metronidazole has been researched along with Kidney Failure, Chronic in 23 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Kidney Failure, Chronic: The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients with CKD/ESRD have a higher risk of initial episode, recurrence, and development of severe CDI than those without CKD or ESRD." | 2.61 | Clostridioides difficile Infection in Chronic Kidney Disease/End-Stage Renal Disease. ( Ramesh, MS; Yee, J, 2019) |
| "Tacrolimus was withheld for one dose and then decreased to 1 mg twice daily." | 1.33 | Potential elevation of tacrolimus trough concentrations with concomitant metronidazole therapy. ( Klem, PM; Page, RL; Rogers, C, 2005) |
| "Nocardia brain abscess is a rare condition, seen most commonly among immunocompromised patients." | 1.33 | A case of isolated Nocardia asteroides brain abscess in a kidney transplant recipient. ( Alişir, S; Cağatay, A; Görçin, S; Güven, D; Oztürk, S; Tufan, F; Türkmen, A, 2006) |
| "Vancomycin was added after sensitivity results." | 1.32 | Staphylococcal pericarditis in a chronic renal failure patient. ( Agarwal, SK; Garg, D; Makhija, A; Pathania, A; Prakash, A; Singh, NP, 2003) |
| "We report convulsions induced by short-term metronidazole therapy used in conventional doses for Clostridium difficile colitis in an elderly patient with chronic renal failure." | 1.31 | Convulsions induced by metronidazole treatment for Clostridium difficile-associated disease in chronic renal failure. ( Beloosesky, Y; Grinblat, J; Grosman, B; Marmelstein, V, 2000) |
| "Colonoscopy revealed a picture of pseudomembranous colitis, and Clostridium difficile toxin was positive." | 1.31 | Pseudomembranous colitis without diarrhea presenting clinically as acute intestinal pseudo-obstruction. ( Pauly, MP; Sheikh, RA; Trudeau, WL; Yasmeen, S, 2001) |
| "In 43 ICU patients undergoing continuous volume constant hemofiltration (CVHF), the pharmacokinetics of 12 drugs were investigated to ensure correct dosage adjustments." | 1.28 | [Dosage adjustment of drugs during continuous hemofiltration. Results and practical consequences of a prospective clinical study]. ( Dehne, M; el Abed, K; Hofmann, W; Kroh, U; Lennartz, H, 1989) |
| " Metronidazole is efficiently cleared and extensively removed by dialysis, and therefore dosage adjustments and alterations in the timing of dosage administration are essential in patients undergoing haemodialysis." | 1.27 | Disposition and removal of metronidazole in patients undergoing haemodialysis. ( Gurr, FW; Kong, C; McLean, AJ; Sabto, J; Somogyi, A; Spicer, WJ, 1983) |
| " However, owing to the relatively wide therapeutic index of the drug, dosage supplementation may be necessary only in seriously ill patients to ensure therapeutic effect." | 1.27 | Hemodialysis clearance of metronidazole and its metabolites. ( Chang, CW; Lau, AH; Sabatini, S, 1986) |
| " Of course, overall expense for the hospitalized patient includes costs of tests for monitoring for toxicity as well as administration costs, which are affected by the dosing frequency." | 1.27 | Choosing antimicrobials. Factors to consider, available agents. ( Pankey, GA; Valainis, GT, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (34.78) | 18.7374 |
| 1990's | 2 (8.70) | 18.2507 |
| 2000's | 8 (34.78) | 29.6817 |
