Acute Febrile Neutrophilic Dermatosis

Condition characterized by large, rapidly extending, erythematous, tender plaques on the upper body usually accompanied by fever and dermal infiltration of neutrophilic leukocytes. It occurs mostly in middle-aged women, is often preceded by an upper respiratory infection, and clinically resembles ERYTHEMA MULTIFORME. Sweet syndrome is associated with LEUKEMIA.

Synonym
Gomm-Button Disease
Dermatosis, Neutrophilic, Febrile, Acute
Acute Febrile Neutrophilic Dermatosis
Sweet's Syndrome
Gomm Button Disease
Neutrophilic Dermatosis, Acute Febrile
Sweet Syndrome

Excerpt	Reference
"Sweet's syndrome (acute febrile neutrophilic dermatosis) is an unusual condition characterized by fever, polymorphonuclear neutrophil leukocytosis of the blood, thick painful plaques on the face, neck and limbs, and a dense dermal infiltrate of mature neutrophils seen histologically."	( Hori, J; Makino, Y; Ogawa, M; Ohto, M; Tanabe, E; Ueda, S; Wakashin, M, 1992)
"Sweet's syndrome is an uncommon and dramatic skin disease associated with systemic symptoms such as fever, headache and arthralgia."	( Bandel, D; Skurnik, Y; von Der Walde, J, 1992)
"Sweet's syndrome is well recognized and not infrequently diagnosed in Spain; however, the range of clinical and pathologic expression may not have been fully realized."	( Cuatrecasas, M; De Moragas, JM; Puig, L; Sitjas, D, 1993)
"Sweet's syndrome, or acute febrile neutrophilic dermatosis, is characterized by fever, neutrophilia, and painful erythematous cutaneous plaques that contain a dense neutrophilic dermal infiltrate."	( Cohen, PR; Walker, DC, 1996)
"Sweet's syndrome is associated with haematological malignancy, particularly acute myelogenous leukaemia, but there are few reports of its association with polycythaemia rubra vera."	( Guerin, DM; Parslew, R; Wong, GA, 2000)
"Sweet's syndrome is a rare extraintestinal manifestation of Crohn's disease and ulcerative colitis."	( Kalish, RA; Kramer, K; Vaz, A, 2000)
"Sweet's syndrome or acute febrile neutrophilic dermatosis is relatively frequent."	( Amri, M; Ben Romdhane, F; Bouzouaia, N; Chakroun, M; Loussaief, C; Mohamed, WB; Zakhama, A; Zili, J, 2001)
"Sweet's syndrome is a rare immunologically mediated condition that belongs to the group of neutrophilic dermatoses that must be differentiated particularly from Behcet's disease."	( Femiano, F; Gombos, F; Scully, C, 2003)
"Sweet's syndrome (or acute febrile neutrophilic dermatosis) is a rare inflammatory disease that is characterized by fever, neutrophilia, and painful erythematous plaques that histologically show a dense dermal infiltrate of neutrophils without associated vasculitis."	( Church, A; Gohar, K; Parsapour, K; Reep, MD; Shah, V; Shwayder, TA, 2003)
"Sweet's syndrome, or acute febrile neutrophilic dermatosis, is a cutaneous condition that typically occurs as tender red plaques or nodules."	( Crum, NF; Fehl, FC; Graham, BS; Higginbottom, PA, 2003)
"Sweet's syndrome is characterized by painful skin plaques, which is associated with dermal neutrophilic infiltration, fever and peripheral blood leukocytosis."	( Choi, HS; Ihm, CG; Kim, HJ; Kim, MJ; Lee, SH; Lee, TH; Lee, TW, 2003)
"Sweet's syndrome (acute febrile neutrophilic dermatosis) is characterized by an acute onset of erythematous plaques, fever, and leukocytosis."	( Ahmed, T; Liu, D; Madahar, CJ; Mathews, T; Seiter, K, 2004)
"Sweet's syndrome is an acute febrile neutrophilic dermatosis that is a known complication of the administration of filgrastim, a drug that causes increased neutrophil proliferation and differentiation."	( Baumann, MA; Bernstein, JM; Kumar, G; Waibel, JS, 2004)
"Sweet's syndrome is a neutrophilic dermatosis characterized by tender, erythematous, pseudovesicular plaques that can be associated with hematologic malignancy."	( Browning, CE; Callen, JP; Dixon, JE; Malone, JC, 2005)
"Sweet's syndrome is an acute febrile neutrophilic dermatosis."	( Cakir, S; Kavak, A; Korkmaz, U; Küçükbayrak, A; Ozdemir, D; Sahin, I; Sencan, I, 2006)
"Sweet's syndrome is an uncommon acute skin disease, associated with a variety of medical problems."	( De Raeve, H; Lambert, J; Rombouts, S; Schroyens, W; Van de Velde, A; Van de Voorde, K; Van Regenmortel, N, 2005)
"Sweet's syndrome or acute febrile neutrophilic dermatosis is not frequently reported from India."	( Mahajan, VK; Sharma, NL; Sharma, RC, 2006)
"Sweet syndrome is the most common neutrophilic dermatosis."	( Bouassida, S; Boudaya, S; Chaaben, H; Hamdouni, K; Masmoudi, A; Turki, H; Zahaf, A, 2007)
"Sweet syndrome is one of the cutaneous processes more frequently associated to systemic diseases."	( Almagro, M; del Pozo, J; Fonseca, E; Malmierca, NM; Martín, CG; Martínez, W; Yebra-Pimentel, MT, 2007)
"Sweet syndrome is a neutrophilic dermatosis defined by diagnostic criteria that include the lack of evidence for leukocytoclastic vasculitis."	( Burgdorf, W; Ratzinger, G; Zelger, B; Zelger, BG, 2007)
"Sweet's syndrome is a dermatosis classically determined by painful erythematous plaques or nodules associated with fever, neutrophilia and dense neutrophilic dermal infiltrate."	( Ayed, MB; Benmously, R; Debbiche, A; Fenniche, S; Marrek, H; Mokhtar, I; Souissi, A; Zarrouk, M, 2007)
"Sweet's syndrome is well recognized by dermatologists and is not infrequently diagnosed in Iran; however, few case series have been reported."	( Ameri, A; Zamanian, A, 2007)
"Sweet's syndrome is a rare adverse effect of ATRA, and has similar features with inflammatory or infective dermatosis."	( Chen, HS; Feng, SZ; Han, MZ; Jiang, EL; Li, DP; Liu, EB; Yan, ZS; Zhou, CL, 2007)
"Sweet's syndrome is characterised by an acute onset of fever, leukocytosis and erythematous plaques with dense neutrophilic infiltrates."	( Bouckaert, F; Kleinen, JM; Peuskens, J, 2008)
"Histiocytoid Sweet's syndrome is a recently described entity which has clinical features identical to typical Sweet's syndrome but is distinguished by a dermal cellular infiltrate composed not of mature neutrophils but of immature granulocytes."	( Fullen, DR; Rodgers, T; Wu, AJ, 2008)
"Sweet's syndrome is a rare cutaneous manifestation of inflammatory bowel disease, with approximately 40 cases reported in the literature."	( Ali, M; Duerksen, DR, 2008)
"Sweet syndrome is a reactive, sterile, pustular dermatosis that occurs in association with infection, malignancy, or connective tissue disease or in response to the use of certain medications."	( Brunner, KL; El-Azhary, RA; Gibson, LE, 2008)
"Sweet syndrome is a reactive neutrophilic dermatosis that develops in response to various systemic illnesses."	( Cockerell, CJ; Hsu, S; Modi, GM; Suwattee, P; Vij, A, 2010)
"Sweet's syndrome is a neutrophilic dermatosis characterized by fever, an elevated neutrophil count, and painful erythematous cutaneous lesions."	( Bessis, D; Gil-Bistes, D; Guillot, B; Kluger, N, 2011)
"Sweet's syndrome is characterized by fever, leucocytosis, neutrophilia and the sudden onset of painful skin lesions."	( Cuyan, D; Deram, B; Ertugrul, T; Koray, T; Mustafa, S; Ozlem, C, 2011)
"Sweet's syndrome is a rare extraintestinal manifestation of Crohn's disease that is usually treated by corticosteroids."	( Büning, J; Fellermann, K; Lehnert, H; Meinhardt, C; Schmidt, KJ, 2011)
"Sweet syndrome is a cutaneous lesion characterized by tender, red inflammatory nodules or papules."	( Choe, YH; Jang, KT; Kim, MJ, 2011)
"Sweet's syndrome or acute febrile neutrophilic dermatosis is characterised by the abrupt onset of painful erythematous plaques or nodules, pyrexia (>38°F) and histopathologic evidence of a dense neutrophilic infiltrate without vasculitis."	( Cubillan, EA; Francisco, CR; Isip-Tan, IT; Patal, PC, 2011)
"Sweet's syndrome is a neutrophilic inflammatory dermatosis presenting with sudden onset tender red to purple papules and nodules, fever and neutrophilia."	( Jain, A; Jindal, R; Mittal, A; Shirazi, N, 2012)
"Sweet's syndrome is the most frequent category among the neutrophilic dermatosis and is diagnosed by clearly defined criteria."	( Azevedo, F; Morais, P; Nogueira, A; Pardal, J; Pedrosa, AF, 2013)
"Sweet's syndrome is a rare condition with potentially disabling implications, characterized by painful skin lesions due to neutrophilic dermal infiltration and systemic inflammatory symptoms."	( Cavazzini, F; Cibien, F; Cuneo, A; Daghia, G; Gafà, R; Leo, G; Lista, E; Martinelli, S; Rigolin, GM; Sofritti, O, 2014)
"Sweet's syndrome or acute febrile neutrophilic dermatosis is characterized by fever, leukocytosis and tender erythematous plaques, which show infiltration by mature neutrophils on histological examination."	( Alamani, M; Kaltsas, G; Kampolis, CF; Moschovi, M; Tzelepis, E; Vlachadami, I, 2016)
"Sweet syndrome is an uncommon skin condition, often idiopathic in origin although it may be reactive to various systemic conditions, recent infections, underlying malignancies, and medications."	( Kwok, T; Mahmood, MN; Salopek, TG, 2014)
"Sweet syndrome (acute febrile neutrophilic dermatosis) is a disorder of unknown etiology."	( Contrucci, RB; Martin, DB, 2015)
"Sweet's syndrome, or acute febrile neutrophilic dermatosis, is an uncommon severe cutaneous condition, not previously associated with allopurinol therapy."	( Arcoraci, V; Cardillo, R; Garaffo, E; Giardina, C; Guarneri, C; Macrì, R; Polimeni, G; Sirna, V, 2016)
"Sweet syndrome is a rare inflammatory condition that was first described by Douglas Sweet in 1964 as an acute febrile neutrophilic dermatosis."	( Abdul-Kafi, O; Jalil, AA; Jalil, SA; Smith, J, 2016)
"Sweet syndrome is a rare disorder that is manifested by constellation of clinical features, including fever, neutrophilic leucocytosis, raised painful plaques on skin and dermal infiltration by neutrophils."	( Ali, F; Khan, U; Lebovic, D; Rizvi, H, 2016)
"Sweet's syndrome is characterized by fever, leukocytosis, and tender erythematous papules or nodules."	( Fujino, H; Sumimoto, SI; Takano, Y; Yachie, A, 2017)
"Sweet syndrome, or acute febrile neutrophilic dermatosis, is a systemic disease process mainly characterized by hyperpyrexia and skin lesions."	( Beck, LA; Carney-Young, K; Hammert, WC; Lipof, JS; Reddy, SC; Southgate, RD, 2018)
"Sweet syndrome is a neutrophilic dermatosis that may be categorized into classic, malignancy-associated, and drug-induced subtypes."	( Ashchyan, HJ; Gowda, A; James, WD; McMahon, CM; Micheletti, RG; Nelson, CA; Noe, MH; Perl, AE; Rosenbach, M; Wu, B, 2018)
"Histiocytoid Sweet syndrome is characterized by a predominant neutrophilic dermal infiltrate."	( Barata, MCC; Cuzzi, T; Gomes, MK; Machado, HSV; Quintella, DC; Ramos-E-Silva, M; Secchin, P, 2018)
"Sweet syndrome is a rare inflammatory disease with rapid onset of painful, edematous skin eruptions, and neutrophilia."	( Aoki, T; Ishihara, D; Kamimura, T; Umeno, T; Urata, S, 2019)
"Sweet syndrome is rare in the pediatric population and usually responds well to treatment, resolving without sequelae."	( Agarwal, P; Baghela, B; Jagati, A; Saikia, S; Shrivastava, S, 2020)
"Sweet syndrome is a neutrophilic dermatosis and is often idiopathic, although its onset may be drug-induced or paraneoplastic."	( Ahangari, D; Colinet, B; Ngendahayo, P; Roquet-Gravy, PP, 2020)
"Subcutaneous Sweet syndrome is a rare variant of Sweet syndrome where the dominant localization of inflammation is within the subcutaneous fat; it is commonly associated with underlying myeloproliferative disease."	( Harp, J; Magro, C; Tee, MW; Thomas, JL, 2023)
"Sweet syndrome is a rare complication of azathioprine treatment with unelucidated clinical features."	( Fan, Z; He, Y; Li, Z; Sun, W; Wang, C; Ye, C, 2023)

Excerpt	Reference
"Sweet's syndrome has been associated with acute myelogenous leukemia at presentation, but only two cases of Sweet's syndrome involving the musculoskeletal system in patients treated with ATRA have been described."	( Crader, SC; Hogan, MC; Letendre, L; Morales, CE; Pruthi, RK; Roberson, AE; van Der Vliet, HJ, 2000)
"Sweet's syndrome has a well-recognized association with malignancies, around half of which have been acute myelogenous leukaemia."	( Evans, AV; Liddell, K; Russell-Jones, R; Sabroe, RA, 2002)
"Drug-induced Sweet's syndrome has a temporal relationship between drug ingestion, clinical presentation and the temporally-related resolution of lesions following drug withdrawal or on treatment with systemic corticosteroids."	( Choi, HS; Ihm, CG; Kim, HJ; Kim, MJ; Lee, SH; Lee, TH; Lee, TW, 2003)
"Sweet's syndrome has a broad spectrum of clinical and pathologic findings in various areas of the world."	( Ameri, A; Zamanian, A, 2007)
"Sweet syndrome has been linked to multiple drugs and malignancies, but has also been linked with states of altered immunity."	( Berkowicz, T; Boruchoff, S; Ianosi-Irimie, M; Laskow, DA; Mann, RA; Osband, AJ, 2009)
"Sweet's syndrome or acute febrile neutrophilic dermatosis has been associated with underlying infection, malignancy, inflammatory disease and certain medications."	( Aliyu, SH; Karas, JA; Pai, S; Rytina, E; Sterling, J, 2012)
"Sweet's syndrome has been reported in association with inflammatory diseases such as Crohn's disease."	( Aounallah, A; Ben Salem, C; Fathallah, N; Hmouda, H; Larif, S; Sakhri, J; Salem, CB; Slim, R, 2015)
"SS, an acute febrile neutrophilic dermatosis, has three common forms-classical or idiopathic, malignancy associated and drug induced."	( Augustine, P; Paramaguru, R; Philips, CA, 2017)

