Page last updated: 2024-09-27

Histiocytic Necrotising Lymphadenitis

Development of lesions in the lymph node characterized by infiltration of the cortex or paracortex by large collections of proliferating histiocytes and complete or, more often, incomplete necrosis of lymphoid tissue.

Synonyms(9)

Synonym
Histiocytic Necrotising Lymphadenitis
Kikuchi's Disease
Kikuchi-Fujimoto's Disease
Lymphadenitis, Histiocytic Necrotizing
Kikuchi-Fujimoto Disease
Nosocomial Kikuchi's Disease
Kikuchi Necrotizing Lymphadenitis
Kikuchi Disease
Histiocytic Necrotizing Lymphadenitis

Research Excerpts

Overview

ExcerptReference
"Kikuchi's disease is a histologically alarming self-limiting condition typically affecting the lymph nodes of young females."( Abraham, M; Chandy, M; Cherian, AM; Danda, D; Das, PK; Harris, VK; Murali, NS, 2000)
"Kikuchi's disease is a rare, self-limited cause of fever and cervical lymphadenitis often misdiagnosed as lymphoma or lupus and inappropriately treated, potentially causing numerous ED visits for unrelieved symptoms."( Schofer, JM; Tanen, DA; Tong, TC, 2005)
"Kikuchi disease is a rare entity characterized by lymphadenopathy and fever."( Abraham, M; Albiges, L; Bonardel, G; Dechaud, C; Lazareth, I; Marini, V; Michon-Pasturel, U; Molinier, V; Priollet, P, 2011)
"KD or histiocytic necrotising lymphadenitis is a rare self-limiting cervical lymphadenitis, often a diagnosis of exclusion."( Bagchi, A; Mallick, S; Mohanty, PK; Nayak, HK, 2013)

Context

ExcerptReference
"Lip involvement by Kikuchi's disease has not been reported, and should be included as one of the possible cutaneous manifestations of Kikuchi's disease."( Imai, K; Nishioka, K; Yokozeki, H, 2002)

Treatment

ExcerptReference
"We present three cases of Kikuchi's disease that benefited significantly from systemic administration of prednisone."( Jang, YJ; Park, KH; Seok, HJ, 2000)
"We describe a case of recurrent Kikuchi's disease in a South Asian-American man that was treated successfully with chloroquine and on recurrence with hydroxychloroquine."( Ariga, R; Chundi, V; Kuchipudi, S; Loew, J; Rezai, K; Sha, BE, 2004)
"We present a case of Kikuchi's disease causing meningitis associated with fever and treated successfully with corticosteroids alone."( Aqel, N; Noursadeghi, M; Pasvol, G, 2005)

Research

Studies (132)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's6 (4.55)12.5806
2000's58 (43.94)18.1394
2010's55 (41.67)28.8240
2020's13 (9.85)9.53
DrugIndicatedRelationship StrengthStudiesTrials
chlorine0low10
pyrazinamide0low10
phenytoin0low10
acetaminophen0low10
aspirin0low20
azathioprine0low10
benzothiazide0low10
carbamazepine0low20
chloroquine0low10
ciprofloxacin0low10
hydroxychloroquine0low100
hydroxyurea0low10
ibuprofen0low40
indomethacin0low10
isoniazid0low10
metronidazole0low10
nifedipine0low10
nimesulide0low10
ofloxacin0low10
prednisolone0low290
prednisone0low200
tyrosine0low10
ampicillin0low10
methylprednisolone0low70
pyrazines0low10
ethambutol0low10
vancomycin0low10
manganese0low10
trolamine salicylate0low60
amoxicillin0low10
piperacillin0low10
cefotiam0low10
iopamidol0low10
cephalosporin c0low20
fluorodeoxyglucose f180low160
fibrinogen0low10
methotrexate0low30
naproxen0low10
chlorite0low10
3-nitrotyrosine0low10
trimethoprim, sulfamethoxazole drug combination0low20
bortezomib0low10
inositol 3-phosphate0low20
meropenem0low20
mycophenolic acid0low10
bromochloroacetic acid0low20
amphotericin b0low10
cefzil0low10
gallium0low10
amoxicillin-potassium clavulanate combination0low20
mocetinostat0low90
ro13-99040low30
minocycline0low20
calca protein, human0low10
cyclin d10low10
muramidase0low20
68ga-dotanoc0low10
folic acid0low10
rifampin0low20
dacarbazine0low10

Protein Targets (781)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, Putative fructose-1,6-bisphosphate aldolase7007
