Smear Layer

Adherent debris produced when cutting the enamel or dentin in cavity preparation. It is about 1 micron thick and its composition reflects the underlying dentin, although different quantities and qualities of smear layer can be produced by the various instrumentation techniques. Its function is presumed to be protective, as it lowers dentin permeability. However, it masks the underlying dentin and interferes with attempts to bond dental material to the dentin.

Synonym
Smear Layer

Excerpt	Reference
"However, this smear layer is acid labile."	( Fogel, HM; Pashley, DH, 1993)
"If smear layer is to be removed, EDTA and NaOCl solutions have been shown to be effective, among various irrigation solutions and techniques, including ultrasonics, that have been tested."	( Sen, BH; Türkün, M; Wesselink, PR, 1995)
"Smear layer is a negative factor which prevents adhesion of the filling material to the dentinal walls."	( Das, M; Garapati, S; Kumar, GA; Ramesh, S; Sharma, D, 2013)
"Smear layer is a layer which is produced during instrumentation."	( Giardino, L; Jafarzadeh, H; Kinoshita, JI; Kobayashi, M; Manabe, A; Mohammadi, Z; Palazzi, F; Shalavi, S; Sharifi, F; Yaripour, S, 2019)
"The smear layer is generated during activation."	( Aranguren, JM; Arias, A; de Gregorio, C; Rius, L; Romero, M, 2021)

Excerpt	Reference
"The smear layer affects slightly the wettability of self-etching adhesives."	( Aguilar-Mendoza, JA; Cabrerizo-Vílchez, MA; González-López, S; Rodríguez-Valverde, MA; Rosales-Leal, JI, 2008)

Excerpt	Reference
"An understanding of the appropriate treatment for smear layers is crucial to the development of improved dentin bonding systems."	( Mitchell, S; Santini, A, 1998)
"(1) SEM observation: In laser-NaF treated group, the smear layer was almost removed, the enamel surface showed partially melted-like and bubble-like appearance, diffuse white-small particles distributed on enamel surface, and melted position, microcrack and microhole appeared whitely blocking-reflection."	( Liu, LC; Zhang, L, 2004)
"Their deproteinizing effects at the treated smear layer-covered dentine surfaces were determined by the measurement of amide:phosphate ratio using ATR-FTIR analysis."	( Foxton, RM; Ichinose, S; Nakajima, M; Prasansuttiporn, T; Tagami, J; Thanatvarakorn, O, 2014)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	1 (0.10)	23.3326
1990's	219 (21.26)	12.5806
2000's	386 (37.48)	18.1394
2010's	362 (35.15)	28.8240
2020's	62 (6.02)	9.53

Drug	Relationship Strength	Studies	Trials
ethylene glycol	low	1	0
acetic acid	medium	8	3
acetone	medium	8	2
formic acid	low	1	0
citric acid, anhydrous	medium	147	26
chlorine	low	9	0
hydrochloric acid	medium	3	1
malic acid	medium	2	2
phosphonoacetic acid	low	1	0
lactic acid	medium	9	2
formaldehyde	medium	5	1
glycine	low	5	0
glycerol	medium	3	1
glycolic acid	low	1	0
iodine	low	1	0
racepinephrine	low	1	0
phytic acid	low	2	0
nickel	medium	93	20
nitrates	low	4	0
nitric acid	low	5	0
hydroxide ion	medium	1	1
oxalic acid	low	9	0
triphosphoric acid	low	1	0
phenol	low	1	0
phosphoric acid	medium	73	18
propylene glycol	low	3	0
pyruvic acid	low	1	0
toluene	low	3	0
urea	medium	12	3
camphor, (+-)-isomer	medium	3	1
cetyltrimethylammonium ion	medium	10	4
cetylpyridinium	medium	2	1
ciprofloxacin	medium	1	1
erythrosine	low	2	0
etidronate	medium	13	1
glutaral	medium	24	1
haloperidol	medium	68	18
lidocaine	low	1	0
2-propanol	low	2	0
mepivacaine	low	1	0
methenamine	low	3	0
metronidazole	medium	1	1
oxymetazoline	low	1	0
potassium chloride	low	2	0
potassium iodide	low	1	0
propidium	low	1	0
sodium fluoride	medium	8	1
sodium iodide	low	1	0
tetrahydrozoline	low	1	0
trientine	low	1	0
2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-5-((phenylamino)carbonyl)-2h-tetrazolium hydroxide	low	1	0
biguanides	low	13	0
lysine	medium	16	4
sucrose	low	2	0
2,3,4,6-tetrachlorophenol	medium	3	1
edetic acid	medium	420	81
tyrosine	low	1	0
methylene blue	medium	12	5
leucine	medium	16	4
egtazic acid	low	5	0
chloroform	low	1	0
sodium citrate, anhydrous	medium	5	3
arginine	low	3	0
ethylene oxide	medium	2	1
iodoform	medium	1	1
tert-butyl alcohol	low	1	0
methylethyl ketone	low	1	0
acrylic acid	medium	28	7
peracetic acid	low	9	0
rhodamine b	medium	5	1
thymol	low	2	0
tolonium chloride	low	2	0
boric acid	medium	2	1
triethylene glycol dimethacrylate	medium	9	1
catechin	low	1	0
thiazoles	low	3	0
silicon carbide	medium	17	4
limestone	low	3	0
cdta	low	1	0
methyl red	low	1	0
hesperidin	low	1	0
4-toluenesulfinic acid	low	3	0
strontium acetate	low	1	0
eosine yellowish-(ys)	medium	2	1
hexamethylene glycol	low	1	0
c.i. 42510	medium	2	1
hydroxyethyl methacrylate	medium	29	2
methacryloyl chloride	low	1	0
durapatite	medium	14	5
sodium hydroxide	medium	1	1
zinc oxide	medium	14	3
hydrofluoric acid	low	2	0
bisphenol a-glycidyl methacrylate	medium	46	10
(nitrilotris(methylene))triphosphonic acid	low	1	0
fluorescein	low	2	0
didecyldimethylammonium	low	1	0
sabinene	medium	2	1
carbonates	low	3	0
lanthanum	low	1	0
neodymium	medium	19	3
platinum	low	1	0
scandium	low	1	0
silver	medium	20	5
titanium	medium	116	23
tungsten	medium	1	1
argon	medium	8	1
chromium	medium	5	1
