cell | 0 | | 1986 | 2013 | 25.4 | low | 0 | 2 | 1 | 1 | 1 | 0 |
| Adenoma, beta-Cell | 0 | | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Adenoma, Islet Cell | 0 | | 1987 | 1987 | 37.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Adenomatosis, Familial Endocrine | 0 | | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Adenomatous Polyposis Coli | 0 | | 2007 | 2014 | 13.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Adenomatous Polyposis Coli, Familial | 0 | | 2007 | 2014 | 13.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Aggression | 0 | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Aging | 0 | | 1986 | 1993 | 33.5 | low | 0 | 1 | 3 | 0 | 0 | 0 |
| Androgen-Independent Prostatic Cancer | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| Anesthesia | 0 | | 2000 | 2004 | 22.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| Angiogenesis, Pathologic | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Anxiety | 0 | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Astrocytoma, Grade IV | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Benign Neoplasms | 0 | | 2006 | 2021 | 9.8 | low | 0 | 0 | 0 | 2 | 1 | 1 |
| Birth Weight | 0 | | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Body Weight | 0 | | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Breast Cancer | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Breast Neoplasms | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Cancer of Colon | 0 | | 1992 | 2017 | 20.0 | low | 0 | 0 | 7 | 4 | 5 | 0 |
| Cancer of Duodenum | 0 | | 1989 | 1995 | 32.0 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| Cancer of Esophagus | 0 | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Cancer of Gastrointestinal Tract | 0 | | 1999 | 2011 | 18.8 | low | 0 | 0 | 1 | 2 | 1 | 0 |
| Cancer of Liver | 0 | | 1986 | 2017 | 26.3 | low | 0 | 3 | 1 | 0 | 2 | 0 |
| Cancer of Lung | 0 | | 1988 | 2023 | 12.2 | low | 0 | 2 | 1 | 0 | 2 | 5 |
| Cancer of Ovary | 0 | | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Cancer of Pancreas | 0 | | 1989 | 2008 | 28.5 | low | 0 | 5 | 3 | 4 | 0 | 0 |
| Cancer of Parathyroid | 0 | | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Cancer of Pituitary | 0 | | 1987 | 1995 | 33.0 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| Cancer of Rectum | 0 | | 1992 | 1993 | 31.5 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| Cancer of Stomach | 0 | | 1984 | 2022 | 21.4 | low | 0 | 1 | 2 | 3 | 1 | 1 |
| Carcinogenesis | 0 | | 2015 | 2017 | 8.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Carcinoma | 0 | | 2000 | 2001 | 23.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| Carcinoma, Anaplastic | 0 | | 2000 | 2001 | 23.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| Carcinoma, Bronchial | 0 | | 1989 | 1989 | 35.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Carcinoma, Bronchogenic | 0 | | 1989 | 1989 | 35.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Carcinoma, Epidermoid | 0 | | 1998 | 2008 | 21.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| Carcinoma, Large Cell | 0 | | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Carcinoma, Neuroendocrine | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 3 |
| Carcinoma, Non-Small Cell Lung | 0 | | 1998 | 2022 | 14.0 | low | 0 | 0 | 1 | 0 | 0 | 1 |
| Carcinoma, Non-Small-Cell Lung | 0 | | 1998 | 2022 | 14.0 | low | 0 | 0 | 1 | 0 | 0 | 1 |
| Carcinoma, Small Cell Lung | 0 | | 2014 | 2022 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 2 |
| Carcinoma, Squamous Cell | 0 | | 1998 | 2008 | 21.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| Cell Transformation, Neoplastic | 0 | | 2007 | 2012 | 14.5 | low | 0 | 0 | 0 | 2 | 2 | 0 |
| Cholera Infantum | 0 | | 1984 | 2011 | 25.5 | low | 0 | 1 | 1 | 1 | 1 | 0 |
| Chronic Hepatitis | 0 | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Chronic Kidney Failure | 0 | | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Cirrhosis, Liver | 0 | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Colonic Neoplasms | 0 | | 1992 | 2017 | 20.0 | low | 0 | 0 | 7 | 4 | 5 | 0 |
| Colonic Polyps | 0 | | 2001 | 2013 | 15.3 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Colorectal Cancer | 0 | | 1993 | 2017 | 20.4 | low | 0 | 0 | 7 | 11 | 4 | 0 |
| Colorectal Neoplasms | 0 | | 1993 | 2017 | 20.4 | low | 0 | 0 | 7 | 11 | 4 | 0 |
| Coma | 0 | | 1988 | 1988 | 36.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Common Bile Duct Neoplasms | 0 | | 1990 | 1990 | 34.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Condition, Preneoplastic | 0 | | 2000 | 2004 | 22.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| Curling Ulcer | 0 | | 1981 | 1993 | 37.5 | low | 0 | 7 | 4 | 0 | 0 | 0 |
| Diarrhea | 0 | | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Diathesis | 0 | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Digestive System Diseases | 0 | | 1988 | 1988 | 36.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Digestive System Disorders | 0 | | 1988 | 1988 | 36.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Disease Exacerbation | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| Disease Models, Animal | 0 | | 2011 | 2012 | 12.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Duodenal Ulcer | 0 | | 1981 | 1993 | 37.5 | low | 0 | 7 | 4 | 0 | 0 | 0 |
| Dyspepsia | 0 | | 1994 | 2000 | 27.0 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| Esophageal Neoplasms | 0 | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Esophagitis | 0 | | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Gastric Ulcer | 0 | | 1984 | 1985 | 39.3 | low | 0 | 3 | 0 | 0 | 0 | 0 |
| Gastrin-Producing Tumor | 0 | | 1988 | 2014 | 31.9 | low | 0 | 7 | 6 | 0 | 1 | 0 |
| Gastrinoma | 0 | | 1988 | 2014 | 31.9 | low | 0 | 7 | 6 | 0 | 1 | 0 |
| Gastritis | 0 | | 1985 | 1989 | 37.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| Gastritis, Atrophic | 0 | | 1985 | 1989 | 37.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| Gastroduodenal Ulcer | 0 | | 1984 | 2011 | 28.0 | low | 0 | 1 | 3 | 0 | 1 | 0 |
| Glioblastoma | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Helicobacter Infections | 0 | | 1993 | 2003 | 25.3 | low | 0 | 0 | 5 | 5 | 0 | 0 |
| Hepatitis, Chronic | 0 | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Hepatitis, Viral, Human | 0 | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Hyperparathyroidism | 0 | | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Hyperplasia | 0 | | 1986 | 2023 | 18.4 | low | 0 | 2 | 1 | 2 | 1 | 2 |
| Hypertrophy | 0 | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Indigestion | 0 | | 1994 | 2000 | 27.0 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| Infections, Helicobacter | 0 | | 1993 | 2003 | 25.3 | low | 0 | 0 | 5 | 5 | 0 | 0 |
| Insulinoma | 0 | | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Invasiveness, Neoplasm | 0 | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Island Cell Tumor | 0 | | 1987 | 1987 | 37.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Kidney Failure | 0 | | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Kidney Failure, Chronic | 0 | | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Leucocythaemia | 0 | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Leukemia | 0 | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Liver Cirrhosis | 0 | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Liver Neoplasms | 0 | | 1986 | 2017 | 26.3 | low | 0 | 3 | 1 | 0 | 2 | 0 |
| Lung Neoplasms | 0 | | 1988 | 2023 | 12.2 | low | 0 | 2 | 1 | 0 | 2 | 5 |