Chain A, JmjC domain-containing histone demethylation protein 3A2002
phosphopantetheinyl transferase8008
bromodomain adjacent to zinc finger domain 2B6006
euchromatic histone-lysine N-methyltransferase 2190019
pyruvate kinase PKM isoform a2002
geminin140014
Glycoprotein hormones alpha chain1001
Guanine nucleotide-binding protein G2002
Tubulin--tyrosine ligase0202
RAR-related orphan receptor gamma160016
ATAD5 protein, partial6006
GLS protein120012
Microtubule-associated protein tau8008
Smad32002
aldehyde dehydrogenase 1 family, member A1150015
thyroid stimulating hormone receptor130013
nuclear receptor subfamily 1, group I, member 3120012
progesterone receptor100010
EWS/FLI fusion protein160016
retinoic acid nuclear receptor alpha variant 1140014
retinoid X nuclear receptor alpha120012
estrogen-related nuclear receptor alpha200020
estrogen nuclear receptor alpha280028
peroxisome proliferator activated receptor gamma120012
aryl hydrocarbon receptor100010
chromobox protein homolog 18008
thyroid hormone receptor beta isoform 2130013
peripheral myelin protein 227007
cytochrome P450 3A4 isoform 18008
Gamma-aminobutyric acid receptor subunit pi83011
ATP-binding cassette sub-family C member 3023023
Multidrug resistance-associated protein 4023025
Solute carrier family 22 member 60606
Carbonic anhydrase 120203
UDP-glucuronosyltransferase 1A90002
Bile salt export pump010010
Voltage-dependent calcium channel gamma-2 subunit9009
Bile salt export pump027027
Cytochrome P450 2B10001
Cytochrome P450 1A10001
Carbonic anhydrase 10607
Carbonic anhydrase 207110
Myoglobin0101
Cytochrome P450 1A10012
Cytochrome P450 1A20405
Prostaglandin G/H synthase 10809
Carbonic anhydrase 30203
Cytochrome P450 3A40707
Cytochrome P450 2D60404
Cytochrome P450 2C9 012012
Polyunsaturated fatty acid lipoxygenase ALOX150303
Gamma-aminobutyric acid receptor subunit beta-183011
Sulfotransferase 1A1 0001
Gamma-aminobutyric acid receptor subunit delta83011
Gamma-aminobutyric acid receptor subunit gamma-283011
UDP-glucuronosyltransferase 1-60001
Glutamate receptor 291010
Gamma-aminobutyric acid receptor subunit alpha-583011
Gamma-aminobutyric acid receptor subunit alpha-383011
Arachidonate 5-lipoxygenase-activating protein0101
UDP-glucuronosyltransferase 1A1 0103
Carbonic anhydrase 40405
Prostaglandin G/H synthase 10707
Carbonic anhydrase 60203
Gamma-aminobutyric acid receptor subunit gamma-183011
Gamma-aminobutyric acid receptor subunit alpha-283011
Gamma-aminobutyric acid receptor subunit alpha-483011
Gamma-aminobutyric acid receptor subunit gamma-383011
Gamma-aminobutyric acid receptor subunit alpha-683011
Carbonic anhydrase 5A, mitochondrial0304
Prostaglandin G/H synthase 208110
Carbonic anhydrase 70203
Nuclear receptor ROR-gamma8008
Cytochrome P450 2J20808
Gamma-aminobutyric acid receptor subunit alpha-184012
Gamma-aminobutyric acid receptor subunit beta-383011
Gamma-aminobutyric acid receptor subunit beta-283011
Carbonic anhydrase 90305
GABA theta subunit83011
Canalicular multispecific organic anion transporter 1023023
Carbonic anhydrase 150304
Carbonic anhydrase 130101
Gamma-aminobutyric acid receptor subunit epsilon83011
Carbonic anhydrase 140203
Carbonic anhydrase 5B, mitochondrial0203
toxin B0001
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE140014
Chain A, Beta-lactamase5005
Chain A, 2-oxoglutarate Oxygenase140014
Beta-lactamase 0002
Beta-lactamase 0002
Beta-lactamase 0003
Beta-lactamase 0002
AR protein240024
apical membrane antigen 1, AMA13003
Beta-lactamase 0002
peptidyl-prolyl cis-trans isomerase NIMA-interacting 13003
DNA polymerase eta isoform 14004
DNA polymerase iota isoform a (long)8008
urokinase-type plasminogen activator precursor4004
plasminogen precursor4004
urokinase plasminogen activator surface receptor precursor4004
DNA polymerase kappa isoform 17007
