Compounds > pirlimycin
Page last updated: 2024-11-07

pirlimycin

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Description

pirlimycin: RN given refers to (mono-HCl(2S-cis)-isomer) [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID157385
CHEMBL ID1652611
SCHEMBL ID301657
MeSH IDM0105291

Synonyms (36)

Synonym
pirlimycin
79548-73-5
pirsue [veterinary] (tn)
pirlimycin (inn)
D08391
(2s,4r)-n-[(1s,2s)-2-chloro-1-[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-4-ethylpiperidine-2-carboxamide
CHEMBL1652611
pirlimycinum
pirlimycinum [inn-latin]
pirlimycin [inn]
l-threo-alpha-galacto-octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-((((2s,4r)-4-ethyl-2-piperidinyl)carbonyl)amino)-1-thio-
lm19jt6g5k ,
pirlimycine
pirlimycina
unii-lm19jt6g5k
pirlimycine [inn-french]
l-threo-alpha-galacto-octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-(((4-ethyl-2-piperidinyl)carbonyl)amino)-1-thio-, (2s-cis)-
pirlimycina [inn-spanish]
methyl 7-chloro-6,7,8-trideoxy-6-cis-4-ethyl-l-pipecolamido)-1-thio-l-threo-.alpha.-d-galacto-octopyranoside
pirlimycin [mi]
l-threo-.alpha.-d-galacto-octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-(((4-ethyl-2-piperidinyl)carbonyl)amino)-1-thio-
SCHEMBL301657
DTXSID30904249 ,
DB11537
Q7198039
NCGC00522015-01
CS-0026130
HY-106597
l-threo-.alpha.-d-galacto-octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-[[[(2s,4r)-4-ethyl-2-piperidinyl]carbonyl]amino]-1-thio-
pirlimycine (inn-french)
pirlimycina (inn-spanish)
dtxcid301333398
pirlimycinum (inn-latin)
pirsue (veterinary)
u-57,930
pirlimicina

Research Excerpts

Pharmacokinetics

ExcerptReferenceRelevance
"A population pharmacokinetic approach was used to analyse milk concentration data to determine whether milk discard times and the clearance of intramammary infusions of pirlimycin could be adequately predicted by readily available demographic variables."( Pharmacokinetics and milk discard times of pirlimycin after intramammary infusion: a population approach.
Whittem, T, 1999)		0.3

Dosage Studied

Milk samples were collected at 12 hourly milking intervals after dosing with pirlimycin during product development from both normal cows (primary data) and cows with naturally occurring mastitis (validation data) The concentration was determined by microbial inhibition assay.

ExcerptRelevanceReference
" On the basis of levels of drug attained in the milk with recommended dosing schedules, we chose MIC breakpoints of < or = 2 micrograms/ml for susceptibility and > or = 4 micrograms/ml for resistance."( Activity of pirlimycin against pathogens from cows with mastitis and recommendations for disk diffusion tests.
Marler, JK; Thornsberry, C; Watts, JL; Yancey, RJ, 1993)		0.29
" Milk samples were collected at 12 hourly milking intervals after dosing with pirlimycin during product development from both normal cows (primary data) and cows with naturally occurring mastitis (validation data) and pirlimycin concentration was determined by microbial inhibition assay."( Pharmacokinetics and milk discard times of pirlimycin after intramammary infusion: a population approach.
Whittem, T, 1999)		0.3
" With the application of this method to samples collected in the first 10 h and then every 24 h for 120 h following intramammary dosing (50 mg/cow; n = 3 cows), pirlimycin was detected at 40."( Method development and validation: solid Phase extraction-ultra performance liquid chromatography-tandem mass spectrometry quantification of pirlimycin in bovine feces and urine.
