| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
2-nitropropane
2-nitropropane: RN given refers to cpd with locant for nitro moiety in 2 position. 2-nitropropane : A secondary nitroalkane that is propane in which a hydrogen at position 2 has been replaced by a nitro group. Mainly used as a solvent (b.p. 120degreeC). | 2.04 | 1 | 0 | secondary nitroalkane | carcinogenic agent;
hepatotoxic agent;
polar aprotic solvent;
xenobiotic |
2-aminofluorene
[no description available] | 1.96 | 1 | 0 | | |
amitrole
Amitrole: A non-selective post-emergence, translocated herbicide. According to the Seventh Annual Report on Carcinogens (PB95-109781, 1994) this substance may reasonably be anticipated to be a carcinogen. (From Merck Index, 12th ed) It is an irreversible inhibitor of CATALASE, and thus impairs activity of peroxisomes.. amitrole : A member of the class of triazoles that is 1H-1,2,4-triazole substituted by an amino group at position 3. Used to control annual grasses and aquatic weeds (but not on food crops because it causes cancer in laboratory animals). Its use within the EU was banned from September 2017 on the grounds of potential groundwater contamination and risks to aquatic life; there have also been concerns about its endocrine-disrupting properties. | 1.96 | 1 | 0 | aromatic amine;
triazoles | carotenoid biosynthesis inhibitor;
EC 1.11.1.6 (catalase) inhibitor;
herbicide |
azathioprine
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed). azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS. | 2.39 | 2 | 0 | aryl sulfide;
C-nitro compound;
imidazoles;
thiopurine | antimetabolite;
antineoplastic agent;
carcinogenic agent;
DNA synthesis inhibitor;
hepatotoxic agent;
immunosuppressive agent;
prodrug |
dimetridazole
Dimetridazole: A compound used to treat histomoniasis in poultry.. dimetridazole : A C-nitro compound that is 5-nitroimidazole in which the hydrogens at positions 1 and 2 are replaced by methyl groups. An antiprotozoal drug, it has been banned by both the Government of Canada and the European Union as a livestock feed additive owing to suspicions of it being carcinogenic. | 2.04 | 1 | 0 | C-nitro compound;
imidazoles | antiparasitic agent;
antiprotozoal drug |
metronidazole
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.. metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death. | 2.04 | 1 | 0 | C-nitro compound;
imidazoles;
primary alcohol | antiamoebic agent;
antibacterial drug;
antimicrobial agent;
antiparasitic agent;
antitrichomonal drug;
environmental contaminant;
prodrug;
radiosensitizing agent;
xenobiotic |
nitroglycerin
Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.. nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.. nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain. | 2.04 | 1 | 0 | nitroglycerol | explosive;
muscle relaxant;
nitric oxide donor;
prodrug;
tocolytic agent;
vasodilator agent;
xenobiotic |
suramin
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.. suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years. | 1.96 | 1 | 0 | naphthalenesulfonic acid;
phenylureas;
secondary carboxamide | angiogenesis inhibitor;
antinematodal drug;
antineoplastic agent;
apoptosis inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
GABA antagonist;
GABA-gated chloride channel antagonist;
purinergic receptor P2 antagonist;
ryanodine receptor agonist;
trypanocidal drug |
trifluralin
Trifluralin: A microtubule-disrupting pre-emergence herbicide.. trifluralin : A substituted aniline that is N,N-dipropylaniline substituted by a nitro groups at positions 2 and 6 and a trifluoromethyl group at position 4. It is an agrochemical used as a pre-emergence herbicide. | 2.04 | 1 | 0 | (trifluoromethyl)benzenes;
C-nitro compound;
substituted aniline | agrochemical;
environmental contaminant;
herbicide;
xenobiotic |
n-hydroxy-2-aminofluorene
N-hydroxy-2-aminofluorene: structure | 1.96 | 1 | 0 | | |
hydroxyacetylaminofluorene