Excerpt	Reference
"We report a case of Sweet's syndrome which responded to treatment with cyclosporin 4 mg/kg/day."	( Berth-Jones, J; Bourke, JF; Graham-Brown, RA, 1992)
"The lesions resembled those of Sweet's syndrome and were associated with fever, sterile culture, blood neutrophil leukocytosis, nonresponse to antibiotic therapy, and rapid response to prednisone."	( Robertson, I; Strutton, G; Weedon, D, 1995)
"the diagnosis of Sweet's syndrome must be considered in patients with agranulocytosis in order to avoid ineffective antibiotics and to initiate a corticosteroid therapy that will accelerate the cure of this benign dermatosis."	( Denoeux, JP; Desablens, B; Dierick, A; Labeille, B; Lok, C; Ruto, F; Torri, O, 1993)
"Before treatment the patient with Sweet's syndrome had high serum levels of interleukin 6 (IL-6), which were reduced to zero after treatment with steroids."	( Lamvik, J; Loraas, A; Matre, J, 1994)
"The diagnosis of Sweet's syndrome was established on the basis of the clinical and histological changes and the improvement observed after steroid therapy."	( Breier, F; Groz, S; Hobisch, G, 1993)
"We postulated that Sweet syndrome was induced by G-CSF treatment."	( Eguchi, H; Inada, H; Kato, H; Shimizu, T; Takahashi, K; Yoshida, I, 1996)
"The standard treatment for Sweet's syndrome (acute febrile neutrophilic dermatosis) is oral corticosteroids."	( Jeanfils, S; Joly, P; Lauret, P; Le Corvaisier-Pieto, C; Thomine, E; Young, P, 1997)
"He had been treated with steroids for Sweet's syndrome for 2 years, and on September 17, 1998 presented with a cough and a fever of 38."	( Hayashi, T; Imanaga, T; Kido, M; Suzuki, S; Yatera, K; Yoshii, C, 2000)
"We report a case of Sweet's syndrome associated with retinoic acid syndrome in a patient with acute promyelocytic leukemia treated with all- trans retinoic acid (ATRA)."	( Astudillo, L; Lamant, L; Loche, F; Pris, J; Reynish, W; Rigal-Huguet, F, 2002)
"Drug-induced Sweet's syndrome has a temporal relationship between drug ingestion, clinical presentation and the temporally-related resolution of lesions following drug withdrawal or on treatment with systemic corticosteroids."	( Choi, HS; Ihm, CG; Kim, HJ; Kim, MJ; Lee, SH; Lee, TH; Lee, TW, 2003)
"Sweet's syndrome is an acute febrile neutrophilic dermatosis that is a known complication of the administration of filgrastim, a drug that causes increased neutrophil proliferation and differentiation."	( Baumann, MA; Bernstein, JM; Kumar, G; Waibel, JS, 2004)
"We report a case of Sweet syndrome secondary to the administration of imatinib to treat CML."	( Ayirookuzhi, SJ; Ma, L; Mills, G; Ramshesh, P, 2005)
"This case report describes a case of Sweet syndrome (SS) related to use of furosemide in a 46-year-old female who was admitted for treatment of congestive heart failure."	( Bashir, Q; Brooks, C; Govindarajan, G; Kuppuswamy, S, 2005)
"A total of 103 patients with Sweet's syndrome have been seen and treated at Scott and White Memorial Hospital since 1996."	( Bennett, LL; Grothaus, PC; Lynch, DJ; O'Halloran, LE, 2005)
"There is a close relationship between Sweet syndrome and leukocytoclastic vasculitis in terms of clinical appearance, histopathological pattern, triggers, disease course, and response to treatment."	( Burgdorf, W; Ratzinger, G; Zelger, B; Zelger, BG, 2007)
"Drug-induced acute febrile neutrophilic dermatosis, or Sweet's syndrome, is rare and, to our knowledge, has not previously been associated with clindamycin therapy."	( Clark, BM; D'Avignon, LC; Glass, KR; Homeyer, DC, 2007)
"The first case of Sweet's syndrome (SS) developed in a APL patient treated with ATRA was reported in mainland of China, and reviewed correlative literature."	( Chen, HS; Feng, SZ; Han, MZ; Jiang, EL; Li, DP; Liu, EB; Yan, ZS; Zhou, CL, 2007)
"Ocular manifestations are uncommon in Sweet's syndrome but it is important to diagnose and treat them."	( Loh, RS; Su, DH; Wong, MH, 2007)
"An association of Sweet syndrome with chronic myeloid leukemia (CML) has been recently observed in patients treated with tyrosine kinase inhibitors."	( Baesecke, J; Baumgart, M; Emmert, S; Gesk, S; Ghadimi, BM; Glass, B; Haase, D; Kaune, KM; Mitteldorf, C; Neumann, C; Siebert, R, 2008)
"Skin infiltrations consistent with Sweet syndrome can occur in patients with septic CML during the treatment with tyrosine kinase inhibitors, including nilotinib."	( Baesecke, J; Baumgart, M; Emmert, S; Gesk, S; Ghadimi, BM; Glass, B; Haase, D; Kaune, KM; Mitteldorf, C; Neumann, C; Siebert, R, 2008)
"We report a case of drug-induced Sweet's syndrome secondary to hepatitis C antiviral therapy."	( Becheanu, G; Cotruta, B; Cotruta, C; Gheorghe, C; Gheorghe, L; Trifu, V, 2008)
"Clinicians should be aware of Sweet's syndrome in patients with otherwise unexplained acute febrile illness and erythematous skin rash in association with mitoxantrone therapy."	( Flaig, M; Gerdes, LA; Hohlfeld, R; Kümpfel, T; Wollenberg, A, 2011)
"We describe a pediatric case of Sweet syndrome presenting 10 days after treatment with azathioprine."	( Choe, YH; Jang, KT; Kim, MJ, 2011)
"Sweet's syndrome (also known as acute febrile neutrophilic dermatosis) in two patients receiving azacitidine therapy is reported."	( Craig, M; Cumpston, A; Trickett, HB, 2012)
"We report the occurrence of Sweet's syndrome in a patient treated with adalimumab for Crohn's disease."	( Avenel, G; Banse, C; Savoye, G; Sobocinski, V; Vittecoq, O, 2015)
"Sweet's syndrome, or acute febrile neutrophilic dermatosis, is an uncommon severe cutaneous condition, not previously associated with allopurinol therapy."	( Arcoraci, V; Cardillo, R; Garaffo, E; Giardina, C; Guarneri, C; Macrì, R; Polimeni, G; Sirna, V, 2016)
"Our case was an unusual presentation of Sweet syndrome in a patient with rectal adenocarcinoma treated with neoadjuvant capecitabine."	( Ali, F; Khan, U; Lebovic, D; Rizvi, H, 2016)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	77 (14.64)	12.5806
2000's	178 (33.84)	18.1394
2010's	207 (39.35)	28.8240
2020's	64 (12.17)	9.53

Drug	Relationship Strength	Studies	Trials
adenine	low	1	0
salicylic acid	low	1	0
bupropion	low	2	0
glycine	low	3	0
dalteparin	low	1	0
phenytoin	low	1	0
acetaminophen	low	2	0
amoxapine	low	1	0
aspirin	low	1	0
azathioprine	low	35	0
busulfan	low	1	0
celecoxib	low	4	0
chloroquine	low	1	0
ciprofloxacin	low	2	0
citalopram	low	1	0
clofazimine	low	2	0
dapsone	low	40	0
diazepam	low	1	0
diclofenac	low	3	0
felodipine	low	1	0
fluconazole	low	2	0
fluorouracil	low	1	0
furosemide	low	1	0
gentamicin	low	1	0
hydralazine	low	3	0
hydroxychloroquine	low	1	0
hydroxyurea	low	2	0
ibuprofen	low	1	0
indomethacin	medium	4	1
isoniazid	low	1	0
ketoconazole	low	1	0
loxoprofen	low	1	0
mesalamine	low	1	0
metronidazole	low	2	0
mitoxantrone	low	3	0
niflumic acid	low	1	0
norfloxacin	low	1	0
ofloxacin	low	1	0
aminosalicylic acid	low	1	0
pentoxifylline	low	2	0
perphenazine	low	1	0
phenylbutazone	low	1	0
potassium iodide	low	12	0
vorinostat	low	1	0
sulfasalazine	low	3	0
thalidomide	low	8	0
ticlopidine	low	1	0
mitomycin	low	1	0
corticosterone	low	1	0
prednisolone	low	115	0
thyroxine	low	2	0
prednisone	low	76	0
ethinyl estradiol	low	1	0
methionine	low	1	0
colchicine	low	32	0
ampicillin	low	1	0
cytarabine	low	12	0
chlorquinaldol	low	1	0
triamcinolone acetonide	low	3	0
methylprednisolone	low	35	0
penicillanic acid	low	1	0
pyrazines	low	10	0
nitroblue tetrazolium	low	1	0
azacitidine	low	15	0
betamethasone	low	6	0
fusarium	low	1	0
vancomycin	low	1	0
vidarabine	low	2	0
technetium	low	1	0
ethinyl estradiol-norgestrel combination	low	1	0
trolamine salicylate	low	21	0
levamisole	low	1	0
daunorubicin	low	2	0
amoxicillin	low	2	0
etoposide	low	1	0
ribavirin	low	1	0
nimustine	low	1	0
idarubicin	low	6	0
propiconazole	low	2	0
piperacillin	low	1	0
clopidogrel	low	1	0
aripiprazole	low	1	0
lamivudine	low	1	0
adenosine	low	1	0
nelfinavir	low	1	0
glucose, (beta-d)-isomer	low	1	0
cephalosporin c	low	2	0
flomoxef	low	1	0
fluorodeoxyglucose f18	low	3	0
clobetasone butyrate	low	1	0
antebate	low	1	0
ranimustine	low	1	0
aceclofenac	low	2	0
clarithromycin	low	2	0
fibrinogen	low	1	0
diflucortolone valerate	low	1	0
imatinib mesylate	low	3	0
tazobactam	low	1	0
methotrexate	low	2	0
levofloxacin	low	2	0
naproxen	low	1	0
erlotinib hydrochloride	low	1	0
dabigatran	low	1	0
lenalidomide	low	5	0
trimethoprim, sulfamethoxazole drug combination	low	10	0
bortezomib	low	12	0
fibrin	low	2	0
mevalonic acid	low	1	0
abacavir	low	1	0
mometasone furoate	low	2	0
tretinoin	low	22	0
tacrolimus	low	2	0
cocaine	low	1	0
mycophenolic acid	low	1	0
clindamycin	low	4	0
aclarubicin	low	1	0
decitabine	low	3	0
melphalan	low	3	0
favipiravir	low	1	0
s 1033	low	1	0
iothalamate meglumine	low	1	0
fludarabine	low	1	0
propylthiouracil	low	2	0
tamoxifen	low	1	0
dasatinib	low	2	0
amphotericin b	low	1	0
clavulanic acid	low	1	0
isotretinoin	low	3	0
s 1108	low	1	0
codeine	low	1	0
acitretin	low	3	0
clobetasol	low	11	0
palbociclib	low	1	0
cefotaxime	low	1	0
nitrofurantoin	low	2	0
staurosporine	low	2	0
midostaurin	low	2	0
mocetinostat	low	7	0
ticagrelor	low	1	0
dapagliflozin	low	1	0
tofacitinib	low	1	0
prasugrel hydrochloride	low	1	0
trametinib	low	3	0
losartan potassium	low	1	0
diflucortolone	low	1	0
virginiamycin	low	1	0
meglumine ioxithalamate	low	1	0
quinupristin	low	1	0
pci 32765	low	1	0
incb-018424	low	4	0
ixazomib	low	3	0
plx4032	low	2	0
baricitinib	low	2	0
piperidines	low	2	0
interleukin-8	low	5	0
dabrafenib	low	3	0
minocycline	low	3	0
norgestrel	low	1	0
dalfopristin	low	1	0
cyclosporine	low	15	0
lactoferrin	low	1	0
exudates	low	2	0
acyclovir	low	2	0
neopterin	low	1	0
rifampin	low	1	0
clozapine	low	2	0
valacyclovir	low	1	0
allopurinol	low	1	0
pemetrexed	low	1	0
eye	low	2	0
leptin	low	1	0
pyrimidinones	low	3	0