Knowlton, KF; Ray, P; Shang, C; Xia, K, )		0.13
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency39.81070.009610.525035.4813AID1479145
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Ceullar Components (1)

Processvia Protein(s)Taxonomy
virion membraneSpike glycoproteinSevere acute respiratory syndrome-related coronavirus
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (105)

Assay IDTitleYearJournalArticle
AID155770In vitro antibacterial activity against the aerobic Pasteurella multocida (Strain UC no.264)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID160396In vitro antibacterial activity against the anaerobic Propionibacterium acnes(Strain UC no.6564)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID50994In vitro antibacterial activity against the anaerobic Clostridium perfringens (Strain UC no.6509)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID206895In vitro antibacterial activity against the aerobic Staphylococcus aureus (Strain UC no.6675)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID125738Bioactivity in abscess, in Bacteroides fragilis infected mice following subcutaneous dose of 200 mg/kg after 60 mins of bleeding1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID206904In vitro antibacterial activity against the aerobic Staphylococcus aureus (Strain UC no.6694)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID50844In vitro antibacterial activity against the anaerobic Clostridium difficile (Strain UC no.6857)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID206395In vivo antibacterial activity against Staphylococcus aureus (UC no 76) infected mice after sc administration (value in parenthesis is 95% confidence interval)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID157259In vitro antibacterial activity against the anaerobic Peptostreptococcus anaerobius(Strain UC no.6321)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID72255In vitro antibacterial activity against the anaerobic Fusobacterium nucleatum (Strain UC no.6516)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID50846In vitro antibacterial activity against the anaerobic Clostridium difficile (Strain UC no.6860)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID128557Bioactivity in blood, in Bacteroides fragilis infected mice following subcutaneous dose of 200 mg/kg after 90 mins of bleeding1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID206897In vitro antibacterial activity against the aerobic Staphylococcus aureus (Strain UC no.6687)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID50847In vitro antibacterial activity against the anaerobic Clostridium difficile (Strain UC no.6861)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID206908In vitro antibacterial activity against the aerobic Staphylococcus aureus (Strain UC no.76)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID206902In vitro antibacterial activity against the aerobic Staphylococcus aureus (Strain UC no.6692)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID125732Bioactivity in abscess, in Bacteroides fragilis infected mice following subcutaneous dose of 200 mg/kg after 120 mins of bleeding1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID50993In vitro antibacterial activity against the anaerobic Clostridium perfringens (Strain UC no.247)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID163080In vivo antibacterial activity against Proteus vulgaris(UC 347) infected mice after oral administration1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID125739Bioactivity in abscess, in Bacteroides fragilis infected mice following subcutaneous dose of 200 mg/kg after 90 mins of bleeding1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID50726In vitro antibacterial activity against the anaerobic Clostridium bifermentans (Strain UC no.6507)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID41258In vitro antibacterial activity against the anaerobic Bacteroides fragilis (Strain UC no.6864)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID128556Bioactivity in blood, in Bacteroides fragilis infected mice following subcutaneous dose of 200 mg/kg after 60 mins of bleeding1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID207859In vitro antibacterial activity against the aerobic Staphylococcus aureus (Strain UC no.6685)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID157240In vitro antibacterial activity against the anaerobic Peptoccus aerogenes (Strain UC no.6319)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID560247Antibacterial activity against Staphylococcus aureus RN4220 by CLSI method2009Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
Novel ABC transporter gene, vga(C), located on a multiresistance plasmid from a porcine methicillin-resistant Staphylococcus aureus ST398 strain.
AID163245In vitro antibacterial activity against the aerobic Proteus vulgaris (Strain UC no.93)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID206768In vitro antibacterial activity against the aerobic Staphylococcus aureus (Strain UC no.570)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID206396In vivo antibacterial activity against Staphylococcus aureus(UC 76) infected mice after oral administration (value in parenthesis is 95% confidence interval)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID206900In vitro antibacterial activity against the aerobic Staphylococcus aureus (Strain UC no.6690)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID208923In vivo antibacterial activity against Streptococcus pneumoniae III(UC 3213) infected mice after oral administration (value in parenthesis is 95% confidence interval)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID206676In vitro antibacterial activity against the aerobic Staphylococcus mitis (Strain UC no.871)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID206809In vitro antibacterial activity against the aerobic Staphylococcus pneumoniae I(Strain UC no.41)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID206906In vitro antibacterial activity against the aerobic Staphylococcus aureus (Strain UC no.6696)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID50727In vitro antibacterial activity against the anaerobic Clostridium botulinum A(Strain UC no.6506)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID157243In vitro antibacterial activity against the anaerobic Peptococcus asaccharolyticus (Strain UC no.6214)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID155758In vivo antibacterial activity against Pasteurella multocida(UC 264) infected mice after oral administration1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID30566In vitro antibacterial activity against the anaerobic Actinomyces naeslundii (Strain UC no.5920)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID206899In vitro antibacterial activity against the aerobic Staphylococcus aureus (Strain UC no.6689)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID560248Antibacterial activity against Staphylococcus aureus RN4220 harboring aadD, tet(L), dfrK and vga(C) gene by CLSI method2009Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
Novel ABC transporter gene, vga(C), located on a multiresistance plasmid from a porcine methicillin-resistant Staphylococcus aureus ST398 strain.
