Page last updated: 2024-09-28

Cervix Incompetence

Incompetent UTERINE CERVIX is usually diagnosed in the second trimester of PREGNANCY. It is characterized by passive painless cervical dilation in the absence of UTERINE CONTRACTION; BLEEDING; INFECTION; and sometimes with the amniotic sac (AMNIOTIC MEMBRANE) bulging through the partially dilated cervix. Left untreated, this condition may lead to premature pregnancy loss, such as HABITUAL ABORTION.

Synonyms(3)

Synonym
Uterine Cervical Incompetence
Incompetent Cervix
Cervix Incompetence

Research Excerpts

Overview

ExcerptReference
"The origin of incompetent cervix is multifactorial, and the success of rescue cerclage is unpredictable."( Buhimschi, CS; Buhimschi, IA; Christner, R; Lee, KY; Weiner, CP, 2005)

Research

Studies (176)

TimeframeStudies, This Condition (%)All Conditions %
pre-199076 (43.18)23.3326
1990's23 (13.07)12.5806
2000's23 (13.07)18.1394
2010's43 (24.43)28.8240
2020's11 (6.25)9.53
DrugIndicatedRelationship StrengthStudiesTrials
phloroglucinol0low10
nitrous oxide0low20
phenytoin0medium11
ethacridine0low10
albuterol0medium21
aspirin0low10
verapamil0low20
clenbuterol0low10
diazepam0low30
valproic acid0medium11
berotek0low30
hexoprenaline0medium21
lidocaine0low20
indomethacin0medium92
isoxsuprine0low10
ketamine0low10
mepivacaine0low10
metronidazole0low20
nylidrin0low10
phenobarbital0low10
potassium chloride0low10
primidone0medium11
terbutaline0low10
estriol0medium62
hydroxyproline0low30
estrone0low20
dehydroepiandrosterone0medium11
androstenedione0low10
17-alpha-hydroxyprogesterone0low20
ampicillin0medium21
isosorbide dinitrate0medium11
pregnenolone0low10
acridines0low10
betamethasone0low10
medroxyprogesterone0low20
erythromycin0low10
potassium hydroxide0low10
magnesium sulfate0low20
vasotocin0low10
isosorbide-5-mononitrate0medium11
bromocriptine0low20
du-212200low30
cefazolin0medium21
mifepristone0medium11
clarithromycin0low10
methotrexate0low10
17 alpha-hydroxyprogesterone caproate0medium94
elastin0low10
oxytocin0medium84
clindamycin0medium21
diethylstilbestrol0low170
enclomiphene0low50
dinoprostone0medium75
dinoprost0low40
misoprostol0low10
15-keto-13,14-dihydroprostaglandin f2alpha0low10
morphine0low10
atosiban0low10
pregnanediol0low50
ergoline0low20
indocyanine green0low10
desmosine0low10
menotropins0low30
ro13-99040low10
piperidines0low10
interleukin-80low40
methylcellulose0low10
transforming growth factor beta0low10
exudates0low10
folic acid0low10

Protein Targets (785)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, Ferritin light chain7007
glp-1 receptor, partial120012
phosphopantetheinyl transferase6006
hypoxia-inducible factor 1 alpha subunit6006
RAR-related orphan receptor gamma140014
SMAD family member 29009
Fumarate hydratase4004
SMAD family member 39009
TDP1 protein240024
GLI family zinc finger 3230023
Microtubule-associated protein tau110011
AR protein270027
Smad37007
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)4004
estrogen receptor 2 (ER beta)120012
nuclear receptor subfamily 1, group I, member 3130013
progesterone receptor160016
cytochrome P450 family 3 subfamily A polypeptide 4180018
glucocorticoid receptor [Homo sapiens]210021
retinoic acid nuclear receptor alpha variant 1150015
retinoid X nuclear receptor alpha150015
estrogen-related nuclear receptor alpha240024
farnesoid X nuclear receptor130013
pregnane X nuclear receptor170017
estrogen nuclear receptor alpha310031
G130013
cytochrome P450 2D6120012
polyprotein4004
67.9K protein4004
bromodomain adjacent to zinc finger domain 2B5005
peroxisome proliferator-activated receptor delta110011
peroxisome proliferator activated receptor gamma150015
vitamin D (1,25- dihydroxyvitamin D3) receptor180018
IDH18008
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a130013