| 2010's | 4 (17.39) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Park, H | 1 |
| Lee, M | 1 |
| Jeong, JS | 1 |
| Ramesh, MS | 1 |
| Yee, J | 1 |
| Boyd, AS | 1 |
| Ortleb, M | 1 |
| Kim, SC | 1 |
| Seo, MY | 1 |
| Lee, JY | 1 |
| Kim, KT | 1 |
| Cho, E | 1 |
| Kim, MG | 1 |
| Jo, SK | 1 |
| Cho, WY | 1 |
| Kim, HK | 1 |
| Compain, F | 1 |
| Rossi, B | 1 |
| Richaud, C | 1 |
| Guerot, E | 1 |
| Rostane, H | 1 |
| Jarraud, S | 1 |
| Podglajen, I | 1 |
| Martínez, JG | 1 |
| Saus, C | 1 |
| Morey, A | 1 |
| Alarcón, A | 1 |
| Singh, NP | 1 |
| Prakash, A | 1 |
| Makhija, A | 1 |
| Garg, D | 1 |
| Pathania, A | 1 |
| Agarwal, SK | 1 |
| Page, RL | 1 |
| Klem, PM | 1 |
| Rogers, C | 1 |
| Tsukada, K | 1 |
| Katoh, H | 1 |
| Miyazaki, T | 1 |
| Kuwano, H | 1 |
| Oztürk, S | 1 |
| Tufan, F | 1 |
| Alişir, S | 1 |
| Görçin, S | 1 |
| Güven, D | 1 |
| Cağatay, A | 1 |
| Türkmen, A | 1 |
| Somogyi, A | 1 |
| Kong, C | 1 |
| Sabto, J | 1 |
| Gurr, FW | 1 |
| Spicer, WJ | 1 |
| McLean, AJ | 1 |
| Kreeft, JH | 2 |
| Ogilvie, RI | 2 |
| Dufresne, LR | 2 |
| Turgeon, PL | 1 |
| Holten, E | 1 |
| Smith-Erichsen, N | 1 |
| Hestin, D | 1 |
| Hanesse, B | 1 |
| Frimat, L | 1 |
| Trechot, P | 1 |
| Netter, P | 1 |
| Kessler, M | 1 |
| Tokushima, H | 1 |
| Tamura, H | 1 |
| Murakawa, M | 1 |
| Matsumura, O | 1 |
| Itakura, Y | 1 |
| Itoyama, S | 1 |
| Mitarai, T | 1 |
| Isoda, K | 1 |
| Beloosesky, Y | 1 |
| Grosman, B | 1 |
| Marmelstein, V | 1 |
| Grinblat, J | 1 |
| Arik, N | 1 |
| Cengiz, N | 1 |
| Bilge, A | 1 |
| Sheikh, RA | 1 |
| Yasmeen, S | 1 |
| Pauly, MP | 1 |
| Trudeau, WL | 1 |
| Ingham, HR | 1 |
| Rich, GE | 1 |
| Selkon, JB | 1 |
| Hale, JH | 1 |
| Roxby, CM | 1 |
| Betty, MJ | 1 |
| Johnson, RW | 1 |
| Uldall, PR | 1 |
| Kroh, U | 1 |
| Hofmann, W | 1 |
| Dehne, M | 1 |
| el Abed, K | 1 |
| Lennartz, H | 1 |
| Lau, AH | 1 |
| Chang, CW | 1 |
| Sabatini, S | 1 |
| Pankey, GA | 1 |
| Valainis, GT | 1 |
3 reviews available for metronidazole and Kidney Failure, Chronic
| Article | Year |
|---|---|
Clostridioides difficile Infection in Chronic Kidney Disease/End-Stage Renal Disease.
Topics: Anti-Bacterial Agents; Antibodies, Monoclonal; Antimicrobial Stewardship; Broadly Neutralizing Antib | 2019 |
Vancomycin-associated neutrophilic dermatitis histologically mimicking Cryptococcus.
Topics: Biopsy, Needle; Coronary Artery Disease; Cryptococcus; Dermatomycoses; Diagnosis, Differential; Drug | 2014 |
[Eradication of Helicobacter pylori in patients with end-stage renal disease undergoing dialysis treatment].
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Amoxicillin; Anti-Bacterial Agents; Clarithromycin; Dialysi | 2005 |
20 other studies available for metronidazole and Kidney Failure, Chronic
| Article | Year |
|---|---|
A case of vasculitis triggered by infective endocarditis in a patient undergoing maintenance hemodialysis: a case report.
Topics: Aged; Anti-Bacterial Agents; Clostridium Infections; Echocardiography, Transesophageal; Endocarditis | 2022 |
Advanced chronic kidney disease: a strong risk factor for Clostridium difficile infection.
Topics: Aged; Anti-Infective Agents; Chi-Square Distribution; Clostridioides difficile; Enterocolitis, Pseud | 2016 |
Photo Quiz: A 44-Year-Old Kidney Transplant Patient with Pneumonia.