AID206896In vitro antibacterial activity against the aerobic Staphylococcus aureus (Strain UC no.6686)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID206898In vitro antibacterial activity against the aerobic Staphylococcus aureus (Strain UC no.6688)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID206907In vitro antibacterial activity against the aerobic Staphylococcus aureus (Strain UC no.746)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID95901In vivo antibacterial activity against Klebsiella pneumoniae(UC no 58) infected mice after sc administration1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID72254In vitro antibacterial activity against the anaerobic Fusobacterium nucleatum (Strain UC no.6324)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID206903In vitro antibacterial activity against the aerobic Staphylococcus aureus (Strain UC no.6693)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID41430In vitro antibacterial activity against the anaerobic Bacteroides thetaiotaomicron (Strain UC no.6512)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID95900In vivo antibacterial activity against Klebsiella pneumoniae(UC 58) infected mice after oral administration1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID206815In vitro antibacterial activity against the aerobic Staphylococcus pyogenes (Strain UC no.152)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID50845In vitro antibacterial activity against the anaerobic Clostridium difficile (Strain UC no.6858)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID41118In vivo antibacterial activity against Bacteroides fragilis(UC no 6428) infected mice after sc administration1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID125733Bioactivity in abscess, in Bacteroides fragilis infected mice following subcutaneous dose of 200 mg/kg after 15 mins of bleeding1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID208793In vivo antibacterial activity against Streptococcus pneumoniae I (UC no 41) infected mice after sc administration (value in parenthesis is 95% confidence interval)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID205739In vitro antibacterial activity against the aerobic Staphylococcus epidermidis (Strain UC no.3389)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID163081In vivo antibacterial activity against Proteus vulgaris(UC no 347) infected mice after sc administration1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID125734Bioactivity in abscess, in Bacteroides fragilis infected mice following subcutaneous dose of 200 mg/kg after 150 mins of bleeding1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID157248In vitro antibacterial activity against the anaerobic Peptococcus magnus(Strain UC no.6258)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID160397In vitro antibacterial activity against the anaerobic Propionibacterium acnes(Strain UC no.6575)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID560249Antibacterial activity against Staphylococcus aureus RN4220 harboring tet(L), dfrK gene by CLSI method2009Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
Novel ABC transporter gene, vga(C), located on a multiresistance plasmid from a porcine methicillin-resistant Staphylococcus aureus ST398 strain.
AID206810In vitro antibacterial activity against the aerobic Staphylococcus pneumoniae III(Strain UC no.3213)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID72265In vitro antibacterial activity against the anaerobic Fusobacterium varium(Strain UC no.6052)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID128550Bioactivity in blood, in Bacteroides fragilis infected mice following subcutaneous dose of 200 mg/kg after 120 mins of bleeding1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID165058In vitro antibacterial activity against the aerobic Pseudomonas aeruginosa (Strain UC no.95)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID155759In vivo antibacterial activity against Pasteurella multocida(UC no 264) infected mice after sc administration1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID72250In vitro antibacterial activity against the anaerobic Fusobacterium necrophorum (Strain UC no.6568)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID51139In vitro antibacterial activity against the anaerobic Clostridium tertium(Strain UC no.6508)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID50860In vitro antibacterial activity against the anaerobic Clostridium novyi B(Strain UC no.6329)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID158494In vivo activity against Plasmodium berghei in mice (Mus musculus) after subcutaneous dose (95% confidence interval)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID206675In vitro antibacterial activity against the aerobic Staphylococcus mitis (Strain UC