thyroid stimulating hormone receptor9009
activating transcription factor 6100010
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a7007
v-jun sarcoma virus 17 oncogene homolog (avian)4004
Histone H2A.x7007
Caspase-72002
vitamin D3 receptor isoform VDRA130013
nuclear factor erythroid 2-related factor 2 isoform 27007
parathyroid hormone/parathyroid hormone-related peptide receptor precursor6006
caspase-32002
thyroid hormone receptor beta isoform 2200020
heat shock protein beta-16006
huntingtin isoform 24004
nuclear factor erythroid 2-related factor 2 isoform 1170017
nuclear receptor ROR-gamma isoform 18008
geminin190019
survival motor neuron protein isoform d7007
replicative DNA helicase0002
recombinase A0022
lamin isoform A-delta10200020
neuropeptide S receptor isoform A7007
Voltage-dependent calcium channel gamma-2 subunit100010
Interferon beta130013
HLA class I histocompatibility antigen, B alpha chain 130013
Cellular tumor antigen p53180018
Glutamate receptor 2100010
Alpha-synuclein64010
Spike glycoprotein9009
Guanine nucleotide-binding protein G5005
Inositol hexakisphosphate kinase 1130013
cytochrome P450 2C9, partial130013
acetylcholinesterase5005
pregnane X receptor5005
arylsulfatase A6006
euchromatic histone-lysine N-methyltransferase 2160016
nuclear receptor subfamily 1, group I, member 23003
chromobox protein homolog 1120012
histone acetyltransferase KAT2A isoform 15005
Glucocorticoid receptor112217
Sex hormone-binding globulin0066
Glycine receptor subunit alpha-1012012
Corticosteroid-binding globulin0606
Adenosine receptor A30606
Replicase polyprotein 1ab0101
Androgen receptor013013
Alpha-1B adrenergic receptor0707
Glycine receptor subunit beta012012
Glycine receptor subunit alpha-2012012
Glycine receptor subunit alpha-3012012
Mitogen-activated protein kinase 3 0101
Alpha-1A adrenergic receptor0707
Sodium-dependent dopamine transporter 0606
TAR DNA-binding protein 439009
ATP-dependent phosphofructokinase100010
thioredoxin reductase120012
aldehyde dehydrogenase 1 family, member A1110011
alpha-galactosidase3003
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 16006
flap endonuclease 17007
DNA polymerase iota isoform a (long)100010
DNA topoisomerase 2-alpha0001
Acetylcholinesterase0303
GLS protein120012
regulator of G-protein signaling 4110011
NPYLR7B0022
peripheral myelin protein 22110011
ATP-binding cassette sub-family C member 3016016
Multidrug resistance-associated protein 4016020
Bile salt export pump029029
Beta-2 adrenergic receptor05611
Beta-1 adrenergic receptor0639
60 kDa chaperonin0202
60 kDa heat shock protein, mitochondrial0303
Beta-3 adrenergic receptor0224
Delta-type opioid receptor0337
10 kDa heat shock protein, mitochondrial0303
Thiosulfate sulfurtransferase0303
Beta-2 adrenergic receptor 0039
60 kDa chaperonin 0303
10 kDa chaperonin 0303
Beta-2 adrenergic receptor0347
Canalicular multispecific organic anion transporter 1015015
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE140014
Chain A, Mutant Al2 6e7p9g0011
Chain A, Beta-lactamase8008
Chain A, 2-oxoglutarate Oxygenase7007
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
Chain A, Cruzipain5005
Beta-lactamase 0001
acid sphingomyelinase4004
apical membrane antigen 1, AMA13003
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase type 20001
Metallo-beta-lactamase VIM-11 0001
Metallo-beta-lactamase VIM-20001
Beta-lactamase 0001
Metallo-beta-lactamase0001
Beta-lactamase 0001
DNA polymerase beta6006
DNA polymerase eta isoform 13003
DNA polymerase kappa isoform 18008
Carbonic anhydrase 10505
Carbonic anhydrase 20516
Beta-lactamase OXA-70001
Solute carrier family 15 member 10303
Solute carrier family 15 member 10101
Angiopoietin-1 receptor0011
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Solute carrier family 15 member 20101
Metallo-beta-lactamase VIM-130001