Beta-lactamase SHV-10002
Beta-lactamase SHV-10003
Beta-lactamase0003
Kappa-type opioid receptor0002
Solute carrier family 15 member 10404
Solute carrier family 15 member 10202
B2 metallo-beta-lactamase 0002
Solute carrier family 15 member 20202
Beta-lactamase 0002
Beta-lactamase 0002
Solute carrier family 15 member 20202
Beta-lactamase 0002
Beta-lactamase 0002
Chain A, HADH2 protein100010
Chain B, HADH2 protein100010
Chain A, Cruzipain5005
interleukin 86006
glucocorticoid receptor [Homo sapiens]150015
farnesoid X nuclear receptor9009
peroxisome proliferator-activated receptor delta120012
vitamin D (1,25- dihydroxyvitamin D3) receptor140014
tumor necrosis factor2002
vitamin D3 receptor isoform VDRA8008
nuclear factor erythroid 2-related factor 2 isoform 1160016
lamin isoform A-delta10170017
Cytochrome P450 2C190404
Potassium voltage-gated channel subfamily H member 2012013
Aurora kinase B0101
Broad substrate specificity ATP-binding cassette transporter ABCG20304
Chain A, Mutant Al2 6e7p9g0011
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Beta-lactamase 0102
acid sphingomyelinase3003
GLI family zinc finger 3100010
Beta-lactamase 0002
Beta-lactamase 0003
Metallo-beta-lactamase type 20014
Metallo-beta-lactamase VIM-11 0002
Metallo-beta-lactamase VIM-20002
Beta-lactamase 0003
Metallo-beta-lactamase0002
Beta-lactamase 0002
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 19009
DNA polymerase beta3003
60 kDa heat shock protein, mitochondrial0303
Beta-lactamase OXA-70002
Spike glycoprotein6129
10 kDa heat shock protein, mitochondrial0303
Angiopoietin-1 receptor0011
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Thiosulfate sulfurtransferase0303
Metallo-beta-lactamase VIM-130003
Efflux transporter 0001
Beta-lactamase 0003
Beta-lactamase Toho-10001
Beta-lactamase 0001
Class D beta-lactamase0002
60 kDa chaperonin 0303
Metallo-beta-lactamase0002
Beta-lactamase 0003
Beta-lactamase 0013
10 kDa chaperonin 0303
Metallo-b-lactamase 0003
Carbapenem-hydrolyzing beta-lactamase KPC0003
Histamine H3 receptor0003
Beta-lactamase class B VIM-2 0014
Beta-lactamase VIM-1 0003
ATP-dependent phosphofructokinase6006
Chain A, TYROSYL-DNA PHOSPHODIESTERASE7007
Chain A, Phospholipase A2 isoform 30011
GTP-binding protein (rab7)0011
ras protein, partial0011
thioredoxin reductase110011
hypothetical protein, conserved2002
cytochrome P450 family 3 subfamily A polypeptide 4100010
cytochrome P450 2D65005
glucocerebrosidase3003
Rac1 protein0011
IDH17007
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
Bloom syndrome protein isoform 17007
muscarinic acetylcholine receptor M14004
lethal factor (plasmid)3003
Prostaglandin-H2 D-isomerase0202
Prostaglandin G/H synthase 1 0405
Prostaglandin G/H synthase 2 0304
Epidermal growth factor receptor0303
Fatty acid-binding protein, liver0303
Integrin beta-32103
Myeloperoxidase0303
Seed linoleate 13S-lipoxygenase-10101
Integrin alpha-IIb2103
Glutathione hydrolase 1 proenzyme0101
Adenosine receptor A10405
Adenosine receptor A2a0506
Substance-P receptor0303
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0202
Ras-related protein Rab-2A0011
Prostaglandin G/H synthase 20707
Rho-associated protein kinase 20202
Nicotinate phosphoribosyltransferase0202
Solute carrier family 22 member 200303
Solute carrier family 22 member 60303
Sigma non-opioid intracellular receptor 10213
Sigma non-opioid intracellular receptor 10011
Chain A, Ferritin light chain4004
acetylcholinesterase5005
SMAD family member 24004
Fumarate hydratase4004
SMAD family member 34004
TDP1 protein170017
thioredoxin glutathione reductase3003
pregnane X nuclear receptor120012
G100010
polyprotein4004
P531001
arylsulfatase A5005
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a110011
thyroid stimulating hormone receptor4004
activating transcription factor 65005