Protein Targets (1,963)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Luciferase	21	0	0	21
cytochrome P450 family 3 subfamily A polypeptide 4	51	0	0	51
cytochrome P450 2D6	26	0	0	26
euchromatic histone-lysine N-methyltransferase 2	58	0	0	58
peripheral myelin protein 22	33	0	0	33
Albumin	0	6	11	20
ATP-dependent translocase ABCB1	0	17	3	26
Replicase polyprotein 1ab	0	4	5	9
Replicase polyprotein 1ab	0	4	5	9
Reverse transcriptase/RNaseH	0	2	2	4
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	11	0	14
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	29	0	0	29
GLS protein	25	0	0	25
GLI family zinc finger 3	45	0	0	45
estrogen receptor 2 (ER beta)	33	0	0	33
progesterone receptor	40	0	0	40
retinoid X nuclear receptor alpha	44	0	0	44
G	31	0	0	31
peroxisome proliferator activated receptor gamma	39	0	0	39
cytochrome P450 2C9 precursor	11	0	0	11
chromobox protein homolog 1	34	0	0	34
potassium voltage-gated channel subfamily H member 2 isoform d	17	0	0	17
ubiquitin carboxyl-terminal hydrolase 2 isoform a	11	0	0	11
histone-lysine N-methyltransferase 2A isoform 2 precursor	5	0	0	5
geminin	59	0	0	59
lamin isoform A-delta10	48	0	0	48
ATP-binding cassette sub-family C member 3	0	65	0	65
Multidrug resistance-associated protein 4	0	65	0	66
Bile salt export pump	0	80	0	80
Interferon beta	48	0	0	48
HLA class I histocompatibility antigen, B alpha chain	31	0	0	31
Transthyretin	0	2	4	9
Mitogen-activated protein kinase 1	0	4	11	15
Histamine H2 receptor	18	1	0	19
Disintegrin and metalloproteinase domain-containing protein 17	8	0	0	8
Inositol hexakisphosphate kinase 1	31	0	0	31
cytochrome P450 2C9, partial	31	0	0	31
RAR-related orphan receptor gamma	47	0	0	47
ATAD5 protein, partial	19	0	0	19
Microtubule-associated protein tau	25	0	0	25
Smad3	18	0	0	18
aldehyde dehydrogenase 1 family, member A1	34	0	0	34
thyroid stimulating hormone receptor	25	0	0	25
nuclear receptor subfamily 1, group I, member 3	41	0	0	41
EWS/FLI fusion protein	54	0	0	54
retinoic acid nuclear receptor alpha variant 1	47	0	0	47
estrogen-related nuclear receptor alpha	56	0	0	56
estrogen nuclear receptor alpha	80	0	0	80
aryl hydrocarbon receptor	29	0	0	29
thyroid hormone receptor beta isoform 2	53	0	0	53
cytochrome P450 3A4 isoform 1	27	0	0	27
Gamma-aminobutyric acid receptor subunit pi	27	7	1	35
Solute carrier family 22 member 6	0	8	0	9
Carbonic anhydrase 12	0	6	0	7
UDP-glucuronosyltransferase 1A9	0	1	0	4
Bile salt export pump	0	19	0	19
Voltage-dependent calcium channel gamma-2 subunit	33	0	0	33
Cytochrome P450 2B1	0	1	0	2
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	17	0	18
Carbonic anhydrase 2	0	18	1	21
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	0	1	2
Cytochrome P450 1A2	0	7	1	9
Prostaglandin G/H synthase 1	0	12	0	13
Carbonic anhydrase 3	0	6	0	6
Cytochrome P450 3A4	0	26	1	32
Cytochrome P450 2D6	0	14	1	16
Cytochrome P450 2C9	0	26	1	30
Polyunsaturated fatty acid lipoxygenase ALOX15	0	8	0	8
Gamma-aminobutyric acid receptor subunit beta-1	27	7	1	35
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	27	7	1	35
Gamma-aminobutyric acid receptor subunit gamma-2	27	7	1	35
UDP-glucuronosyltransferase 1-6	0	3	0	4
Glutamate receptor 2	34	1	0	35
Gamma-aminobutyric acid receptor subunit alpha-5	27	7	1	35
Gamma-aminobutyric acid receptor subunit alpha-3	27	7	1	35
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	7	0	11
Carbonic anhydrase 4	0	8	0	9
Prostaglandin G/H synthase 1	0	12	0	13
Carbonic anhydrase 6	0	6	0	7
Gamma-aminobutyric acid receptor subunit gamma-1	27	7	1	35
Gamma-aminobutyric acid receptor subunit alpha-2	27	7	1	35
Gamma-aminobutyric acid receptor subunit alpha-4	27	7	1	35
Gamma-aminobutyric acid receptor subunit gamma-3	27	7	1	35
Gamma-aminobutyric acid receptor subunit alpha-6	27	7	1	35
Carbonic anhydrase 5A, mitochondrial	0	8	0	9
Prostaglandin G/H synthase 2	0	16	7	25
Carbonic anhydrase 7	0	6	0	7
Nuclear receptor ROR-gamma	15	1	1	17
Cytochrome P450 2J2	0	14	0	15
Gamma-aminobutyric acid receptor subunit alpha-1	27	9	1	37
Gamma-aminobutyric acid receptor subunit beta-3	27	7	1	35
Gamma-aminobutyric acid receptor subunit beta-2	27	7	1	35
Carbonic anhydrase 9	0	10	0	12
GABA theta subunit	27	7	1	35
Canalicular multispecific organic anion transporter 1	0	62	0	63
Carbonic anhydrase 15	0	5	0	5
Carbonic anhydrase 13	0	4	0	5
Gamma-aminobutyric acid receptor subunit epsilon	27	7	1	35
Carbonic anhydrase 14	0	6	0	7
Carbonic anhydrase 5B, mitochondrial	0	6	0	7
toxin B	0	0	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	10	0	0	10
USP1 protein, partial	31	0	0	31
TDP1 protein	70	0	0	70
AR protein	68	0	0	68
glucocorticoid receptor [Homo sapiens]	58	0	0	58
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	42	0	0	42
vitamin D3 receptor isoform VDRA	21	0	0	21
flap endonuclease 1	14	0	0	14
serine/threonine-protein kinase PLK1	3	0	0	3
eyes absent homolog 2 isoform a	3	0	0	3
DNA polymerase eta isoform 1	8	0	0	8
survival motor neuron protein isoform d	24	0	0	24
histone acetyltransferase KAT2A isoform 1	19	0	0	19
Rap guanine nucleotide exchange factor 3	5	0	0	5
Cellular tumor antigen p53	45	0	0	45
Rap guanine nucleotide exchange factor 4	6	0	0	6
72 kDa type IV collagenase	0	2	0	2
5-hydroxytryptamine receptor 2B	0	15	1	16
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	14	0	0	14
Chain B, HADH2 protein	14	0	0	14
Chain A, ATP-DEPENDENT DNA HELICASE Q1	8	0	0	8
Chain A, Ferritin light chain	18	0	0	18
Thymidine kinase	0	1	0	1
thioredoxin reductase	33	0	0	33
phosphopantetheinyl transferase	19	0	0	19
arylsulfatase A	19	0	0	19
activating transcription factor 6	18	0	0	18
Histone H2A.x	23	0	0	23
Bloom syndrome protein isoform 1	19	0	0	19
hemoglobin subunit beta	4	0	0	4
atrial natriuretic peptide receptor 1 precursor	5	0	0	5
Solute carrier family 22 member 1	0	6	0	7
Purine nucleoside phosphorylase	0	2	0	2
Thymidine kinase, cytosolic	0	1	0	3
POU domain, class 2, transcription factor 2	0	0	0	1
Purine nucleoside phosphorylase	0	0	2	2
Solute carrier family 22 member 6	0	6	0	8
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	5	0	8
Thymidine kinase	0	2	0	2
Chain A, MTA/SAH nucleosidase	0	1	0	1
Chain A, Ribosome-inactivating protein alpha-trichosanthin	0	0	1	1
Chain A, Ricin A chain	0	0	1	1
Chain A, Ribosome-inactivating protein 3	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
pregnane X nuclear receptor	48	0	0	48
nuclear factor erythroid 2-related factor 2 isoform 2	25	0	0	25
heat shock protein beta-1	19	0	0	19
importin subunit beta-1 isoform 1	8	0	0	8
snurportin-1	8	0	0	8
tumor susceptibility gene 101 protein	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	4	0	0	4
Cyclin-dependent kinase 1	0	3	11	14
Heat shock protein HSP 90-beta	0	1	0	1
Xanthine dehydrogenase/oxidase	0	3	0	3
TAR DNA-binding protein 43	17	1	0	18
Protein mono-ADP-ribosyltransferase PARP15	0	2	0	2
Leucine-rich repeat serine/threonine-protein kinase 2	0	2	5	7
ATPase family AAA domain-containing protein 5	27	0	0	27
Ataxin-2	38	0	0	38
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain B, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
Chain A, Uncharacterized protein MJ0883	0	0	1	1
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
regulator of G-protein signaling 4	11	0	0	11
NPYLR7B	0	0	2	2
IDH1	25	0	0	25
glycogen synthase kinase-3 beta isoform 1	0	0	4	4
mitogen-activated protein kinase 1	12	0	0	12
nuclear receptor ROR-gamma isoform 1	22	0	0	22
high affinity choline transporter 1 isoform a	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Calcium dependent protein kinase	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	6	6
Sodium/nucleoside cotransporter 2	0	2	0	2
Epidermal growth factor receptor	0	15	12	27
Phosphoglycerate kinase 1	0	1	0	1
Adenosine deaminase	0	0	0	1
Avidin	0	0	1	1
Adenosine deaminase	0	0	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	7	6	13
Insulin receptor	0	2	11	14
Phosphoglycerate kinase 2	0	1	0	1
Heat shock protein HSP 90-alpha	0	2	1	3
Platelet-derived growth factor receptor beta	0	5	11	17
Adenosine receptor A3	0	18	2	21
Heat shock 70 kDa protein 1A	0	1	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
Fibroblast growth factor receptor 1	0	2	11	14
Inosine-5'-monophosphate dehydrogenase 2	0	3	8	11
Endoplasmin	0	1	1	2
Inosine-5'-monophosphate dehydrogenase 1	0	3	0	3
Fibroblast growth factor receptor 2	0	0	5	6
Fibroblast growth factor receptor 4	0	0	5	6
Fibroblast growth factor receptor 3	0	0	5	6
Streptavidin	0	0	1	1
Adenosylhomocysteinase	0	0	0	3
Adenosine receptor A1	0	7	1	8
Adenosine receptor A3	0	2	0	2
Adenosine receptor A2a	0	7	3	11
Adenosine receptor A2b	0	1	1	3
Adenosine receptor A2b	0	1	1	2
Adenylate kinase 2, mitochondrial	0	1	0	1
Adenosine receptor A1	0	6	2	9
Adenosine receptor A2a	0	5	1	6
Adenylate kinase isoenzyme 1	0	1	0	1
Phosphatidylinositol 4-kinase alpha	0	2	0	3
Adenosine receptor A1	0	1	1	2
Adenosine kinase	0	0	11	12
Adenosine deaminase	0	0	0	3
Equilibrative nucleoside transporter 2	0	2	0	2
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	3
Histone-lysine N-methyltransferase, H3 lysine-79 specific	0	1	0	1
Equilibrative nucleoside transporter 1	0	2	0	2
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	3
Solute carrier family 28 member 3	0	2	0	2
Adenosine kinase	0	1	0	2
Phosphatidylinositol 4-kinase beta	0	2	5	8
5-methylthioadenosine/S-adenosylhomocysteine deaminase	0	0	0	1
Adenosine transporter 1	0	0	0	1
interleukin 8	13	0	0	13
transcriptional regulator ERG isoform 3	9	0	0	9
ras-related protein Rab-9A	9	0	0	9
nuclear factor erythroid 2-related factor 2 isoform 1	48	0	0	48
Polyphenol oxidase 2	0	3	0	4
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase	0	1	0	1
Nuclear receptor ROR-gamma	0	1	0	1
Xanthine dehydrogenase/oxidase	0	3	1	5
Shiga toxin subunit A	0	1	0	1
Histamine H3 receptor	0	1	0	5
Chain A, 2-oxoglutarate Oxygenase	23	0	0	23
thioredoxin glutathione reductase	9	0	0	9
microphthalmia-associated transcription factor isoform 9	0	2	0	2
Tyrosine-protein phosphatase non-receptor type 1	0	1	1	4
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	15	0	0	15
Chain A, Beta-lactamase	15	0	0	15
endonuclease IV	10	0	0	10
hypoxia-inducible factor 1 alpha subunit	21	0	0	21
Fumarate hydratase	27	0	0	27
NFKB1 protein, partial	11	0	0	11
Thrombopoietin	9	0	0	9
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	16	0	0	16
isocitrate dehydrogenase 1, partial	2	0	0	2
polyprotein	27	0	0	27
67.9K protein	30	0	0	30
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	14	0	0	14
v-jun sarcoma virus 17 oncogene homolog (avian)	16	0	0	16
cytochrome P450 2D6 isoform 1	11	0	0	11
peripheral myelin protein 22 isoform 1	16	0	0	16
cellular tumor antigen p53 isoform a	10	0	0	10
D(1A) dopamine receptor	8	0	0	8
thyroid hormone receptor beta isoform a	19	0	0	19
atrial natriuretic peptide receptor 2 precursor	6	0	0	6
serine/threonine-protein kinase mTOR isoform 1	14	0	0	14
M-phase phosphoprotein 8	13	0	0	13
transient receptor potential cation channel subfamily V member 1	3	0	0	3
muscarinic acetylcholine receptor M1	14	0	0	14
neuropeptide S receptor isoform A	9	0	0	9
Polyunsaturated fatty acid lipoxygenase ALOX15B	8	0	0	8
5-hydroxytryptamine receptor 4	0	10	0	10
Aldo-keto reductase family 1 member B1	0	18	0	18
Muscarinic acetylcholine receptor M2	0	13	1	14
Muscarinic acetylcholine receptor M4	0	10	1	11
5-hydroxytryptamine receptor 1A	0	4	1	5
Muscarinic acetylcholine receptor M5	0	10	0	10
Alpha-2A adrenergic receptor	0	13	0	13
Muscarinic acetylcholine receptor M1	0	10	1	11
D(2) dopamine receptor	0	9	1	13
Alpha-2B adrenergic receptor	0	16	0	16
Alpha-2C adrenergic receptor	0	9	0	9
Muscarinic acetylcholine receptor M3	0	9	1	10
D(1A) dopamine receptor	0	11	0	12
D(4) dopamine receptor	0	6	0	8
Sodium-dependent noradrenaline transporter	0	22	0	22
Alpha-1D adrenergic receptor	0	11	0	11
5-hydroxytryptamine receptor 2A	0	8	0	10
5-hydroxytryptamine receptor 2C	0	12	1	13
Sodium-dependent serotonin transporter	0	21	1	22
5-hydroxytryptamine receptor 7	0	4	0	4
Histamine H1 receptor	0	9	2	13
D(3) dopamine receptor	0	7	1	10
D(1A) dopamine receptor	6	0	0	6
Sulfotransferase 1A1	0	3	1	5
5-hydroxytryptamine receptor 6	0	8	0	9
Inositol monophosphatase 1	9	0	0	9
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Sulfotransferase 2A1	0	1	0	1
Histamine H4 receptor	0	3	1	4
ATP-dependent phosphofructokinase	21	0	0	21
Beta-lactamase	0	2	0	4
Beta-lactamase	0	2	0	6
Beta-lactamase	0	0	0	4