Efflux transporter 0001
Beta-lactamase 0001
Beta-lactamase Toho-10001
Beta-lactamase 0001
Class D beta-lactamase0001
Metallo-beta-lactamase0001
Solute carrier family 15 member 20101
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-b-lactamase 0001
Carbapenem-hydrolyzing beta-lactamase KPC0001
Histamine H3 receptor0001
Beta-lactamase class B VIM-2 0001
Beta-lactamase VIM-1 0001
Chain A, HADH2 protein6006
Chain B, HADH2 protein6006
interleukin 84004
nonstructural protein 13003
Bloom syndrome protein isoform 17007
peripheral myelin protein 22 isoform 14004
potassium voltage-gated channel subfamily H member 2 isoform d6006
importin subunit beta-1 isoform 13003
mitogen-activated protein kinase 17007
nuclear factor NF-kappa-B p105 subunit isoform 11001
snurportin-13003
GTP-binding nuclear protein Ran isoform 12002
muscleblind-like protein 1 isoform 14004
Beta-glucuronidase0202
Cholinesterase0101
Aromatase0305
Gastrin/cholecystokinin type B receptor0102
Testosterone 17-beta-dehydrogenase 30101
Nuclear receptor ROR-gamma5005
Chain A, TYROSYL-DNA PHOSPHODIESTERASE7007
Chain A, Phospholipase A2 isoform 30011
GTP-binding protein (rab7)0011
ras protein, partial0011
thyroid stimulating hormone receptor6006
hypothetical protein, conserved3003
EWS/FLI fusion protein8008
glucocerebrosidase4004
Rac1 protein0011
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
muscarinic acetylcholine receptor M13003
lethal factor (plasmid)2002
Prostaglandin-H2 D-isomerase0202
Solute carrier family 22 member 60303
Prostaglandin G/H synthase 1 0304
Prostaglandin G/H synthase 2 0304
Epidermal growth factor receptor0303
Fatty acid-binding protein, liver0202
Integrin beta-32103
Myeloperoxidase0101
Prostaglandin G/H synthase 10405
Seed linoleate 13S-lipoxygenase-10101
Integrin alpha-IIb2103
Glutathione hydrolase 1 proenzyme0101
Prostaglandin G/H synthase 10707
Adenosine receptor A10213
Adenosine receptor A2a0213
Substance-P receptor0303
Prostaglandin G/H synthase 20516
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0101
Ras-related protein Rab-2A0011
Gamma-aminobutyric acid receptor subunit alpha-13418
Prostaglandin G/H synthase 20303
Rho-associated protein kinase 20202
Nicotinate phosphoribosyltransferase0202
Solute carrier family 22 member 200303
Solute carrier family 22 member 60303
Sigma non-opioid intracellular receptor 10516
Sigma non-opioid intracellular receptor 10011
Vasopressin V2 receptor0213
Oxytocin receptor0426
Vasopressin V1a receptor0516
Vasopressin V1b receptor0213
Oxytocin receptor0314
beta-2 adrenergic receptor2002
aryl hydrocarbon receptor4004
thyroid hormone receptor beta isoform a9009
galanin receptor type 30101
ORF730011
Genome polyprotein 0112
dopamine D1 receptor4004
ATAD5 protein, partial7007
D(1A) dopamine receptor3003
serine/threonine-protein kinase mTOR isoform 13003
peptidyl-prolyl cis-trans isomerase NIMA-interacting 14004
5-hydroxytryptamine receptor 40808
ATP-dependent translocase ABCB10505
ATP-dependent translocase ABCB108117
Cytochrome P450 3A40729
5-hydroxytryptamine receptor 1A0101
Alpha-2A adrenergic receptor0819
D(2) dopamine receptor0415
Alpha-2B adrenergic receptor0808
Alpha-2C adrenergic receptor0606
D0101
D(3) dopamine receptor0101
5-hydroxytryptamine receptor 1A010111
Alpha-2B adrenergic receptor0101
ATP-dependent translocase ABCB10517
D(1A) dopamine receptor0404
Alpha-2C adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Alpha-1D adrenergic receptor0404
D(1B) dopamine receptor0101
5-hydroxytryptamine receptor 2A0819
5-hydroxytryptamine receptor 2C0819
5-hydroxytryptamine receptor 1B0606
D(4) dopamine receptor0101
D(3) dopamine receptor0808
5-hydroxytryptamine receptor 2B010010
5-hydroxytryptamine receptor 60606
D(2) dopamine receptor0213
ATPase family AAA domain-containing protein 58008
Ataxin-2100010