Hydroxyacetylaminofluorene: A N-hydroxylated derivative of 2-ACETYLAMINOFLUORENE that has demonstrated carcinogenic action. | 1.96 | 1 | 0 | 2-acetamidofluorenes | |
2-acetylaminofluorene
2-Acetylaminofluorene: A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines. | 1.96 | 1 | 0 | 2-acetamidofluorenes | antimitotic;
carcinogenic agent;
epitope;
mutagen |
chloramphenicol
Amphenicol: Chloramphenicol and its derivatives. | 2.04 | 1 | 0 | C-nitro compound;
carboxamide;
diol;
organochlorine compound | antibacterial drug;
antimicrobial agent;
Escherichia coli metabolite;
geroprotector;
Mycoplasma genitalium metabolite;
protein synthesis inhibitor |
p-aminoazobenzene
p-Aminoazobenzene: Used in the form of its salts as a dye and as an intermediate in manufacture of Acid Yellow, diazo dyes, and indulines.. 4-(phenylazo)aniline : Azobenzene substituted at one of the 4-positions by an amino group. It has a role as a dye and an allergen. | 1.96 | 1 | 0 | | |
dimethylnitrosamine
Dimethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties. It causes serious liver damage and is a hepatocarcinogen in rodents. | 1.96 | 1 | 0 | nitrosamine | geroprotector;
mutagen |
chloroform
Chloroform: A commonly used laboratory solvent. It was previously used as an anesthetic, but was banned from use in the U.S. due to its suspected carcinogenicity.. chloroform : A one-carbon compound that is methane in which three of the hydrogens are replaced by chlorines. | 1.96 | 1 | 0 | chloromethanes;
one-carbon compound | carcinogenic agent;
central nervous system drug;
inhalation anaesthetic;
non-polar solvent;
refrigerant |
nitroethane
nitroethane : A nitroalkane that is ethane substituted by a nitro group. | 2.04 | 1 | 0 | primary nitroalkane | |
1-phenylazo-2-naphthylamine
[no description available] | 1.96 | 1 | 0 | | |
2-nitroanisole
2-nitroanisole : A member of the class of 2-nitroanisoles that is anisole in which one of the hydrogens ortho to the methoxy group is replaced by a nitro group. | 2.04 | 1 | 0 | 2-nitroanisoles | carcinogenic agent |
2-naphthylamine
2-Naphthylamine: A naphthalene derivative with carcinogenic action.. 2-naphthylamine : A naphthylamine carrying the amino group at position 2. | 1.96 | 1 | 0 | naphthylamine | carcinogenic agent |
3,3'-dichlorobenzidine
3,3'-Dichlorobenzidine: A material used in the manufacture of azo dyes that is toxic to skin and carcinogenic in several species. | 1.96 | 1 | 0 | biphenyls;
monochlorobenzenes;
organochlorine compound | |
4-biphenylamine
4-biphenylamine: used in detection of sulfates, & as a carcinogen in cancer research; RN given refers to parent cpd; structure. biphenyl-4-amine : An aminobiphenyl that is biphenyl substituted by an amino group at position 4. | 1.96 | 1 | 0 | aminobiphenyl | carcinogenic agent |
benzidine
benzidine: RN given refers to parent cpd. benzidine : A member of the class of biphenyls that is 1,1'-biphenyl in which the hydrogen at the para-position of each phenyl group has been replaced by an amino group. | 1.96 | 1 | 0 | biphenyls;
substituted aniline | carcinogenic agent |
o-aminoazotoluene
o-Aminoazotoluene: An azo dye with carcinogenic properties. | 1.96 | 1 | 0 | | |
nitrobenzene
nitrobenzene : A nitroarene consisting of benzene carrying a single nitro substituent. An industrial chemical used widely in the production of aniline. | 2.04 | 1 | 0 | nitroarene;
nitrobenzenes | |
4-nitroaniline
[no description available] | 2.04 | 1 | 0 | nitroaniline | bacterial xenobiotic metabolite |
methylenebis(chloroaniline)
Methylenebis(chloroaniline): Aromatic diamine used in the plastics industry as curing agent for epoxy resins and urethane rubbers. It causes bladder, liver, lung, and other neoplasms.. 4,4'-methylene-bis-(2-chloroaniline) : A chloroaniline that consists of two 2-chloroaniline units joined by a methylene bridge. | 1.96 | 1 | 0 | chloroaniline | metabolite |
4,4'-diaminodiphenylmethane
4,4'-diaminodiphenylmethane: RN given refers to parent cpd; structure. 4,4'-diaminodiphenylmethane : An aromatic amine that is diphenylmethane substituted at the 4-position of each benzene ring by an amino group. | 1.96 | 1 | 0 | aromatic amine | allergen;