v-jun sarcoma virus 17 oncogene homolog (avian)5005
Histone H2A.x6006
peripheral myelin protein 22 isoform 15005
hemoglobin subunit beta1001
cellular tumor antigen p53 isoform a3003
heat shock protein beta-14004
survival motor neuron protein isoform d7007
M-phase phosphoprotein 85005
muscleblind-like protein 1 isoform 17007
Interferon beta130013
HLA class I histocompatibility antigen, B alpha chain 100010
Cellular tumor antigen p53140014
Inositol hexakisphosphate kinase 1100010
ATPase family AAA domain-containing protein 57007
Ataxin-28008
Protein-arginine deiminase type-40404
cytochrome P450 2C9, partial100010
Luciferase6006
cytochrome P450 2D6 isoform 14004
cytochrome P450 2C9 precursor6006
Histamine H2 receptor7007
Chain H, Proteasome component PUP10101
Chain I, Proteasome component PUP30101
Chain K, Proteasome component PRE20101
Chain L, Proteasome component C50101
Chain K, Proteasome component PRE20101
Chain L, Proteasome component C50101
Proteasome subunit beta type-110101
PPM1D protein5005
caspase 7, apoptosis-related cysteine protease1001
estrogen receptor 2 (ER beta)7007
caspase-31001
nuclear receptor subfamily 1, group I, member 24004
Caspase-71001
caspase-31001
26S proteasome non-ATPase regulatory subunit 110101
26S proteasome non-ATPase regulatory subunit 120101
26S proteasome non-ATPase regulatory subunit 140101
Proteasome subunit alpha type-70101
Histone deacetylase 30303
26S proteasome non-ATPase regulatory subunit 30101
Prothrombin0101
Chymotrypsinogen A0101
Cathepsin B0101
Neutrophil elastase0101
Cathepsin G0202
Lysosomal protective protein0101
Chymotrypsinogen B0101
26S proteasome regulatory subunit 6A0101
Nuclear factor NF-kappa-B p105 subunit0101
Proteasome subunit beta type-10102
Chymase0101
Proteasome subunit alpha type-10101
Proteasome subunit alpha type-20101
Proteasome subunit alpha type-30101
Proteasome subunit alpha type-40101
Proteasome subunit beta type-80101
Proteasome subunit beta type-80101
Proteasome subunit beta type-90101
Proteasome subunit alpha type-50101
Proteasome subunit beta type-40101
Proteasome subunit beta type-60101
Proteasome subunit beta type-50203
26S proteasome regulatory subunit 70101
Lon protease homolog, mitochondrial0101
Proteasome subunit beta type-100101
26S proteasome regulatory subunit 6B0101
26S proteasome non-ATPase regulatory subunit 80101
Proteasome subunit beta type-30101
Proteasome subunit beta type-20102
26S proteasome non-ATPase regulatory subunit 70101
26S proteasome non-ATPase regulatory subunit 40101
26S proteasome complex subunit SEM10101
Proteasome subunit alpha type-60101
26S proteasome regulatory subunit 40101
26S proteasome regulatory subunit 80101
26S proteasome regulatory subunit 10B0101
Beta-carbonic anhydrase 10101
Nuclear factor NF-kappa-B p100 subunit 0101
Transcription factor p650101
26S proteasome non-ATPase regulatory subunit 20101
Histone deacetylase 10303
26S proteasome non-ATPase regulatory subunit 60101
Proteasomal ubiquitin receptor ADRM10101
ATP-dependent Clp protease proteolytic subunit0112
Carbonic anhydrase 130101
NACHT, LRR and PYD domains-containing protein 3 0101
Proteasome subunit alpha-type 80101
Histone deacetylase 20303
Proteasome subunit beta type-70101
26S proteasome non-ATPase regulatory subunit 10101
Histone deacetylase 80202
Histone deacetylase 60202
26S proteasome non-ATPase regulatory subunit 130101
USP1 protein, partial9009
thyroid hormone receptor beta isoform a6006
nuclear factor erythroid 2-related factor 2 isoform 29009
mitogen-activated protein kinase 14004
Vpr1001
Albumin0022
Major prion protein0022
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0202
Sodium channel protein type 3 subunit alpha0101
UDP-glucuronosyltransferase 2B70002
Cytochrome P450 2B60022
Sodium channel protein type 4 subunit alpha0305