Chain A, Putative fructose-1,6-bisphosphate aldolase5005
Chain A, JmjC domain-containing histone demethylation protein 3A5005
Luciferase5005
Solute carrier family 22 member 60205
Solute carrier family 22 member 80205
Solute carrier family 22 member 110104
Solute carrier family 22 member 80101
urokinase-type plasminogen activator precursor4004
plasminogen precursor4004
urokinase plasminogen activator surface receptor precursor4004
streptokinase A precursor0022
Potassium voltage-gated channel subfamily H member 2010010
Solute carrier organic anion transporter family member 1B30304
Solute carrier organic anion transporter family member 1B10505
Protein-arginine deiminase type-40202
Beta-glucuronidase0101
Glucose-6-phosphate 1-dehydrogenase0404
G-protein coupled bile acid receptor 10011
Glucose-6-phosphate 1-dehydrogenase 0101
NPC1-like intracellular cholesterol transporter 10011
Gamma-aminobutyric acid 0202
Gamma-aminobutyric acid receptor subunit pi0303
Gamma-aminobutyric acid receptor subunit pi3317
Gamma-aminobutyric acid receptor subunit delta0303
Voltage-dependent L-type calcium channel subunit alpha-1F0404
Alpha-1-acid glycoprotein 10001
Albumin0146
Albumin0011
Gamma-aminobutyric acid receptor subunit alpha-10202
Gamma-aminobutyric acid receptor subunit beta-10202
Neuronal acetylcholine receptor subunit alpha-40202
Gamma-aminobutyric acid receptor subunit alpha-20202
Gamma-aminobutyric acid receptor subunit alpha-30202
Neuronal acetylcholine receptor subunit beta-20202
Gamma-aminobutyric acid receptor subunit alpha-10325
Gamma-aminobutyric acid receptor subunit beta-13317
Translocator protein0124
Gamma-aminobutyric acid receptor subunit alpha-60202
Gamma-aminobutyric acid receptor subunit beta-10303
Gamma-aminobutyric acid receptor subunit delta3317
Gamma-aminobutyric acid receptor subunit gamma-20314
Gamma-aminobutyric acid receptor subunit gamma-23317
Gamma-aminobutyric acid receptor subunit alpha-53317
Gamma-aminobutyric acid receptor subunit alpha-33317
Gamma-aminobutyric acid receptor subunit alpha-40202
Gamma-aminobutyric acid receptor subunit gamma-20202
Gamma-aminobutyric acid receptor subunit gamma-20202
Gamma-aminobutyric acid receptor subunit delta0202
Gamma-aminobutyric acid receptor subunit gamma-13317
Gamma-aminobutyric acid receptor subunit alpha-23317
Gamma-aminobutyric acid receptor subunit alpha-20202
Gamma-aminobutyric acid receptor subunit alpha-30202
Gamma-aminobutyric acid receptor subunit gamma-30202
Gamma-aminobutyric acid receptor subunit alpha-43317
Gamma-aminobutyric acid receptor subunit beta-30314
Gamma-aminobutyric acid receptor subunit gamma-33317
Gamma-aminobutyric acid receptor subunit alpha-63317
Translocator protein0101
Translocator protein0101
Cholecystokinin receptor type A0101
Gamma-aminobutyric acid receptor subunit alpha-50325
Gamma-aminobutyric acid receptor subunit alpha-30314
Gamma-aminobutyric acid receptor subunit alpha-20314
Gamma-aminobutyric acid receptor subunit beta-20314
Gamma-aminobutyric acid receptor subunit alpha-40303
Gamma-aminobutyric acid receptor subunit beta-10202
Gamma-aminobutyric acid receptor subunit alpha-10202
Gamma-aminobutyric acid receptor subunit beta-33317
Gamma-aminobutyric acid receptor subunit beta-30202
Gamma-aminobutyric acid receptor subunit beta-23317
Gamma-aminobutyric acid receptor subunit epsilon0303
Voltage-dependent L-type calcium channel subunit alpha-1D 0404
Neuronal acetylcholine receptor subunit alpha-70101
Voltage-dependent L-type calcium channel subunit alpha-1S0404
Voltage-dependent L-type calcium channel subunit alpha-1C0404
Gamma-aminobutyric acid receptor subunit alpha-60303
Gamma-aminobutyric acid receptor subunit alpha-50202
Gamma-aminobutyric acid receptor subunit gamma-10303
Gamma-aminobutyric acid receptor subunit pi0202