| Metastase | 0 | | 2003 | 2012 | 17.7 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| Multiple Primary Neoplasms | 0 | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Neoplasm Metastasis | 0 | | 2003 | 2012 | 17.7 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| Neoplasms | 0 | | 2006 | 2021 | 9.8 | low | 0 | 0 | 0 | 2 | 1 | 1 |
| Neuroendocrine Tumors | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 3 |
| Ovarian Neoplasms | 0 | | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Pancreatic Neoplasms | 0 | | 1989 | 2008 | 28.5 | low | 0 | 5 | 3 | 4 | 0 | 0 |
| Parathyroid Neoplasms | 0 | | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Peptic Ulcer | 0 | | 1984 | 2011 | 28.0 | low | 0 | 1 | 3 | 0 | 1 | 0 |
| Pituitary Neoplasms | 0 | | 1987 | 1995 | 33.0 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| Precancerous Conditions | 0 | | 2000 | 2004 | 22.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| Pregnancy | 0 | | 1989 | 1993 | 33.3 | low | 0 | 1 | 2 | 0 | 0 | 0 |
| Prostatic Neoplasms, Castration-Resistant | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| Rectal Neoplasms | 0 | | 1992 | 1993 | 31.5 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| Renal Insufficiency | 0 | | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Sensitivity and Specificity | 0 | | 1998 | 2021 | 14.5 | low | 0 | 0 | 1 | 0 | 0 | 1 |
| Small Cell Lung Carcinoma | 0 | | 2014 | 2022 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 2 |
| Stomach Neoplasms | 0 | | 1984 | 2022 | 21.4 | low | 0 | 1 | 2 | 3 | 1 | 1 |
| Stomach Ulcer | 0 | | 1984 | 1985 | 39.3 | low | 0 | 3 | 0 | 0 | 0 | 0 |
| Viral Hepatitis, Human | 0 | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Zollinger-Ellison Syndrome | 0 | | 1980 | 1998 | 36.5 | low | 0 | 10 | 6 | 0 | 0 | 0 |
Progastrin: a potential predictive marker of liver metastasis in colorectal cancer.International journal of colorectal disease, , Volume: 32, Issue:7, 2017
Characterization of gastrins and their receptor in solid human gastric adenocarcinomas.Scandinavian journal of gastroenterology, , Volume: 48, Issue:6, 2013
The biological and therapeutic importance of gastrin gene expression in pancreatic adenocarcinomas.Cancer research, , Aug-15, Volume: 64, Issue:16, 2004
Expression of gastrin in developing gastric adenocarcinoma.The British journal of surgery, , Volume: 88, Issue:4, 2001
Clinicopathologic characteristics of patients with nonsmall cell lung carcinoma with elevated serum progastrin-releasing peptide levels.Cancer, , Mar-15, Volume: 82, Issue:6, 1998
Expression but incomplete maturation of progastrin in colorectal carcinomas.Gastroenterology, , Volume: 104, Issue:4, 1993
Gastrin in non-neoplastic pancreatic tissue from patients with and without gastrinomas.Scandinavian journal of gastroenterology, , Volume: 25, Issue:9, 1990
[Amino-terminal fragment of human big gastrin-like immunoreactivity in antral mucosal extracts from patients with upper gastrointestinal diseases].Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, , Volume: 81, Issue:7, 1984
Activation of pro-oncogenic pathways in colorectal hyperplastic polyps.BMC cancer, , Nov-08, Volume: 13, 2013
Beta-catenin/Tcf-4 inhibition after progastrin targeting reduces growth and drives differentiation of intestinal tumors.Gastroenterology, , Volume: 133, Issue:5, 2007
Progastrin expression predisposes mice to colon carcinomas and adenomas in response to a chemical carcinogen.Gastroenterology, , Volume: 119, Issue:1, 2000
The significance of elevated levels of gastrin in patients with pituitary adenoma.Clinical endocrinology, , Volume: 27, Issue:4, 1987
Hyperparathyroid glands contain G-17 and G-34 gastrin.The Journal of surgical research, , Volume: 41, Issue:3, 1986
[Significance of an elevated concentration of gastrin in patients with pituitary adenoma].Archivos de investigacion medica, , Volume: 18, Issue:4
Developmental expression of the gastrin and cholecystokinin genes in rat colon.Gastroenterology, , Volume: 104, Issue:4, 1993
Low tissue gastrin content in the ovine distal duodenum is associated with increased percentage of G34.Comparative biochemistry and physiology. Comparative physiology, , Volume: 104, Issue:3, 1993
Progastrin expression in mammalian pancreas.Proceedings of the National Academy of Sciences of the United States of America, , Volume: 87, Issue:1, 1990
Occurrence and neonatal development of N-terminal (1-15) immunoreactivity of big gastrin in the rat antrum.Gastroenterologia Japonica, , Volume: 21, Issue:3, 1986
Plasma hPGBMC cancer, , Apr-04, Volume: 23, Issue:1, 2023
[On detection of chromogranin A, synaptophysin, neuronspecific enolase and progastrin-releasing peptide in small cell lung cancer].Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine], , Jul-06, Volume: 56, Issue:7, 2022
Clinicopathologic characteristics of patients with nonsmall cell lung carcinoma with elevated serum progastrin-releasing peptide levels.Cancer, , Mar-15, Volume: 82, Issue:6, 1998
Immunohistochemical examination of gastrin, gastrin precursors, and gastrin/CCK-2 receptor in human esophageal squamous cell carcinomas.Pathology oncology research : POR, , Volume: 14, Issue:4, 2008
Clinicopathologic characteristics of patients with nonsmall cell lung carcinoma with elevated serum progastrin-releasing peptide levels.Cancer, , Mar-15, Volume: 82, Issue:6, 1998
The G-protein coupled receptor 56, expressed in colonic stem and cancer cells, binds progastrin to promote proliferation and carcinogenesis.Oncotarget, , Jun-20, Volume: 8, Issue:25, 2017
Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem-like Cells.Cancer research, , 06-15, Volume: 76, Issue:12, 2016
Progastrin represses the alternative activation of human macrophages and modulates their influence on colon cancer epithelial cells.PloS one, , Volume: 9, Issue:6, 2014
A new biomarker that predicts colonic neoplasia outcome in patients with hyperplastic colonic polyps.Cancer prevention research (Philadelphia, Pa.), , Volume: 5, Issue:4, 2012
P53 gene mutation increases progastrin dependent colonic proliferation and colon cancer formation in mice.Cancer investigation, , Volume: 30, Issue:4, 2012
Activation of NF-kappaB is required for mediating proliferative and antiapoptotic effects of progastrin on proximal colonic crypts of mice, in vivo.Oncogene, , Sep-18, Volume: 27, Issue:42, 2008
Annexin II binds progastrin and gastrin-like peptides, and mediates growth factor effects of autocrine and exogenous gastrins on colon cancer and intestinal epithelial cells.Oncogene, , Jan-18, Volume: 26, Issue:3, 2007
Intestinal expression of mutant and wild-type progastrin significantly increases colon carcinogenesis in response to azoxymethane in transgenic mice.Cancer, , Mar-15, Volume: 100, Issue:6, 2004
Precursor peptide progastrin(1-80) reduces apoptosis of intestinal epithelial cells and upregulates cytochrome c oxidase Vb levels and synthesis of ATP.American journal of physiology. Gastrointestinal and liver physiology, , Volume: 285, Issue:6, 2003
Mice overexpressing progastrin are predisposed for developing aberrant colonic crypt foci in response to AOM.American journal of physiology. Gastrointestinal and liver physiology, , Volume: 278, Issue:3, 2000
Progastrin expression predisposes mice to colon carcinomas and adenomas in response to a chemical carcinogen.Gastroenterology, , Volume: 119, Issue:1, 2000
Gastrin gene products and gastrin receptors in colon cancer.Gastroenterology, , Volume: 111, Issue:1, 1996
