Page last updated: 2024-09-28

Sinusitis, Sphenoid

Inflammation of the NASAL MUCOSA in the SPHENOID SINUS. Isolated sphenoid sinusitis is uncommon. It usually occurs in conjunction with other paranasal sinusitis.

Synonyms(3)

Synonym
Sphenoid Sinusitis
Sphenoidal Sinusitis
Sinusitis, Sphenoid

Research Excerpts

Overview

ExcerptReference
"Isolated sphenoid sinusitis is rare, but crtitical complications such as cranial nerve involvement, brain abscess, and bacterial meningitis may happen."( Aoki, M; Aoki, Y; Kimura, T; Tonhyo, C, 2005)
"Acute isolated sphenoid sinusitis is a relatively uncommon entity."( Bessou, P; Bing, F; Boubagra, K; Reyt, E; Righini, CA, 2009)

Research

Studies (56)

TimeframeStudies, This Condition (%)All Conditions %
pre-19902 (3.57)23.3326
1990's11 (19.64)12.5806
2000's21 (37.50)18.1394
2010's19 (33.93)28.8240
2020's3 (5.36)9.53
DrugIndicatedRelationship StrengthStudiesTrials
dalteparin0low10
aspirin0low10
fluconazole0low10
flucytosine0low10
ketoconazole0low20
metformin0low10
metronidazole0low10
prednisolone0low20
kanamycin a0low10
ampicillin0low20
methylprednisolone0low10
vancomycin0low40
gadolinium0low10
transferrin0low10
amoxicillin0low20
propiconazole0low70
itraconazole0low40
triazoles0low60
voriconazole0low80
imipenem, anhydrous0low10
meropenem0low10
clindamycin0low10
micafungin0low20
amphotericin b0low120
clavulanic acid0low10
phenylephrine hydrochloride0low50
nitrofurazone0low10
cefotaxime0low10
cilastatin0low10
amoxicillin-potassium clavulanate combination0low20
cilastatin, imipenem drug combination0low10
ro13-99040low30
acyclovir0low10
eye0low30
gq1b ganglioside0low10