Sphingosine-1-phosphate lyase 10101
GABA theta subunit3317
Gamma-aminobutyric acid receptor subunit gamma-30303
Gamma-aminobutyric acid receptor subunit alpha-40202
Gamma-aminobutyric acid receptor subunit epsilon3317
Gamma-aminobutyric acid receptor subunit theta0202
Gamma-aminobutyric acid receptor subunit gamma-10202
Gamma-aminobutyric acid receptor subunit theta0303
15-lipoxygenase, partial2002
USP1 protein, partial6006
cellular tumor antigen p53 isoform a2002
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
serine/threonine-protein kinase PLK12002
histone-lysine N-methyltransferase 2A isoform 2 precursor3003
cytochrome P450 3A4 isoform 13003
high affinity choline transporter 1 isoform a0101
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Nuclear receptor subfamily 1 group I member 20101
Estrogen receptor110315
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
Tyrosine-protein kinase Fyn0303
Aldo-keto reductase family 1 member B10505
Polyunsaturated fatty acid 5-lipoxygenase0101
Muscarinic acetylcholine receptor M10404
Polyunsaturated fatty acid lipoxygenase ALOX150404
Muscarinic acetylcholine receptor M30404
Substance-K receptor0404
Sodium-dependent noradrenaline transporter 0415
Thromboxane-A synthase 0202
Adenosine receptor A2a0202
Adenosine receptor A10202
Sodium-dependent serotonin transporter010010
Mu-type opioid receptor0618
Delta-type opioid receptor0416
Kappa-type opioid receptor0618
Histamine H2 receptor3003
Estrogen-related receptor gamma0011
Disintegrin and metalloproteinase domain-containing protein 171001
Inositol monophosphatase 14004
Aldehyde oxidase0101
UDP-glucose 4-epimerase0101
Mitogen-activated protein kinase 140202
Estrogen receptor beta15310
Broad substrate specificity ATP-binding cassette transporter ABCG20315
Cysteinyl leukotriene receptor 10202
Solute carrier family 22 member 20002
Solute carrier family 22 member 1 0305
Thromboxane A2 receptor 0112
Prostaglandin E2 receptor EP1 subtype0325
Prostaglandin E2 receptor EP4 subtype0314
Prostaglandin F2-alpha receptor0202
Prostaglandin F2-alpha receptor0224
Prostaglandin E2 receptor EP3 subtype0325
Prostaglandin E2 receptor EP2 subtype0314
Prostaglandin F2-alpha receptor0011
Prostacyclin receptor0314
Solute carrier organic anion transporter family member 2A10103
Prostaglandin D2 receptor0101
Solute carrier family 22 member 70003
Solute carrier organic anion transporter family member 2A10103
Solute carrier organic anion transporter family member 2A10101
Solute carrier organic anion transporter family member 2B10101
Solute carrier family 22 member 70002
prostaglandin E2 receptor EP2 subtype1001
Solute carrier organic anion transporter family member 1A50001
Prostaglandin E2 receptor EP3 subtype0202
Prostaglandin E2 receptor EP4 subtype0202
Prostaglandin E2 receptor EP1 subtype0202
Prostaglandin E2 receptor EP4 subtype0112
Prostaglandin E2 receptor EP2 subtype0202
Prostaglandin E2 receptor EP2 subtype0112
Solute carrier family 22 member 70001
Solute carrier organic anion transporter family member 1B20001
Beta-2 adrenergic receptor0101
Beta-3 adrenergic receptor0011
chaperonin-containing TCP-1 beta subunit homolog2002
ubiquitin-conjugating enzyme E2 N0101
protein AF-9 isoform a0002
Receptor tyrosine-protein kinase erbB-20101
Muscarinic acetylcholine receptor M20202
Muscarinic acetylcholine receptor M40202
Muscarinic acetylcholine receptor M50202
Cytochrome P450 2D60101
C-8 sterol isomerase0101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Motilin receptor0011
low molecular weight phosphotyrosine protein phosphatase isoform c0101
Motilin receptor0112
Rap guanine nucleotide exchange factor 34004
30S ribosomal protein S60112
30S ribosomal protein S70112
50S ribosomal protein L150112
50S ribosomal protein L100112
50S ribosomal protein L110112