Gastrin gene expression is required for the proliferation and tumorigenicity of human colon cancer cells.Cancer research, , Sep-15, Volume: 56, Issue:18, 1996
Incomplete processing of progastrin expressed by human colon cancer cells: role of noncarboxyamidated gastrins.The American journal of physiology, , Volume: 266, Issue:3 Pt 1, 1994
Expression but incomplete maturation of progastrin in colorectal carcinomas.Gastroenterology, , Volume: 104, Issue:4, 1993
Post-translational processing of gastrin in neoplastic human colonic tissues.Biochemical and biophysical research communications, , Dec-15, Volume: 189, Issue:2, 1992
JMV1155: a novel inhibitor of glycine-extended progastrin-mediated growth of a human colon cancer in vivo.Anticancer research, , Volume: 19, Issue:1A
Activation of pro-oncogenic pathways in colorectal hyperplastic polyps.BMC cancer, , Nov-08, Volume: 13, 2013
A new biomarker that predicts colonic neoplasia outcome in patients with hyperplastic colonic polyps.Cancer prevention research (Philadelphia, Pa.), , Volume: 5, Issue:4, 2012
Plasma levels of progastrin but not amidated gastrin or glycine extended gastrin are elevated in patients with colorectal carcinoma.Gut, , Volume: 48, Issue:1, 2001
Helicobacter pylori related hypergastrinaemia is the result of a selective increase in gastrin 17.Gut, , Volume: 34, Issue:6, 1993
Processing-independent analysis (PIA)--a new diagnostic tool.Scandinavian journal of clinical and laboratory investigation. Supplementum, , Volume: 204, 1991
Radioimmunoassay for sequence 38-54 of human progastrin: increased diagnostic specificity of gastrin-cell diseases.Clinica chimica acta; international journal of clinical chemistry, , Nov-15, Volume: 192, Issue:1, 1990
Progastrin in serum from Zollinger-Ellison patients. An indicator of malignancy?Gastroenterology, , Volume: 98, Issue:6, 1990
NH2-terminal of gastrin-17 in duodenal ulcer disease: identification of progastrin-17.Biochemical and biophysical research communications, , Jul-31, Volume: 146, Issue:2, 1987
Postprandial changes in serum concentrations of gastrin-17, gastrin-34, and total gastrin in patients with duodenal or gastric ulcers and in normal subjects.Clinical therapeutics, , Volume: 7, Issue:6, 1985
Decreased sulfation of serum and tissue gastrin in hypergastrinemia of antral origin.Digestion, , Volume: 31, Issue:1, 1985
Abnormal processing of antral gastrin in active duodenal ulcer disease.European journal of clinical investigation, , Volume: 14, Issue:3, 1984
Similar acid stimulatory potencies of synthetic human big and little gastrins in man.The Journal of clinical investigation, , Volume: 73, Issue:5, 1984
Evidence that gastrin 34 is preferentially released from the human duodenum.Gastroenterology, , Volume: 83, Issue:1 Pt 2, 1982
More so-called big-big gastrin in patients with duodenal ulcer after feeding.Annals of clinical biochemistry, , Volume: 18 (Pt 2), 1981
Carboxyl terminal glycine extended progastrin (gastrin-G) in gastric antral mucosa of patients with gastric or duodenal ulcer and in gastrinomas.Journal of gastroenterology and hepatology, , Volume: 5, Issue:5
Plasma Progastrin-Releasing Peptide and Chromogranin A Assays for Diagnosing and Monitoring Lung Well-Differentiated Neuroendocrine Tumors: A Brief Report.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, , Volume: 18, Issue:3, 2023
Activation of pro-oncogenic pathways in colorectal hyperplastic polyps.BMC cancer, , Nov-08, Volume: 13, 2013
Functional cross-talk between beta-catenin and NFkappaB signaling pathways in colonic crypts of mice in response to progastrin.The Journal of biological chemistry, , Aug-14, Volume: 284, Issue:33, 2009
Signaling pathways associated with colonic mucosa hyperproliferation in mice overexpressing gastrin precursors.Cancer research, , Apr-01, Volume: 65, Issue:7, 2005
Overexpression of glycine-extended gastrin in transgenic mice results in increased colonic proliferation.The Journal of clinical investigation, , Volume: 103, Issue:8, 1999
Expression of the C-terminal flanking peptide of human progastrin in human gastroduodenal mucosa, G-cell hyperplasia and islet cell tumours producing gastrin.Molecular and cellular probes, , Volume: 1, Issue:1, 1987
Hyperparathyroid glands contain G-17 and G-34 gastrin.The Journal of surgical research, , Volume: 41, Issue:3, 1986
JMV1155: a novel inhibitor of glycine-extended progastrin-mediated growth of a human colon cancer in vivo.Anticancer research, , Volume: 19, Issue:1A
Progastrin: a potential predictive marker of liver metastasis in colorectal cancer.International journal of colorectal disease, , Volume: 32, Issue:7, 2017
The C-terminal flanking peptide of progastrin induces gastric cell apoptosis and stimulates colonic cell division in vivo.Peptides, , Volume: 46, 2013
Expression of gastrin, gastrin/CCK-B and gastrin/CCK-C receptors in human colorectal carcinomas.Journal of cancer research and clinical oncology, , Volume: 121, Issue:11, 1995
The human gastrin precursor. Characterization of phosphorylated forms and fragments.The Biochemical journal, , Dec-15, Volume: 256, Issue:3, 1988
Isolation and characterization of the intact gastrin precursor from a gastrinoma.FEBS letters, , Jan-05, Volume: 210, Issue:2, 1987
Evaluation of NH2-terminus gastrins in gastrinoma syndrome.The Journal of clinical endocrinology and metabolism, , Volume: 62, Issue:5, 1986
Plasma Progastrin-Releasing Peptide and Chromogranin A Assays for Diagnosing and Monitoring Lung Well-Differentiated Neuroendocrine Tumors: A Brief Report.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, , Volume: 18, Issue:3, 2023
Comment on "Plasma Progastrin-Releasing Peptide and Chromogranin A Assays for Diagnosing and Monitoring Lung Well-Differentiated Neuroendocrine Tumors: A Brief Report".Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, , Volume: 18, Issue:11, 2023
[On detection of chromogranin A, synaptophysin, neuronspecific enolase and progastrin-releasing peptide in small cell lung cancer].Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine], , Jul-06, Volume: 56, Issue:7, 2022
The diagnostic value of the combination of carcinoembryonic antigen, squamous cell carcinoma-related antigen, CYFRA 21-1, neuron-specific enolase, tissue polypeptide antigen, and progastrin-releasing peptide in small cell lung cancer discrimination.The International journal of biological markers, , Volume: 36, Issue:4, 2021
[Multicenter Evaluation of A New Progastrin-releasing Peptide (ProGRP) Immunoassay across Europe and China].Zhongguo fei ai za zhi = Chinese journal of lung cancer, , Aug-20, Volume: 20, Issue:8, 2017
Peptide imprinted receptors for the determination of the small cell lung cancer associated biomarker progastrin releasing peptide.Journal of chromatography. A, , Nov-28, Volume: 1370, 2014
Clinicopathologic characteristics of patients with nonsmall cell lung carcinoma with elevated serum progastrin-releasing peptide levels.Cancer, , Mar-15, Volume: 82, Issue:6, 1998
Gastrin in human bronchogenic carcinomas: constant expression but variable processing of progastrin.Cancer research, , Jun-01, Volume: 49, Issue:11, 1989
Processing-independent radioimmunoanalysis: a general analytical principle applied to progastrin and its products.Analytical biochemistry, , Volume: 175, Issue:2, 1988
Progastrin overexpression imparts tumorigenic/metastatic potential to embryonic epithelial cells: phenotypic differences between transformed and nontransformed stem cells.International journal of cancer, , Oct-01, Volume: 131, Issue:7, 2012