Sodium channel protein type 9 subunit alpha0404
Frizzled-80011
P2X purinoceptor 40101
Carbonic anhydrase0102
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase0101
Spike glycoprotein0123
Replicase polyprotein 1ab0123
glucose-6-phosphate 1-dehydrogenase isoform b0101
flap endonuclease 14004
Transmembrane protease serine 20123
Dihydrofolate reductase 0303
DNA ligase0101
Riboflavin-binding protein0011
Amyloid-beta precursor protein0101
Histidine-rich protein PFHRP-II0102
Procathepsin L0325
Muscarinic acetylcholine receptor M20304
Muscarinic acetylcholine receptor M40203
Muscarinic acetylcholine receptor M50203
Alpha-2A adrenergic receptor0303
Replicase polyprotein 1a0123
Replicase polyprotein 1ab0123
Replicase polyprotein 1ab0224
Spike glycoprotein0101
Replicase polyprotein 1ab0224
Muscarinic acetylcholine receptor M10203
Ribosyldihydronicotinamide dehydrogenase [quinone]0101
Alpha-2B adrenergic receptor0202
Alpha-2C adrenergic receptor0202
DNA ligase 10101
Muscarinic acetylcholine receptor M30203
Serine/threonine-protein kinase mTOR0101
Nuclear receptor subfamily 4 group A member 20011
Beta-secretase 10101
Calcium-dependent protein kinase 10011
MO15-related protein kinase Pfmrk 0101
DNA ligase A0101
Sigma intracellular receptor 20202
Phosphoethanolamine N-methyltransferase0101
Angiotensin-converting enzyme 2 0123
Cysteine proteinase falcipain 2a 0101
Cysteine proteinase falcipain 2a 0101
DNA gyrase subunit B0101
DNA gyrase subunit A0101
DNA gyrase subunit B0102
DNA gyrase subunit A0306
DNA gyrase subunit B0306
DNA topoisomerase 4 subunit A0101
DNA topoisomerase 4 subunit B0102
DNA topoisomerase 4 subunit A0102
DNA topoisomerase 2-alpha0104
DNA gyrase subunit A0102
Multidrug resistance protein MdtK0011
DNA gyrase subunit B0405
DNA gyrase subunit A0405
Enoyl-[acyl-carrier-protein] reductase [NADH]0206
DNA topoisomerase 4 subunit A0101
DNA topoisomerase 4 subunit B0101
Integrase 0101
hypoxia-inducible factor 1 alpha subunit5005
Matrix metalloproteinase-90202
Inositol monophosphatase 14004
Isocitrate lyase0202
Pantothenate synthetase0202
Chain A, Dihydrofolate reductase0011
glp-1 receptor, partial3003
alpha-galactosidase3003
lysosomal alpha-glucosidase preproprotein1001
Thymidylate synthase0404
Thymidylate synthase0303
Dihydrofolate reductase0235
Aldo-keto reductase family 1 member B10202
Alpha-synuclein2103
Folylpolyglutamate synthase, mitochondrial0104
Solute carrier organic anion transporter family member 1A30204
Folylpolyglutamate synthase, mitochondrial0104
Multidrug resistance associated protein0103
Genome polyprotein 0101
Alpha-1D adrenergic receptor0202
Cyclic GMP-AMP synthase0101
Toll-like receptor 90101
Toll-like receptor 70101
NFKB1 protein, partial3003
Gamma-aminobutyric acid receptor subunit pi0202
Gamma-aminobutyric acid receptor subunit delta0202
Stromelysin-10112
Gamma-aminobutyric acid receptor subunit alpha-10202
Urease subunit alpha0101
Gamma-aminobutyric acid receptor subunit beta-10202
Gamma-aminobutyric acid receptor subunit gamma-20202
Ribonucleoside-diphosphate reductase large subunit0101
Gamma-aminobutyric acid receptor subunit beta-30202
Gamma-aminobutyric acid receptor subunit alpha-50202
Gamma-aminobutyric acid receptor subunit alpha-30202
Gamma-aminobutyric acid receptor subunit alpha-20202
Gamma-aminobutyric acid receptor subunit beta-20202
Gamma-aminobutyric acid receptor subunit alpha-40202
Urease subunit beta0101
Gamma-aminobutyric acid receptor subunit epsilon0202
Gamma-aminobutyric acid receptor subunit alpha-60202
Gamma-aminobutyric acid receptor subunit gamma-10202
Gamma-aminobutyric acid receptor subunit gamma-30202
Gamma-aminobutyric acid receptor subunit theta0202
nonstructural protein 13003
67.9K protein6006
transcriptional regulator ERG isoform 33003
importin subunit beta-1 isoform 12002
snurportin-12002