no.153)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID41257In vitro antibacterial activity against the anaerobic Bacteroides fragilis (Strain UC no.6862)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID128553Bioactivity in blood, in Bacteroides fragilis infected mice following subcutaneous dose of 200 mg/kg after 30 mins of bleeding1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID71072In vitro antibacterial activity against the aerobic Escherichia coli (Strain UC no.45)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID41114In vitro antibacterial activity against the anaerobic Bacteroides distasonis (Strain UC no.6518)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID206905In vitro antibacterial activity against the aerobic Staphylococcus aureus (Strain UC no.6695)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID208954In vivo antibacterial activity against Streptococcus pyogenes(UC 152) infected mice after oral administration (value in parenthesis is 95% confidence interval)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID41256In vitro antibacterial activity against the anaerobic Bacteroides fragilis (Strain UC no.6513)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID205750In vitro antibacterial activity against the aerobic Staphylococcus epidermidis (Strain UC no.719)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID206369In vitro antibacterial activity against the aerobic Staphylococcus faecalis (Strain UC no.694)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID125737Bioactivity in abscess, in Bacteroides fragilis infected mice following subcutaneous dose of 200 mg/kg after 45 mins of bleeding1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID51137In vitro antibacterial activity against the anaerobic Clostridium sordellii (Strain UC no.6505)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID208797In vivo antibacterial activity against Streptococcus pneumoniae III (UC no 3213) infected mice after sc administration (value in parenthesis is 95% confidence interval)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID71151In vitro antibacterial activity against the anaerobic Eubacterium lentum(Strain UC no.6522)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID208794In vivo antibacterial activity against Streptococcus pneumoniae I(UC 41) infected mice after oral administration (value in parenthesis is 95% confidence interval)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID51140In vitro antibacterial activity against the anaerobic Clostridium tetani(Strain UC no.6521)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID50729In vitro antibacterial activity against the anaerobic Clostridium cadaveris (Strain UC no.6510)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID128554Bioactivity in blood, in Bacteroides fragilis infected mice following subcutaneous dose of 200 mg/kg after 360 mins of bleeding1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID71059In vivo antibacterial activity against Escherichia coli(UC no 311) infected mice after sc administration1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID560250Antibacterial activity against Staphylococcus aureus RN4220 harboring aadD and tet(L) gene by CLSI method2009Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
Novel ABC transporter gene, vga(C), located on a multiresistance plasmid from a porcine methicillin-resistant Staphylococcus aureus ST398 strain.
AID128551Bioactivity in blood, in Bacteroides fragilis infected mice following subcutaneous dose of 200 mg/kg after 15 mins of bleeding1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID128555Bioactivity in blood, in Bacteroides fragilis infected mice following subcutaneous dose of 200 mg/kg after 45 mins of bleeding1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID125735Bioactivity in abscess, in Bacteroides fragilis infected mice following subcutaneous dose of 200 mg/kg after 30 mins of bleeding1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID41255In vitro antibacterial activity against the anaerobic Bacteroides fragilis (Strain UC no.6428)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID41410In vitro antibacterial activity against the anaerobic Bacteroides melaninogenicus (Strain UC no.6326)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID71058In vivo antibacterial activity against Escherichia coli(UC 311) infected mice after oral administration1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID200522In vitro antibacterial activity against the aerobic Salmonella schottmuelleri (Strain UC no.126)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID158493In vivo activity against Plasmodium berghei in mice (Mus musculus) on oral administration1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID207635In vitro antibacterial activity for minimum inhibition concentration (MIC) required to inhibit growth of Staphylococcus aureus1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID50843In vitro antibacterial activity against the anaerobic Clostridium difficile (Strain UC no.6834)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID128552Bioactivity in blood, in Bacteroides fragilis infected mice following subcutaneous dose of 200 mg/kg after 150 mins of bleeding1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID206894In vitro antibacterial activity against the aerobic Staphylococcus aureus (Strain UC no.571)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID125736Bioactivity in abscess, in Bacteroides fragilis infected mice following subcutaneous dose of 200 mg/kg after 360 mins of bleeding1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID208953In vivo antibacterial activity against Streptococcus pyogenes (UC no 152) infected mice after sc administration (value in parenthesis is 95% confidence interval)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID96266In vitro antibacterial activity against the aerobic Klebsiella pneumoniae (Strain UC no.58)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID71152In vitro antibacterial activity against the anaerobic Eubacterium limosum(Strain UC no.6515)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
AID206901In vitro antibacterial activity against the aerobic Staphylococcus aureus (Strain UC no.6691)1984Journal of medicinal chemistry, Feb, Volume: 27, Issue:2
Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, 1,2 a potent antibacterial agent.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (51)

TimeframeStudies, This Drug (%)All Drugs %
pre-199010 (19.61)18.7374
1990's8 (15.69)18.2507
2000's17 (33.33)29.6817
2010's12 (23.53)24.3611
2020's4 (7.84)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials8 (14.55%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other47 (85.45%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
gentamicin
Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.		2.0110
metronidazole
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.. metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.		1.9810C-nitro compound;
imidazoles;
primary alcohol		antiamoebic agent;
antibacterial drug;
antimicrobial agent;
antiparasitic agent;
antitrichomonal drug;
environmental contaminant;
prodrug;
radiosensitizing agent;
xenobiotic
sulfamethazine
Sulfamethazine: A sulfanilamide anti-infective agent. It has a spectrum of antimicrobial action similar to other sulfonamides.. sulfamethazine : A sulfonamide consisting of pyrimidine with methyl substituents at the 4- and 6-positions and a 4-aminobenzenesulfonamido group at the 2-position.		2.1710pyrimidines;
sulfonamide antibiotic;
sulfonamide		antibacterial drug;
antiinfective agent;
antimicrobial agent;
carcinogenic agent;
drug allergen;
EC 2.5.1.15 (dihydropteroate synthase) inhibitor;
environmental contaminant;
ligand;
xenobiotic
trimethoprim
Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.. trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.		2.0510aminopyrimidine;
methoxybenzenes		antibacterial drug;
diuretic;
drug allergen;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
environmental contaminant;
xenobiotic
chloramphenicol
Amphenicol: Chloramphenicol and its derivatives.		1.9610C-nitro compound;
carboxamide;
diol;
organochlorine compound		antibacterial drug;
antimicrobial agent;
Escherichia coli metabolite;
geroprotector;
Mycoplasma genitalium metabolite;
protein synthesis inhibitor
cephalothin
Cephalothin: A cephalosporin antibiotic.. cefalotin : A semisynthetic, first-generation cephalosporin antibiotic with acetoxymethyl and (2-thienylacetyl)nitrilo moieties at positions 3 and 7, respectively, of the core structure. Administered parenterally during surgery and to treat a wide spectrum of blood infections.		2.0110azabicycloalkene;
beta-lactam antibiotic allergen;
carboxylic acid;
cephalosporin;
semisynthetic derivative;
thiophenes		antibacterial drug;
antimicrobial agent
kanamycin a
Kanamycin: Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major component, and kanamycins B and C, the minor components.. kanamycin : Kanamycin is a naturally occurring antibiotic complex from Streptomyces kanamyceticus that consists of several components: kanamycin A, the major component (also usually designated as kanamycin), and kanamycins B, C, D and X the minor components.		2.0510kanamycinsbacterial metabolite
carbostyril
Quinolones: A group of derivatives of naphthyridine carboxylic acid, quinoline carboxylic acid, or NALIDIXIC ACID.. quinolin-2(1H)-one : A quinolone that is 1,2-dihydroquinoline substituted by an oxo group at position 2.		1.9910monohydroxyquinoline;
quinolone		bacterial xenobiotic metabolite
methicillin