Role of progastrins and gastrins and their receptors in GI and pancreatic cancers: targets for treatment.Current pharmaceutical design, , Volume: 10, Issue:19, 2004
Adherens junctions and tight junctions are regulated via different pathways by progastrin in epithelial cells.Journal of cell science, , Apr-01, Volume: 116, Issue:Pt 7, 2003
A novel method to detect hPGAnalytical methods : advancing methods and applications, , 10-08, Volume: 13, Issue:38, 2021
The oncogenic and druggable hPG80 (Progastrin) is overexpressed in multiple cancers and detected in the blood of patients.EBioMedicine, , Volume: 51, 2020
Cell-specific precursor processing.Results and problems in cell differentiation, , Volume: 50, 2010
Gastrin and cancer: a review.Cancer letters, , Jul-08, Volume: 238, Issue:1, 2006
Characterization of gastrin-cholecystokinin 2 receptor interaction in relation to c-fos induction.Endocrine-related cancer, , Volume: 15, Issue:1, 2008
Antiapoptotic effects of progastrin on pancreatic cancer cells are mediated by sustained activation of nuclear factor-{kappa}B.Cancer research, , Aug-01, Volume: 67, Issue:15, 2007
Role of progastrins and gastrins and their receptors in GI and pancreatic cancers: targets for treatment.Current pharmaceutical design, , Volume: 10, Issue:19, 2004
The biological and therapeutic importance of gastrin gene expression in pancreatic adenocarcinomas.Cancer research, , Aug-15, Volume: 64, Issue:16, 2004
Processing-independent analysis in the diagnosis of gastrinomas.Scandinavian journal of gastroenterology, , Volume: 33, Issue:4, 1998
Gastrin in non-neoplastic pancreatic tissue from patients with and without gastrinomas.Scandinavian journal of gastroenterology, , Volume: 25, Issue:9, 1990
Gastrinoma in vitro: morphological and physiological studies of primary cell cultures.Gastroenterology, , Volume: 98, Issue:4, 1990
Carboxyl terminal glycine extended progastrin (gastrin-G) in human gastric mucosa and gastrinomas.Clinica chimica acta; international journal of clinical chemistry, , Feb-15, Volume: 179, Issue:2, 1989
Immunohistochemical characterization of gastrinomas with antibodies specific to different fragments of progastrin.Gastroenterologie clinique et biologique, , Volume: 13, Issue:11, 1989
[Gastrin--human gene, processing, degradation].Nihon rinsho. Japanese journal of clinical medicine, , Volume: 47, Issue:10, 1989
Gastrin processing in primary culture of gastrinoma cells.Hormone research, , Volume: 32, Issue:1-3, 1989
Intraocular transplants of a human gastrinoma in immuno-suppressed rats: morphological, chromatographic and functional studies.Regulatory peptides, , Volume: 24, Issue:1, 1989
Gastrin in gastrointestinal diseases.Gastroenterology, , Volume: 141, Issue:3, 2011
Processing-independent analysis in the diagnosis of gastrinomas.Scandinavian journal of gastroenterology, , Volume: 33, Issue:4, 1998
Gastrin and somatostatin in Helicobacter pylori infected antral mucosa.Gut, , Volume: 35, Issue:5, 1994
Helicobacter pylori infection and exaggerated gastrin release. Effects of inflammation and progastrin processing.Scandinavian journal of gastroenterology, , Volume: 28, Issue:8, 1993
[Amino-terminal fragment of human big gastrin-like immunoreactivity in antral mucosal extracts from patients with upper gastrointestinal diseases].Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, , Volume: 81, Issue:7, 1984
Specificity of prohormone convertase endoproteolysis of progastrin in AtT-20 cells.The Journal of clinical investigation, , Volume: 96, Issue:3, 1995
The significance of elevated levels of gastrin in patients with pituitary adenoma.Clinical endocrinology, , Volume: 27, Issue:4, 1987
[Significance of an elevated concentration of gastrin in patients with pituitary adenoma].Archivos de investigacion medica, , Volume: 18, Issue:4
Developmental expression of the gastrin and cholecystokinin genes in rat colon.Gastroenterology, , Volume: 104, Issue:4, 1993
Plasma gastrin and somatostatin in newborn infants and their relationship to catecholamines.Journal of developmental physiology, , Volume: 14, Issue:3, 1990
Plasma concentrations of cholecystokinin, CCK-8, and CCK-33, 39 in rats, determined by a method based on enzyme digestion of gastrin before HPLC and RIA detection of CCK.Gut, , Volume: 30, Issue:2, 1989
Increased gastrin precursor secretion in preterm infants and their mothers at birth.Journal of pediatric endocrinology & metabolism : JPEM, , Volume: 13, Issue:9
The diagnostic value of the combination of carcinoembryonic antigen, squamous cell carcinoma-related antigen, CYFRA 21-1, neuron-specific enolase, tissue polypeptide antigen, and progastrin-releasing peptide in small cell lung cancer discrimination.The International journal of biological markers, , Volume: 36, Issue:4, 2021
Processing-independent analysis in the diagnosis of gastrinomas.Scandinavian journal of gastroenterology, , Volume: 33, Issue:4, 1998
Association between Serum Progastrin Biomarker Level and Gastric Cancer.Asian Pacific journal of cancer prevention : APJCP, , Oct-01, Volume: 23, Issue:10, 2022
Characterization of gastrins and their receptor in solid human gastric adenocarcinomas.Scandinavian journal of gastroenterology, , Volume: 48, Issue:6, 2013
Influence of COX-2 inhibition by rofecoxib on serum and tumor progastrin and gastrin levels and expression of PPARgamma and apoptosis-related proteins in gastric cancer patients.Digestive diseases and sciences, , Volume: 48, Issue:10, 2003
Serum progastrin and its products, gastric acid secretion and serum pepsinogen I in gastric cancer.Digestion, , Volume: 68, Issue:4, 2003
Expression of gastrin in developing gastric adenocarcinoma.The British journal of surgery, , Volume: 88, Issue:4, 2001
Expression of progastrin-derived peptides and gastrin receptors in a panel of gastrointestinal carcinoma cell lines.Journal of gastroenterology and hepatology, , Volume: 13, Issue:2, 1998
Regulation of growth of human gastric cancer by gastrin and glycine-extended progastrin.Gastroenterology, , Volume: 113, Issue:3, 1997
[Amino-terminal fragment of human big gastrin-like immunoreactivity in antral mucosal extracts from patients with upper gastrointestinal diseases].Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, , Volume: 81, Issue:7, 1984
Decreased sulfation of serum and tissue gastrin in hypergastrinemia of antral origin.Digestion, , Volume: 31, Issue:1, 1985
Postprandial changes in serum concentrations of gastrin-17, gastrin-34, and total gastrin in patients with duodenal or gastric ulcers and in normal subjects.Clinical therapeutics, , Volume: 7, Issue:6, 1985
Abnormal processing of antral gastrin in active duodenal ulcer disease.European journal of clinical investigation, , Volume: 14, Issue:3, 1984
Carboxyl terminal glycine extended progastrin (gastrin-G) in gastric antral mucosa of patients with gastric or duodenal ulcer and in gastrinomas.Journal of gastroenterology and hepatology, , Volume: 5, Issue:5
Processing-independent analysis in the diagnosis of gastrinomas.Scandinavian journal of gastroenterology, , Volume: 33, Issue:4, 1998
Processing-independent analysis (PIA)--a new diagnostic tool.Scandinavian journal of clinical and laboratory investigation. Supplementum, , Volume: 204, 1991
Progastrin in serum from Zollinger-Ellison patients. An indicator of malignancy?Gastroenterology, , Volume: 98, Issue:6, 1990
Progastrin in pancreas and the Zollinger-Ellison syndrome.Scandinavian journal of gastroenterology, , Volume: 25, Issue:12, 1990
Radioimmunoassay for sequence 38-54 of human progastrin: increased diagnostic specificity of gastrin-cell diseases.Clinica chimica acta; international journal of clinical chemistry, , Nov-15, Volume: 192, Issue:1, 1990