Acid-sensing ion channel 30101
Solute carrier organic anion transporter family member 1A40203
Dihydrofolate reductase0405
Albumin0369
Albumin0101
Cholinesterase0101
Fatty acid-binding protein, intestinal0101
Polyunsaturated fatty acid 5-lipoxygenase0307
Acetylcholinesterase0101
Prostaglandin G/H synthase 10202
Caspase-10304
Prostaglandin G/H synthase 2 0305
UDP-glucuronosyltransferase 1A30001
Aldo-keto reductase family 1 member C30404
Caspase-30202
Solute carrier organic anion transporter family member 1A10202
Caspase-40202
Caspase-50202
Caspase-90202
Acid-sensing ion channel 10101
Mu-type opioid receptor0101
Fatty-acid amide hydrolase 10101
Prostaglandin G/H synthase 20203
TAR DNA-binding protein 434004
Solute carrier family 22 member 60304
Prostaglandin G/H synthase 1 0305
Solute carrier family 22 member 80203
Dehydrogenase/reductase SDR family member 90101
Chain A, membrane-associated prostaglandin E synthase-20101
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)5005
Parkin2002
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)2002
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
ras-related protein Rab-9A1001
serine/threonine-protein kinase mTOR isoform 12002
nuclear receptor ROR-gamma isoform 15005
neuropeptide S receptor isoform A1001
Prostaglandin E synthase0101
3',5'-cyclic-AMP phosphodiesterase 0101
Solute carrier organic anion transporter family member 2B1 0404
Cytochrome c oxidase subunit 20101
Phospholipase A2, major isoenzyme0101
ATP-dependent translocase ABCB10202
Neuronal acetylcholine receptor subunit alpha-40101
Interleukin-80101
Androgen receptor0213
Neuronal acetylcholine receptor subunit beta-20101
Aldo-keto reductase family 1 member B10202
Aldo-keto reductase family 1 member C40202
Sodium-dependent dopamine transporter0101
Sodium- and chloride-dependent GABA transporter 10101
Thromboxane-A synthase 0202
Serum paraoxonase/arylesterase 10101
Indoleamine 2,3-dioxygenase 10202
Nitric oxide synthase, inducible0101
Prostaglandin E2 receptor EP3 subtype0101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Prostaglandin E2 receptor EP4 subtype0101
Multidrug resistance-associated protein 1 0102
Bifunctional epoxide hydrolase 20101
Prostaglandin E2 receptor EP1 subtype0101
Peroxisome proliferator-activated receptor gamma0044
Sodium- and chloride-dependent betaine transporter0101
C-X-C chemokine receptor type 30101
Aldo-keto reductase family 1 member C2 0202
Prostaglandin D2 receptor 0202
Lactoylglutathione lyase0101
Aldo-keto reductase family 1 member C10202
Uracil nucleotide/cysteinyl leukotriene receptor0101
Solute carrier family 22 member 70001
Sigma intracellular receptor 20101
Prostaglandin E2 receptor EP2 subtype0101
Multidrug and toxin extrusion protein 10101
Dehydrogenase/reductase SDR family member 90101
P2Y purinoceptor 120101
Solute carrier organic anion transporter family member 1B30406
Cytosolic phospholipase A2 gamma0101
Prostaglandin D2 receptor 20112
Solute carrier organic anion transporter family member 1B10406
3-oxoacyl-[acyl-carrier-protein] synthase 3 0101
potassium voltage-gated channel subfamily H member 2 isoform d1001
histone acetyltransferase KAT2A isoform 14004
N-glycosylase/DNA lyase0101
Polyphenol oxidase 20102
Formamidopyrimidine-DNA glycosylase0101
Cytochrome P450 2C80101
Cytochrome P450 2A60101
Macrophage migration inhibitory factor0101
Endonuclease III-like protein 10101
Putative FAD-containing monooxygenase MymA0101
Dihydrofolate reductase0202
Endonuclease 8-like 10101
Metallo-beta-lactamase VIM-19 0002
streptokinase A precursor0022
Beta-lactamase0001
Beta-lactamase TEM0001
Metallo-beta-lactamase VIM-20002
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase IMP-1 0001
BlaVIM-1 0002
Beta-lactamase 0001
Beta-lactamase 0001
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
dopamine D1 receptor2002