Methicillin: One of the PENICILLINS which is resistant to PENICILLINASE but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection.. methicillin : A penicillin that is 6-aminopenicillanic acid in which one of the amino hydrogens is replaced by a 2,6-dimethoxybenzoyl group.		2.3720penicillin allergen;
penicillin		antibacterial drug
cloxacillin
Cloxacillin: A semi-synthetic antibiotic that is a chlorinated derivative of OXACILLIN.. cloxacillin : A semisynthetic penicillin antibiotic carrying a 3-(2-chlorophenyl)-5-methylisoxazole-4-carboxamido group at position 6.		2.3820penicillin allergen;
penicillin;
semisynthetic derivative		antibacterial agent;
antibacterial drug
oxacillin
Oxacillin: An antibiotic similar to FLUCLOXACILLIN used in resistant staphylococci infections.. oxacillin : A penicillin antibiotic carrying a 5-methyl-3-phenylisoxazole-4-carboxamide group at position 6beta.		2.4620penicillinantibacterial agent;
antibacterial drug
ampicillin
Ampicillin: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.. ampicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group.		2.6830beta-lactam antibiotic;
penicillin allergen;
penicillin		antibacterial drug
acetonitrile
acetonitrile: RN given refers to unlabeled cpd. acetonitrile : A nitrile that is hydrogen cyanide in which the hydrogen has been replaced by a methyl group.		1.9810aliphatic nitrile;
volatile organic compound		EC 3.5.1.4 (amidase) inhibitor;
NMR chemical shift reference compound;
polar aprotic solvent
methylene chloride
Methylene Chloride: A chlorinated hydrocarbon that has been used as an inhalation anesthetic and acts as a narcotic in high concentrations. Its primary use is as a solvent in manufacturing and food technology.. dichloromethane : A member of the class of chloromethanes that is methane in which two of the hydrogens have been replaced by chlorine. A dense, non-flammible colourless liquid at room temperature (b.p. 40degreeC, d = 1.33) which is immiscible with water, it is widely used as a solvent, a paint stripper, and for the removal of caffeine from coffee and tea.		1.9810chloromethanes;
volatile organic compound		carcinogenic agent;
polar aprotic solvent;
refrigerant
framycetin
Framycetin: A component of NEOMYCIN that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed). framycetin : A tetracyclic antibacterial agent derived from neomycin, being a glycoside ester of neamine and neobiosamine B.		2.0510aminoglycosideallergen;
antibacterial drug;
Escherichia coli metabolite
erythromycin
Erythromycin: A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.. erythromycin : Any of several wide-spectrum macrolide antibiotics obtained from actinomycete Saccharopolyspora erythraea (formerly known as Streptomyces erythraeus).. erythromycin A : An erythromycin that consists of erythronolide A having 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl and 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl residues attahced at positions 4 and 6 respectively.		2.9240cyclic ketone;
erythromycin
spectinomycin
Spectinomycin: An antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of GONORRHEA.. spectinomycin dihydrochloride : A hydrochloride obtained by combining spectinomycin with two molar equivalents of hydrochloric acid. An antibiotic that is active against gram-negative bacteria and used (as its pentahydrate) to treat gonorrhea.. spectinomycin : A pyranobenzodioxin and antibiotic that is active against gram-negative bacteria and used (as its dihydrochloride pentahydrate) to treat gonorrhea. It is produced by the bacterium Streptomyces spectabilis.		1.9810cyclic acetal;
cyclic hemiketal;
cyclic ketone;
pyranobenzodioxin;
secondary alcohol;
secondary amino compound		antibacterial drug;
antimicrobial agent;
bacterial metabolite
carbenicillin
Carbenicillin: Broad-spectrum semisynthetic penicillin derivative used parenterally. It is susceptible to gastric juice and penicillinase and may damage platelet function.. carbenicillin : A penicillin antibiotic having a 6beta-2-carboxy-2-phenylacetamido side-chain.		1.9610penicillin allergen;
penicillin		antibacterial drug
cephalexin
Cephalexin: A semisynthetic cephalosporin antibiotic with antimicrobial activity similar to that of CEPHALORIDINE or CEPHALOTHIN, but somewhat less potent. It is effective against both gram-positive and gram-negative organisms.. cephalexin : A semisynthetic first-generation cephalosporin antibiotic having methyl and beta-(2R)-2-amino-2-phenylacetamido groups at the 3- and 7- of the cephem skeleton, respectively. It is effective against both Gram-negative and Gram-positive organisms, and is used for treatment of infections of the skin, respiratory tract and urinary tract.		2.2110beta-lactam antibiotic allergen;
cephalosporin;
semisynthetic derivative		antibacterial drug
clonixin