Gastrin in non-neoplastic pancreatic tissue from patients with and without gastrinomas.Scandinavian journal of gastroenterology, , Volume: 25, Issue:9, 1990
Isolation and characterization of the intact gastrin precursor from a gastrinoma.FEBS letters, , Jan-05, Volume: 210, Issue:2, 1987
Progastrin and its glycine-extended posttranslational processing intermediates in human gastrointestinal tissues.Gastroenterology, , Volume: 92, Issue:6, 1987
Biosynthesis of gastrin. Localization of the precursor and peptide products using electron microscopic-immunogold methods.Gastroenterology, , Volume: 92, Issue:5 Pt 1, 1987
[Plasma gastrin and progastrin levels in healthy controls and patients with gastrinoma].Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, , Volume: 83, Issue:7, 1986
Identification of progastrin in gastrinomas, antrum, and duodenum by a novel radioimmunoassay.The Journal of clinical investigation, , Volume: 77, Issue:2, 1986
Evaluation of NH2-terminus gastrins in gastrinoma syndrome.The Journal of clinical endocrinology and metabolism, , Volume: 62, Issue:5, 1986
Light and electron microscope localization of G-17- and G-34-like immunoreactivities of human gastrinomas.Ultrastructural pathology, , Volume: 8, Issue:4, 1985
Amino terminal fragments of human progastrin from gastrinoma.Biochemical and biophysical research communications, , Aug-30, Volume: 123, Issue:1, 1984
Misuse of gastrin radioimmunoassay kits.Lancet (London, England), , Aug-06, Volume: 2, Issue:8345, 1983
N-Terminal sequence of human big gastrin: sequence, synthetic and immunochemical studies.Hoppe-Seyler's Zeitschrift fur physiologische Chemie, , Volume: 361, Issue:11, 1980
Carboxyl terminal glycine extended progastrin (gastrin-G) in gastric antral mucosa of patients with gastric or duodenal ulcer and in gastrinomas.Journal of gastroenterology and hepatology, , Volume: 5, Issue:5
Progastrin: a potential predictive marker of liver metastasis in colorectal cancer.International journal of colorectal disease, , Volume: 32, Issue:7, 2017
Progastrin a new pro-angiogenic factor in colorectal cancer.Oncogene, , Jun-11, Volume: 34, Issue:24, 2015
Circulating gastrin concentrations in patients at increased risk of developing colorectal carcinoma.Journal of gastroenterology and hepatology, , Volume: 29, Issue:3, 2014
MicroRNA-148b suppresses cell growth by targeting cholecystokinin-2 receptor in colorectal cancer.International journal of cancer, , Sep-01, Volume: 131, Issue:5, 2012
Inactivating cholecystokinin-2 receptor inhibits progastrin-dependent colonic crypt fission, proliferation, and colorectal cancer in mice.The Journal of clinical investigation, , Volume: 119, Issue:9, 2009
Expression of gastrin precursors by CD133-positive colorectal cancer cells is crucial for tumour growth.Biochimica et biophysica acta, , Volume: 1793, Issue:3, 2009
The wnt target jagged-1 mediates the activation of notch signaling by progastrin in human colorectal cancer cells.Cancer research, , Aug-01, Volume: 69, Issue:15, 2009
Characterization of gastrin-cholecystokinin 2 receptor interaction in relation to c-fos induction.Endocrine-related cancer, , Volume: 15, Issue:1, 2008
Beta-catenin/Tcf-4 inhibition after progastrin targeting reduces growth and drives differentiation of intestinal tumors.Gastroenterology, , Volume: 133, Issue:5, 2007
Production, secretion, and biological activity of the C-terminal flanking peptide of human progastrin.Gastroenterology, , Volume: 131, Issue:5, 2006
PPARalpha agonists stimulate progastrin production in human colorectal carcinoma cells.Regulatory peptides, , Aug-15, Volume: 120, Issue:1-3, 2004
Adherens junctions and tight junctions are regulated via different pathways by progastrin in epithelial cells.Journal of cell science, , Apr-01, Volume: 116, Issue:Pt 7, 2003
Progastrin and cyclooxygenase-2 in colorectal cancer.Digestive diseases and sciences, , Volume: 47, Issue:9, 2002
Plasma levels of progastrin but not amidated gastrin or glycine extended gastrin are elevated in patients with colorectal carcinoma.Gut, , Volume: 48, Issue:1, 2001
Biology and pathology of non-amidated gastrins.Scandinavian journal of clinical and laboratory investigation. Supplementum, , Volume: 234, 2001
Expression of progastrin-derived peptides and gastrin receptors in a panel of gastrointestinal carcinoma cell lines.Journal of gastroenterology and hepatology, , Volume: 13, Issue:2, 1998
Binding of progastrin fragments to the 78 kDa gastrin-binding protein.FEBS letters, , Feb-06, Volume: 359, Issue:1, 1995
Expression of gastrin, gastrin/CCK-B and gastrin/CCK-C receptors in human colorectal carcinomas.Journal of cancer research and clinical oncology, , Volume: 121, Issue:11, 1995
Expression, processing, and secretion of gastrin in patients with colorectal carcinoma.Gastroenterology, , Volume: 109, Issue:4, 1995
Expression but incomplete maturation of progastrin in colorectal carcinomas.Gastroenterology, , Volume: 104, Issue:4, 1993
Expression of the gastrin gene in the normal human colon and colorectal adenocarcinoma.Cancer research, , Jun-15, Volume: 53, Issue:12, 1993
Identification of progastrin derived peptides in colorectal carcinoma extracts.Gut, , Volume: 34, Issue:1, 1993
An evaluation of chromogranin A versus gastrin and progastrin in gastrinoma diagnosis and control.Biomarkers in medicine, , Volume: 8, Issue:4, 2014
Processing-independent analysis in the diagnosis of gastrinomas.Scandinavian journal of gastroenterology, , Volume: 33, Issue:4, 1998
Brief report: a duodenal gastrinoma in a patient with diarrhea and normal serum gastrin concentrations.The New England journal of medicine, , Sep-07, Volume: 333, Issue:10, 1995
Purification and structural characterization of progastrin-derived peptides from a human gastrinoma.The Journal of biological chemistry, , Jul-05, Volume: 266, Issue:19, 1991
Processing-independent analysis (PIA)--a new diagnostic tool.Scandinavian journal of clinical and laboratory investigation. Supplementum, , Volume: 204, 1991
Gastrin in non-neoplastic pancreatic tissue from patients with and without gastrinomas.Scandinavian journal of gastroenterology, , Volume: 25, Issue:9, 1990
Gastrinoma in vitro: morphological and physiological studies of primary cell cultures.Gastroenterology, , Volume: 98, Issue:4, 1990
Immunohistochemical characterization of gastrinomas with antibodies specific to different fragments of progastrin.Gastroenterologie clinique et biologique, , Volume: 13, Issue:11, 1989
Carboxyl terminal glycine extended progastrin (gastrin-G) in human gastric mucosa and gastrinomas.Clinica chimica acta; international journal of clinical chemistry, , Feb-15, Volume: 179, Issue:2, 1989
Intraocular transplants of a human gastrinoma in immuno-suppressed rats: morphological, chromatographic and functional studies.Regulatory peptides, , Volume: 24, Issue:1, 1989
Gastrin processing in primary culture of gastrinoma cells.Hormone research, , Volume: 32, Issue:1-3, 1989
[Gastrin--human gene, processing, degradation].Nihon rinsho. Japanese journal of clinical medicine, , Volume: 47, Issue:10, 1989
The human gastrin precursor. Characterization of phosphorylated forms and fragments.The Biochemical journal, , Dec-15, Volume: 256, Issue:3, 1988
Processing-independent radioimmunoanalysis: a general analytical principle applied to progastrin and its products.Analytical biochemistry, , Volume: 175, Issue:2, 1988