erbium	medium	23	6
gold	low	3	0
xenon	low	1	0
yttrium	medium	16	7
zirconium	medium	11	5
aluminum chloride	low	3	0
phosphoric acid, trisodium salt	low	1	0
hypochlorous acid	low	9	0
ferric chloride	low	4	0
ferrous sulfate	medium	1	1
potassium nitrate	low	2	0
calcium phosphate, dibasic, anhydrous	low	2	0
calcium phosphate, monobasic, anhydrous	low	1	0
tricalcium phosphate	medium	10	1
silver nitrate	medium	2	1
calcium sulfate	medium	1	1
calcium hypochlorite	low	1	0
zinc phosphate	medium	5	1
fluorine	low	1	0
chlorine	medium	4	1
ferric sulfate	low	3	0
chlorine dioxide	low	1	0
clodronic acid	low	1	0
tricalcium silicate	low	1	0
hexafluorosilicate	low	2	0
fluorides	medium	24	2
tri-n-butylborane	low	1	0
phenyl acetate	low	2	0
carbamide peroxide	medium	6	2
calcium oxalate	low	3	0
glutamic acid	medium	17	4
4-methacryloxyethyltrimellitic acid anhydride	medium	6	1
octenidine	low	1	0
sudan black b	medium	1	1
lanthanum chloride	low	1	0
thiazolyl blue	low	3	0
epigallocatechin gallate	low	1	0
fluorophosphate	low	2	0
glyceryl methacrylate	low	5	0
n-phenylglycine	low	1	0
cresatin	low	1	0
tetrabutylammonium tetrafluoroborate	low	1	0
camphorated parachlorophenol	medium	3	1
2,2-di(4-methacryloxyphenyl)propane	low	2	0
1,6-hexanediol dimethacrylate	medium	1	1
lanthanum trifluoride	low	1	0
n2 dental cement	medium	2	1
procyanidin	medium	1	1
titanium tetrafluoride	medium	4	1
n-(4-tolyl)glycine-glycidyl methacrylate	low	1	0
prisma-fil	low	1	0
c & b metabond	medium	3	1
gk 101e	low	1	0
4-methacryloxyethyltrimellitic acid	low	1	0
methacryloyloxydecyl dihydrogen phosphate	low	2	0
proline	low	1	0
n-methacryloyl glycine	low	1	0
hydroxyl radical	low	2	0
potassium titanylphosphate	low	2	0
carbodiimides	low	1	0
calcium pyrophosphate	low	2	0
paromomycin	low	1	0
iron (3+) oxalate	low	1	0
organophosphonates	medium	2	1
erythritol	low	1	0
calcein am	low	1	0
fibrin	medium	8	3
maleic acid	medium	24	3
potassium thiocyanate	low	1	0
sodium bicarbonate	low	2	0
sodium benzoate	low	1	0
sorbic acid	low	1	0
pyrophosphate	low	1	0
safranine t	low	1	0
tungsten carbide	low	7	0
succimer	low	2	0
methacryloyl tyrosineamide	low	1	0
redta	low	3	0
silicon nitride	medium	1	1
sodium dodecyl sulfate	low	2	0
17-ketosteroids	low	1	0
apigenin	low	1	0
aluminum	medium	4	1
strontium	low	2	0
bismuth	medium	24	6
gallium	low	1	0
nitrofurazone	low	1	0
silicon	medium	1	1
phosphorus	low	11	0
1,5-bis(2-methoxy-4-nitro-5-sulfophenyl)-3-((phenylamino)carbonyl)formazan	low	1	0
oxalates	medium	23	2
tytin	low	1	0
chlorhexidine	medium	66	12
formazans	low	1	0
aluminum oxide	low	3	0
fluorapatite	low	1	0
cardanol	low	1	0
indocyanine green	low	1	0
cellulose	low	3	0
vendex	medium	9	1
ubiquinone	low	1	0
lucifer yellow	low	1	0
hexafluorosilicic acid	low	1	0
silicate cement	low	3	0
chitosan	low	7	0
sodium hypochlorite	medium	393	82
tetracycline	medium	26	4
minocycline	medium	2	1
salicylates	medium	6	1
doxycycline hyclate	medium	3	1
gluma	low	12	0
caseins	medium	5	2
feldspar	low	1	0
4-acryloxyethyltrimellitic acid	low	1	0
chondroitin sulfates	low	1	0
all-bond 2	medium	5	2
formocresol	low	2	0

Protein Targets (1,044)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
GLI family zinc finger 3	33	0	0	33
AR protein	36	0	0	36
nuclear receptor subfamily 1, group I, member 3	21	0	0	21
progesterone receptor	23	0	0	23
estrogen nuclear receptor alpha	53	0	0	53
nuclear factor erythroid 2-related factor 2 isoform 1	33	0	0	33
Cellular tumor antigen p53	25	0	0	25
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	20	0	0	20
hypoxia-inducible factor 1 alpha subunit	14	0	0	14
RAR-related orphan receptor gamma	33	0	0	33
aldehyde dehydrogenase 1 family, member A1	14	0	0	14
retinoic acid nuclear receptor alpha variant 1	36	0	0	36
retinoid X nuclear receptor alpha	23	0	0	23
peroxisome proliferator-activated receptor delta	19	0	0	19
activating transcription factor 6	9	0	0	9
v-jun sarcoma virus 17 oncogene homolog (avian)	22	0	0	22
Histone H2A.x	19	0	0	19
thyroid hormone receptor beta isoform a	14	0	0	14
heat shock protein beta-1	13	0	0	13
lamin isoform A-delta10	23	0	0	23
Voltage-dependent calcium channel gamma-2 subunit	20	0	0	20
Glutamate receptor 2	20	2	1	23
Chain A, HADH2 protein	6	0	0	6
Chain B, HADH2 protein	6	0	0	6
Luciferase	16	0	0	16
interleukin 8	6	0	0	6
thyroid stimulating hormone receptor	15	0	0	15
estrogen receptor 2 (ER beta)	13	0	0	13
glucocorticoid receptor [Homo sapiens]	27	0	0	27
estrogen-related nuclear receptor alpha	34	0	0	34
farnesoid X nuclear receptor	17	0	0	17
pregnane X nuclear receptor	21	0	0	21
peroxisome proliferator activated receptor gamma	19	0	0	19
aryl hydrocarbon receptor	16	0	0	16
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	6	0	0	6
thyroid hormone receptor beta isoform 2	26	0	0	26
mitogen-activated protein kinase 1	9	0	0	9
Nuclear receptor ROR-gamma	11	0	0	11
Peroxisome proliferator-activated receptor alpha	2	0	0	2
ATPase family AAA domain-containing protein 5	9	0	0	9
Ataxin-2	11	0	0	11
Free fatty acid receptor 3	0	0	1	1
Free fatty acid receptor 2	0	1	1	2
Tyrosine-protein kinase Lck	0	0	1	1
Tyrosine-protein kinase Fyn	0	0	1	1
Fibrinogen C domain-containing protein 1	0	1	0	1
TDP1 protein	24	0	0	24