Clonixin: Anti-inflammatory analgesic.. clonixin : A pyridinemonocarboxylic acid that is nicotinic acid substituted at position 2 by a (2-methyl-3-chlorophenyl)amino group. Used (as its lysine salt) for treatment of renal colic, muscular pain and moderately severe migraine attacks.		2.0410aminopyridine;
organochlorine compound;
pyridinemonocarboxylic acid		antipyretic;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
lipoxygenase inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
platelet aggregation inhibitor;
vasodilator agent
cephapirin
Cephapirin: Cephalosporin antibiotic, partly plasma-bound, that is effective against gram-negative and gram-positive organisms.. cephapirin : A cephalosporin with acetoxymethyl and 2(pyridin-4-ylsulfanyl)acetamido substituents at positions 3 and 7, respectively, of the cephem skeleton. It is used (as its sodium salt) as an antibiotic, being effective against gram-negative and gram-positive organisms.		9.4141cephalosporinantibacterial drug
amoxicillin
Amoxicillin: A broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum levels with oral administration.. amoxicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-(4-hydroxyphenyl)acetamido group.		2.4420penicillin allergen;
penicillin		antibacterial drug
flunixin meglumine
flunixin meglumine : An organoammonium salt obtained by combining flunixin with one molar equivalent of 1-deoxy-1-(methylamino)-D-glucitol. A relatively potent non-narcotic, nonsteroidal analgesic with anti-inflammatory, anti-endotoxic and anti-pyretic properties; used in veterinary medicine for treatment of horses, cattle and pigs.		2.0410organoammonium saltantipyretic;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug
trospectomycin
trospectomycin: active against Neisseria gonorrhoeae; RN refers to 2R-(2alpha,4abeta,5abeta,6beta,7beta,8beta,9beta,9alpha,9aalpha,10abeta)-(9CI)-isomer		6.9810dioxanes
cephalosporin c
cephalosporin C: RN given refers to parent cpd; structure in Merck, 9th ed, #1937. cephalosporin C : A cephalosporin antibiotic carrying a 3-acetoxymethyl substituent and a 6-oxo-N(6)-L-lysino group at position 7.		5.0852cephalosporinfungal metabolite
enrofloxacin
Enrofloxacin: A fluoroquinolone antibacterial and antimycoplasma agent that is used in veterinary practice.. enrofloxacin : A quinolinemonocarboxylic acid that is 1,4-dihydroquinoline-3-carboxylic acid substituted by an oxo group at position 4, a fluoro group at position 6, a cyclopropyl group at position 1 and a 4-ethylpiperazin-1-yl group at position 7. It is a veterinary antibacterial agent used for the treatment of pets.		2.4320cyclopropanes;
N-alkylpiperazine;
N-arylpiperazine;
organofluorine compound;
quinolinemonocarboxylic acid;
quinolone		antibacterial agent;
antimicrobial agent;
antineoplastic agent
danofloxacin
[no description available]		2.110quinolines
sulbactam
[no description available]		2.0110penicillanic acids
biotin
vitamin B7 : Any member of a group of vitamers that belong to the chemical structural class called biotins that exhibit biological activity against vitamin B7 deficiency. Vitamin B7 deficiency is very rare in individuals who take a normal balanced diet. Foods rich in biotin are egg yolk, liver, cereals, vegetables (spinach, mushrooms) and rice. Symptoms associated with vitamin B7 deficiency include thinning hair, scaly skin rashes around eyes, nose and mouth, and brittle nails. The vitamers include biotin and its ionized and salt forms.		7.1310biotins;
vitamin B7		coenzyme;
cofactor;
Escherichia coli metabolite;
fundamental metabolite;
human metabolite;
mouse metabolite;
nutraceutical;
prosthetic group;
Saccharomyces cerevisiae metabolite
cefoxitin
Cefoxitin: A semisynthetic cephamycin antibiotic resistant to beta-lactamase.. cefoxitin : A semisynthetic cephamycin antibiotic which, in addition to the methoxy group at the 7alpha position, has 2-thienylacetamido and carbamoyloxymethyl side-groups. It is resistant to beta-lactamase.		1.9610beta-lactam antibiotic allergen;
cephalosporin;
cephamycin;
semisynthetic derivative		antibacterial drug
hetacillin
[no description available]		2.110penicillinantibacterial drug
sultamicillin
sultamicillin: contains ampicillin & sulbactam		2.0110penicillanic acid ester
clindamycin
Clindamycin: An antibacterial agent that is a semisynthetic analog of LINCOMYCIN.. clindamycin : A carbohydrate-containing antibiotic that is the semisynthetic derivative of lincomycin, a natural antibiotic.		8.47508
tiamulin
tiamulin: 81723 HFU and tiamutin are for fumarate salt; prevents senescence in ascomycete; pleuromutilin derivative; RN given refers to ((3aS-(3aalpha,4beta,5alpha,6alpha,8beta,9alpha,9abeta,10S*))-isomer. tiamulin : A carbotricyclic compound that is pleuromutilin in which the hydroxyacetate group is replaced by a 2-{[2-(diethylamino)ethyl]sulfanyl}acetate group. An antibacterial drug, tiamulin is used in veterinary medicine (generally as its hydrogen fumarate salt) for the treatment of swine dysentery caused by Serpulina hyodysenteriae.		2.0510carbotricyclic compound;