Carboxyl terminal glycine extended progastrin (gastrin-G) in gastric antral mucosa of patients with gastric or duodenal ulcer and in gastrinomas.Journal of gastroenterology and hepatology, , Volume: 5, Issue:5
Serum progastrin and its products, gastric acid secretion and serum pepsinogen I in gastric cancer.Digestion, , Volume: 68, Issue:4, 2003
Influence of COX-2 inhibition by rofecoxib on serum and tumor progastrin and gastrin levels and expression of PPARgamma and apoptosis-related proteins in gastric cancer patients.Digestive diseases and sciences, , Volume: 48, Issue:10, 2003
Progastrin and its products from patients with chronic viral hepatitis and liver cirrhosis.Scandinavian journal of gastroenterology, , Volume: 38, Issue:6, 2003
Progastrin and cyclooxygenase-2 in colorectal cancer.Digestive diseases and sciences, , Volume: 47, Issue:9, 2002
Plasma levels of progastrin but not amidated gastrin or glycine extended gastrin are elevated in patients with colorectal carcinoma.Gut, , Volume: 48, Issue:1, 2001
Expression of progastrin-derived peptides and somatostatin in fundus and antrum of nonulcer dyspepsia subjects with and without Helicobacter pylori infection.Digestive diseases and sciences, , Volume: 45, Issue:10, 2000
Expression, processing, and secretion of gastrin in patients with colorectal carcinoma.Gastroenterology, , Volume: 109, Issue:4, 1995
Gastrin and somatostatin in Helicobacter pylori infected antral mucosa.Gut, , Volume: 35, Issue:5, 1994
Helicobacter pylori infection and exaggerated gastrin release. Effects of inflammation and progastrin processing.Scandinavian journal of gastroenterology, , Volume: 28, Issue:8, 1993
Helicobacter pylori related hypergastrinaemia is the result of a selective increase in gastrin 17.Gut, , Volume: 34, Issue:6, 1993
[On detection of chromogranin A, synaptophysin, neuronspecific enolase and progastrin-releasing peptide in small cell lung cancer].Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine], , Jul-06, Volume: 56, Issue:7, 2022
The diagnostic value of the combination of carcinoembryonic antigen, squamous cell carcinoma-related antigen, CYFRA 21-1, neuron-specific enolase, tissue polypeptide antigen, and progastrin-releasing peptide in small cell lung cancer discrimination.The International journal of biological markers, , Volume: 36, Issue:4, 2021
Peptide imprinted receptors for the determination of the small cell lung cancer associated biomarker progastrin releasing peptide.Journal of chromatography. A, , Nov-28, Volume: 1370, 2014
[On detection of chromogranin A, synaptophysin, neuronspecific enolase and progastrin-releasing peptide in small cell lung cancer].Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine], , Jul-06, Volume: 56, Issue:7, 2022
The diagnostic value of the combination of carcinoembryonic antigen, squamous cell carcinoma-related antigen, CYFRA 21-1, neuron-specific enolase, tissue polypeptide antigen, and progastrin-releasing peptide in small cell lung cancer discrimination.The International journal of biological markers, , Volume: 36, Issue:4, 2021
Peptide imprinted receptors for the determination of the small cell lung cancer associated biomarker progastrin releasing peptide.Journal of chromatography. A, , Nov-28, Volume: 1370, 2014
The G-protein coupled receptor 56, expressed in colonic stem and cancer cells, binds progastrin to promote proliferation and carcinogenesis.Oncotarget, , Jun-20, Volume: 8, Issue:25, 2017
CCK2R identifies and regulates gastric antral stem cell states and carcinogenesis.Gut, , Volume: 64, Issue:4, 2015
Impaired feedback of gastric functions in carboxypeptidase E-deficient mice.Biochemical and biophysical research communications, , Jan-19, Volume: 267, Issue:2, 2000
Effect of antrectomy and drug-induced achlorhydria on urinary excretion of N-terminal big gastrin immunoreactivity in rats.Regulatory peptides, , Nov-19, Volume: 49, Issue:1, 1993
Purification of N-terminal hexapeptide of big gastrin from human urine.Biochemical and biophysical research communications, , Nov-15, Volume: 172, Issue:3, 1990
Purification and structural determination of urinary NH2-terminal big gastrin fragments.Biochemical and biophysical research communications, , May-15, Volume: 160, Issue:3, 1989
Hypergastrinemia and achlorhydria in chronic renal failure.Nephron, , Volume: 40, Issue:2, 1985
Progastrin: a potential predictive marker of liver metastasis in colorectal cancer.International journal of colorectal disease, , Volume: 32, Issue:7, 2017
Characterization of gastrins and their receptor in solid human gastric adenocarcinomas.Scandinavian journal of gastroenterology, , Volume: 48, Issue:6, 2013
The biological and therapeutic importance of gastrin gene expression in pancreatic adenocarcinomas.Cancer research, , Aug-15, Volume: 64, Issue:16, 2004
Expression of gastrin in developing gastric adenocarcinoma.The British journal of surgery, , Volume: 88, Issue:4, 2001
Clinicopathologic characteristics of patients with nonsmall cell lung carcinoma with elevated serum progastrin-releasing peptide levels.Cancer, , Mar-15, Volume: 82, Issue:6, 1998
Expression but incomplete maturation of progastrin in colorectal carcinomas.Gastroenterology, , Volume: 104, Issue:4, 1993
Gastrin in non-neoplastic pancreatic tissue from patients with and without gastrinomas.Scandinavian journal of gastroenterology, , Volume: 25, Issue:9, 1990
[Amino-terminal fragment of human big gastrin-like immunoreactivity in antral mucosal extracts from patients with upper gastrointestinal diseases].Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, , Volume: 81, Issue:7, 1984
Activation of pro-oncogenic pathways in colorectal hyperplastic polyps.BMC cancer, , Nov-08, Volume: 13, 2013
Beta-catenin/Tcf-4 inhibition after progastrin targeting reduces growth and drives differentiation of intestinal tumors.Gastroenterology, , Volume: 133, Issue:5, 2007
Progastrin expression predisposes mice to colon carcinomas and adenomas in response to a chemical carcinogen.Gastroenterology, , Volume: 119, Issue:1, 2000
The significance of elevated levels of gastrin in patients with pituitary adenoma.Clinical endocrinology, , Volume: 27, Issue:4, 1987
Hyperparathyroid glands contain G-17 and G-34 gastrin.The Journal of surgical research, , Volume: 41, Issue:3, 1986
[Significance of an elevated concentration of gastrin in patients with pituitary adenoma].Archivos de investigacion medica, , Volume: 18, Issue:4
Gastrin biosynthesis in the antrum of patients with pernicious anemia.Gastroenterology, , Volume: 112, Issue:3, 1997
Radioimmunoassay for sequence 38-54 of human progastrin: increased diagnostic specificity of gastrin-cell diseases.Clinica chimica acta; international journal of clinical chemistry, , Nov-15, Volume: 192, Issue:1, 1990
Decreased sulfation of serum and tissue gastrin in hypergastrinemia of antral origin.Digestion, , Volume: 31, Issue:1, 1985
Abnormal processing of antral gastrin in active duodenal ulcer disease.European journal of clinical investigation, , Volume: 14, Issue:3, 1984
Plasma hPGBMC cancer, , Apr-04, Volume: 23, Issue:1, 2023
[On detection of chromogranin A, synaptophysin, neuronspecific enolase and progastrin-releasing peptide in small cell lung cancer].Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine], , Jul-06, Volume: 56, Issue:7, 2022
Clinicopathologic characteristics of patients with nonsmall cell lung carcinoma with elevated serum progastrin-releasing peptide levels.Cancer, , Mar-15, Volume: 82, Issue:6, 1998
Immunohistochemical examination of gastrin, gastrin precursors, and gastrin/CCK-2 receptor in human esophageal squamous cell carcinomas.Pathology oncology research : POR, , Volume: 14, Issue:4, 2008