ClpP1001
15-lipoxygenase, partial2002
Thymidylate synthase 0101
Thymidylate synthase 0101
polyunsaturated fatty acid lipoxygenase ALOX122002
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
transactivating tegument protein VP16 [Human herpesvirus 1]0101
caspase-1 isoform alpha precursor1001
nuclear receptor coactivator 3 isoform a0101
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0203
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Tyrosine-protein kinase ABL10011
Bifunctional dihydrofolate reductase-thymidylate synthase0101
5-hydroxytryptamine receptor 2C0102
High mobility group protein B10011
Dihydrofolate reductase0101
Thymidylate synthase0101
Glucose-6-phosphate 1-dehydrogenase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
5-hydroxytryptamine receptor 2A0303
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20011
Bifunctional purine biosynthesis protein ATIC0202
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Kappa-type opioid receptor0101
Reduced folate transporter0202
6-phosphogluconate dehydrogenase, decarboxylating0101
Caspase-71001
Pteridine reductase 10101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Solute carrier family 22 member 110001
Nuclear receptor subfamily 1 group I member 20033
Glucocorticoid receptor06213
Glycine receptor subunit alpha-10606
Androgen receptor0303
Glycine receptor subunit beta0606
Glycine receptor subunit alpha-20606
Glycine receptor subunit alpha-30606
Nuclear receptor subfamily 1 group I member 20011
Thioredoxin reductase 0101
Flavodoxin0001
Voltage-dependent L-type calcium channel subunit alpha-1F0505
Voltage-dependent L-type calcium channel subunit alpha-1D 0505
Voltage-dependent L-type calcium channel subunit alpha-1S0505
Voltage-dependent L-type calcium channel subunit alpha-1C0506
Lanosterol 14-alpha demethylase0202
Matrilysin0101
Multidrug transporter MdfA0101
Protein mono-ADP-ribosyltransferase PARP150101
Nuclear receptor corepressor 10101
Integrin beta-10101
Leukotriene A-4 hydrolase0202
Integrin alpha-40101
Histone deacetylase 40101
Histone deacetylase 70101
Histone deacetylase 11 0101
Histone deacetylase 50101
Nuclear receptor corepressor 20101
Chain A, Inosine-5'-Monophosphate Dehydrogenase 20101
Inosine-5'-monophosphate dehydrogenase 20202
Glutamate receptor 11102
Glutamate receptor 31102
Glutamate receptor 41102
Inosine-5'-monophosphate dehydrogenase 1 0202
Sodium-dependent serotonin transporter0202
Inosine-5'-monophosphate dehydrogenase0102
UDP-glucuronosyltransferase 1A70001
UDP-glucuronosyltransferase 1A100001
UDP-glucuronosyltransferase 1A80001
Hormone-sensitive lipase0101
pregnane X receptor2002
Thrombopoietin1001
regulator of G-protein signaling 42002
beta-2 adrenergic receptor1001
cytochrome P450 2C19 precursor1001
D(1A) dopamine receptor1001
perilipin-50101
perilipin-10101
atrial natriuretic peptide receptor 2 precursor1001
serine/threonine-protein kinase PLK12002
eyes absent homolog 2 isoform a1001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a0101
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
Voltage-dependent L-type calcium channel subunit alpha-1C0202
5-hydroxytryptamine receptor 40202
Potassium channel subfamily K member 20011
Glutathione reductase, mitochondrial0202
Adenosine receptor A30202
Phospholipase A2, membrane associated0001
Alpha-1B adrenergic receptor0303
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Potassium voltage-gated channel subfamily A member 50101
3-oxo-5-alpha-steroid 4-dehydrogenase 1 0101
Platelet-activating factor receptor0001
Voltage-dependent L-type calcium channel subunit alpha-1D0101
5-hydroxytryptamine receptor 2C0202
Adenosine receptor A2a0101
Adenosine receptor A10202
3-oxo-5-alpha-steroid 4-dehydrogenase 20101
Sodium channel protein type 1 subunit alpha0202
C-C chemokine receptor type 20202