euchromatic histone-lysine N-methyltransferase 2	20	0	0	20
peripheral myelin protein 22	10	0	0	10
Choline O-acetyltransferase	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	13	0	0	13
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	15	0	0	15
Chain A, Putative fructose-1,6-bisphosphate aldolase	5	0	0	5
Chain A, 2-oxoglutarate Oxygenase	7	0	0	7
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain A, Cruzipain	4	0	0	4
Chain A, Transthyretin	0	0	1	1
Chain A, Transthyretin	0	0	1	1
Chain A, Transthyretin	0	0	1	1
Chain A, Transthyretin	0	0	1	1
Chain B, Transthyretin	0	0	1	1
Chain A, Transthyretin	0	0	1	1
Chain B, Transthyretin	0	0	1	1
Chain A, Casein kinase II subunit alpha	0	1	0	1
Chain A, Casein kinase II subunit alpha	0	1	0	1
Chain A, Casein Kinase Ii Subunit Alpha	0	1	0	1
endonuclease IV	3	0	0	3
BRCA1	1	0	0	1
RGS12	1	0	0	1
15-lipoxygenase, partial	5	0	0	5
phosphopantetheinyl transferase	11	0	0	11
ATAD5 protein, partial	7	0	0	7
USP1 protein, partial	7	0	0	7
NFKB1 protein, partial	3	0	0	3
GLS protein	12	0	0	12
PPM1D protein	2	0	0	2
Microtubule-associated protein tau	7	0	0	7
Thrombopoietin	2	0	0	2
Smad3	6	0	0	6
apical membrane antigen 1, AMA1	3	0	0	3
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	3	0	0	3
regulator of G-protein signaling 4	4	0	0	4
cytochrome P450 family 3 subfamily A polypeptide 4	13	0	0	13
EWS/FLI fusion protein	8	0	0	8
G	6	0	0	6
cytochrome P450 2D6	12	0	0	12
Neuraminidase	0	3	0	3
67.9K protein	7	0	0	7
glucocerebrosidase	4	0	0	4
Parkin	2	0	0	2
vitamin D (1,25- dihydroxyvitamin D3) receptor	17	0	0	17
arylsulfatase A	7	0	0	7
pyruvate kinase	1	0	0	1
IDH1	7	0	0	7
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	12	0	0	12
Replicase polyprotein 1ab	0	3	0	3
cytochrome P450 2D6 isoform 1	5	0	0	5
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
peripheral myelin protein 22 isoform 1	4	0	0	4
hemoglobin subunit beta	1	0	0	1
cellular tumor antigen p53 isoform a	5	0	0	5
cytochrome P450 2C19 precursor	5	0	0	5
cytochrome P450 2C9 precursor	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 2	4	0	0	4
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	4	0	0	4
histone deacetylase 9 isoform 3	5	0	0	5
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	1	0	0	1
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
flap endonuclease 1	8	0	0	8
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	5	0	0	5
DNA polymerase eta isoform 1	5	0	0	5
DNA polymerase iota isoform a (long)	9	0	0	9
nuclear receptor ROR-gamma isoform 1	6	0	0	6
geminin	17	0	0	17
DNA polymerase kappa isoform 1	9	0	0	9
survival motor neuron protein isoform d	4	0	0	4
cytochrome P450 3A4 isoform 1	7	0	0	7
M-phase phosphoprotein 8	2	0	0	2
pyruvate kinase PKM isoform b	1	0	0	1
neuropeptide S receptor isoform A	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	7	2	0	9
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Polyphenol oxidase 2	0	3	0	5
Aldo-keto reductase family 1 member B10	0	2	0	2
G2/mitotic-specific cyclin-B2	0	1	0	1
Poly [ADP-ribose] polymerase tankyrase-1	0	1	0	1
Lysozyme C-1	0	1	0	1
Cationic trypsin	0	1	0	1
Carbonic anhydrase 1	0	22	0	24
Carbonic anhydrase 2	0	24	1	27
Interferon beta	7	0	0	7
HLA class I histocompatibility antigen, B alpha chain	6	0	0	6
Transthyretin	0	0	2	2
Estrogen receptor	0	1	0	1
Glucocorticoid receptor	0	0	0	2
Cytochrome P450 1A1	0	2	0	2
Amyloid-beta precursor protein	0	4	0	4
Integrin beta-3	5	0	1	6
Myeloperoxidase	0	1	0	1
Cytochrome P450 1A2	0	2	0	2
Cyclin-dependent kinase 1	0	1	0	1
Beta-glucuronidase	0	1	0	1
Aldo-keto reductase family 1 member B1	0	4	0	4
Seed linoleate 13S-lipoxygenase-1	0	1	0	3
ATP-dependent translocase ABCB1	0	3	1	5
Neutrophil elastase	0	3	0	3
Integrin alpha-IIb	5	0	1	6
Ornithine decarboxylase	1	0	0	1
Poly [ADP-ribose] polymerase 1	0	1	0	1
Replicase polyprotein 1a	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Replicase polyprotein 1ab	0	3	0	3
Androgen receptor	0	1	0	2
Sialidase	0	1	0	1
Serine/threonine-protein kinase pim-1	0	1	0	2
Aromatase	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
Cystic fibrosis transmembrane conductance regulator	0	1	1	2
17-beta-hydroxysteroid dehydrogenase type 1	0	1	0	1
Pyruvate kinase PKM	0	1	0	1
G2/mitotic-specific cyclin-B1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Urease subunit alpha	0	2	0	2
Aldo-keto reductase family 1 member B1	0	1	0	1
G2/mitotic-specific cyclin-B	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	7	2	0	9
Mucin-1	0	1	0	1
Glycogen synthase kinase-3 beta	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	7	2	0	9
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	7	2	0	9
Casein kinase II subunit alpha'	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	7	2	0	9
Gamma-aminobutyric acid receptor subunit alpha-3	7	2	0	9
Amine oxidase [flavin-containing] A	0	2	0	2
Acetylcholinesterase	0	4	0	4
Carbonic anhydrase 4	0	19	0	20
Gamma-aminobutyric acid receptor subunit gamma-1	7	2	0	9
Gamma-aminobutyric acid receptor subunit alpha-2	7	2	0	9
Amine oxidase [flavin-containing] B	0	1	0	1
Dipeptidyl peptidase 4	0	2	0	2
Proteasome subunit beta type-5	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	7	2	0	9