Clinicopathologic characteristics of patients with nonsmall cell lung carcinoma with elevated serum progastrin-releasing peptide levels.Cancer, , Mar-15, Volume: 82, Issue:6, 1998
Progastrin overexpression imparts tumorigenic/metastatic potential to embryonic epithelial cells: phenotypic differences between transformed and nontransformed stem cells.International journal of cancer, , Oct-01, Volume: 131, Issue:7, 2012
P53 gene mutation increases progastrin dependent colonic proliferation and colon cancer formation in mice.Cancer investigation, , Volume: 30, Issue:4, 2012
Beta-catenin/Tcf-4 inhibition after progastrin targeting reduces growth and drives differentiation of intestinal tumors.Gastroenterology, , Volume: 133, Issue:5, 2007
Role of Annexin-II in GI cancers: interaction with gastrins/progastrins.Cancer letters, , Jul-08, Volume: 252, Issue:1, 2007
The G-protein coupled receptor 56, expressed in colonic stem and cancer cells, binds progastrin to promote proliferation and carcinogenesis.Oncotarget, , Jun-20, Volume: 8, Issue:25, 2017
Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem-like Cells.Cancer research, , 06-15, Volume: 76, Issue:12, 2016
Progastrin represses the alternative activation of human macrophages and modulates their influence on colon cancer epithelial cells.PloS one, , Volume: 9, Issue:6, 2014
A new biomarker that predicts colonic neoplasia outcome in patients with hyperplastic colonic polyps.Cancer prevention research (Philadelphia, Pa.), , Volume: 5, Issue:4, 2012
P53 gene mutation increases progastrin dependent colonic proliferation and colon cancer formation in mice.Cancer investigation, , Volume: 30, Issue:4, 2012
Activation of NF-kappaB is required for mediating proliferative and antiapoptotic effects of progastrin on proximal colonic crypts of mice, in vivo.Oncogene, , Sep-18, Volume: 27, Issue:42, 2008
Annexin II binds progastrin and gastrin-like peptides, and mediates growth factor effects of autocrine and exogenous gastrins on colon cancer and intestinal epithelial cells.Oncogene, , Jan-18, Volume: 26, Issue:3, 2007
Intestinal expression of mutant and wild-type progastrin significantly increases colon carcinogenesis in response to azoxymethane in transgenic mice.Cancer, , Mar-15, Volume: 100, Issue:6, 2004
Precursor peptide progastrin(1-80) reduces apoptosis of intestinal epithelial cells and upregulates cytochrome c oxidase Vb levels and synthesis of ATP.American journal of physiology. Gastrointestinal and liver physiology, , Volume: 285, Issue:6, 2003
Progastrin expression predisposes mice to colon carcinomas and adenomas in response to a chemical carcinogen.Gastroenterology, , Volume: 119, Issue:1, 2000
Mice overexpressing progastrin are predisposed for developing aberrant colonic crypt foci in response to AOM.American journal of physiology. Gastrointestinal and liver physiology, , Volume: 278, Issue:3, 2000
Gastrin gene expression is required for the proliferation and tumorigenicity of human colon cancer cells.Cancer research, , Sep-15, Volume: 56, Issue:18, 1996
Gastrin gene products and gastrin receptors in colon cancer.Gastroenterology, , Volume: 111, Issue:1, 1996
Incomplete processing of progastrin expressed by human colon cancer cells: role of noncarboxyamidated gastrins.The American journal of physiology, , Volume: 266, Issue:3 Pt 1, 1994
Expression but incomplete maturation of progastrin in colorectal carcinomas.Gastroenterology, , Volume: 104, Issue:4, 1993
Post-translational processing of gastrin in neoplastic human colonic tissues.Biochemical and biophysical research communications, , Dec-15, Volume: 189, Issue:2, 1992
JMV1155: a novel inhibitor of glycine-extended progastrin-mediated growth of a human colon cancer in vivo.Anticancer research, , Volume: 19, Issue:1A
Brief report: a duodenal gastrinoma in a patient with diarrhea and normal serum gastrin concentrations.The New England journal of medicine, , Sep-07, Volume: 333, Issue:10, 1995
Carboxyl terminal glycine extended progastrin (gastrin-G) in human gastric mucosa and gastrinomas.Clinica chimica acta; international journal of clinical chemistry, , Feb-15, Volume: 179, Issue:2, 1989
Helicobacter pylori related hypergastrinaemia is the result of a selective increase in gastrin 17.Gut, , Volume: 34, Issue:6, 1993
Processing-independent analysis (PIA)--a new diagnostic tool.Scandinavian journal of clinical and laboratory investigation. Supplementum, , Volume: 204, 1991
Progastrin in serum from Zollinger-Ellison patients. An indicator of malignancy?Gastroenterology, , Volume: 98, Issue:6, 1990
Radioimmunoassay for sequence 38-54 of human progastrin: increased diagnostic specificity of gastrin-cell diseases.Clinica chimica acta; international journal of clinical chemistry, , Nov-15, Volume: 192, Issue:1, 1990
NH2-terminal of gastrin-17 in duodenal ulcer disease: identification of progastrin-17.Biochemical and biophysical research communications, , Jul-31, Volume: 146, Issue:2, 1987
Postprandial changes in serum concentrations of gastrin-17, gastrin-34, and total gastrin in patients with duodenal or gastric ulcers and in normal subjects.Clinical therapeutics, , Volume: 7, Issue:6, 1985
Decreased sulfation of serum and tissue gastrin in hypergastrinemia of antral origin.Digestion, , Volume: 31, Issue:1, 1985
Abnormal processing of antral gastrin in active duodenal ulcer disease.European journal of clinical investigation, , Volume: 14, Issue:3, 1984
Similar acid stimulatory potencies of synthetic human big and little gastrins in man.The Journal of clinical investigation, , Volume: 73, Issue:5, 1984
Evidence that gastrin 34 is preferentially released from the human duodenum.Gastroenterology, , Volume: 83, Issue:1 Pt 2, 1982
More so-called big-big gastrin in patients with duodenal ulcer after feeding.Annals of clinical biochemistry, , Volume: 18 (Pt 2), 1981
Carboxyl terminal glycine extended progastrin (gastrin-G) in gastric antral mucosa of patients with gastric or duodenal ulcer and in gastrinomas.Journal of gastroenterology and hepatology, , Volume: 5, Issue:5
Gastrin in gastrointestinal diseases.Gastroenterology, , Volume: 141, Issue:3, 2011
Peptide processing and biology in human disease.Current opinion in endocrinology, diabetes, and obesity, , Volume: 16, Issue:1, 2009
Temporal profiles of urinary excretion of NH2-terminal big gastrin immunoreactivity in humans.The American journal of gastroenterology, , Volume: 85, Issue:11, 1990
[Amino-terminal fragment of human big gastrin-like immunoreactivity in antral mucosal extracts from patients with upper gastrointestinal diseases].Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, , Volume: 81, Issue:7, 1984
Gastrin in gastrointestinal diseases.Gastroenterology, , Volume: 141, Issue:3, 2011
Role of Annexin-II in GI cancers: interaction with gastrins/progastrins.Cancer letters, , Jul-08, Volume: 252, Issue:1, 2007
Role of progastrins and gastrins and their receptors in GI and pancreatic cancers: targets for treatment.Current pharmaceutical design, , Volume: 10, Issue:19, 2004
Overexpression of glycine-extended gastrin in transgenic mice results in increased colonic proliferation.The Journal of clinical investigation, , Volume: 103, Issue:8, 1999
Progastrin: a potential predictive marker of liver metastasis in colorectal cancer.International journal of colorectal disease, , Volume: 32, Issue:7, 2017
The C-terminal flanking peptide of progastrin induces gastric cell apoptosis and stimulates colonic cell division in vivo.Peptides, , Volume: 46, 2013