50S ribosomal protein L7/L120112
50S ribosomal protein L190112
50S ribosomal protein L10112
50S ribosomal protein L200112
50S ribosomal protein L270112
50S ribosomal protein L280112
50S ribosomal protein L290112
50S ribosomal protein L310112
50S ribosomal protein L31 type B0112
50S ribosomal protein L320112
50S ribosomal protein L330112
50S ribosomal protein L340112
50S ribosomal protein L350112
50S ribosomal protein L360112
30S ribosomal protein S100112
30S ribosomal protein S110112
30S ribosomal protein S120112
30S ribosomal protein S130112
30S ribosomal protein S160112
30S ribosomal protein S180112
30S ribosomal protein S190112
30S ribosomal protein S200112
30S ribosomal protein S20112
30S ribosomal protein S30112
30S ribosomal protein S40112
30S ribosomal protein S50112
30S ribosomal protein S80112
30S ribosomal protein S90112
50S ribosomal protein L130112
50S ribosomal protein L140112
50S ribosomal protein L160112
50S ribosomal protein L230112
30S ribosomal protein S150112
50S ribosomal protein L170112
50S ribosomal protein L210112
50S ribosomal protein L300112
50S ribosomal protein L60112
30S ribosomal protein S140112
30S ribosomal protein S170112
30S ribosomal protein S10112
50S ribosomal protein L180112
Cytochrome P450 2C9 0404
Chitinase B0101
Low molecular weight phosphotyrosine protein phosphatase0101
Cytochrome P450 2J20202
50S ribosomal protein L20112
50S ribosomal protein L30112
50S ribosomal protein L240112
50S ribosomal protein L40112
50S ribosomal protein L220112
50S ribosomal protein L50112
30S ribosomal protein S210112
50S ribosomal protein L250112
Cytochrome P450 1B10202
Lanosterol 14-alpha demethylase0303
50S ribosomal protein L36 20112
Multidrug and toxin extrusion protein 10303
UDP-glucuronosyltransferase 2B70103
Solute carrier organic anion transporter family member 1A10202
Lanosterol 14-alpha demethylase0011
Olfactory receptor 51E20011
UDP-glucuronosyltransferase 1A100001
endonuclease IV2002
NFKB1 protein, partial1001
GALC protein2002
hexokinase-4 isoform 11001
glucokinase regulatory protein1001
Steryl-sulfatase0101
17-beta-hydroxysteroid dehydrogenase type 10203
Mu-type opioid receptor0429
Mu-type opioid receptor0213
Ghrelin O-acyltransferase0101
Telomerase reverse transcriptase0101
Coagulation factor XII0101
Liver carboxylesterase 10202
Chain A, Dihydrofolate reductase0011
lysosomal alpha-glucosidase preproprotein2002
Thymidylate synthase0404
Thymidylate synthase0303
Dihydrofolate reductase0235
Aldo-keto reductase family 1 member B10202
Folylpolyglutamate synthase, mitochondrial0104
Solute carrier organic anion transporter family member 1A30203
Folylpolyglutamate synthase, mitochondrial0104
Multidrug resistance associated protein0103
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E0011
Neutral amino acid transporter A0101
Asc-type amino acid transporter 10101
Neutral amino acid transporter B(0)0101
Proton-coupled amino acid transporter 10101
Amino acid transporter0101
Chain A, membrane-associated prostaglandin E synthase-20101
Parkin2002
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
cytochrome P450 2D6 isoform 11001
cytochrome P450 2C9 precursor2002
ras-related protein Rab-9A1001
M-phase phosphoprotein 83003
Prostaglandin E synthase0101
3',5'-cyclic-AMP phosphodiesterase 0101
Solute carrier organic anion transporter family member 2B1 0202
Cytochrome c oxidase subunit 20101
Phospholipase A2, major isoenzyme0101
Procathepsin L0101
Interleukin-80101
Androgen receptor1225
Polyunsaturated fatty acid 5-lipoxygenase0102
Aldo-keto reductase family 1 member B10202
Aldo-keto reductase family 1 member C40101
Prostaglandin G/H synthase 10101
Sodium-dependent dopamine transporter0101
Sodium- and chloride-dependent GABA transporter 10101
Serum paraoxonase/arylesterase 10101
Indoleamine 2,3-dioxygenase 10101
Caspase-10001