Protein Targets (434)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain E, Purine nucleoside phosphorylase0101
Chain A, HADH2 protein4004
Chain B, HADH2 protein4004
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
Chain A, Ferritin light chain3003
Thymidine kinase 0101
thioredoxin reductase4004
phosphopantetheinyl transferase5005
GLS protein5005
TDP1 protein7007
Smad32002
thyroid stimulating hormone receptor3003
EWS/FLI fusion protein7007
arylsulfatase A2002
euchromatic histone-lysine N-methyltransferase 25005
activating transcription factor 62002
Histone H2A.x3003
Bloom syndrome protein isoform 13003
hemoglobin subunit beta1001
atrial natriuretic peptide receptor 1 precursor1001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
lamin isoform A-delta108008
Solute carrier family 22 member 1 0203
ATP-binding cassette sub-family C member 3013013
Multidrug resistance-associated protein 4013013
Solute carrier family 22 member 60304
Bile salt export pump0404
Bile salt export pump015015
Purine nucleoside phosphorylase0101
Thymidine kinase, cytosolic0001
POU domain, class 2, transcription factor 20001
Cytochrome P450 2C9 0606
Cytochrome P450 2J20303
Disintegrin and metalloproteinase domain-containing protein 171001
Purine nucleoside phosphorylase0011
Solute carrier family 22 member 60304
Thymidine kinase 0101
Solute carrier family 22 member 80304
Canalicular multispecific organic anion transporter 1013013
Thymidine kinase0101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE5005
Chain A, Beta-lactamase3003
Chain A, 2-oxoglutarate Oxygenase5005
Beta-lactamase 0102
Beta-lactamase 0104
Beta-lactamase 0004
Beta-lactamase 0104
AR protein100010
apical membrane antigen 1, AMA13003
estrogen nuclear receptor alpha130013
Beta-lactamase 0002
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
DNA polymerase eta isoform 12002
DNA polymerase iota isoform a (long)6006
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
DNA polymerase kappa isoform 13003
Beta-lactamase SHV-10103
Beta-lactamase SHV-10206
Beta-lactamase0105
Kappa-type opioid receptor0003
Solute carrier family 15 member 10404
Solute carrier family 15 member 10202
B2 metallo-beta-lactamase 0004
Solute carrier family 15 member 20303
Beta-lactamase 0103
Beta-lactamase 0103
Solute carrier family 15 member 20303
Beta-lactamase 0103
Beta-lactamase 0003
Chain A, Cruzipain2002
interleukin 82002
glucocorticoid receptor [Homo sapiens]9009
farnesoid X nuclear receptor5005
peroxisome proliferator-activated receptor delta5005
vitamin D (1,25- dihydroxyvitamin D3) receptor3003
tumor necrosis factor1001
vitamin D3 receptor isoform VDRA4004
nuclear factor erythroid 2-related factor 2 isoform 17007
peripheral myelin protein 223003
Cytochrome P450 1A20101
Cytochrome P450 3A40607
Cytochrome P450 2D60101
Cytochrome P450 2C190202
Nuclear receptor ROR-gamma4004
Potassium voltage-gated channel subfamily H member 20303
Aurora kinase B0101
Broad substrate specificity ATP-binding cassette transporter ABCG20202
Chain A, Mutant Al2 6e7p9g0011
Beta-lactamase 0103
acid sphingomyelinase1001
GLI family zinc finger 3100010
retinoic acid nuclear receptor alpha variant 18008
Beta-lactamase 0204
Beta-lactamase 0004
Metallo-beta-lactamase type 20015
Metallo-beta-lactamase VIM-11 0004
Metallo-beta-lactamase VIM-20004
Beta-lactamase 0004
Metallo-beta-lactamase0004
Beta-lactamase 0204
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
chromobox protein homolog 15005
thyroid hormone receptor beta isoform 25005
DNA polymerase beta1001
geminin8008
Carbonic anhydrase 10303
Carbonic anhydrase 20303
60 kDa heat shock protein, mitochondrial0202
Beta-lactamase OXA-70001
Spike glycoprotein4004
10 kDa heat shock protein, mitochondrial0202
Angiopoietin-1 receptor0011
Beta-lactamase 0104
Beta-lactamase 0104
Beta-lactamase 0104
Thiosulfate sulfurtransferase0202
Metallo-beta-lactamase VIM-130004
Efflux transporter 0001
Beta-lactamase 0004
Beta-lactamase Toho-10002
Beta-lactamase 0001
Class D beta-lactamase0102
60 kDa chaperonin 0202
Metallo-beta-lactamase0004
Beta-lactamase 0105
Beta-lactamase 0014
10 kDa chaperonin 0202
Metallo-b-lactamase 0005
Carbapenem-hydrolyzing beta-lactamase KPC0206
Histamine H3 receptor0004
Beta-lactamase class B VIM-2 0016
Beta-lactamase VIM-1 0004
ATP-dependent phosphofructokinase2002
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain A, Phospholipase A2 isoform 30011
GTP-binding protein (rab7)0011
ras protein, partial0011
aldehyde dehydrogenase 1 family, member A14004
hypothetical protein, conserved1001
cytochrome P450 family 3 subfamily A polypeptide 46006
estrogen-related nuclear receptor alpha9009
cytochrome P450 2D63003
glucocerebrosidase1001
Rac1 protein0011
IDH13003
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
muscarinic acetylcholine receptor M11001