Beta-lactamase	0	2	0	6
apical membrane antigen 1, AMA1	9	0	0	9
Beta-lactamase	0	0	0	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	10	0	0	10
DNA polymerase iota isoform a (long)	23	0	0	23
urokinase-type plasminogen activator precursor	16	0	0	16
plasminogen precursor	16	0	0	16
urokinase plasminogen activator surface receptor precursor	16	0	0	16
DNA polymerase kappa isoform 1	19	0	0	19
Beta-lactamase SHV-1	0	2	0	5
Beta-lactamase SHV-1	0	4	0	8
Beta-lactamase	0	2	0	6
Kappa-type opioid receptor	0	0	0	4
Solute carrier family 15 member 1	0	7	0	8
Solute carrier family 15 member 1	0	3	0	3
B2 metallo-beta-lactamase	0	0	0	3
Solute carrier family 15 member 2	0	3	0	3
Beta-lactamase	0	2	0	5
Beta-lactamase	0	1	0	4
Solute carrier family 15 member 2	0	4	0	4
Beta-lactamase	0	2	0	5
Beta-lactamase	0	0	0	4
Chain A, Cruzipain	9	0	0	9
farnesoid X nuclear receptor	36	0	0	36
peroxisome proliferator-activated receptor delta	33	0	0	33
vitamin D (1,25- dihydroxyvitamin D3) receptor	34	0	0	34
tumor necrosis factor	1	0	0	1
Cytochrome P450 2C19	0	13	1	16
Potassium voltage-gated channel subfamily H member 2	0	35	0	36
Aurora kinase B	0	2	12	14
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Beta-lactamase	0	3	0	5
acid sphingomyelinase	3	0	0	3
Beta-lactamase	0	2	0	5
Beta-lactamase	0	1	0	5
Metallo-beta-lactamase type 2	0	0	0	4
Metallo-beta-lactamase VIM-11	0	0	0	3
Metallo-beta-lactamase VIM-2	0	0	0	3
Beta-lactamase	0	0	0	4
Metallo-beta-lactamase	0	0	0	3
Beta-lactamase	0	2	0	5
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	12	0	0	12
DNA polymerase beta	6	0	0	6
60 kDa heat shock protein, mitochondrial	0	5	0	5
Beta-lactamase OXA-7	0	0	0	2
Spike glycoprotein	28	1	5	34
10 kDa heat shock protein, mitochondrial	0	5	0	5
Angiopoietin-1 receptor	0	0	7	7
Beta-lactamase	0	1	0	4
Beta-lactamase	0	1	0	4
Beta-lactamase	0	1	0	4
Thiosulfate sulfurtransferase	0	5	0	5
Metallo-beta-lactamase VIM-13	0	0	0	4
Efflux transporter	0	0	0	1
Beta-lactamase	0	1	0	5
Beta-lactamase Toho-1	0	0	0	2
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	2	0	4
60 kDa chaperonin	0	6	0	6
Metallo-beta-lactamase	0	0	0	3
Beta-lactamase	0	2	0	6
Beta-lactamase	0	0	0	2
10 kDa chaperonin	0	6	0	6
Metallo-b-lactamase	0	0	0	6
Carbapenem-hydrolyzing beta-lactamase KPC	0	4	0	8
Beta-lactamase class B VIM-2	0	0	0	6
Beta-lactamase VIM-1	0	0	0	4
5-hydroxytryptamine receptor 3E	0	2	0	2
acetylcholinesterase	16	0	0	16
SMAD family member 2	13	0	0	13
PPM1D protein	22	0	0	22
SMAD family member 3	13	0	0	13
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	8	0	0	8
thyroid stimulating hormone receptor	19	0	0	19
lysosomal alpha-glucosidase preproprotein	4	0	0	4
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Solute carrier family 22 member 2	0	5	0	5
5-hydroxytryptamine receptor 3A	0	2	0	2
5-hydroxytryptamine receptor 3B	0	2	0	2
5-hydroxytryptamine receptor 2C	0	6	0	7
Neuronal acetylcholine receptor subunit alpha-4	3	3	0	6
Neuronal acetylcholine receptor subunit beta-2	3	3	0	6
5-hydroxytryptamine receptor 2A	0	7	0	7
Alpha-1B adrenergic receptor	0	19	1	20
D	0	4	0	4
5-hydroxytryptamine receptor 1A	0	15	2	17
D(1B) dopamine receptor	0	2	0	3
Alpha-1D adrenergic receptor	0	7	1	8
D(4) dopamine receptor	0	3	0	3
Histamine H1 receptor	0	2	2	4
5-hydroxytryptamine receptor 7	0	3	0	3
Alpha-1A adrenergic receptor	0	3	0	3
Alpha-1B adrenergic receptor	0	2	0	2
Alpha-1A adrenergic receptor	0	19	1	20
5-hydroxytryptamine receptor 3A	0	2	0	2
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	2	0	2
D(2) dopamine receptor	0	5	0	5
5-hydroxytryptamine receptor 3D	0	2	0	2
Multidrug and toxin extrusion protein 2	0	4	0	4
5-hydroxytryptamine receptor 3C	0	2	0	2
Multidrug and toxin extrusion protein 1	0	10	0	10
Histamine H3 receptor	0	2	0	2
Chain A, Phospholipase A2 isoform 3	0	0	1	1
GTP-binding protein (rab7)	0	0	2	2
ras protein, partial	0	0	2	2
hypothetical protein, conserved	2	0	0	2
glucocerebrosidase	9	0	0	9
Rac1 protein	0	0	2	2
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	2	2
lethal factor (plasmid)	11	0	0	11
Prostaglandin-H2 D-isomerase	0	2	0	2
Prostaglandin G/H synthase 1	0	7	0	8
Prostaglandin G/H synthase 2	0	5	0	6
Fatty acid-binding protein, liver	0	5	0	5
Integrin beta-3	7	1	0	8
Myeloperoxidase	0	5	0	5
Seed linoleate 13S-lipoxygenase-1	0	2	0	2
Integrin alpha-IIb	7	1	0	8
Glutathione hydrolase 1 proenzyme	0	1	0	1
Substance-P receptor	0	3	0	3
Urotensin-2 receptor	0	2	0	2
4-aminobutyrate aminotransferase, mitochondrial	0	2	0	2
Ras-related protein Rab-2A	0	0	2	2
Prostaglandin G/H synthase 2	0	10	0	10
Rho-associated protein kinase 2	0	2	0	2
Nicotinate phosphoribosyltransferase	0	4	0	4
Solute carrier family 22 member 20	0	4	0	4
Solute carrier family 22 member 6	0	4	0	4
Sigma non-opioid intracellular receptor 1	0	12	1	13
Sigma non-opioid intracellular receptor 1	0	2	1	3
glp-1 receptor, partial	18	0	0	18
pregnane X receptor	11	0	0	11
Parkin	9	0	0	9
huntingtin isoform 2	9	0	0	9
DNA (cytosine-5)-methyltransferase 1	0	3	0	3
Histone-lysine N-methyltransferase EHMT2	0	3	0	3
P53	1	0	0	1
muscleblind-like protein 1 isoform 1	12	0	0	12
Protein-arginine deiminase type-4	0	6	0	6
Bone morphogenetic protein receptor type-1B	0	0	11	11
Membrane-associated progesterone receptor component 1	0	0	8	8
Serine/threonine-protein kinase PLK4	0	0	11	11
ATP-dependent RNA helicase DDX3X	0	0	11	11
Pyridoxal kinase	0	0	11	11
Citron Rho-interacting kinase	0	0	11	11
Serine/threonine-protein kinase Chk1	0	1	11	12
Aurora kinase A	0	2	11	13
Cyclin-G-associated kinase	0	2	11	13
Ephrin type-B receptor 6	0	0	11	11
Peroxisomal acyl-coenzyme A oxidase 3	0	0	11	11
Receptor-interacting serine/threonine-protein kinase 2	0	3	11	14
Dynamin-like 120 kDa protein, mitochondrial	0	0	11	11
Tyrosine-protein kinase JAK2	0	9	10	22
Eukaryotic translation initiation factor 5B	0	0	7	7
Rho-associated protein kinase 2	0	1	11	12
Serine/threonine-protein kinase ULK1	0	0	11	11
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	11	11
Ribosomal protein S6 kinase alpha-5	0	1	11	12
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	11	11
Ribosomal protein S6 kinase alpha-4	0	0	11	11
Serine/threonine-protein kinase 16	0	0	11	11
Serine/threonine-protein kinase 10	0	0	11	11
Serine/threonine-protein kinase D3	0	1	11	12
Structural maintenance of chromosomes protein 2	0	0	10	10
Mitogen-activated protein kinase kinase kinase 6	0	0	11	11
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	11	11
Serine/threonine-protein kinase LATS1	0	0	11	11
Serine/threonine-protein kinase PAK 4	0	0	11	11
Tyrosine-protein kinase ABL1	0	9	14	25
Guanine nucleotide-binding protein G(i) subunit alpha-2	0	0	9	9
ADP/ATP translocase 2	0	0	11	11
Protein kinase C beta type	0	1	11	12
Tyrosine-protein kinase Lck	0	9	11	20
Tyrosine-protein kinase Fyn	0	7	11	18
Glycogen phosphorylase, liver form	0	0	11	11
Tyrosine-protein kinase Fes/Fps	0	0	11	11
Adenine phosphoribosyltransferase	0	0	6	6
Tyrosine-protein kinase Yes	0	2	11	13
Tyrosine-protein kinase Lyn	0	3	11	14
Proto-oncogene tyrosine-protein kinase receptor Ret	0	2	11	13
Insulin-like growth factor 1 receptor	0	1	11	12
Signal recognition particle receptor subunit alpha	0	0	8	8
Cytochrome c1, heme protein, mitochondrial	0	0	11	11
Hepatocyte growth factor receptor	0	0	11	11
Tyrosine-protein kinase HCK	0	4	11	15
Serine/threonine-protein kinase A-Raf	0	2	11	13
Glycogen phosphorylase, brain form	0	0	11	11
Breakpoint cluster region protein	0	5	13	20
Serine/threonine-protein kinase pim-1	0	1	11	12
DNA topoisomerase 2-alpha	0	3	10	23
Cyclin-dependent kinase 4	0	2	11	13
ADP/ATP translocase 3	0	0	11	11
Proto-oncogene tyrosine-protein kinase Src	0	6	11	17
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	10	10
Serine/threonine-protein kinase B-raf	0	2	13	17
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	11	11
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	4	11	15
Tyrosine-protein kinase Fer	0	0	11	11
Protein kinase C alpha type	0	3	11	14
cAMP-dependent protein kinase catalytic subunit alpha	0	0	11	11
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	11	11
Casein kinase II subunit alpha'	0	1	11	12
Ras-related protein Rab-6A	0	0	10	10
Ephrin type-A receptor 1	0	0	10	10
Multifunctional protein ADE2	0	0	11	11
cAMP-dependent protein kinase catalytic subunit gamma	0	0	10	10
cAMP-dependent protein kinase catalytic subunit beta	0	0	11	11
Ferrochelatase, mitochondrial	0	0	12	12
Ribosomal protein S6 kinase beta-1	0	1	11	12
Tyrosine-protein kinase JAK1	0	8	13	24
Cyclin-dependent kinase 2	0	5	12	17
Beta-adrenergic receptor kinase 1	0	0	11	11
Probable ATP-dependent RNA helicase DDX6	0	0	11	11
Mitogen-activated protein kinase 3	0	1	11	12
MAP/microtubule affinity-regulating kinase 3	0	0	11	11
Deoxycytidine kinase	0	0	11	12
Ephrin type-A receptor 2	0	3	11	14
Ephrin type-B receptor 2	0	1	11	12
Non-receptor tyrosine-protein kinase TYK2	0	6	13	22
UMP-CMP kinase	0	0	6	6
Phosphatidylethanolamine-binding protein 1	0	0	9	9
Wee1-like protein kinase	0	0	11	11
Heme oxygenase 2	0	0	11	11
S-adenosylmethionine synthase isoform type-2	0	0	11	11
DnaJ homolog subfamily A member 1	0	0	11	11
RAC-alpha serine/threonine-protein kinase	0	2	11	13
RAC-beta serine/threonine-protein kinase	0	1	11	12
DNA replication licensing factor MCM4	0	0	10	10
Myosin-10	0	0	8	8
Dual specificity mitogen-activated protein kinase kinase 2	0	5	11	16
Receptor-type tyrosine-protein kinase FLT3	0	8	11	19
Bone morphogenetic protein receptor type-1A	0	0	11	11
Activin receptor type-1B	0	0	11	11
TGF-beta receptor type-1	0	1	11	12
Serine/threonine-protein kinase receptor R3	0	0	8	8
TGF-beta receptor type-2	0	0	11	11
Electron transfer flavoprotein subunit beta	0	0	7	7
Tyrosine-protein kinase CSK	0	3	11	14
Glycine--tRNA ligase	0	0	11	11
Protein kinase C iota type	0	1	11	12
Exosome RNA helicase MTR4	0	0	11	11
Tyrosine-protein kinase Tec	0	3	11	14
Tyrosine-protein kinase ABL2	0	0	11	11
Tyrosine-protein kinase FRK	0	1	11	12
G protein-coupled receptor kinase 6	0	0	7	7
Tyrosine-protein kinase SYK	0	2	11	13
26S proteasome regulatory subunit 6B	0	1	11	12
Mitogen-activated protein kinase 8	0	1	11	12
Mitogen-activated protein kinase 9	0	0	11	11
Dual specificity mitogen-activated protein kinase kinase 3	0	0	11	11
Casein kinase I isoform alpha	0	1	10	11
Casein kinase I isoform delta	0	0	11	11
MAP kinase-activated protein kinase 2	0	2	11	13
Elongation factor Tu, mitochondrial	0	0	11	11
Cysteine--tRNA ligase, cytoplasmic	0	0	8	8
Casein kinase I isoform epsilon	0	0	11	11
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	11	11
Dual specificity protein kinase CLK1	0	0	11	11
Dual specificity protein kinase CLK2	0	0	11	11
Dual specificity protein kinase CLK3	0	0	9	9
Glycogen synthase kinase-3 alpha	0	0	11	11
Glycogen synthase kinase-3 beta	0	1	11	12
Cyclin-dependent kinase 7	0	2	11	13
Cyclin-dependent kinase 9	0	2	11	13
Ras-related protein Rab-27A	0	0	9	9
Interleukin-1 receptor-associated kinase 1	0	0	11	11
Ribosomal protein S6 kinase alpha-3	0	2	11	13
Serine/threonine-protein kinase Nek2	0	0	11	11
Serine/threonine-protein kinase Nek3	0	0	11	11
Tyrosine-protein kinase JAK3	0	8	7	19
Dual specificity mitogen-activated protein kinase kinase 6	0	0	11	11
LIM domain kinase 1	0	1	11	12
LIM domain kinase 2	0	1	11	12
Mitogen-activated protein kinase 10	0	0	11	11
Tyrosine--tRNA ligase, cytoplasmic	0	0	11	11
5'-AMP-activated protein kinase subunit gamma-1	0	0	11	12
Ephrin type-B receptor 3	0	0	11	11
Ephrin type-A receptor 5	0	0	11	11
Ephrin type-B receptor 4	0	1	11	12
Ephrin type-A receptor 4	0	0	11	11
Adenylate kinase 2, mitochondrial	0	0	11	11
Ras-related protein Rab-10	0	0	11	11
Actin-related protein 3	0	0	11	11
Actin-related protein 2	0	0	10	10
GTP-binding nuclear protein Ran	0	0	11	11
Casein kinase I isoform gamma-2	0	0	11	11
Cyclin-dependent kinase 3	0	0	11	11
Cyclin-dependent kinase 6	0	2	11	13
Cyclin-dependent-like kinase 5	0	2	11	13
Cyclin-dependent kinase 16	0	0	11	11
Cyclin-dependent kinase 17	0	0	11	11
ATP-dependent 6-phosphofructokinase, platelet type	0	0	11	11
Dual specificity mitogen-activated protein kinase kinase 1	0	4	11	15
DNA topoisomerase 2-beta	0	1	12	20
Protein kinase C theta type	0	1	11	12
Activin receptor type-1	0	0	11	11
Macrophage-stimulating protein receptor	0	0	11	11
Focal adhesion kinase 1	0	1	11	12
Protein kinase C delta type	0	2	11	13
Tyrosine-protein kinase BTK	0	6	12	18
Activated CDC42 kinase 1	0	1	11	12