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	7	2	0	9
Gamma-aminobutyric acid receptor subunit alpha-6	7	2	0	9
Substance-P receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	2
Mu-type opioid receptor	0	2	1	5
Receptor-type tyrosine-protein kinase FLT3	0	1	0	1
Testosterone 17-beta-dehydrogenase 3	0	1	0	1
17-beta-hydroxysteroid dehydrogenase type 2	0	1	0	1
Acetylcholinesterase	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Delta-type opioid receptor	0	0	0	2
Kappa-type opioid receptor	0	0	0	2
Homeobox protein Nkx-2.5	0	1	0	1
Tyrosine-protein kinase SYK	0	1	1	2
Histamine H2 receptor	7	0	0	8
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	1	2
Xanthine dehydrogenase/oxidase	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Glycogen synthase kinase-3 alpha	0	1	0	1
Glycogen synthase kinase-3 beta	0	1	0	1
Estrogen receptor	0	0	1	1
Death-associated protein kinase 1	0	2	0	2
Mitogen-activated protein kinase 10	0	1	0	1
Beta-secretase 1	0	3	0	4
Gamma-aminobutyric acid receptor subunit alpha-1	7	2	0	9
Gamma-aminobutyric acid receptor subunit beta-3	7	2	0	9
Gamma-aminobutyric acid receptor subunit beta-2	7	2	0	9
Casein kinase II subunit beta	0	1	0	1
Casein kinase II subunit alpha	0	2	0	2
Urease subunit beta	0	2	0	2
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	1	0	2
Lactoperoxidase	0	1	0	2
Xanthine dehydrogenase/oxidase	0	1	0	1
MO15-related protein kinase Pfmrk	0	1	0	1
Inositol monophosphatase 1	3	0	0	3
Cyclin-dependent kinase 6	0	1	0	1
Cyclin-dependent-like kinase 5	0	1	0	1
Cyclin homolog	0	1	0	1
Transcription factor GATA-4	0	1	0	1
Cyclin-dependent kinase 5 activator 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Mitogen-activated protein kinase 14	0	2	0	2
Cytochrome P450 1B1	0	2	0	2
Carbonic anhydrase 3	0	4	0	4
Substance-K receptor	0	2	0	2
Reverse transcriptase/RNaseH	0	2	0	2
Integrase	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Casein kinase II subunit alpha 3	0	1	0	1
Inositol polyphosphate multikinase	0	1	0	1
G2/mitotic-specific cyclin-B3	0	1	0	1
GABA theta subunit	7	2	0	9
Inositol hexakisphosphate kinase 1	6	0	0	6
Estrogen receptor beta	0	1	0	1
Enoyl-acyl-carrier protein reductase	0	3	0	3
Aurora kinase B	0	1	0	1
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Myocilin	0	0	1	1
Cyclin-dependent kinase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	7	2	0	9
Prenyltransferase homolog	0	0	0	1
Poly [ADP-ribose] polymerase tankyrase-2	0	1	0	1
MAP kinase-interacting serine/threonine-protein kinase 2	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
NADPH oxidase 4	0	1	0	1
Dipeptidyl peptidase 3	0	1	0	1
Estrogen receptor beta	0	0	1	1
Inositol hexakisphosphate kinase 2	0	1	0	1
Short transient receptor potential channel 5	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Sialidase-2	0	1	0	1
cytochrome P450 2C9, partial	6	0	0	6
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
ATP-dependent phosphofructokinase	10	0	0	10
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
thioredoxin reductase	10	0	0	10
alpha-galactosidase	3	0	0	3
chromobox protein homolog 1	9	0	0	9
muscarinic acetylcholine receptor M1	4	0	0	4
lethal factor (plasmid)	11	0	0	11
Cytochrome P450 3A4	0	2	0	4
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	2	0	2
Chain A, Hyaluronidase, phage associated	0	1	0	1
acetylcholinesterase	15	0	0	15
thioredoxin glutathione reductase	6	0	0	6
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	2
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	4	1	5
Spike glycoprotein	9	0	0	9
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Chain A, Beta-lactamase	5	0	0	5
glp-1 receptor, partial	6	0	0	6
SMAD family member 2	7	0	0	7
SMAD family member 3	7	0	0	7
TSHR protein	2	0	0	2
thyroid stimulating hormone receptor	13	0	0	13
Alpha-synuclein	6	1	0	7
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
Carbonic anhydrase	0	11	0	12
Carbonic anhydrase 15	0	6	0	7
Chain A, ATP-DEPENDENT DNA HELICASE Q1	7	0	0	7
Bloom syndrome protein isoform 1	7	0	0	7
DNA polymerase beta	4	0	0	4
Prostaglandin G/H synthase 1	0	1	0	1
Arginase	0	2	0	2
Pancreatic triacylglycerol lipase	0	1	0	1
Prothrombin	0	1	2	3
Prostaglandin G/H synthase 1	0	0	1	1
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 6	0	7	0	8
Sucrase-isomaltase, intestinal	0	1	0	1
Adenosine receptor A1	1	3	0	5
Adenosine receptor A2a	0	2	0	3
Melatonin receptor type 1A	0	0	1	1
Melatonin receptor type 1B	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
Dihydroorotate dehydrogenase	0	1	0	1
interferon gamma precursor	0	0	0	2
Chain A, JmjC domain-containing histone demethylation protein 3A	8	0	0	8
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
acid sphingomyelinase	2	0	0	2
PAX8	0	0	0	1
pregnane X receptor	1	0	0	1
caspase 7, apoptosis-related cysteine protease	5	0	0	5
PINK1	1	0	0	1
heat shock protein 90	0	0	1	1
caspase-3	5	0	0	5
calcineurin A1, putative	0	0	1	1
hepatocyte nuclear factor 4-alpha isoform 2	0	2	0	2
perilipin-5	0	2	0	2
perilipin-1	0	2	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	5	0	0	5
transcriptional regulator ERG isoform 3	3	0	0	3
huntingtin isoform 2	3	0	0	3
importin subunit beta-1 isoform 1	3	0	0	3