lethal factor (plasmid)2002
Prostaglandin-H2 D-isomerase0101
Prostaglandin G/H synthase 1 0202
Prostaglandin G/H synthase 2 0202
Epidermal growth factor receptor0101
Fatty acid-binding protein, liver0202
Integrin beta-31102
Myeloperoxidase0101
Prostaglandin G/H synthase 10101
Seed linoleate 13S-lipoxygenase-10101
Integrin alpha-IIb1102
Glutathione hydrolase 1 proenzyme0101
Prostaglandin G/H synthase 10202
Adenosine receptor A10101
Adenosine receptor A2a0101
Substance-P receptor0101
Prostaglandin G/H synthase 20303
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0101
Ras-related protein Rab-2A0011
Gamma-aminobutyric acid receptor subunit alpha-12103
Prostaglandin G/H synthase 20101
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 60101
Sigma non-opioid intracellular receptor 10011
Sigma non-opioid intracellular receptor 10011
Beta-lactamase 0102
Beta-lactamase 0203
Metallo-beta-lactamase VIM-19 0003
Beta-lactamase 0102
Albumin0022
Beta-lactamase 0001
Beta-lactamase 0102
Metallo-beta-lactamase VIM-20003
Solute carrier family 22 member 70101
BlaVIM-1 0003
Beta-lactamase 0001
Beta-lactamase 0104
Solute carrier family 22 member 110101
Solute carrier family 22 member 80202
Solute carrier family 22 member 70101
Beta-2 adrenergic receptor0101
Beta-1 adrenergic receptor0101
Dipeptidase 10101
Beta-3 adrenergic receptor0101
Beta-lactamase 0101
Beta-lactamase0101
Beta-lactamase0303
Beta-lactamase0103
Neutrophil elastase0101
Beta-lactamase OXA-10101
Cytochrome P450 2B60202
Beta-lactamase TEM0205
Beta-lactamase0101
Beta-lactamase 0101
Beta-lactamase 0101
Protein-arginine deiminase type-40101
Chain A, BCL-2-RELATED PROTEIN A10011
acetylcholinesterase3003
retinoid X nuclear receptor alpha5005
pregnane X nuclear receptor8008
G6006
unnamed protein product0101
transcriptional regulator ERG isoform 32002
heat shock protein HSP 90-alpha isoform 20002
cytochrome P450 3A4 isoform 12002
bcl-2-like protein 11 isoform 10011
Gamma-aminobutyric acid receptor subunit pi2002
Histone deacetylase 30101
Rap guanine nucleotide exchange factor 32002
Chymotrypsinogen A0202
Interferon beta7007
HLA class I histocompatibility antigen, B alpha chain 6006
Cellular tumor antigen p539009
Steroid 17-alpha-hydroxylase/17,20 lyase0303
Heme oxygenase 1 0101
ATP-dependent translocase ABCB10303
ATP-dependent translocase ABCB10303
Lanosterol 14-alpha demethylase0123
Aromatase0303
Gamma-aminobutyric acid receptor subunit beta-12002
Cytochrome P450 11B1, mitochondrial0202
Gamma-aminobutyric acid receptor subunit delta2002
Gamma-aminobutyric acid receptor subunit gamma-22002
Cytochrome P450 11B2, mitochondrial0202
Gamma-aminobutyric acid receptor subunit alpha-52002
Gamma-aminobutyric acid receptor subunit alpha-32002
ATP-dependent translocase ABCB10303
Gamma-aminobutyric acid receptor subunit gamma-12002
Gamma-aminobutyric acid receptor subunit alpha-22002
Heme oxygenase 20101
Gamma-aminobutyric acid receptor subunit alpha-42002
Gamma-aminobutyric acid receptor subunit gamma-32002
Gamma-aminobutyric acid receptor subunit alpha-62002
Malate dehydrogenase, cytoplasmic0202
Histone deacetylase 40101
Gamma-aminobutyric acid receptor subunit beta-32002
Gamma-aminobutyric acid receptor subunit beta-22002
Cytochrome P450 1440033
Steroid C26-monooxygenase0033
Steroid C26-monooxygenase0033
Mycocyclosin synthase0011
Lanosterol 14-alpha demethylase0011
Lanosterol 14-alpha demethylase0011
TAR DNA-binding protein 433003
Histone deacetylase 10101
Lanosterol 14-alpha demethylase0426
Sterol 14-alpha demethylase0022
Sterol 14-alpha demethylase0112
Histone deacetylase 70101
GABA theta subunit2002
Inositol hexakisphosphate kinase 16006
Histone deacetylase 20101
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
14-alpha sterol demethylase 0022
Histone deacetylase 80101
Gamma-aminobutyric acid receptor subunit epsilon2002
Histone deacetylase 60101
Histone deacetylase 90101
Histone deacetylase 50101
cytochrome P450 2C9, partial6006
heat shock protein 90, putative0002
likely tRNA 2'-phosphotransferase0101
Skn7p0001
nonstructural protein 13003
heat shock protein 900011
calcineurin A1, putative0011
serine/threonine-protein kinase PLK11001
HSP40, subfamily A [Plasmodium falciparum 3D7]0001
potassium voltage-gated channel subfamily H member 2 isoform d1001
Beta-lactamase 0001
Metallo-beta-lactamase type 20001
Beta-lactamase 0001
Beta-lactamase 0002
Beta-lactamase 0002
Beta-lactamase 0001
Beta-lactamase IMP-1 0002
Beta-lactamase 0002
hypoxia-inducible factor 1 alpha subunit4004
RAR-related orphan receptor gamma5005
Fumarate hydratase1001
GALC protein2002
estrogen receptor 2 (ER beta)4004
nuclear receptor subfamily 1, group I, member 35005
polyprotein1001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
heat shock protein beta-12002