Epithelial discoidin domain-containing receptor 1	0	5	11	16
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	11	11
Serine/threonine-protein kinase 4	0	0	11	11
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	11	12
Dual specificity mitogen-activated protein kinase kinase 5	0	0	11	11
Mitogen-activated protein kinase 7	0	0	11	11
Serine/threonine-protein kinase PAK 2	0	0	10	10
Serine/threonine-protein kinase 3	0	0	11	11
Mitogen-activated protein kinase kinase kinase 1	0	0	11	11
Integrin-linked protein kinase	0	0	11	11
Rho-associated protein kinase 1	0	0	11	11
Non-receptor tyrosine-protein kinase TNK1	0	0	11	11
Serine/threonine-protein kinase ATR	0	0	3	3
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	11	11
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	11	11
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	11	11
Activin receptor type-2B	0	0	11	11
Bone morphogenetic protein receptor type-2	0	0	11	11
Protein-tyrosine kinase 6	0	2	11	13
cGMP-dependent protein kinase 1	0	0	11	11
Cyclin-dependent kinase 13	0	0	11	11
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	11	11
Protein-tyrosine kinase 2-beta	0	0	11	11
Maternal embryonic leucine zipper kinase	0	0	11	11
Structural maintenance of chromosomes protein 1A	0	0	9	9
Chromodomain-helicase-DNA-binding protein 4	0	0	9	9
Peroxisomal acyl-coenzyme A oxidase 1	0	0	6	6
Ephrin type-A receptor 7	0	0	10	10
Delta(24)-sterol reductase	0	0	10	10
Ribosomal protein S6 kinase alpha-1	0	2	11	13
Dual specificity testis-specific protein kinase 1	0	0	9	9
Myosin light chain kinase, smooth muscle	0	0	11	11
Mitogen-activated protein kinase 11	0	2	11	13
Serine/threonine-protein kinase STK11	0	0	11	11
Serine/threonine-protein kinase N1	0	0	11	11
Serine/threonine-protein kinase N2	0	0	11	11
Mitogen-activated protein kinase 14	0	5	13	18
Calcium/calmodulin-dependent protein kinase type IV	0	0	11	11
Mitogen-activated protein kinase kinase kinase 11	0	0	11	11
MAP kinase-activated protein kinase 3	0	0	4	4
Discoidin domain-containing receptor 2	0	4	11	15
AP2-associated protein kinase 1	0	3	11	14
Myosin light chain kinase 3	0	0	11	11
Uncharacterized aarF domain-containing protein kinase 5	0	0	7	7
Putative heat shock protein HSP 90-beta 2	0	0	11	11
Rab-like protein 3	0	0	9	9
Serine/threonine-protein kinase MRCK alpha	0	0	11	11
Serine/threonine-protein kinase MRCK gamma	0	0	11	11
Acyl-CoA dehydrogenase family member 10	0	0	10	10
Serine/threonine-protein kinase ULK3	0	0	11	11
Uncharacterized protein FLJ45252	0	0	11	11
Acyl-CoA dehydrogenase family member 11	0	0	9	9
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	11	11
Serine/threonine-protein kinase MARK2	0	0	11	11
ATP-dependent RNA helicase DHX30	0	0	6	6
Serine/threonine-protein kinase TAO1	0	0	11	11
STE20-related kinase adapter protein alpha	0	0	11	11
Myosin-14	0	0	11	11
AarF domain-containing protein kinase 1	0	0	11	11
ATP-dependent RNA helicase DDX42	0	0	7	7
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	11	11
MAP kinase-activated protein kinase 5	0	1	11	12
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	0	0	6	6
Misshapen-like kinase 1	0	0	10	10
Atypical kinase COQ8A, mitochondrial	0	0	11	11
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	11	11
Mitogen-activated protein kinase 15	0	0	11	11
Serine/threonine-protein kinase Nek9	0	0	11	11
ATP-dependent RNA helicase DDX1	0	0	11	11
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	11	11
Calcium/calmodulin-dependent protein kinase type 1G	0	0	7	7
Serine/threonine-protein kinase Nek1	0	0	11	11
PAS domain-containing serine/threonine-protein kinase	0	0	10	10
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	11	11
EKC/KEOPS complex subunit TP53RK	0	0	11	11
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	2	11	13
Mitogen-activated protein kinase kinase kinase 5	0	0	11	11
Mitogen-activated protein kinase kinase kinase 3	0	0	11	11
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	11	11
Nucleolar GTP-binding protein 1	0	0	10	10
Serine/threonine-protein kinase D2	0	0	11	11
NUAK family SNF1-like kinase 2	0	0	11	11
RNA cytidine acetyltransferase	0	0	11	11
Serine/threonine-protein kinase SIK2	0	1	11	12
STE20-like serine/threonine-protein kinase	0	0	11	11
Serine/threonine-protein kinase TAO3	0	0	11	11
dCTP pyrophosphatase 1	0	0	11	11
Dual specificity protein kinase CLK4	0	0	11	11
Casein kinase I isoform gamma-1	0	0	11	11
Serine/threonine-protein kinase PAK 6	0	0	10	10
Phenylalanine--tRNA ligase beta subunit	0	0	11	11
Isoleucine--tRNA ligase, mitochondrial	0	0	7	7
BMP-2-inducible protein kinase	0	0	11	11
Obg-like ATPase 1	0	0	8	8
Midasin	0	0	11	11
Interleukin-1 receptor-associated kinase 4	0	0	11	11
Mitogen-activated protein kinase kinase kinase 20	0	1	11	12
Cyclin-dependent kinase 12	0	0	11	11
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	11	11
Serine/threonine-protein kinase 26	0	0	11	11
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	10	10
Serine/threonine-protein kinase NLK	0	0	11	11
5'-AMP-activated protein kinase subunit gamma-2	0	0	11	12
Serine/threonine-protein kinase TBK1	0	1	11	12
Septin-9	0	0	11	11
Ribosomal protein S6 kinase alpha-6	0	0	11	11
TRAF2 and NCK-interacting protein kinase	0	0	11	11
Serine/threonine-protein kinase TAO2	0	0	11	11
Long-chain-fatty-acid--CoA ligase 5	0	0	5	5
Serine/threonine-protein kinase ICK	0	0	11	11
RAC-gamma serine/threonine-protein kinase	0	1	11	12
Serine/threonine-protein kinase 38-like	0	0	8	8
Serine/threonine-protein kinase SIK3	0	1	11	12
Mitogen-activated protein kinase kinase kinase 2	0	0	11	11
Thyroid hormone receptor-associated protein 3	0	0	9	9
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	11	11
Receptor-interacting serine/threonine-protein kinase 3	0	1	11	12
Serine/threonine-protein kinase MRCK beta	0	0	11	11
Interleukin-1 receptor-associated kinase 3	0	0	11	11
Serine/threonine-protein kinase 24	0	0	10	10
Casein kinase I isoform gamma-3	0	0	11	11
Mitogen-activated protein kinase kinase kinase 4	0	0	11	11
nuclear receptor subfamily 1, group I, member 2	11	0	0	11
galanin receptor type 3	0	1	0	1
Glucocorticoid receptor	0	15	2	22
Glycine receptor subunit alpha-1	0	14	0	14
Glycine receptor subunit beta	0	14	0	14
Glycine receptor subunit alpha-2	0	14	0	14
Glycine receptor subunit alpha-3	0	14	0	14
ORF73	0	0	1	1
Chain H, Proteasome component PUP1	0	1	0	1
Chain I, Proteasome component PUP3	0	1	0	1
Chain K, Proteasome component PRE2	0	1	0	1
Chain L, Proteasome component C5	0	1	0	1
Chain K, Proteasome component PRE2	0	1	0	1
Chain L, Proteasome component C5	0	1	0	1
Proteasome subunit beta type-11	0	2	0	2
caspase 7, apoptosis-related cysteine protease	13	0	0	13
caspase-3	13	0	0	13
Caspase-7	10	0	0	10
caspase-3	10	0	0	10
26S proteasome non-ATPase regulatory subunit 11	0	1	0	1
26S proteasome non-ATPase regulatory subunit 12	0	1	0	1
26S proteasome non-ATPase regulatory subunit 14	0	1	0	1
Proteasome subunit alpha type-7	0	2	0	2
Histone deacetylase 3	0	7	1	11
26S proteasome non-ATPase regulatory subunit 3	0	1	0	1
Prothrombin	0	3	0	4
Chymotrypsinogen A	0	3	0	3
Cathepsin B	0	1	0	1
Neutrophil elastase	0	2	0	2
Cathepsin G	0	2	0	2
Lysosomal protective protein	0	1	0	1
Chymotrypsinogen B	0	1	0	1
26S proteasome regulatory subunit 6A	0	1	0	1
Nuclear factor NF-kappa-B p105 subunit	0	1	0	1
Proteasome subunit beta type-1	0	2	0	3
Chymase	0	1	0	1
Proteasome subunit alpha type-1	0	2	0	2
Proteasome subunit alpha type-2	0	2	0	2
Proteasome subunit alpha type-3	0	2	0	2
Proteasome subunit alpha type-4	0	2	0	2
Proteasome subunit beta type-8	0	2	0	2
Proteasome subunit beta type-8	0	1	0	1
Proteasome subunit beta type-9	0	2	0	2
Proteasome subunit alpha type-5	0	2	0	2
Proteasome subunit beta type-4	0	2	0	2
Proteasome subunit beta type-6	0	2	0	2
Proteasome subunit beta type-5	0	4	0	5
26S proteasome regulatory subunit 7	0	1	0	1
Lon protease homolog, mitochondrial	0	1	0	1
Proteasome subunit beta type-10	0	2	0	2
26S proteasome non-ATPase regulatory subunit 8	0	1	0	1
Proteasome subunit beta type-3	0	2	0	2
Proteasome subunit beta type-2	0	2	0	3
26S proteasome non-ATPase regulatory subunit 7	0	1	0	1
26S proteasome non-ATPase regulatory subunit 4	0	1	0	1
26S proteasome complex subunit SEM1	0	1	0	1
Proteasome subunit alpha type-6	0	2	0	2
26S proteasome regulatory subunit 4	0	1	0	1
26S proteasome regulatory subunit 8	0	1	0	1
26S proteasome regulatory subunit 10B	0	1	0	1
Beta-carbonic anhydrase 1	0	2	0	2
Nuclear factor NF-kappa-B p100 subunit	0	1	0	1
Transcription factor p65	0	1	0	1
26S proteasome non-ATPase regulatory subunit 2	0	1	0	1
Histone deacetylase 1	0	8	2	13
26S proteasome non-ATPase regulatory subunit 6	0	1	0	1
Proteasomal ubiquitin receptor ADRM1	0	1	0	1
ATP-dependent Clp protease proteolytic subunit	0	2	2	4
Carbonic anhydrase 13	0	2	0	2
NACHT, LRR and PYD domains-containing protein 3	0	2	0	2
Proteasome subunit alpha-type 8	0	2	0	2
Histone deacetylase 2	0	7	2	12
Proteasome subunit beta type-7	0	2	0	2
26S proteasome non-ATPase regulatory subunit 1	0	1	0	1
Histone deacetylase 8	0	7	2	12
Histone deacetylase 6	0	8	2	13
26S proteasome non-ATPase regulatory subunit 13	0	1	0	1
Acetylcholine receptor subunit alpha	0	1	0	1
Acetylcholine receptor subunit gamma	0	1	0	1
Integrin alpha-5	0	1	0	1
Acetylcholine receptor subunit beta	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	2	0	6
Neuronal acetylcholine receptor subunit beta-2	0	1	0	2
Cytochrome P450 2B6	0	9	1	13
UDP-glucuronosyltransferase 1A4	0	2	0	5
Sodium-dependent dopamine transporter	0	7	0	7
Neuronal acetylcholine receptor subunit beta-4	0	1	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
UDP-glucuronosyltransferase 2B10	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	2
Sodium-dependent dopamine transporter	0	16	0	16
Acetylcholine receptor subunit delta	0	1	0	1
15-lipoxygenase, partial	6	0	0	6
Matrix metalloproteinase-9	0	2	0	2
Beta-lactamase	0	2	0	4
Beta-lactamase	0	3	0	4
Metallo-beta-lactamase VIM-19	0	0	0	3
Beta-lactamase	0	2	0	4
Beta-lactamase	0	0	0	1
Beta-lactamase	0	2	0	4
Metallo-beta-lactamase VIM-2	0	0	0	3
Solute carrier family 22 member 7	0	1	0	3
BlaVIM-1	0	0	0	3
Beta-lactamase	0	0	0	1
Beta-lactamase	0	2	0	4
Solute carrier family 22 member 11	0	1	0	2
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 22 member 7	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
thyrotropin-releasing hormone receptor	4	0	0	4
interferon gamma precursor	0	0	0	3
prostaglandin E2 receptor EP2 subtype	0	0	0	1
Prostaglandin E synthase	0	2	0	2
3-phosphoinositide-dependent protein kinase 1	0	1	5	6
cGMP-specific 3',5'-cyclic phosphodiesterase	0	2	0	2
Cytochrome c oxidase subunit 1	0	1	0	1
Cytochrome c oxidase subunit 2	0	1	0	1
Catechol O-methyltransferase	0	1	0	1
Cytochrome c oxidase subunit 2	0	3	0	3
Procathepsin L	0	3	5	8
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	3
Quinolone resistance protein NorA	0	2	0	2
Beta-3 adrenergic receptor	0	6	0	6
Calpain-2 catalytic subunit	0	1	0	1
Prostaglandin G/H synthase 1	0	3	0	3
Cruzipain	0	3	0	3
Sodium/hydrogen exchanger 1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	3	0	3
Sodium-dependent serotonin transporter	0	6	1	8
Delta-type opioid receptor	0	2	0	2
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	2	0	2
Bifunctional epoxide hydrolase 2	0	2	0	2
Prostaglandin G/H synthase 2	0	6	0	8
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Histone deacetylase 4	0	5	1	9
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	3	0	3
Carbonic anhydrase 2	0	1	0	1
Prostaglandin G/H synthase 2	0	4	0	5
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Sigma intracellular receptor 2	0	5	0	5
Delta carbonic anhydrase	0	1	0	1
Prostaglandin G/H synthase 1	0	6	0	8
Carbonic anhydrase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Cyclooxygenase-2	0	2	0	2
Histone deacetylase 7	0	5	2	10
Carbonic anhydrase 4	0	3	0	3
Polyamine deacetylase HDAC10	0	4	1	8
Histone deacetylase 11	0	5	1	9
P2Y purinoceptor 12	0	3	0	3
Histone deacetylase 9	0	4	1	8
Histone deacetylase 5	0	5	1	9
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
Spike glycoprotein	0	1	5	6
Replicase polyprotein 1ab	0	3	6	9
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
Transmembrane protease serine 2	0	1	5	6
Dihydrofolate reductase	0	3	0	3
DNA ligase	0	1	0	1
Riboflavin-binding protein	0	0	1	1
Major prion protein	0	0	1	1
Amyloid-beta precursor protein	3	4	0	7
Histidine-rich protein PFHRP-II	0	1	0	2
Replicase polyprotein 1a	0	1	5	6