ubiquitin-conjugating enzyme E2 N	0	1	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	2	0	0	2
protein AF-9 isoform a	0	0	0	2
snurportin-1	3	0	0	3
melanocortin receptor 4	0	1	0	1
CAAX prenyl protease	0	0	0	1
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
bcl-2-related protein A1	0	1	0	1
urokinase plasminogen activator surface receptor precursor	3	0	0	3
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	2	0	2
glycogen synthase kinase-3 alpha	0	0	0	1
hexokinase HKDC1	0	1	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	2
bcl-2-like protein 11 isoform 1	0	0	1	1
Synaptojanin-2	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Solute carrier family 22 member 1	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	4	0	0	4
Synaptojanin-1	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Glutathione reductase, mitochondrial	0	6	0	8
72 kDa type IV collagenase	0	4	0	4
Matrix metalloproteinase-9	0	3	0	3
Trypanothione reductase	0	1	0	1
TAR DNA-binding protein 43	4	0	0	4
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Multidrug and toxin extrusion protein 1	0	2	0	2
Spermine oxidase	0	1	0	1
ATP-binding cassette sub-family C member 3	0	5	0	5
Multidrug resistance-associated protein 4	0	5	0	5
Bile salt export pump	0	8	0	8
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	2
DNA gyrase subunit A	0	1	0	3
DNA gyrase subunit B	0	1	0	3
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	1	0	2
Cytochrome P450 2D6	0	2	0	2
DNA topoisomerase 2-alpha	0	1	0	4
Cytochrome P450 2C9	0	3	0	3
DNA gyrase subunit A	0	1	0	2
Cytochrome P450 2C19	0	1	0	1
Multidrug resistance protein MdtK	0	0	1	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	0	0	1
Potassium voltage-gated channel subfamily H member 2	0	6	0	7
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	5	0	5
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Beta-lactamase	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	3	0	3
3-dehydroquinate dehydratase	0	0	1	1
ATP-citrate synthase	0	1	0	2
Ribonuclease T	0	0	0	1
Cell death-related nuclease 4	0	0	0	1
3-dehydroquinate dehydratase	0	0	1	1
Prolyl 4-hydroxylase	0	3	0	3
Alpha-ketoglutarate-dependent dioxygenase FTO	0	4	0	4
Type IV secretion-like conjugative transfer relaxase protein TraI	0	2	0	2
Stromelysin-1	0	3	0	3
Macrophage metalloelastase	0	1	0	1
Eyes absent homolog 2	0	2	0	2
Angiotensin-converting enzyme	0	2	0	2
Metallo-beta-lactamase VIM-13	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase VIM-1	0	1	0	1
D(1A) dopamine receptor	4	0	0	4
Chain A, Troponin C, slow skeletal and cardiac muscles	0	0	1	1
Chain A, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	0	1	1
Chain A, POLYMERASE PA	0	1	0	1
Chain A, Polymerase Pa	0	1	0	1
Chain A, Polymerase Pa	0	1	0	1
Chain A, Polymerase Pa	0	1	0	1
Chain A, Polymerase Pa	0	1	0	1
Genome polyprotein	0	2	1	3
bromodomain adjacent to zinc finger domain 2B	6	0	0	6
lysosomal alpha-glucosidase preproprotein	1	0	0	1
galactokinase	1	0	0	1
pyruvate kinase PKM isoform a	2	0	0	2
POsterior Segregation	0	0	2	2
Prostaglandin E synthase	0	1	0	1
Telomerase reverse transcriptase	0	1	0	1
Polycomb protein EED	0	0	1	1
NAD kinase	0	2	1	3
Dihydrofolate reductase	0	0	0	1
Urokinase-type plasminogen activator	0	1	0	1
Tissue-type plasminogen activator	0	1	0	1
Polymerase acidic protein	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Plasminogen activator inhibitor 1	0	1	0	1
Heme oxygenase 1	0	1	0	1
Urokinase-type plasminogen activator	0	1	0	1
Heat shock protein HSP 90-beta	0	1	0	1
Hepatocyte growth factor receptor	0	2	0	2
Matrilysin	0	2	0	2
60 kDa chaperonin	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	0	1	0	1
Alpha-amylase 1A	0	1	0	1
Apoptosis regulator Bcl-2	0	2	0	2
Microtubule-associated protein tau	0	4	1	5
60 kDa heat shock protein, mitochondrial	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Fatty acid synthase	0	1	0	1
CPG DNA methylase	0	1	0	1
Lethal factor	0	1	0	1
Phosphoglycerate mutase 1	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
Heme oxygenase 2	0	1	0	1
Sodium-dependent noradrenaline transporter	0	2	2	4
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
Cannabinoid receptor 2	0	1	0	1
Signal transducer and activator of transcription 1-alpha/beta	0	0	1	1
DNA repair protein RAD52 homolog	0	1	0	1
Fatty acid synthase	0	1	0	1
Matrix metalloproteinase-14	0	1	0	1
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6	0	1	0	1
Squalene monooxygenase	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
BH3-interacting domain death agonist	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
Bcl-2-like protein 1	0	1	0	1
Induced myeloid leukemia cell differentiation protein Mcl-1	0	1	0	1
Histone acetyltransferase p300	0	1	0	1
Alpha-(1,3)-fucosyltransferase 7	0	1	0	1
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1	0	1	0	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	1	0	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	1	0	1
Bcl-2-related protein A1	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	2	0	2
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	1	0	1
10 kDa chaperonin	0	1	0	1
3-oxoacyl-[acyl-carrier-protein] reductase	0	1	0	1
MAP kinase-activated protein kinase 5	0	1	0	1