carcinogenic agent |
2-tolidine
2-tolidine: RN given refers to parent cpd; structure | 1.96 | 1 | 0 | biphenyls | |
2,4-dinitrotoluene
2,4-dinitrotoluene : A dinitrotoluene in which the methyl group is ortho to one of the nitro groups and para to the other. It is the most common isomer of dinitrotoluene. | 2.04 | 1 | 0 | dinitrotoluene | |
2-amino-5-nitrothiazole
2-amino-5-nitrothiazole: RN given refers to cpd without isomeric designation | 2.04 | 1 | 0 | C-nitro compound;
thiazoles | |
yellow ob
[no description available] | 1.96 | 1 | 0 | | |
thiazoles
[no description available] | 2.65 | 3 | 0 | 1,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene | |
2,7-diacetylaminofluorene
2,7-diacetylaminofluorene: has been found to induce leukemia in animals; minor descriptor (75-84); on-line search 2-ACETYLAMINOFLUORENE/AA (75-84); Index Medicus search 2-ACETYLAMINOFLUORENE/AA (80-82), FLUORENES (75-79) | 1.96 | 1 | 0 | | |
tetranitromethane
[no description available] | 2.04 | 1 | 0 | organonitrogen compound | |
2,7-fluorenediamine
2,7-fluorenediamine: peroxidase reagent for blood smears; RN given refers to parent cpd | 1.96 | 1 | 0 | | |
furothiazole
furothiazole: carcinogen for mouse, rat, dog, hamster; structure | 2.04 | 1 | 0 | aromatic amide | |
5-nitroacenaphthene
[no description available] | 2.04 | 1 | 0 | nitronaphthalene | |
n-hydroxy-1-naphthylamine
N-hydroxy-1-naphthylamine: carcinogen | 1.96 | 1 | 0 | N-substituted amine | |
1-aminoanthracene
[no description available] | 1.96 | 1 | 0 | anthracenamine | |
2-anthramine
2-anthramine: structure | 1.96 | 1 | 0 | anthracenamine | |
acetylcysteine
N-acetyl-L-cysteine : An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine. | 1.96 | 1 | 0 | acetylcysteine;
L-cysteine derivative;
N-acetyl-L-amino acid | antidote to paracetamol poisoning;
antiinfective agent;
antioxidant;
antiviral drug;
ferroptosis inhibitor;
geroprotector;
human metabolite;
mucolytic;
radical scavenger;
vulnerary |
4,4'-methylene bis(2-methylaniline)
4,4'-methylene bis(2-methylaniline): structure | 1.96 | 1 | 0 | diarylmethane | |
9-aminophenanthrene
[no description available] | 1.96 | 1 | 0 | phenanthrenamine | |
n-methylamino-2-nitro-4-n',n'-bis(2-hydroxyethyl)aminobenzene
N-methylamino-2-nitro-4-N',N'-bis(2-hydroxyethyl)aminobenzene: structure | 2.04 | 1 | 0 | C-nitro compound | |
3-methoxy-4-aminoazobenzene
[no description available] | 1.96 | 1 | 0 | | |
n-hydroxy-n-(2-fluorenyl)benzamide
N-hydroxy-N-(2-fluorenyl)benzamide: structure given in first source | 1.96 | 1 | 0 | | |
4-acetylaminobiphenyl
[no description available] | 1.96 | 1 | 0 | biphenyls | |
2-acetamidophenanthrene
[no description available] | 1.96 | 1 | 0 | | |
dimethylnitramine
[no description available] | 2.04 | 1 | 0 | | |
n-hydroxy-4-acetylaminobiphenyl
N-hydroxy-4-acetylaminobiphenyl: structure. N-hydroxy-4-acetylaminobiphenyl : A hydroxamic acid that is biphenyl-4-amine bearing N-hydroxy and N-acetyl substituents. | 1.96 | 1 | 0 | hydroxamic acid | |
1-nitropyrene
[no description available] | 2.04 | 1 | 0 | nitroarene | carcinogenic agent |
acetoxyacetylaminofluorene
Acetoxyacetylaminofluorene: An alkylating agent that forms DNA ADDUCTS at the C-8 position in GUANINE, resulting in single strand breaks. It has demonstrated carcinogenic action.. N-acetoxy-2-acetamidofluorene : A 2-acetamidofluorene compound in which the parent 2-acetamidofluorene is substituted on nitrogen by an acetoxy group. | 1.96 | 1 | 0 | 2-acetamidofluorenes | carcinogenic agent;
mutagen |
3-acetylaminofluorene
3-acetylaminofluorene: non-carcinogenic structural isomer of carcinogen N-2-fluorenylacetamide | 1.96 | 1 | 0 | | |
2',3-dimethyl-4-aminobiphenyl
2',3-dimethyl-4-aminobiphenyl: RN given refers to parent cpd; structure | 1.96 | 1 | 0 | | |
fanft
FANFT: A potent nitrofuran derivative tumor initiator. It causes bladder tumors in all animals studied and is mutagenic to many bacteria. | 2.67 | 3 | 0 | | |
N-fluorenylacetamide