Nitric oxide synthase, inducible0101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Multidrug resistance-associated protein 1 0316
Bifunctional epoxide hydrolase 20101
Prostaglandin G/H synthase 2 0101
Peroxisome proliferator-activated receptor gamma0011
Aldo-keto reductase family 1 member C30202
Sodium- and chloride-dependent betaine transporter0101
C-X-C chemokine receptor type 30101
Aldo-keto reductase family 1 member C2 0101
Prostaglandin D2 receptor 0202
Lactoylglutathione lyase0101
Aldo-keto reductase family 1 member C10101
Prostaglandin G/H synthase 20102
Uracil nucleotide/cysteinyl leukotriene receptor0101
Sigma intracellular receptor 20101
Prostaglandin G/H synthase 1 0101
Dehydrogenase/reductase SDR family member 90101
P2Y purinoceptor 120101
Cytosolic phospholipase A2 gamma0101
Prostaglandin D2 receptor 20112
Glutamate receptor ionotropic, NMDA 2D0101
Acetylcholinesterase0202
Glutamate receptor ionotropic, NMDA 3B0101
Glutamate receptor ionotropic, NMDA 1 0202
Sodium channel protein type 4 subunit alpha0304
Cholinesterase0101
Glutamate receptor ionotropic, NMDA 2A 0202
Glutamate receptor ionotropic, NMDA 2B0202
Glutamate receptor ionotropic, NMDA 2C0202
Glutamate receptor ionotropic, NMDA 10202
Glutamate receptor ionotropic, NMDA 2A0202
Glutamate receptor ionotropic, NMDA 2B0202
Glutamate receptor ionotropic, NMDA 2C0101
Glutamate receptor ionotropic, NMDA 2D0202
Glutamate receptor ionotropic, NMDA 3A0101
Glutamate receptor ionotropic, NMDA 3B0202
Glutamate receptor ionotropic, NMDA 3A0202
Potassium channel subfamily K member 30202
Potassium channel subfamily K member 20101
Sodium channel protein type 1 subunit alpha0202
Sodium channel protein type 2 subunit alpha0303
Sodium channel protein type 3 subunit alpha0202
Potassium voltage-gated channel subfamily A member 50101
Sodium channel protein type 5 subunit alpha0303
Sodium channel protein type 9 subunit alpha0202
Potassium voltage-gated channel subfamily D member 20101
Potassium channel subfamily K member 180101
Sodium channel protein type 3 subunit alpha0303
PINK11001
Cytochrome P450 2C190101
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
ClpP1001
Thymidylate synthase 0101
Thymidylate synthase 0101
polyunsaturated fatty acid lipoxygenase ALOX121001
transcriptional regulator ERG isoform 32002
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
transactivating tegument protein VP16 [Human herpesvirus 1]0101
caspase-1 isoform alpha precursor1001
nuclear receptor coactivator 3 isoform a0101
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
Bile salt export pump0303
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0203
Dihydrofolate reductase0203
Dihydrofolate reductase 0202
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Tyrosine-protein kinase ABL10011
Bifunctional dihydrofolate reductase-thymidylate synthase0101
5-hydroxytryptamine receptor 2C0102
High mobility group protein B10011
Dihydrofolate reductase0101
Thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
5-hydroxytryptamine receptor 2A0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0112
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20011
Bifunctional purine biosynthesis protein ATIC0202
Kappa-type opioid receptor0315
Reduced folate transporter0202
6-phosphogluconate dehydrogenase, decarboxylating0101
Caspase-71001
Dihydrofolate reductase0101
Pteridine reductase 10101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Chain E, Fibrin beta chain0101
T cell receptor, partial1001
luteinizing hormone receptor1001
integrase, partial0101
lens epithelium-derived growth factor p750101
Caspase 6, apoptosis-related cysteine peptidase0001
PPM1D protein1001
TSHR protein1001
Apoptotic peptidase activating factor 10101
thioredoxin glutathione reductase2002
caspase 7, apoptosis-related cysteine protease1001
