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epsilon-lactone

Any lactone with a seven-membered ring.

ChEBI ID: 50239

Members (5)

MemberDefinitionRole
1-hydroxy-4-oxahomoadamantan-5-one1-hydroxy-4-oxahomoadamantan-5-one
4-oxahomoadamantan-5-one4-oxahomoadamantan-5-one
caprolactoneA epsilon-lactone that is oxepane substituted by an oxo group at position 2.hexano-6-lactone
diflomotecanAn organic heteropentacyclic compound that is (5R)-8-[(6,7-difluoroquinolin-3-yl)methyl]-5-ethyl-5-hydroxy-1,4,5,8-tetrahydrooxepino[3,4-c]pyridine-3,9-dione in which position 7 of the oxepinopyridine moiety is joined to position 3 of the difluoroquinoine ring by a single bond. An E-ring modified camptothecin analogue that has greater lactone stability in plasma compared with other topoisomerase I inhibitors.diflomotecan
homocamptothecinAn organic heteropentacyclic compound that is (5R)-5-ethyl-5-hydroxy-8-(quinolin-3-ylmethyl)-1,4,5,8-tetrahydrooxepino[3,4-c]pyridine-3,9-dione in which position 7 of the oxepinopyridine group has been joined to position 2 of the quinoline ring by a single bond. A semisynthetic analogue of camptothecin, it is an inhibitor of topoisomerase I.(R)-homocamptothecin

Research

Studies (791)

TimeframeStudies, Drugs in This Class (%)All Drugs %
pre-19901 (0.13)18.7374
1990's11 (1.39)18.2507
2000's226 (28.57)29.6817
2010's378 (47.79)24.3611
2020's175 (22.12)2.80

Study Types

Publication TypeStudies, Drugs in This Class (%)All Drugs (%)
Trials6 (0.73%)5.53%
Reviews18 (2.18%)6.00%
Case Studies2 (0.24%)4.05%
Observational0 (0.00%)0.25%
Other800 (96.85%)84.16%