Expression of gastrin, gastrin/CCK-B and gastrin/CCK-C receptors in human colorectal carcinomas.Journal of cancer research and clinical oncology, , Volume: 121, Issue:11, 1995
The human gastrin precursor. Characterization of phosphorylated forms and fragments.The Biochemical journal, , Dec-15, Volume: 256, Issue:3, 1988
Isolation and characterization of the intact gastrin precursor from a gastrinoma.FEBS letters, , Jan-05, Volume: 210, Issue:2, 1987
Evaluation of NH2-terminus gastrins in gastrinoma syndrome.The Journal of clinical endocrinology and metabolism, , Volume: 62, Issue:5, 1986
Comment on "Plasma Progastrin-Releasing Peptide and Chromogranin A Assays for Diagnosing and Monitoring Lung Well-Differentiated Neuroendocrine Tumors: A Brief Report".Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, , Volume: 18, Issue:11, 2023
Plasma Progastrin-Releasing Peptide and Chromogranin A Assays for Diagnosing and Monitoring Lung Well-Differentiated Neuroendocrine Tumors: A Brief Report.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, , Volume: 18, Issue:3, 2023
[On detection of chromogranin A, synaptophysin, neuronspecific enolase and progastrin-releasing peptide in small cell lung cancer].Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine], , Jul-06, Volume: 56, Issue:7, 2022
The diagnostic value of the combination of carcinoembryonic antigen, squamous cell carcinoma-related antigen, CYFRA 21-1, neuron-specific enolase, tissue polypeptide antigen, and progastrin-releasing peptide in small cell lung cancer discrimination.The International journal of biological markers, , Volume: 36, Issue:4, 2021
[Multicenter Evaluation of A New Progastrin-releasing Peptide (ProGRP) Immunoassay across Europe and China].Zhongguo fei ai za zhi = Chinese journal of lung cancer, , Aug-20, Volume: 20, Issue:8, 2017
Peptide imprinted receptors for the determination of the small cell lung cancer associated biomarker progastrin releasing peptide.Journal of chromatography. A, , Nov-28, Volume: 1370, 2014
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Influence of COX-2 inhibition by rofecoxib on serum and tumor progastrin and gastrin levels and expression of PPARgamma and apoptosis-related proteins in gastric cancer patients.Digestive diseases and sciences, , Volume: 48, Issue:10, 2003
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MicroRNA-148b suppresses cell growth by targeting cholecystokinin-2 receptor in colorectal cancer.International journal of cancer, , Sep-01, Volume: 131, Issue:5, 2012
Inactivating cholecystokinin-2 receptor inhibits progastrin-dependent colonic crypt fission, proliferation, and colorectal cancer in mice.The Journal of clinical investigation, , Volume: 119, Issue:9, 2009
The wnt target jagged-1 mediates the activation of notch signaling by progastrin in human colorectal cancer cells.Cancer research, , Aug-01, Volume: 69, Issue:15, 2009
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Characterization of gastrin-cholecystokinin 2 receptor interaction in relation to c-fos induction.Endocrine-related cancer, , Volume: 15, Issue:1, 2008
Beta-catenin/Tcf-4 inhibition after progastrin targeting reduces growth and drives differentiation of intestinal tumors.Gastroenterology, , Volume: 133, Issue:5, 2007
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PPARalpha agonists stimulate progastrin production in human colorectal carcinoma cells.Regulatory peptides, , Aug-15, Volume: 120, Issue:1-3, 2004
Adherens junctions and tight junctions are regulated via different pathways by progastrin in epithelial cells.Journal of cell science, , Apr-01, Volume: 116, Issue:Pt 7, 2003
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Plasma levels of progastrin but not amidated gastrin or glycine extended gastrin are elevated in patients with colorectal carcinoma.Gut, , Volume: 48, Issue:1, 2001
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Identification of progastrin derived peptides in colorectal carcinoma extracts.Gut, , Volume: 34, Issue:1, 1993
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Processing-independent analysis in the diagnosis of gastrinomas.Scandinavian journal of gastroenterology, , Volume: 33, Issue:4, 1998
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Processing-independent analysis (PIA)--a new diagnostic tool.Scandinavian journal of clinical and laboratory investigation. Supplementum, , Volume: 204, 1991
Gastrinoma in vitro: morphological and physiological studies of primary cell cultures.Gastroenterology, , Volume: 98, Issue:4, 1990
Gastrin in non-neoplastic pancreatic tissue from patients with and without gastrinomas.Scandinavian journal of gastroenterology, , Volume: 25, Issue:9, 1990
Carboxyl terminal glycine extended progastrin (gastrin-G) in human gastric mucosa and gastrinomas.Clinica chimica acta; international journal of clinical chemistry, , Feb-15, Volume: 179, Issue:2, 1989
Gastrin processing in primary culture of gastrinoma cells.Hormone research, , Volume: 32, Issue:1-3, 1989
Intraocular transplants of a human gastrinoma in immuno-suppressed rats: morphological, chromatographic and functional studies.Regulatory peptides, , Volume: 24, Issue:1, 1989
Immunohistochemical characterization of gastrinomas with antibodies specific to different fragments of progastrin.Gastroenterologie clinique et biologique, , Volume: 13, Issue:11, 1989
[Gastrin--human gene, processing, degradation].Nihon rinsho. Japanese journal of clinical medicine, , Volume: 47, Issue:10, 1989
Processing-independent radioimmunoanalysis: a general analytical principle applied to progastrin and its products.Analytical biochemistry, , Volume: 175, Issue:2, 1988
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Carboxyl terminal glycine extended progastrin (gastrin-G) in gastric antral mucosa of patients with gastric or duodenal ulcer and in gastrinomas.Journal of gastroenterology and hepatology, , Volume: 5, Issue:5
Progastrin and its products from patients with chronic viral hepatitis and liver cirrhosis.Scandinavian journal of gastroenterology, , Volume: 38, Issue:6, 2003
Serum progastrin and its products, gastric acid secretion and serum pepsinogen I in gastric cancer.Digestion, , Volume: 68, Issue:4, 2003
Influence of COX-2 inhibition by rofecoxib on serum and tumor progastrin and gastrin levels and expression of PPARgamma and apoptosis-related proteins in gastric cancer patients.Digestive diseases and sciences, , Volume: 48, Issue:10, 2003
Progastrin and cyclooxygenase-2 in colorectal cancer.Digestive diseases and sciences, , Volume: 47, Issue:9, 2002
Plasma levels of progastrin but not amidated gastrin or glycine extended gastrin are elevated in patients with colorectal carcinoma.Gut, , Volume: 48, Issue:1, 2001
Expression of progastrin-derived peptides and somatostatin in fundus and antrum of nonulcer dyspepsia subjects with and without Helicobacter pylori infection.Digestive diseases and sciences, , Volume: 45, Issue:10, 2000
Expression, processing, and secretion of gastrin in patients with colorectal carcinoma.Gastroenterology, , Volume: 109, Issue:4, 1995
Gastrin and somatostatin in Helicobacter pylori infected antral mucosa.Gut, , Volume: 35, Issue:5, 1994
Helicobacter pylori infection and exaggerated gastrin release. Effects of inflammation and progastrin processing.Scandinavian journal of gastroenterology, , Volume: 28, Issue:8, 1993
Helicobacter pylori related hypergastrinaemia is the result of a selective increase in gastrin 17.Gut, , Volume: 34, Issue:6, 1993
Pharmacokinetics (1)
Dosage (2)