Replicase polyprotein 1ab	0	1	5	6
Spike glycoprotein	0	1	1	2
DNA ligase 1	0	1	0	1
Serine/threonine-protein kinase mTOR	0	3	5	8
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Beta-secretase 1	0	1	0	1
Calcium-dependent protein kinase 1	0	0	1	1
MO15-related protein kinase Pfmrk	0	1	0	1
DNA ligase A	0	1	0	1
Sigma intracellular receptor 2	0	2	0	2
Phosphoethanolamine N-methyltransferase	0	1	0	1
Angiotensin-converting enzyme 2	0	1	5	6
Cysteine proteinase falcipain 2a	0	1	0	1
Cysteine proteinase falcipain 2a	0	1	0	1
Nrf2	2	0	0	2
LAP4	0	0	1	1
RPL19A	0	0	1	1
Vpr	5	0	0	5
DNA dC->dU-editing enzyme APOBEC-3F isoform a	3	0	0	3
Glycoprotein hormones alpha chain	2	0	0	2
Botulinum neurotoxin type A	0	1	0	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	2
DNA gyrase subunit A	0	4	0	7
DNA gyrase subunit B	0	4	0	7
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	2	0	3
DNA gyrase subunit A	0	1	0	2
Multidrug resistance protein MdtK	0	0	2	2
DNA gyrase subunit B	0	4	0	5
DNA gyrase subunit A	0	5	0	6
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	2	0	5
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
Integrase	0	4	0	4
NPC intracellular cholesterol transporter 1 precursor	6	0	0	6
Sodium-dependent noradrenaline transporter	0	1	0	1
Tryptophan 5-hydroxylase 1	0	2	0	2
Angiotensin-converting enzyme	0	10	0	10
Aldo-keto reductase family 1 member B1	0	3	0	3
Acetylcholinesterase	0	4	0	4
Aromatase	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Sodium-dependent dopamine transporter	0	3	0	3
Nuclear receptor subfamily 3 group C member 3	0	10	0	10
Transporter	0	6	0	6
streptokinase A precursor	0	0	6	6
Solute carrier organic anion transporter family member 1B3	0	13	0	16
Solute carrier organic anion transporter family member 1B1	0	10	0	13
Beta-lactamase	0	2	0	2
Beta-lactamase	0	2	0	2
Beta-lactamase	0	4	0	4
Beta-lactamase	0	3	0	5
Beta-lactamase OXA-1	0	2	0	3
Beta-lactamase TEM	0	4	0	6
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	2	0	2
nonstructural protein 1	13	0	0	13
Guanine nucleotide-binding protein G	6	0	0	6
mitogen-activated protein kinase kinase kinase kinase 2 isoform 1	0	0	1	1
mitogen-activated protein kinase kinase kinase 3 isoform 1	0	0	1	1
Estrogen receptor	0	0	3	4
C-terminal-binding protein 1	1	0	0	1
Estrogen receptor beta	0	0	3	4
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	7	0	0	7
Cytochrome P450 2C8	0	7	0	9
Liver carboxylesterase 1	0	0	0	2
P2Y purinoceptor 12	0	4	0	4
Beta-1 adrenergic receptor	0	1	0	1
bromodomain adjacent to zinc finger domain 2B	10	0	0	10
Adenylate cyclase type 1	0	1	0	1
cytochrome P450 2C19 precursor	6	0	0	6
short transient receptor potential channel 6 isoform 1	0	0	1	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	10	0	10
Albumin	0	0	3	3
Muscarinic acetylcholine receptor M1	0	4	0	4
Muscarinic acetylcholine receptor M3	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Calmodulin-1	0	1	0	1
Beta-2 adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M2	0	2	0	2
Beta-1 adrenergic receptor	0	1	0	1
D(3) dopamine receptor	0	2	0	2
Alpha-2B adrenergic receptor	0	4	1	5
D(2) dopamine receptor	0	2	0	2
Endothelin receptor type B	0	1	0	1
Adenylate cyclase type 3	0	1	0	1
Alpha-2C adrenergic receptor	0	4	1	5
Alpha-2A adrenergic receptor	0	4	1	5
5-hydroxytryptamine receptor 3A	0	1	0	1
Endothelin receptor type B	0	1	0	1
Histamine H2 receptor	0	6	0	6
D(1B) dopamine receptor	0	2	0	2
Beta-3 adrenergic receptor	0	1	0	1
Adenylate cyclase type 2	0	1	0	1
Adenylate cyclase type 4	0	1	0	1
5-hydroxytryptamine receptor 1B	0	5	0	5
5-hydroxytryptamine receptor 1D	0	3	0	3
5-hydroxytryptamine receptor 1F	0	3	0	3
5-hydroxytryptamine receptor 2B	0	4	1	5
Histamine H1 receptor	0	2	0	2
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
5-hydroxytryptamine receptor 3A	0	2	0	2
Adenylate cyclase type 8	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	0	1
D(2) dopamine receptor	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Calmodulin	0	0	1	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	10	0	10
5-hydroxytryptamine receptor 2B	0	1	0	1
Adenylate cyclase type 6	0	1	0	1
Adenylate cyclase type 5	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	10	0	10
Voltage-dependent L-type calcium channel subunit alpha-1C	0	10	0	10
Transporter	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
5-hydroxytryptamine receptor 1A	0	2	0	2
Adenylyl cyclase 7	0	1	0	1
D	0	2	0	2
5-hydroxytryptamine receptor 3B	0	2	0	2
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	5	0	5
Gamma-aminobutyric acid receptor subunit delta	0	5	0	5
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	5	2	7
Gamma-aminobutyric acid receptor subunit beta-1	0	5	0	5
Gamma-aminobutyric acid receptor subunit gamma-2	0	5	1	6
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-3	0	5	1	6
5-hydroxytryptamine receptor 6	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	5	2	7
Gamma-aminobutyric acid receptor subunit alpha-3	0	5	1	6
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	3	1	5
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	5	1	6
Gamma-aminobutyric acid receptor subunit beta-2	0	5	1	6
Gamma-aminobutyric acid receptor subunit alpha-4	0	5	0	5
Gamma-aminobutyric acid receptor subunit epsilon	0	5	0	5
Glutamate receptor ionotropic, NMDA 2A	0	3	1	5
Glutamate receptor ionotropic, NMDA 2B	0	5	1	7
Glutamate receptor ionotropic, NMDA 2C	0	3	1	5
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	3	0	3
Leukotriene B4 receptor 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	5	0	5
Glutamate receptor ionotropic, NMDA 2D	0	3	1	5
5-hydroxytryptamine receptor 4	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	5	0	5
Glutamate receptor ionotropic, NMDA 3B	0	3	1	5
Gamma-aminobutyric acid receptor subunit gamma-3	0	5	0	5
Leukotriene B4 receptor 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	3	1	5
Gamma-aminobutyric acid receptor subunit theta	0	5	0	5
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	8	1	9
Delta-type opioid receptor	0	9	0	9
Kappa-type opioid receptor	0	8	0	8
Mu-type opioid receptor	0	1	0	1
Cytochrome P450 2D4	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
PAX8	0	0	0	2
nuclear receptor subfamily 0 group B member 1	0	2	0	2
steroidogenic factor 1	0	2	0	2
caspase-1 isoform alpha precursor	3	0	0	3
Solute carrier family 22 member 3	0	5	0	5
Tubulin alpha-1A chain	0	3	1	4
Tubulin beta chain	0	3	1	4
Plasma kallikrein	0	0	0	1
Tubulin beta-4A chain	0	3	2	6
ATP-dependent translocase ABCB1	0	5	0	5
Tubulin beta chain	0	3	2	6
Tubulin alpha-3C chain	0	3	2	6
ATP-dependent translocase ABCB1	0	6	0	6
Tubulin alpha-1B chain	0	3	2	6
Tubulin alpha-4A chain	0	3	2	6
Tubulin beta-4B chain	0	3	2	6
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	3	2	6
Tubulin beta-2A chain	0	3	2	6
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	3	2	6
Tubulin beta-2B chain	0	3	0	3
Tubulin alpha-3E chain	0	3	2	6
Tubulin alpha-1A chain	0	3	2	6
Similar to alpha-tubulin isoform 1	0	2	0	2
Similar to alpha-tubulin isoform 1	0	2	0	2
CREB-binding protein	1	0	0	1
Tubulin alpha-1C chain	0	3	2	6
Tubulin beta-6 chain	0	3	2	6
Tubulin beta-2B chain	0	3	2	6
Tubulin beta-1 chain	0	3	2	6
GALC protein	2	0	0	2
Solute carrier family 22 member 3	0	1	0	1
Sex hormone-binding globulin	0	0	2	2
Corticosteroid-binding globulin	0	2	0	2
Mineralocorticoid receptor	0	2	2	4
Androgen receptor	0	15	0	15
C-8 sterol isomerase	0	2	0	2
Solute carrier organic anion transporter family member 1A1	0	3	0	3
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	3	1	4
Solute carrier family 22 member 1	0	3	0	3
Solute carrier family 22 member 2	0	2	0	2
LMP1 [Human herpesvirus 4]	0	0	0	3
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	3	0	3
transactivating tegument protein VP16 [Human herpesvirus 1]	0	3	0	3
nuclear receptor coactivator 3 isoform a	0	3	0	3
Thymidine kinase 2, mitochondrial	0	1	0	1
Thymidine kinase	0	1	0	1
Thymidylate synthase	0	4	0	5
Thymidine kinase	0	1	0	1
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	1	0	2
E3 ubiquitin-protein ligase Mdm2	0	2	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Deoxynucleoside kinase	0	1	0	1
Coagulation factor X	0	1	0	1
Plasminogen	0	1	0	1
Coagulation factor XII	0	1	0	1
Tissue-type plasminogen activator	0	1	0	1
Vitamin K-dependent protein C	0	1	0	1
Serine protease hepsin	0	1	0	1
Trypsin-1	0	1	0	1
Trypsin-2	0	1	0	1
Trypsin-3	0	1	0	1
Cell division cycle 7-related protein kinase	0	0	6	6
Pirin	0	2	0	2
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	9	9
Nuclear receptor subfamily 1 group I member 2	0	0	8	8
Cyclin-dependent kinase-like 5	0	0	8	8
GTPase KRas	0	2	0	2
RAF proto-oncogene serine/threonine-protein kinase	0	4	6	12
High affinity nerve growth factor receptor	0	0	10	10
Tyrosine-protein kinase Fgr	0	1	8	9
Dual specificity protein kinase TTK	0	0	8	8
Dual specificity mitogen-activated protein kinase kinase 4	0	0	9	9
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	7	7
Choline-phosphate cytidylyltransferase A	0	0	5	5
Serine/threonine-protein kinase PLK1	0	0	9	9
Heat shock factor protein 1	0	2	0	2
Protein kinase C zeta type	0	2	4	6
Tyrosine-protein kinase Mer	0	0	9	9
Receptor-interacting serine/threonine-protein kinase 1	0	1	5	6
Cyclin-dependent kinase 10	0	0	3	3
Serine/threonine-protein kinase N3	0	0	7	7
Dual serine/threonine and tyrosine protein kinase	0	1	5	6
MAP/microtubule affinity-regulating kinase 4	0	0	10	10
Dual specificity testis-specific protein kinase 2	0	0	7	7
Serine/threonine-protein kinase pim-2	0	0	9	9
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	10	10
Cholinesterase	0	2	1	3
Sodium/glucose cotransporter 1	0	1	1	2
Sodium/glucose cotransporter 2	0	1	1	2
Sodium/glucose cotransporter 2	0	0	1	1
Sodium/myo-inositol cotransporter 2	0	1	0	1
Solute carrier family 5 member 4	0	1	0	1
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase	0	1	0	1
Dihydrofolate reductase	0	4	0	4
Leukotriene C4 synthase	0	0	5	5
tyrosine-protein kinase Yes	9	0	0	9
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0	2	5	7
Serine/threonine-protein kinase 25	0	0	5	5
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	0	0	5	5
Serine/threonine-protein kinase RIO3	0	0	5	5
Dual specificity mitogen-activated protein kinase kinase 7	0	1	5	6
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	1	5	7
Peripheral plasma membrane protein CASK	0	0	5	5
Serine/threonine-protein kinase DCLK1	0	0	5	5
Inhibitor of nuclear factor kappa-B kinase subunit alpha	0	1	5	6
Muscle, skeletal receptor tyrosine-protein kinase	0	0	5	5
Mitogen-activated protein kinase 13	0	2	5	7
Mitogen-activated protein kinase kinase kinase 13	0	0	5	5
Death-associated protein kinase 3	0	0	5	5
NUAK family SNF1-like kinase 1	0	1	5	6
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	0	0	5	5
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	0	0	5	5
Serine/threonine-protein kinase PAK 3	0	0	5	5
Serine/threonine-protein kinase 17B	0	0	5	5
Cyclin-dependent kinase 14	0	0	5	5
Serine/threonine-protein kinase OSR1	0	0	5	5
Serine/threonine-protein kinase Chk2	0	0	5	5
Tyrosine-protein kinase ABL1	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	2	3
Neuronal proto-oncogene tyrosine-protein kinase Src	0	0	0	1
Proto-oncogene tyrosine-protein kinase LCK	0	2	0	2
Macrophage colony-stimulating factor 1 receptor	0	6	5	11
Proto-oncogene tyrosine-protein kinase ROS	0	1	5	6
Wee1-like protein kinase 2	0	0	5	5
Uncharacterized serine/threonine-protein kinase SBK3	0	0	5	5
Mast/stem cell growth factor receptor Kit	0	4	6	10
Cytochrome P450 2A6	0	3	0	3
Myosin light chain kinase, smooth muscle	0	0	3	3
Angiotensin-converting enzyme	0	1	0	1
Insulin receptor-related protein	0	0	5	5
Potassium voltage-gated channel subfamily E member 1	0	3	0	3
Platelet-derived growth factor receptor alpha	0	4	6	10
Tyrosine-protein kinase Blk	0	1	0	1
Vascular endothelial growth factor receptor 1	0	0	5	5
Interferon-induced, double-stranded RNA-activated protein kinase	0	0	5	5
Serine/threonine-protein kinase MAK	0	0	5	5
Cyclin-dependent kinase 11B	0	0	5	5
Receptor tyrosine-protein kinase erbB-3	0	1	5	6
Protein kinase C eta type	0	1	5	6
Activin receptor type-2A	0	0	5	5
Ephrin type-A receptor 3	0	0	5	5
Ephrin type-A receptor 8	0	0	5	5
Leukocyte tyrosine kinase receptor	0	0	5	5
Tyrosine-protein kinase receptor UFO	0	0	5	5
Mitogen-activated protein kinase 4	0	0	5	5
G protein-coupled receptor kinase 4	0	0	5	5
