metronidazole has been researched along with Leukoencephalopathy Syndrome, Posterior in 3 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Reversible posterior leukoencephalopathy syndrome (RPLS) is a clinical syndrome of varying etiologies with similar neuroimaging findings." | 1.43 | Reversible Posterior Leukoencephalopathy Syndrome Associated with Treatment for Acute Exacerbation of Ulcerative Colitis. ( Ashida, T; Kikuchi, S; Maemoto, A; Orii, F, 2016) |
| " In this pictorial essay, we review the two most common brain injury patterns, posterior reversible encephalopathy syndrome (PRES) and acute toxic leukoencephalopathy (ATL)." | 1.37 | Medication neurotoxicity in children. ( Chaturvedi, A; Ishak, GE; Iyer, RS; Khanna, PC; Pruthi, S, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Hosaka, T | 1 |
| Terada, M | 1 |
| Okubo, K | 1 |
| Iwabuchi, S | 1 |
| Kajii, E | 1 |
| Kikuchi, S | 1 |
| Orii, F | 1 |
| Maemoto, A | 1 |
| Ashida, T | 1 |
| Iyer, RS | 1 |
| Chaturvedi, A | 1 |
| Pruthi, S | 1 |
| Khanna, PC | 1 |
| Ishak, GE | 1 |
3 other studies available for metronidazole and Leukoencephalopathy Syndrome, Posterior
| Article | Year |
|---|---|
Management of a rare case of metronidazole-induced encephalopathy presenting as posterior reversible encephalopathy syndrome: a case report.
Topics: Brain Diseases; Humans; Magnetic Resonance Imaging; Metronidazole; Posterior Leukoencephalopathy Syn | 2023 |
Reversible Posterior Leukoencephalopathy Syndrome Associated with Treatment for Acute Exacerbation of Ulcerative Colitis.
Topics: Anti-Infective Agents; Anti-Inflammatory Agents; Blood Transfusion; Colitis, Ulcerative; Contraindic | 2016 |
Medication neurotoxicity in children.
Topics: Adolescent; Angiogenesis Inhibitors; Anti-Infective Agents; Antibodies, Monoclonal, Humanized; Bevac | 2011 |