[no description available] | 1.96 | 1 | 0 | fluorenes | |
anft
ANFT: RN given refers to unlabeled cpd | 2.39 | 2 | 0 | | |
2-Amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole
[no description available] | 2.04 | 1 | 0 | C-nitro compound;
furans | |
acridine orange
Acridine Orange: A cationic cytochemical stain specific for cell nuclei, especially DNA. It is used as a supravital stain and in fluorescence cytochemistry. It may cause mutations in microorganisms.. acridine orange : Fluorescent dye useful for cell cycle determination. It is cell-permeable, and interacts with DNA and RNA by intercalation or electrostatic attractions respectively.. acridine orange free base : A member of the class of aminoacridines that is acridine carrying two dimethylamino substituents at positions 3 and 6. The hydrochloride salt is the fluorescent dye 'acridine orange', used for cell cycle determination. | 1.96 | 1 | 0 | aminoacridines;
aromatic amine;
tertiary amino compound | fluorochrome;
histological dye |
n-hydroxy-2-naphthylamine
[no description available] | 1.96 | 1 | 0 | | |
n-acetoxy-4-acetylaminobiphenyl
[no description available] | 1.96 | 1 | 0 | | |
7-iodo-n-2-acetylaminofluorene
[no description available] | 1.96 | 1 | 0 | | |
n-hydroxy-4-aminoazobenzene
N-hydroxy-4-aminoazobenzene: RN given refers to parent cpd | 1.96 | 1 | 0 | | |
4-dimethylaminostilbene
4-dimethylaminostilbene: RN given refers to cpd without isomeric designation; structure | 1.96 | 1 | 0 | | |
4-acetylaminostilbene
4-acetylaminostilbene: RN given refers to non-specified isomer | 1.96 | 1 | 0 | | |
4-aminostilbene
4-aminostilbene: RN given refers to cpd without isomeric designation | 1.96 | 1 | 0 | | |
furylfuramide
Furylfuramide: Used formerly as antimicrobial food additive. It causes mutations in many cell cultures and may be carcinogenic.. (Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide : A member of the class of acrylamides that is acrylamide which is substituted at positions 2 and 3 by 2-furyl and 5-nitro-2-furyl groups, respectively (the trans isomer). Formerly used as a food preservative, it was withdrawn from the market following suspicions of carcenogenicity. | 2.04 | 1 | 0 | acrylamides;
C-nitro compound;
nitrofuran antibiotic;
primary carboxamide | |
4,4'-diaminostilbene
[no description available] | 1.96 | 1 | 0 | | |
nitrofurazone
Nitrofurazone: A topical anti-infective agent effective against gram-negative and gram-positive bacteria. It is used for superficial WOUNDS AND INJURIES and skin infections. Nitrofurazone has also been administered orally in the treatment of TRYPANOSOMIASIS.. nitrofurazone : A semicarbazone resulting from the formal condensation of semicarbazide with 5-nitrofuraldehyde. A broad spectrum antibacterial drug, although with little activity against Pseudomonas species, it is used as a local application for burns, ulcers, wounds and skin infections. | 2.04 | 1 | 0 | | |
nitrofurantoin
Nitrofurantoin: A urinary anti-infective agent effective against most gram-positive and gram-negative organisms. Although sulfonamides and antibiotics are usually the agents of choice for urinary tract infections, nitrofurantoin is widely used for prophylaxis and long-term suppression.. nitrofurantoin : An imidazolidine-2,4-dione that is hydantoin substituted at position 1 by a [(5-nitro-2-furyl)methylene]amino group. An antibiotic that damages bacterial DNA. | 2.04 | 1 | 0 | imidazolidine-2,4-dione;
nitrofuran antibiotic;
organonitrogen heterocyclic antibiotic;
organooxygen heterocyclic antibiotic | antibacterial drug;
antiinfective agent;
hepatotoxic agent |
furaltadon monohydrochloride, (s)-isomer
[no description available] | 2.04 | 1 | 0 | | |
methylnitronitrosoguanidine
Methylnitronitrosoguanidine: A nitrosoguanidine derivative with potent mutagenic and carcinogenic properties.. N-methyl-N'-nitro-N-nitrosoguanidine : An N-nitroguanidine compound having nitroso and methyl substituents at the N'-position | 2.04 | 1 | 0 | nitroso compound | alkylating agent |