Topics: Acute Kidney Injury; Adult; Anti-Bacterial Agents; Bacterial Proteins; Bacterial Toxins; beta-Lactam | 2017 |
[Crohn's disease and renal amyloidosis. Acute renal failure].
Topics: Acetaminophen; Acute Kidney Injury; Adrenal Cortex Hormones; Adult; Amyloidosis; Analgesics, Non-Nar | 2002 |
Staphylococcal pericarditis in a chronic renal failure patient.
Topics: Adult; Anti-Bacterial Agents; Anti-Infective Agents; Ceftriaxone; Echocardiography; Female; Humans; | 2003 |
Potential elevation of tacrolimus trough concentrations with concomitant metronidazole therapy.
Topics: Adult; Creatinine; Drug Interactions; Drug Therapy, Combination; Humans; Kidney Failure, Chronic; Ki | 2005 |
A case of isolated Nocardia asteroides brain abscess in a kidney transplant recipient.
Topics: Adult; Antifungal Agents; Brain Abscess; Female; Humans; Immunosuppressive Agents; Kidney Failure, C | 2006 |
Disposition and removal of metronidazole in patients undergoing haemodialysis.
Topics: Adolescent; Adult; Female; Humans; Kidney Failure, Chronic; Kinetics; Male; Metronidazole; Middle Ag | 1983 |
Metronidazole kinetics in dialysis patients.
Topics: Adult; Aged; Female; Half-Life; Humans; Kidney Failure, Chronic; Kinetics; Male; Metabolic Clearance | 1983 |
Biologic activity of metronidazole in plasma and urine of volunteers with normal or impaired renal function.
Topics: Adult; Aged; Biological Assay; Chromatography, High Pressure Liquid; Female; Humans; Kidney Failure, | 1983 |
Concentration of metronidazole in serum during peritoneal dialysis.
Topics: Adult; Biological Assay; Half-Life; Humans; Kidney Failure, Chronic; Male; Metronidazole; Peritoneal | 1981 |
Metronidazole-associated hepatotoxicity in a hemodialyzed patient.
Topics: Aged; Bacteremia; Chemical and Drug Induced Liver Injury; Female; Humans; Kidney Failure, Chronic; M | 1994 |
Eradication of Helicobacter pylori restores elevation of serum gastrin concentrations in patients with end-stage renal disease.
Topics: Ammonia; Anti-Bacterial Agents; Anti-Ulcer Agents; Drug Therapy, Combination; Female; Gastric Juice; | 1998 |
Convulsions induced by metronidazole treatment for Clostridium difficile-associated disease in chronic renal failure.
Topics: Aged; Anti-Infective Agents; Enterocolitis, Pseudomembranous; Female; Humans; Kidney Failure, Chroni | 2000 |
Metronidazole-induced encephalopathy in a uremic patient: a case report.
Topics: Anti-Infective Agents; Brain Diseases; Female; Humans; Kidney Failure, Chronic; Metronidazole; Middl | 2001 |
Pseudomembranous colitis without diarrhea presenting clinically as acute intestinal pseudo-obstruction.
Topics: Aged; Anti-Infective Agents; Biopsy; Colonic Pseudo-Obstruction; Colonoscopy; Contrast Media; Diabet | 2001 |
Treatment with metronidazole of three patients with serious infections due to Bacteroides fragilis.
Topics: Adolescent; Bacteroides fragilis; Bacteroides Infections; Brain Abscess; Female; Humans; Kidney Fail | 1975 |
[Dosage adjustment of drugs during continuous hemofiltration. Results and practical consequences of a prospective clinical study].
Topics: Adult; Aged; Cefotaxime; Ceftazidime; Digitoxin; Digoxin; Hemofiltration; Humans; Imipenem; Kidney F | 1989 |
Hemodialysis clearance of metronidazole and its metabolites.
Topics: Acute Kidney Injury; Adult; Cellulose; Female; Humans; Kidney Failure, Chronic; Kinetics; Male; Memb | 1986 |
Choosing antimicrobials. Factors to consider, available agents.
Topics: Aminoglycosides; Anti-Bacterial Agents; Bacteria; Bacterial Infections; Cephalosporins; Clindamycin; | 1985 |