CREB-binding protein	0	1	0	1
Histone acetyltransferase KAT2B	0	1	0	1
Bcl-2-like protein 2	0	1	0	1
Bcl2-associated agonist of cell death	0	1	0	1
Histone acetyltransferase KAT5	0	1	0	1
3-oxoacyl-acyl-carrier protein reductase	0	1	0	1
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)	0	1	0	1
Bcl-2-like protein 10	0	1	0	1
Zinc finger protein mex-5	0	0	2	2
chaperonin-containing TCP-1 beta subunit homolog	2	0	0	2
Fumarate hydratase	4	0	0	4
hypothetical protein, conserved	3	0	0	3
polyprotein	4	0	0	4
thyrotropin-releasing hormone receptor	3	0	0	3
vitamin D3 receptor isoform VDRA	7	0	0	7
eyes absent homolog 2 isoform a	2	0	0	2
histone acetyltransferase KAT2A isoform 1	10	0	0	10
relaxin receptor 1 isoform 1	1	0	0	1
Flavin reductase (NADPH)	0	0	1	1
large T antigen	0	1	0	1
Chain A, Ferritin light chain	2	0	0	2
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
beta-2 adrenergic receptor	2	0	0	2
Metabotropic glutamate receptor 8	0	2	0	2
Metabotropic glutamate receptor 6	0	1	1	3
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Glutamate receptor 1	0	2	1	3
Glutamate receptor 3	0	2	1	3
Glutamate receptor 4	0	2	1	3
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	2
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, NMDA 1	0	6	2	9
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Excitatory amino acid transporter 1	0	2	0	3
Excitatory amino acid transporter 2	0	2	0	3
Excitatory amino acid transporter 3	0	2	0	3
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	5	2	8
Glutamate receptor ionotropic, NMDA 2B	0	5	2	8
Glutamate receptor ionotropic, NMDA 2C	0	5	2	8
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Metabotropic glutamate receptor 1	0	1	1	3
Metabotropic glutamate receptor 2	0	1	1	3
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	2
Glutamate receptor ionotropic, NMDA 2D	0	5	2	8
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	5	2	8
Glutamate receptor ionotropic, NMDA 3A	0	5	2	8
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	3	0	3
Proton-coupled amino acid transporter 1	0	3	0	4
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	2	2
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
nonstructural protein 1	2	0	0	2
Adenylate cyclase type 1	0	1	0	1
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
transient receptor potential cation channel subfamily V member 1	1	0	0	1
Cocaine esterase	0	1	0	1
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	1	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
5-hydroxytryptamine receptor 4	0	4	0	4
Potassium channel subfamily K member 2	0	2	0	2
Albumin	0	0	1	1
Major prion protein	0	0	1	1
Vitamin D-binding protein	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Integrin beta-1	0	1	0	1
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	3	0	3
Muscarinic acetylcholine receptor M1	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
5-hydroxytryptamine receptor 1A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Muscarinic acetylcholine receptor M5	0	4	0	4
Alpha-2A adrenergic receptor	0	4	1	5
Beta-2 adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M1	0	2	0	2
Integrin alpha-4	0	1	0	1
D(2) dopamine receptor	0	2	1	5
5-hydroxytryptamine receptor 2A	0	2	0	2
Alpha-1B adrenergic receptor	0	4	0	4
Carbonyl reductase [NADPH] 1	0	0	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	2
Beta-1 adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	4	0	4
D	0	2	0	2
D(3) dopamine receptor	0	3	0	3
5-hydroxytryptamine receptor 1A	0	4	1	5
Alpha-2B adrenergic receptor	0	3	1	4
D(2) dopamine receptor	0	2	0	2
Muscarinic acetylcholine receptor M3	0	1	0	1
D(1A) dopamine receptor	0	2	0	3
D(4) dopamine receptor	0	2	1	5
D(1B) dopamine receptor	0	2	0	3
Adenylate cyclase type 3	0	1	0	1
Alpha-2C adrenergic receptor	0	3	1	4
UDP-glucuronosyltransferase 1A4	0	0	0	1
Alpha-2A adrenergic receptor	0	3	1	4
Alpha-1D adrenergic receptor	0	5	0	5
Sodium-dependent dopamine transporter	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
Histamine H2 receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	4	1	5
D(1B) dopamine receptor	0	2	0	2
Beta-3 adrenergic receptor	0	1	0	1
Adenylate cyclase type 2	0	1	0	1
Adenylate cyclase type 4	0	1	0	1
5-hydroxytryptamine receptor 2A	0	4	0	4
5-hydroxytryptamine receptor 2C	0	4	0	4
5-hydroxytryptamine receptor 1B	0	3	1	4
5-hydroxytryptamine receptor 1D	0	1	1	2
D(4) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 1F	0	1	1	2
5-hydroxytryptamine receptor 2B	0	2	0	2
Histamine H1 receptor	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	2
Sodium-dependent serotonin transporter	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
C-8 sterol isomerase	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	4	0	4
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	2	1	3
5-hydroxytryptamine receptor 2A	0	1	0	1
Histamine H1 receptor	0	2	0	2
Alpha-1B adrenergic receptor	0	2	1	3
D(3) dopamine receptor	0	2	1	5
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	2	0	2
Adenylate cyclase type 8	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
5-hydroxytryptamine receptor 2B	0	4	0	4
Alpha-1A adrenergic receptor	0	5	0	5