isocitrate dehydrogenase 1, partial1001
luciferase1001
caspase-31001
serine-protein kinase ATM isoform a1001
neutrophil cytosol factor 10101
caspase-9 isoform alpha precursor0101
histone deacetylase 9 isoform 31001
pyruvate kinase PKM isoform a1001
caspase-3 isoform a preproprotein0101
Vpr1001
POsterior Segregation0011
DNA repair protein RAD52 homolog isoform a0001
Glutathione reductase0101
Glutathione reductase, mitochondrial0102
Glycoprotein hormones alpha chain1001
Albumin0001
Amyloid-beta precursor protein0101
Dihydrolipoyl dehydrogenase, mitochondrial0102
Microtubule-associated protein tau0112
Amine oxidase [flavin-containing] A0101
Alpha-1D adrenergic receptor0101
Cruzipain0101
Thioredoxin reductase 1, cytoplasmic0102
Dihydrolipoyl dehydrogenase 0102
Zinc finger protein mex-50011
phosphoglycerate kinase1001
Thioredoxin reductase 0101
Flavodoxin0001
Chain A, PROGESTERONE RECEPTOR0101
Glucocorticoid receptor 0101
atrial natriuretic peptide receptor 2 precursor1001
Progesterone receptor0215
Tegument protein VP160011
Glucocorticoid receptor0113
Glucocorticoid receptor0101
Mineralocorticoid receptor 1215
Coagulation factor VII0101
Cytochrome P450 2C80202
Thyroid hormone receptor alpha0101
Thyroid hormone receptor beta0101
Steroid 17-alpha-hydroxylase/17,20 lyase 0101
Tissue factor0202
D(1A) dopamine receptor1001
Progesterone receptor0011
Glucocorticoid receptor0101
Opioid receptor, delta 1b 0101
Opioid receptor homologue0101
Acyl-CoA desaturase 10101
Muscarinic acetylcholine receptor M10101
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M40101
Muscarinic acetylcholine receptor M50101
Muscarinic acetylcholine receptor M20101
Proteinase-activated receptor 10112
Sodium-dependent serotonin transporter0101
Delta-type opioid receptor0203
Kappa-type opioid receptor0214
UDP-glucuronosyltransferase 1A30001
Kappa-type opioid receptor0303
Mu-type opioid receptor0215
Nociceptin receptor0101
5-hydroxytryptamine receptor 70202
Mu-type opioid receptor0101
Mas-related G-protein coupled receptor member X20011
Mu-type opioid receptor0101
Vasopressin V1a receptor0101
Vasopressin V1b receptor0101
Oxytocin receptor0011
Vasopressin V2 receptor 0101
Sodium channel protein type 1 subunit alpha0202
Sodium channel protein type 2 subunit alpha0202
atrial natriuretic peptide receptor 1 precursor1001
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Replicase polyprotein 1ab0101
Beta-secretase 10101
Carbonic anhydrase 40101
Carbonic anhydrase 5A, mitochondrial0101
Taste receptor type 2 member 310011
Taste receptor type 2 member 600011
Carbonic anhydrase 90101
Sodium/potassium/calcium exchanger 40112
Taste receptor type 2 member 140011
Taste receptor type 2 member 130011
Taste receptor type 2 member 90011
Taste receptor type 2 member 40011
Sodium/potassium/calcium exchanger 20112
Beta-adrenergic receptor kinase 10011
Cocaine esterase0101
Histone deacetylase 30202
UDP-glucuronosyltransferase 1A90001
Cytochrome P450 2A60101
Aldo-keto reductase family 1 member A10101
UDP-glucuronosyltransferase 1-60001
Aldo-keto reductase family 1 member A10101
Histone deacetylase 40202
Histone deacetylase 10202
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member B70101
Sigma non-opioid intracellular receptor 10101
Histone deacetylase 70202
Histone deacetylase 20202
Polyamine deacetylase HDAC100202
Histone deacetylase 11 0202
Histone deacetylase 80202
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
Histone deacetylase 60202
Histone deacetylase 90202
Histone deacetylase 50202
Glycoprotein0101
Muscarinic acetylcholine receptor M20011
Catechol O-methyltransferase0101
Potassium voltage-gated channel subfamily A member 30101
Histamine H2 receptor0202
Chloroquine resistance transporter0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]