carboxylic ester;
cyclic ketone;
organic sulfide;
secondary alcohol;
semisynthetic derivative;
tertiary amino compound;
tetracyclic diterpenoid		antibacterial drug
lincomycin
Lincomycin: An antibiotic produced by Streptomyces lincolnensis var. lincolnensis. It has been used in the treatment of staphylococcal, streptococcal, and Bacteroides fragilis infections.. lincomycin : A carbohydrate-containing antibiotic produced by the actinomyces Streptomyces lincolnensis.		2.6730carbohydrate-containing antibiotic;
L-proline derivative;
monocarboxylic acid amide;
pyrrolidinecarboxamide;
S-glycosyl compound		antimicrobial agent;
bacterial metabolite
streptogramin a
Streptogramin A: A specific streptogramin group A antibiotic produced by Streptomyces graminofaciens and other bacteria.		2.05101,3-oxazoles;
cyclic ketone;
enamide;
lactam;
macrolide antibiotic;
macrolide;
pyrroline;
secondary alcohol;
secondary carboxamide;
tertiary carboxamide		antibacterial drug;
Mycoplasma genitalium metabolite
phosphorus
Phosphorus: A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.		2.5320monoatomic phosphorus;
nonmetal atom;
pnictogen		macronutrient
valnemulin
[no description available]		2.0510
rifamycins
[no description available]		1.9610
ceftiofur
ceftiofur: structure in first source		9.9142
tilmicosin
tilmicosin: semi-synthetic antibiotic. tilmicosin : A macrolide antibiotic with formula C46H80N2O13. It is used for the treatment of respiratory disease in cattle at high risk of developing bovine respiratory disease associated with Mannheimia haemolytica.		2.110
tylosin
[no description available]		7.9540
novobiocin
Novobiocin: An antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189). novobiocin : A coumarin-derived antibiotic obtained from Streptomyces niveus.		2.9140carbamate ester;
ether;
hexoside;
hydroxycoumarin;
monocarboxylic acid amide;
monosaccharide derivative;
phenols		antibacterial agent;
antimicrobial agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
Escherichia coli metabolite;
hepatoprotective agent
tetracycline
Tetracycline: A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.. tetracycline : A broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria.		2.3920
chlortetracycline
Chlortetracycline: A TETRACYCLINE with a 7-chloro substitution.. chlortetracycline : A member of the class of tetracyclines with formula C22H23ClN2O8 isolated from Streptomyces aureofaciens.		2.1710
oxytetracycline, anhydrous
Oxytetracycline: A TETRACYCLINE analog isolated from the actinomycete STREPTOMYCES RIMOSUS and used in a wide variety of clinical conditions.. oxytetracycline : A tetracycline used for treatment of infections caused by a variety of Gram positive and Gram negative microorganisms including Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae (respiratory infections), and Diplococcus pneumoniae.		2.520
mirincamycin
[no description available]		6.9810
ConditionIndicatedRelationship StrengthStudiesTrials
Infections, Plasmodium
[description not available]		01.9610
Infections, Staphylococcal
[description not available]		06.41153
Bacteroides Infections
Infections with bacteria of the genus BACTEROIDES.		01.9610
Group A Strep Infection
[description not available]		05.262
Malaria
A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.		01.9610
Staphylococcal Infections
Infections with bacteria of the genus STAPHYLOCOCCUS.		06.41153
Streptococcal Infections
Infections with bacteria of the genus STREPTOCOCCUS.		05.262
Swine Diseases
Diseases of domestic swine and of the wild boar of the genus Sus.		02.0510
Mastitis, Bovine
INFLAMMATION of the UDDER in cows.		07.89278
Breast Diseases
Pathological processes of the BREAST.		02.1510
Bovine Diseases
[description not available]		02.4820
Eperythrozoonosis
[description not available]		02.110
Bacterial Infections, Gram-Positive
[description not available]		03.4311
Gram-Positive Bacterial Infections
Infections caused by bacteria that retain the crystal violet stain (positive) when treated by the gram-staining method.		03.4311
E coli Infections
[description not available]		03.8121
Infections, Klebsiella
[description not available]		03.3911
Escherichia coli Infections
Infections with bacteria of the species ESCHERICHIA COLI.		03.8121
Klebsiella Infections
Infections with bacteria of the genus KLEBSIELLA.		03.3911
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.		03.150
Recrudescence
[description not available]		03.4111
Chronic Illness
[description not available]		03.4111
Chronic Disease
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).		03.4111
Bacterial Disease
[description not available]		02.0310
Bacterial Infections
Infections by bacteria, general or unspecified.		02.0310
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		01.9610
Mastitis
INFLAMMATION of the BREAST, or MAMMARY GLAND.		01.9610