Alpha-1A adrenergic receptor0303
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Potassium voltage-gated channel subfamily A member 10101
C-terminal-binding protein 11001
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
Sodium channel protein type 5 subunit alpha0202
Leukotriene B4 receptor 10001
Myosin light chain kinase, smooth muscle0101
Transient receptor potential cation channel subfamily A member 10011
Potassium channel subfamily K member 2 0101
Beta-2 adrenergic receptor0001
Indoleamine 2,3-dioxygenase 20101
Voltage-dependent L-type calcium channel subunit alpha-1D0101
Sodium channel protein type 2 subunit alpha0202
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Leukotriene B4 receptor 20001
Sodium channel protein type 3 subunit alpha0202
Sodium channel protein type 11 subunit alpha0101
Sodium channel protein type 8 subunit alpha0101
Sodium channel protein type 10 subunit alpha0101
Interstitial collagenase0101
Aromatase0101
Sodium-dependent dopamine transporter 0202
STE240001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
CAAX prenyl protease0001
Trypsin0001
Gamma-aminobutyric acid 0101
endonuclease IV1001
atrial natriuretic peptide receptor 1 precursor1001
Gamma-aminobutyric acid receptor subunit alpha-60101
5-hydroxytryptamine receptor 1A0101
Gamma-aminobutyric acid receptor subunit gamma-20101
Gamma-aminobutyric acid receptor subunit delta0101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit alpha-30101
Gamma-aminobutyric acid receptor subunit gamma-30101
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit alpha-10101
Gamma-aminobutyric acid receptor subunit beta-30101
Gamma-aminobutyric acid receptor subunit alpha-50101
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit theta0101
Gamma-aminobutyric acid receptor subunit gamma-10101
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
luciferase0001
Estrogen receptor0202
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Glutamine synthetase0011
Histamine H1 receptor0011
Nociceptin receptor0011
Estrogen receptor beta0202
NAD-dependent protein deacetylase sirtuin-60101
DNA-directed RNA polymerase subunit beta0101
NH(3)-dependent NAD(+) synthetase0101
Arylacetamide deacetylase0102
Solute carrier organic anion transporter family member 1A20102
Glutathione S-transferase omega-10101
DNA-directed RNA polymerase subunit beta0101
Chain X, Thyroid hormone receptor beta-10011
Chain X, Thyroid hormone receptor beta-10011
Solute carrier organic anion transporter family member 1A50001
Rap guanine nucleotide exchange factor 31001
Transthyretin0102
Thyroid hormone receptor alpha0011
Thyroid hormone receptor beta0011
Proliferating cell nuclear antigen0101
Retinoic acid receptor RXR-alpha0022
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 4C10101
Monocarboxylate transporter 80001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
Chain A, CHORISMATE MUTASE0101
Chain A, TYROSYL-tRNA SYNTHETASE0011
Plasma kallikrein0001
Glutamate receptor ionotropic, NMDA 1 0001
Carbonic anhydrase0001
Glutamate receptor ionotropic, NMDA 2A 0001
Glutamate receptor ionotropic, NMDA 2B0001
Glutamate receptor ionotropic, NMDA 2C0001
Large neutral amino acids transporter small subunit 10101
SLC16A10 protein0001
Carbonic anhydrase 0001
Carbonic anhydrase-like protein, putative0001
Carbonic anhydrase0001
Carbonic anhydrase0001
Glutamate receptor ionotropic, NMDA 2D0001
Carbonic anhydrase 0001
Glutamate receptor ionotropic, NMDA 3B0001
Monocarboxylate transporter 100001
Taste receptor type 2 member 140001
Glutamate receptor ionotropic, NMDA 3A0001
Alpha-2B adrenergic receptor0101
Alpha-2C adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Alpha-1D adrenergic receptor0101
D-alanyl-D-alanine dipeptidase0101
Transporter0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]