Tyrosine-protein kinase receptor Tie-1	0	0	5	5
Vascular endothelial growth factor receptor 3	0	0	5	5
Vascular endothelial growth factor receptor 2	0	4	5	9
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	3	5	8
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	1	5	6
Megakaryocyte-associated tyrosine-protein kinase	0	0	5	5
Tyrosine-protein kinase TXK	0	3	6	9
Tyrosine-protein kinase ZAP-70	0	0	5	5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	5	6
Cyclin-dependent kinase 8	0	0	5	5
Tyrosine-protein kinase Blk	0	4	6	10
Potassium voltage-gated channel subfamily KQT member 1	0	3	0	3
Cytoplasmic tyrosine-protein kinase BMX	0	3	6	9
cAMP-dependent protein kinase catalytic subunit PRKX	0	0	6	6
Serine/threonine-protein kinase Nek4	0	0	5	5
Death-associated protein kinase 1	0	0	5	5
Mitogen-activated protein kinase 12	0	2	5	7
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	5	6
Ephrin type-B receptor 1	0	0	5	5
Hormonally up-regulated neu tumor-associated kinase	0	0	5	5
Serine/threonine-protein kinase SIK1	0	2	5	7
Receptor-interacting serine/threonine-protein kinase 4	0	0	5	5
Cell division control protein 2 homolog	0	0	5	5
Calcium-dependent protein kinase 1	0	0	5	5
Tubulin alpha-1A chain	0	0	3	3
Casein kinase II subunit alpha	0	1	5	6
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	0	0	5	5
SRSF protein kinase 2	0	0	5	5
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Mitogen-activated protein kinase kinase kinase 9	0	0	5	5
Serine/threonine-protein kinase PknB	0	0	5	5
Cyclin-dependent kinase-like 1	0	0	5	5
Myelin transcription factor 1	0	1	0	1
Protein kinase C epsilon type	0	1	5	6
Mitogen-activated protein kinase kinase kinase 10	0	0	5	5
Tyrosine-protein kinase receptor TYRO3	0	0	5	5
Cyclin-dependent kinase 18	0	0	7	7
Tyrosine-protein kinase ITK/TSK	0	3	6	9
Myotonin-protein kinase	0	0	5	5
Mitogen-activated protein kinase kinase kinase 12	0	0	5	5
Serine/threonine-protein kinase PAK 1	0	0	5	5
cGMP-dependent protein kinase 2	0	0	5	5
Serine/threonine-protein kinase PRP4 homolog	0	0	5	5
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	0	5	5
Calcium/calmodulin-dependent protein kinase type 1	0	0	5	5
Sodium channel protein type 5 subunit alpha	0	4	0	4
Serine/threonine-protein kinase D1	0	1	5	6
Serine/threonine-protein kinase 38	0	0	7	7
Receptor tyrosine-protein kinase erbB-4	0	2	6	8
Ribosomal protein S6 kinase alpha-2	0	0	5	5
Rhodopsin kinase GRK1	0	0	5	5
NT-3 growth factor receptor	0	0	5	5
BDNF/NT-3 growth factors receptor	0	0	5	5
Mitogen-activated protein kinase 6	0	0	5	5
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	0	0	5	5
Serine/threonine-protein kinase SBK1	0	0	5	5
Mitogen-activated protein kinase kinase kinase 19	0	0	5	5
Serine/threonine-protein kinase TNNI3K	0	0	5	5
Serine/threonine-protein kinase Nek5	0	0	5	5
Breakpoint cluster region protein	0	1	0	1
Mitogen-activated protein kinase kinase kinase 15	0	0	5	5
Serine/threonine-protein kinase tousled-like 2	0	0	5	5
Serine/threonine-protein kinase 32C	0	0	5	5
Serine/threonine-protein kinase pim-3	0	0	5	5
Serine/threonine-protein kinase VRK2	0	0	5	5
Myosin light chain kinase family member 4	0	0	5	5
Homeodomain-interacting protein kinase 1	0	0	5	5
Calcium/calmodulin-dependent protein kinase type 1D	0	0	5	5
Cyclin-dependent kinase-like 3	0	0	5	5
Serine/threonine-protein kinase BRSK2	0	0	5	5
Serine/threonine-protein kinase NIM1	0	0	5	5
Serine/threonine-protein kinase ULK2	0	0	5	5
Serine/threonine-protein kinase DCLK2	0	0	5	5
Calcium/calmodulin-dependent protein kinase kinase 1	0	0	5	5
Casein kinase I isoform alpha-like	0	0	5	5
Homeodomain-interacting protein kinase 4	0	0	5	5
Myosin-IIIa	0	0	5	5
Ankyrin repeat and protein kinase domain-containing protein 1	0	0	5	5
Serine/threonine-protein kinase Nek11	0	0	5	5
Serine/threonine-protein kinase BRSK1	0	0	5	5
Serine/threonine-protein kinase 35	0	0	5	5
Serine/threonine-protein kinase Nek7	0	0	7	7
Rhodopsin kinase GRK7	0	0	5	5
Serine/threonine-protein kinase 32A	0	0	5	5
Myosin-IIIb	0	0	5	5
Dual specificity tyrosine-phosphorylation-regulated kinase 2	0	0	5	5
Cyclin-dependent kinase-like 2	0	0	5	5
Serine/threonine-protein kinase Sgk3	0	0	5	5
Atypical kinase COQ8B, mitochondrial	0	0	5	5
Cyclin-dependent kinase 15	0	0	5	5
SRSF protein kinase 1	0	0	5	5
Protein cereblon	0	4	3	11
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	0	0	5	5
Serine/threonine-protein kinase RIO1	0	0	5	5
MAP kinase-interacting serine/threonine-protein kinase 1	0	0	5	5
Serine/threonine-protein kinase RIO2	0	0	5	5
Cyclin-dependent kinase 19	0	0	5	5
Transient receptor potential cation channel subfamily M member 6	0	0	5	5
Testis-specific serine/threonine-protein kinase 1	0	0	5	5
Serine/threonine-protein kinase 33	0	0	5	5
Serine/threonine-protein kinase DCLK3	0	0	5	5
Myosin light chain kinase 2, skeletal/cardiac muscle	0	0	5	5
Homeodomain-interacting protein kinase 2	0	0	5	5
Tyrosine-protein kinase Srms	0	0	5	5
Homeodomain-interacting protein kinase 3	0	0	5	5
Serine/threonine-protein kinase PLK3	0	0	5	5
MAP kinase-interacting serine/threonine-protein kinase 2	0	0	5	5
Serine/threonine-protein kinase Nek6	0	0	5	5
SNF-related serine/threonine-protein kinase	0	0	5	5
Serine/threonine-protein kinase LATS2	0	0	5	5
Serine/threonine-protein kinase 36	0	0	5	5
Serine/threonine-protein kinase 32B	0	0	5	5
Serine/threonine-protein kinase PLK2	0	0	5	5
Serine/threonine-protein kinase MARK1	0	0	5	5
Serine/threonine-protein kinase PAK 5	0	0	5	5
eIF-2-alpha kinase GCN2	0	0	5	5
Serine/threonine-protein kinase 17A	0	0	5	5
STE20/SPS1-related proline-alanine-rich protein kinase	0	0	5	5
Ephrin type-A receptor 6	0	0	5	5
Death-associated protein kinase 2	0	0	5	5
Potassium voltage-gated channel subfamily D member 3	0	3	0	3
Serine/threonine-protein kinase tousled-like 1	0	0	5	5
ALK tyrosine kinase receptor	0	0	5	5
SRSF protein kinase 3	0	0	5	5
Cyclin-dependent kinase 11A	0	0	5	5
Aurora kinase C	0	0	5	5
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	0	5	5
Microtubule-associated serine/threonine-protein kinase 1	0	0	5	5
NF-kappa-B essential modulator	0	1	0	1
Chain A, Breast cancer type 1 susceptibility protein	2	0	0	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	8	0	0	8
runt-related transcription factor 1 isoform AML1b	1	0	0	1
core-binding factor subunit beta isoform 2	1	0	0	1
NADH-ubiquinone oxidoreductase chain 4	0	0	0	1
Carbonyl reductase [NADPH] 1	0	0	0	1
Glutamate receptor 1	2	1	0	3
Glutamate receptor 3	2	1	0	3
Glutamate receptor 4	2	1	0	3
Platelet-activating factor receptor	2	0	0	2
Multidrug resistance-associated protein 1	0	4	0	6
exodeoxyribonuclease V subunit RecD	0	1	0	1
exodeoxyribonuclease V subunit RecB	0	1	0	1
exodeoxyribonuclease V subunit RecC	0	1	0	1
Gamma-aminobutyric acid	0	2	0	2
Alpha-1-acid glycoprotein 1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Translocator protein	0	2	1	4
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
Translocator protein	0	1	0	1
Translocator protein	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	0	2
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Sphingosine-1-phosphate lyase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit theta	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
Aldo-keto reductase family 1 member B10	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Dihydrofolate reductase	0	7	0	8
Interleukin-8	0	2	0	2
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	0	1
Fatty acid-binding protein, intestinal	0	2	0	2
Aldo-keto reductase family 1 member B1	0	3	0	3
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
C-X-C chemokine receptor type 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
UDP-glucuronosyltransferase 1A3	0	0	0	2
Sodium- and chloride-dependent betaine transporter	0	2	0	2
UDP-glucuronosyltransferase 1A7	0	1	0	2
UDP-glucuronosyltransferase 1A10	0	1	0	2
Serine/threonine-protein kinase B-raf	0	2	0	2
Estrogen receptor	0	6	2	9
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Aldehyde oxidase	0	2	0	2
Nuclear receptor subfamily 1 group I member 3	0	1	0	1
Estrogen receptor beta	0	5	2	7
Regulatory protein E2	0	0	1	1
DNA topoisomerase 1	0	1	0	2
DNA topoisomerase 2	0	0	0	2
Serum paraoxonase/arylesterase 1	0	3	0	3
Caspase-3	0	3	0	3
DNA topoisomerase 2-alpha	0	0	0	1
Cathepsin B	0	1	0	1
procathepsin L isoform 1 preproprotein	0	1	0	1
fructose-bisphosphate aldolase	0	1	0	1
Alpha-synuclein	4	2	0	6
Bile acid receptor	0	2	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	4	4
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
unnamed protein product	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	2
bcl-2-like protein 11 isoform 1	0	0	1	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	3	0	3
Heme oxygenase 1	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	1	2
Aromatase	0	4	0	4
Cytochrome P450 11B1, mitochondrial	0	2	0	2
Cytochrome P450 11B2, mitochondrial	0	2	0	2
Heme oxygenase 2	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	2	0	2
Cytochrome P450 144	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Mycocyclosin synthase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Lanosterol 14-alpha demethylase	0	5	2	7
Sterol 14-alpha demethylase	0	0	1	1
Sterol 14-alpha demethylase	0	1	1	2
14-alpha sterol demethylase	0	0	1	1
heat shock protein 90, putative	0	0	0	2
likely tRNA 2'-phosphotransferase	0	1	0	1
corticotropin-releasing hormone receptor 2	0	1	1	2
corticotropin releasing factor-binding protein	0	1	1	2
5'-nucleotidase	0	1	0	1
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Skn7p	0	0	0	1
Solute carrier family 22 member 8	0	0	0	1
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	2	0	2
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Sodium/bile acid cotransporter	0	3	0	3
G-protein coupled receptor 35	0	3	2	5
CDGSH iron-sulfur domain-containing protein 1	0	4	0	4
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Asialoglycoprotein receptor 1	0	1	1	2
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	2	0	2
Proton-coupled amino acid transporter 1	0	1	0	1
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	1	1	2
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
pyruvate kinase	2	0	0	2
pyruvate kinase PKM isoform b	3	0	0	3
N-glycosylase/DNA lyase	0	2	0	2
Ornithine decarboxylase	3	0	0	4
Aspartate aminotransferase, cytoplasmic	0	1	0	1
Lactoperoxidase	0	1	0	1
Single-stranded DNA cytosine deaminase	3	0	0	3
Genome polyprotein	0	1	0	1
Cyclic GMP-AMP synthase	0	1	0	1
Toll-like receptor 9	0	1	0	1
Toll-like receptor 7	0	1	0	1
Stromelysin-1	0	1	2	3
Urease subunit alpha	0	1	0	1
Ribonucleoside-diphosphate reductase large subunit	0	1	0	1
Urease subunit beta	0	1	0	1
Acid-sensing ion channel 3	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	2	0	3
Albumin	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	4	0	8
Caspase-1	0	4	0	5
Aldo-keto reductase family 1 member C3	0	4	0	4
Caspase-4	0	2	0	2
Caspase-5	0	2	0	2
Caspase-9	0	2	0	2
Acid-sensing ion channel 1	0	1	0	1
Fatty-acid amide hydrolase 1	0	2	0	2
Dehydrogenase/reductase SDR family member 9	0	1	0	1
DNA polymerase III, partial	3	0	0	3
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	3
Cytochrome P450 3A5	0	2	0	3
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase IMP-1	0	0	0	1
Beta-lactamase	0	0	0	1
Oxysterols receptor LXR-beta	0	1	0	1
Tyrosine-protein kinase JAK2	0	0	1	1
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	2	0	2
Solute carrier organic anion transporter family member 2B1	0	6	0	7
Phospholipase A2, major isoenzyme	0	2	0	2
Androgen receptor	0	2	1	3
Aldo-keto reductase family 1 member C4	0	2	0	2
Thromboxane-A synthase	0	5	0	5
Nitric oxide synthase, inducible	0	1	0	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	4	4
C-X-C chemokine receptor type 3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	2	0	2
Prostaglandin D2 receptor	0	2	0	2
Solute carrier organic anion transporter family member 1A3	0	1	0	3
Lactoylglutathione lyase	0	1	0	1
Aldo-keto reductase family 1 member C1	0	2	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Cytosolic phospholipase A2 gamma	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
Formamidopyrimidine-DNA glycosylase	0	1	0	1
Macrophage migration inhibitory factor	0	1	0	1
Endonuclease III-like protein 1	0	1	0	1
Pantothenate synthetase	0	1	0	1
Isocitrate lyase	0	1	0	1
Putative FAD-containing monooxygenase MymA	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Endonuclease 8-like 1	0	1	0	1