5-hydroxytryptamine receptor 2A	0	1	0	1
D(1A) dopamine receptor	1	1	0	2
5-hydroxytryptamine receptor 6	0	3	0	3
5-hydroxytryptamine receptor 7	0	1	0	1
Cytochrome P450 2J2	0	2	0	2
D(2) dopamine receptor	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
D(2) dopamine receptor	0	2	0	2
AP-2 complex subunit sigma	0	1	0	1
N-acetyltransferase Eis	0	2	0	2
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
5-hydroxytryptamine receptor 2B	0	1	0	1
Adenylate cyclase type 6	0	1	0	1
Adenylate cyclase type 5	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Sodium channel protein type 5 subunit alpha	0	2	0	2
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	2	0	2
Calcitonin gene-related peptide type 1 receptor	0	1	0	1
Genome polyprotein	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Zinc finger protein 664	0	1	0	1
Vesicular acetylcholine transporter	0	1	0	1
Transporter	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Protease	0	2	0	2
Adenylyl cyclase 7	0	1	0	1
D	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	2	0	2
Transient receptor potential cation channel subfamily V member 4	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	2	0	2
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1	0	1	0	1
Lysine-specific histone demethylase 1A	0	1	0	1
Calmodulin-1	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
Nischarin	0	1	0	1
Heparanase	0	0	1	1
Carbonic anhydrase	0	3	0	3
Carbonic anhydrase	0	3	0	3
Carbonic anhydrase 5A, mitochondrial	0	13	0	14
Carbonic anhydrase 7	0	5	0	6
Carbonic anhydrase 9	0	14	1	16
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	3	0	4
Carbonic anhydrase 13	0	5	0	5
Carbonic anhydrase 5B, mitochondrial	0	7	0	8
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Phospholipase A-2-activating protein	0	1	0	1
Potassium channel subfamily K member 3	0	2	0	2
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Aspartate Aminotransferase	0	0	1	1
Chain B, Aspartate Aminotransferase	0	0	1	1
Chain A, Aspartate Aminotransferase	0	0	1	1
Chain B, Aspartate Aminotransferase	0	0	1	1
Chain A, Aspartate aminotransferase	0	0	1	1
Chain B, Aspartate aminotransferase	0	0	1	1
Chain A, Aspartate aminotransferase	0	0	1	1
Chain A, Aspartate aminotransferase	0	0	1	1
Chain A, Aspartate aminotransferase	0	0	1	1
Chain B, Aspartate aminotransferase	0	0	1	1
Methyl-accepting chemotaxis protein NahY	0	0	1	1
Myc proto-oncogene protein	0	1	0	1
RmtA	0	1	0	1
Protein arginine N-methyltransferase 1	0	1	0	1
Chain E, Fibrin beta chain	0	1	0	1
T cell receptor, partial	1	0	0	1
luteinizing hormone receptor	1	0	0	1
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
Apoptotic peptidase activating factor 1	0	1	0	1
isocitrate dehydrogenase 1, partial	1	0	0	1
luciferase	1	0	0	1
serine-protein kinase ATM isoform a	1	0	0	1
neutrophil cytosol factor 1	0	1	0	1
caspase-9 isoform alpha precursor	0	1	0	1
caspase-3 isoform a preproprotein	0	1	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
Vpr	1	0	0	1
muscleblind-like protein 1 isoform 1	2	0	0	2
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
Glutathione reductase	0	1	0	1
Glycoprotein hormones alpha chain	1	0	0	1
Dihydrolipoyl dehydrogenase, mitochondrial	0	1	0	2
Cruzipain	0	1	0	1
Guanine nucleotide-binding protein G	1	0	0	1
Thioredoxin reductase 1, cytoplasmic	0	1	0	2
Dihydrolipoyl dehydrogenase	0	1	0	2
phosphoglycerate kinase	1	0	0	1
Thioredoxin reductase	0	1	0	1
Flavodoxin	0	0	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
Albumin	0	0	1	1
Multidrug transporter MdfA	0	2	0	2
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Protein-arginine deiminase type-4	0	3	0	3
Sodium/iodide cotransporter	0	1	0	1
Snake venom metalloproteinase BaP1	0	1	0	1
NAD(+) hydrolase SARM1	0	2	0	2
Chain A, Pyruvate kinase, M2 isozyme	0	1	0	1
Chain A, Phosphonopyruvate hydrolase	0	1	0	1
Chain A, Phosphoenolpyruvate-protein phosphotransferase	0	1	0	1
chaperonin GroEL	1	0	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 1B	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Nischarin	0	1	0	1
30S ribosomal protein S6	0	2	0	2
30S ribosomal protein S7	0	2	0	2
50S ribosomal protein L15	0	2	0	2
50S ribosomal protein L10	0	2	0	2
50S ribosomal protein L11	0	2	0	2
50S ribosomal protein L7/L12	0	2	0	2
50S ribosomal protein L19	0	2	0	2
50S ribosomal protein L1	0	2	0	2
50S ribosomal protein L20	0	2	0	2
50S ribosomal protein L27	0	2	0	2
50S ribosomal protein L28	0	2	0	2
50S ribosomal protein L29	0	2	0	2
50S ribosomal protein L31	0	2	0	2
50S ribosomal protein L31 type B	0	2	0	2
50S ribosomal protein L32	0	2	0	2
50S ribosomal protein L33	0	2	0	2
50S ribosomal protein L34	0	2	0	2
50S ribosomal protein L35	0	2	0	2
50S ribosomal protein L36	0	2	0	2
30S ribosomal protein S10	0	2	0	2
30S ribosomal protein S11	0	2	0	2
30S ribosomal protein S12	0	2	0	2
30S ribosomal protein S13	0	2	0	2
30S ribosomal protein S16	0	2	0	2
30S ribosomal protein S18	0	2	0	2
30S ribosomal protein S19	0	2	0	2
30S ribosomal protein S20	0	2	0	2
30S ribosomal protein S2	0	2	0	2
30S ribosomal protein S3	0	2	0	2
30S ribosomal protein S4	0	2	0	2
30S ribosomal protein S5	0	2	0	2
30S ribosomal protein S8	0	2	0	2
30S ribosomal protein S9	0	2	0	2