Voltage-dependent calcium channel gamma-2 subunit4004
Glutamate receptor 24004
3-oxoacyl-[acyl-carrier-protein] synthase 30101
Gap junction alpha-1 protein0101
Gap junction beta-2 protein0101
Acyl-protein thioesterase 10101
Estrogen receptor beta0101
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial0101
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial0202
Cytochrome P450 26A10101
3',5'-cyclic-AMP phosphodiesterase 0101
Camphor 5-monooxygenase0001
Phospholipase A2, major isoenzyme0101
Epoxide hydrolase 10001
Aldo-keto reductase family 1 member B10202
Muscarinic acetylcholine receptor M20202
Cytochrome P450 2C11 0101
Steroid 21-hydroxylase0101
Alpha-2A adrenergic receptor0303
Cytochrome P450 2C80101
Steroid 17-alpha-hydroxylase/17,20 lyase 0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Polyunsaturated fatty acid lipoxygenase ALOX150101
Cholesterol side-chain cleavage enzyme, mitochondrial 0101
5-hydroxytryptamine receptor 2A0101
Indoleamine 2,3-dioxygenase 10101
Cytochrome P450 2A20101
Cytochrome P450 11B1, mitochondrial 0101
Translocator protein0101
Alpha-2B adrenergic receptor0202
Cytochrome P450 7A1 0101
Estrogen receptor0101
Substance-K receptor0202
UDP-glucuronosyltransferase 1A1 0101
Sodium-dependent noradrenaline transporter 0202
Thromboxane-A synthase 0101
Histamine H2 receptor0202
Gonadotropin-releasing hormone receptor0112
Sodium-dependent serotonin transporter0202
Type-1 angiotensin II receptor0101
Delta-type opioid receptor0202
Cytochrome P450 4F20101
Sodium-dependent dopamine transporter 0202
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial0202
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial0101
Sodium/bile acid cotransporter0101
Cytochrome P450 7A10101
Lanosterol 14-alpha demethylase 0202
aryl hydrocarbon receptor4004
streptokinase A precursor0011
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a6006
histone acetyltransferase KAT2A isoform 12002
Solute carrier family 22 member 20101
Dihydrofolate reductase0101
Dipeptidyl peptidase 40101
Solute carrier family 22 member 10001
Multidrug and toxin extrusion protein 10101
PPM1D protein1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)3003
progesterone receptor5005
bromodomain adjacent to zinc finger domain 2B1001
nuclear receptor subfamily 1, group I, member 22002
nuclear factor erythroid 2-related factor 2 isoform 23003
muscleblind-like protein 1 isoform 12002
Nuclear receptor subfamily 1 group I member 20011
Glucocorticoid receptor06213
Glycine receptor subunit alpha-10606
Androgen receptor0303
Glycine receptor subunit beta0606
Glycine receptor subunit alpha-20606
Glycine receptor subunit alpha-30606
ATPase family AAA domain-containing protein 53003
Ataxin-23003
Nuclear receptor subfamily 1 group I member 20011
Thioredoxin reductase 0101
thyroid hormone receptor beta isoform a3003
mitogen-activated protein kinase 12002
Flavodoxin0001
Voltage-dependent L-type calcium channel subunit alpha-1F0202
Voltage-dependent L-type calcium channel subunit alpha-1D 0202
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Voltage-dependent L-type calcium channel subunit alpha-1C0202
thioredoxin glutathione reductase2002
peroxisome proliferator activated receptor gamma3003
thyroid stimulating hormone receptor2002
v-jun sarcoma virus 17 oncogene homolog (avian)3003
cellular tumor antigen p53 isoform a1001
importin subunit beta-1 isoform 11001
snurportin-11001
nuclear receptor ROR-gamma isoform 13003
survival motor neuron protein isoform d1001
Metabotropic glutamate receptor 50101
Snake venom metalloproteinase BaP10101
NAD(+) hydrolase SARM10202
glp-1 receptor, partial2002
beta-2 adrenergic receptor1001
lysosomal alpha-glucosidase preproprotein1001
mu-type opioid receptor isoform MOR-10011
Vpr1001
5-hydroxytryptamine receptor 2A0011
Neuronal acetylcholine receptor subunit alpha-41001
Neuronal acetylcholine receptor subunit beta-21001
luciferase0001
Estrogen receptor0202
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Histamine H1 receptor0011
Nociceptin receptor0011
Estrogen receptor beta0202
pregnane X receptor2002
SMAD family member 21001
SMAD family member 31001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Histamine H2 receptor1001
Guanine nucleotide-binding protein G1001
Alpha-1B adrenergic receptor0101
Alpha-2B adrenergic receptor0101
Alpha-2C adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Alpha-1D adrenergic receptor0101
Sodium-dependent serotonin transporter0101
Alpha-1A adrenergic receptor0101
D-alanyl-D-alanine dipeptidase0101
Transporter0101
Sterol 14-alpha-demethylase0011
14-alpha sterol demethylase 0011
Cholesterol side-chain cleavage enzyme, mitochondrial 0011
14-alpha sterol demethylase 0011
Cholesterol 24-hydroxylase0213
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]