Ornithine decarboxylase	0	0	0	2
Retinoic acid receptor alpha	0	2	2	4
Retinoic acid receptor gamma	0	2	2	4
Retinoic acid receptor beta	0	2	2	4
Cellular retinoic acid-binding protein 2	0	0	2	2
Retinoic acid receptor RXR-alpha	0	2	2	4
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-gamma	0	2	2	4
Cellular retinoic acid-binding protein 1	0	2	0	3
Cellular retinoic acid-binding protein 1	0	0	2	2
Estrogen receptor beta	0	1	0	2
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	0	1	0	1
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	0	2	0	2
Cytochrome P450 26A1	0	1	0	1
Camphor 5-monooxygenase	0	0	0	1
Epoxide hydrolase 1	0	0	0	1
Cytochrome P450 2C11	0	1	0	1
Steroid 21-hydroxylase	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Cholesterol side-chain cleavage enzyme, mitochondrial	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	3	0	3
Cytochrome P450 2A2	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	2	0	2
Cytochrome P450 7A1	0	1	0	1
Estrogen receptor	0	1	0	2
Substance-K receptor	0	6	0	6
Gonadotropin-releasing hormone receptor	0	1	1	2
Type-1 angiotensin II receptor	0	1	0	1
Cytochrome P450 4F2	0	1	0	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	2	0	2
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	1	0	1
Cytochrome P450 7A1	0	1	0	1
Lanosterol 14-alpha demethylase	0	2	0	2
Hsf1 protein	0	0	1	1
Capsid protein	0	1	1	2
Dihydroorotate dehydrogenase	0	1	0	1
Genome polyprotein	0	1	0	1
Protease	0	3	1	6
Histone-lysine N-methyltransferase SETD7	0	1	0	1
Cysteine protease	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 22	0	1	0	1
P2X purinoceptor 7	0	1	0	1
Cereblon isoform 4	0	3	0	3
Bromodomain-containing protein 4	0	2	0	2
DNA-binding protein Ikaros	0	0	1	4
DNA damage-binding protein 1	0	2	1	3
Zinc finger protein Aiolos	0	0	1	1
dopamine D1 receptor	5	0	0	5
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Alkaline phosphatase, placental type	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Intestinal-type alkaline phosphatase	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
Phospholipase A-2-activating protein	0	1	0	1
CAAX prenyl protease 2 isoform 2	0	0	0	1
DNA primase	0	1	0	1
Type-1A angiotensin II receptor	0	1	0	1
Type-1B angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	2	0	2
Type-1 angiotensin II receptor	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Tumor necrosis factor	0	2	1	3
Neuraminidase	0	1	0	1
60 kDa chaperonin	0	2	0	2
Cystathionine gamma-lyase	0	2	0	2
Caspase-7	3	0	0	3
Cystine/glutamate transporter	0	2	0	2
Hydroxyacid oxidase 1	0	1	0	1
large T antigen	0	1	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
ClpP	1	0	0	1
Thymidylate synthase	0	2	0	2
alpha-galactosidase	3	0	0	3
Thymidylate synthase	0	2	0	2
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	3	0	4
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	3	0	4
Thymidylate synthase	0	3	0	3
Thymidylate synthase	0	4	0	4
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	3	2	5
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	2	0	2
Folate receptor alpha	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	3	0	3
Bifunctional purine biosynthesis protein ATIC	0	5	0	5
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	3	0	3
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	3	0	4
Multidrug resistance associated protein	0	1	0	2
Thioredoxin reductase	0	1	0	1
Flavodoxin	0	0	0	1
Protein delta homolog 1	0	0	1	1
Aspartyl/asparaginyl beta-hydroxylase	0	2	0	2
Poly [ADP-ribose] polymerase tankyrase-2	0	0	1	1
Matrilysin	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Chain A, Probable serine/threonine-protein kinase pknB	0	1	0	1
WRN	1	0	0	1
nonstructural protein 1	0	1	0	1
LANA	0	0	0	1
phospholipase A2, group III	0	1	0	1
histone-lysine N-methyltransferase NSD2 isoform 1	0	0	0	1
protein AF-9 isoform a	0	0	0	2
dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	0	1
rac GTPase-activating protein 1 isoform a	0	1	0	1
Casein kinase II subunit beta	0	1	0	1
NEDD8-activating enzyme E1 regulatory subunit	0	0	1	1
Casein kinase II subunit alpha 3	0	1	0	1
NEDD8-activating enzyme E1 catalytic subunit	0	0	1	1
phosphoglycerate kinase	1	0	0	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Nuclear receptor corepressor 1	0	3	0	3
Integrin beta-1	0	1	0	1
Leukotriene A-4 hydrolase	0	2	0	2
Integrin alpha-4	0	1	0	1
Nuclear receptor corepressor 2	0	3	0	3
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
Progesterone receptor	0	3	1	5
Chain A, Inosine-5'-Monophosphate Dehydrogenase 2	0	1	0	1
Inosine-5'-monophosphate dehydrogenase	0	1	0	2
UDP-glucuronosyltransferase 1A8	0	0	0	1
Hormone-sensitive lipase	0	1	0	1
Chain A, ASPARTYLPROTEASE	0	1	0	1
Chain B, ASPARTYLPROTEASE	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Protease	0	2	1	4
Chain A, Phospholipase A2 isoform 3	0	0	1	1
histone deacetylase 9 isoform 3	3	0	0	3
Transient receptor potential cation channel subfamily M member 2	0	1	0	1
Transcription factor SOX-18	0	1	0	1
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	1	0	1
Transcriptional enhancer factor TEF-3	0	1	1	2
STE24	0	0	0	1
CAAX prenyl protease	0	0	0	1
Trypsin	0	0	0	1
Chain B, Cell division protein kinase 6	0	1	0	1
Chain B, Cell division protein kinase 6	0	1	0	1
Cyclin-T1	0	2	0	2
Cyclin-K	0	1	0	1
G2/mitotic-specific cyclin-B1	0	2	0	2
Cyclin-A2	0	2	0	2
Acetylcholinesterase	0	1	0	1
G1/S-specific cyclin-D1	0	2	0	2
G1/S-specific cyclin-E1	0	2	0	2
G1/S-specific cyclin-D2	0	1	0	1
G1/S-specific cyclin-D3	0	2	0	2
Cyclin-H	0	2	0	2
CDK-activating kinase assembly factor MAT1	0	1	0	1
Cyclin-A1	0	1	0	1
Cyclin-dependent kinase 5 activator 1	0	1	0	1
Testosterone 17-beta-dehydrogenase 3	0	1	0	1
Putative nucleoside diphosphate kinase	0	0	1	1
Nucleoside diphosphate kinase B	0	0	1	1
Nuclear receptor subfamily 4 group A member 3	0	1	0	1
Peroxiredoxin-like 2A	0	1	0	1
Platelet glycoprotein VI	0	1	0	1
Chain A, Thymidylate Synthase	0	1	0	1
Chain A, Thymidylate Synthase	0	1	0	1
Chain A, Thymidylate Synthase	0	1	0	1
Serine hydroxymethyltransferase, cytosolic	0	1	1	2
Thymidylate synthase	0	1	0	1
vasopressin V1b receptor	1	0	0	1
relaxin receptor 1 isoform 1	1	0	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	1	0	1
Chitotriosidase-1	0	2	1	3
Endochitinase B1	0	2	1	3
NADPH oxidase 1	0	1	0	1
Snq2p	0	0	0	1
ubiquitin-conjugating enzyme E2 N	0	2	0	2
bcl-2-related protein A1	0	1	0	1
Aldehyde oxidase 1	0	1	0	1
Retinal dehydrogenase 1	0	1	0	1
Pleiotropic ABC efflux transporter of multiple drugs	0	1	0	2
Aldehyde oxidase 1	0	1	0	1
Aldehyde oxidase 1	0	1	0	1
Estrogen receptor 1	0	1	0	1
fMet-Leu-Phe receptor	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	2
Sodium channel protein type 9 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Beta-lactamase	0	0	0	1
Chain A, AKAP9-BRAF fusion protein	0	1	0	1
Dual specificity mitogen-activated protein kinase kinase 4	0	0	1	1
luciferase	0	0	0	1
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
NADH-cytochrome b5 reductase 3	0	1	0	1
Thyroid peroxidase	0	1	0	1
Taste receptor type 2 member 38	0	0	1	2
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
NS5	0	0	1	1
Polymerase basic protein 2	0	0	1	1
RNA-directed RNA polymerase catalytic subunit	0	0	1	1
Polymerase acidic protein	0	0	2	2
Adenosine receptor A1	0	1	0	1
Genome polyprotein	0	0	1	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
NH(3)-dependent NAD(+) synthetase	0	1	0	1
Arylacetamide deacetylase	0	1	0	2
Solute carrier organic anion transporter family member 1A2	0	1	0	2
Glutathione S-transferase omega-1	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Low-density lipoprotein receptor	0	1	0	1
Fibronectin	0	1	0	1
Macrophage colony-stimulating factor 1 receptor	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 4	0	1	0	1
Ras-related C3 botulinum toxin substrate 1	0	0	1	1
Multidrug resistance-associated protein 1	0	1	0	1
Proprotein convertase subtilisin/kexin type 9	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Tyrosine-protein phosphatase YopH	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Carbonic anhydrase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Chain A, Ribosomal protein S6 kinase alpha-1	0	1	0	1
Chain X, Tyrosine-protein kinase Lyn	0	1	0	1
Chain A, Dual specificity protein kinase TTK	0	0	1	1
Chain A, Dual specificity protein kinase TTK	0	0	1	1
Chain A, Glutathione S-transferase	0	1	0	1
Interstitial collagenase	0	1	0	1
Fibroblast growth factor 1	0	0	1	1
Flavin reductase (NADPH)	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	2	0	2
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
Chain A, CES1 protein	0	1	0	1
Lysosomal acid glucosylceramidase	0	0	1	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C alpha type	0	1	0	1
Beta-1 adrenergic receptor	0	2	0	2
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Steroid hormone receptor ERR1	0	1	0	1
Transcriptional activator protein LuxR	0	1	0	1
Substance-P receptor	0	2	0	2
B2 bradykinin receptor	0	2	0	2
Melanocortin receptor 4	0	2	0	2
Melanocortin receptor 5	0	2	0	2
Melanocortin receptor 3	0	2	0	2
Estrogen-related receptor gamma	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Phospholipase D1	0	1	0	1
Platelet-activating factor acetylhydrolase	0	2	0	2
Phospholipase D1	0	1	0	1
Protein kinase C eta type	0	1	0	1
Emopamil-binding protein-like	0	1	0	1
7-dehydrocholesterol reductase	0	1	1	2
Protein kinase C theta type	0	1	0	1
B2 bradykinin receptor	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Metallo-beta-lactamase type 2	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
Metallo-beta-lactamase L1 type 3	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
Retinoic acid receptor RXR-alpha	0	2	4	6
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
P2Y purinoceptor 13	0	1	0	1
Chain A, Tyrosine-protein kinase	0	1	0	1
Chain A, Tyrosine-protein kinase	0	1	0	1
Chain A, Tyrosine-protein kinase JAK2	0	1	0	1
Serine/threonine-protein kinase Sgk1	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	0	1	0	1
Tyrosine-protein kinase JAK3	0	1	0	1
Tyrosine-protein kinase JAK2	0	1	0	1
Tyrosine-protein kinase JAK3	0	1	0	1
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
Retinoic acid receptor alpha	0	2	2	7
Retinoic acid receptor beta	0	2	2	7
Retinoic acid receptor gamma	0	2	2	7
Alpha-1A adrenergic receptor	0	1	0	1
Retinoic acid receptor RXR-beta	0	2	2	4
Nuclear receptor ROR-alpha	0	1	0	1
Retinoic acid receptor RXR-gamma	0	2	2	4
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Nuclear receptor ROR-beta	0	1	0	1
Valacyclovir hydrolase	0	0	0	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Adenosylhomocysteinase	0	1	0	1
RNA-directed RNA polymerase	0	1	1	2
Chain A, Histone deacetylase-like amidohydrolase	0	1	0	1
Chain A, Histone deacetylase-like amidohydrolase	0	1	0	1
Histone deacetylase 8	0	1	0	1
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7	0	0	0	1
Histone deacetylase	0	1	0	1
Lysine-specific demethylase 4E	0	1	0	1
Gli1	0	1	0	1
cystic fibrosis transmembrane conductance regulator	0	1	0	1
protein Wnt-3a precursor	0	1	0	1
Histone deacetylase 1	0	2	0	2
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Lysine-specific histone demethylase 1A	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Protein Tat	0	0	1	1
Aminopeptidase N	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX12	0	0	0	1
Cannabinoid receptor 1	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Phosphatidylinositol 3-kinase regulatory subunit alpha	0	1	0	1
Apoptosis regulator BAX	0	0	1	1
Histone deacetylase 1	0	1	0	1
Histone deacetylase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Renin	0	1	0	1
Histone deacetylase 3	0	1	0	1
Histone deacetylase-like amidohydrolase	0	2	1	3
Histone deacetylase	0	1	0	1
HD2 type histone deacetylase HDA106	0	2	0	2
Carboxypeptidase B2	0	1	0	1
Histone deacetylase 7	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 4	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
REST corepressor 3	0	1	0	1
Histone deacetylase	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Acute Febrile Neutrophilic Dermatosis

Synonyms(7)

Research Excerpts

Overview

Context

Treatment

Research

Studies (526)

Protein Targets (1,963)

Acute Febrile Neutrophilic Dermatosis

Synonyms(7)

Research Excerpts

Overview

Context

Treatment

Research

Studies (526)

Drugs Studied (184)

Protein Targets (1,963)