50S ribosomal protein L13	0	2	0	2
50S ribosomal protein L14	0	2	0	2
50S ribosomal protein L16	0	2	0	2
50S ribosomal protein L23	0	2	0	2
30S ribosomal protein S15	0	2	0	2
50S ribosomal protein L17	0	2	0	2
50S ribosomal protein L21	0	2	0	2
50S ribosomal protein L30	0	2	0	2
50S ribosomal protein L6	0	2	0	2
30S ribosomal protein S14	0	2	0	2
30S ribosomal protein S17	0	2	0	2
30S ribosomal protein S1	0	2	0	2
50S ribosomal protein L18	0	2	0	2
50S ribosomal protein L2	0	2	0	2
50S ribosomal protein L3	0	2	0	2
50S ribosomal protein L24	0	2	0	2
50S ribosomal protein L4	0	2	0	2
50S ribosomal protein L22	0	2	0	2
50S ribosomal protein L5	0	2	0	2
30S ribosomal protein S21	0	2	0	2
50S ribosomal protein L25	0	2	0	2
50S ribosomal protein L36 2	0	2	0	2
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Lysozyme	0	0	1	1
Chain A, Lysozyme	0	0	1	1
Chain A, Lysozyme	0	0	1	1
Chain A, Lysozyme	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Carbonic anhydrase 12	0	2	0	3
Endolysin	0	0	2	2
Carbonic anhydrase 3	0	2	0	3
Sulfotransferase 1A1	0	0	0	1
Cannabinoid receptor 1	0	2	0	2
Carbonic anhydrase	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	3	0	4
Carbonic anhydrase 13	0	1	0	1
Carbonic anhydrase 14	0	2	0	3
Chain A, Alkaline Phosphatase	0	1	0	1
Chain A, ALKALINE PHOSPHATASE	0	1	0	1
DNA polymerase III, partial	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Fe(3+)-Zn(2+) purple acid phosphatase	0	2	0	2
Ornithine transcarbamylase, mitochondrial	0	1	0	1
2-dehydropantoate 2-reductase	0	1	0	1
Nociceptin receptor	0	1	0	1
Chain D, PROTEIN (PHOSPHOGLYCERATE MUTASE 1)	0	1	0	1
Chain A, PROTEIN (PHOSPHOGLYCERATE MUTASE 1)	0	1	0	1
Chain A, Beta-arrestin 1	0	0	1	1
Taste receptor type 2 member 31	0	0	1	1
Taste receptor type 2 member 60	0	0	1	1
Sodium/potassium/calcium exchanger 4	0	1	1	2
Taste receptor type 2 member 14	0	0	1	2
Taste receptor type 2 member 13	0	0	1	1
Taste receptor type 2 member 9	0	0	1	1
Taste receptor type 2 member 4	0	0	1	1
Sodium/potassium/calcium exchanger 2	0	1	1	2
Glutamate 5-kinase	0	0	0	1
Neutral amino acid transporter A	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Amino acid transporter	0	1	0	1
runt-related transcription factor 1 isoform AML1b	1	0	0	1
core-binding factor subunit beta isoform 2	1	0	0	1
caspase-1 isoform alpha precursor	1	0	0	1
Cholinesterase	0	2	0	2
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Caspase-7	1	0	0	1
Chain A, dATP pyrophosphohydrolase	0	1	0	1
Chain A, Adenylate cyclase type 5	0	1	0	1
Chain B, Adenylate cyclase type 2	0	1	0	1
Monocarboxylate transporter 4	0	0	0	1
Monocarboxylate transporter 2	0	0	0	1
Monocarboxylate transporter 1	0	0	0	1
C-terminal-binding protein 2	0	1	0	1
Monocarboxylate transporter 2	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
dopamine D1 receptor	1	0	0	1
NPYLR7B	0	0	1	1
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
Beta-adrenergic receptor kinase 1	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, 146aa long hypothetical transcriptional regulator	0	0	1	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain B, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain C, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Anthranilate phosphoribosyltransferase	0	1	0	1
tyrosine-protein kinase Yes	1	0	0	1
Transforming growth factor beta-1 proprotein	0	1	0	1
TGF-beta receptor type-1	0	1	0	1
Mothers against decapentaplegic homolog 3	0	1	0	1
Carbonic anhydrase	0	3	0	3
Carbonic anhydrase	0	3	0	3
Bifunctional epoxide hydrolase 2	0	1	0	1
Chain A, MALTOPORIN	0	0	1	1
Chain B, MALTOPORIN	0	0	1	1
C-terminal-binding protein 1	1	0	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
Tetracycline resistance protein, class B	0	0	0	1
Neutrophil collagenase	0	1	0	1
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
P2Y purinoceptor 12	0	1	0	1
Solute carrier family 22 member 11	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
Chain A, ODORANT-BINDING PROTEIN	0	1	0	1
Chain A, ODORANT-BINDING PROTEIN	0	1	0	1
Chain B, Odorant-binding Protein	0	1	0	1
Chain A, ODORANT-BINDING PROTEIN	0	1	0	1
Chain A, ODORANT-BINDING PROTEIN	0	1	0	1
Chain A, ODORANT-BINDING PROTEIN	0	1	0	1
Acetylcholinesterase	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Cholinesterase	0	1	0	1
Secreted chorismate mutase	0	1	0	1
Heat sensitive channel TRPV3	0	0	1	1
Transient receptor potential cation channel subfamily A member 1	0	1	1	2
Transient receptor potential cation channel subfamily M member 8	0	1	1	2
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
Diamine acetyltransferase 1	0	0	0	1
Thialysine N-epsilon-acetyltransferase	0	0	0	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Plasma kallikrein	0	0	0	1
Carbonic anhydrase	0	0	0	1
SLC16A10 protein	0	0	0	1
Carbonic anhydrase	0	0	0	1
Tubulin--tyrosine ligase	0	1	0	1
Monocarboxylate transporter 10	0	0	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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Protein Targets (1,044)

Smear Layer

Synonyms(1)

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Treatment

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Studies (1,030)

Drugs Studied (249)

Protein Targets (1,044)