Page last updated: 2024-08-05 11:54:26
epsilon-lactone
Any lactone with a seven-membered ring.
ChEBI ID: 50239
Members (5)
Member | Definition | Role |
---|---|---|
1-hydroxy-4-oxahomoadamantan-5-one | 1-hydroxy-4-oxahomoadamantan-5-one | |
4-oxahomoadamantan-5-one | 4-oxahomoadamantan-5-one | |
caprolactone | A epsilon-lactone that is oxepane substituted by an oxo group at position 2. | hexano-6-lactone |
diflomotecan | An organic heteropentacyclic compound that is (5R)-8-[(6,7-difluoroquinolin-3-yl)methyl]-5-ethyl-5-hydroxy-1,4,5,8-tetrahydrooxepino[3,4-c]pyridine-3,9-dione in which position 7 of the oxepinopyridine moiety is joined to position 3 of the difluoroquinoine ring by a single bond. An E-ring modified camptothecin analogue that has greater lactone stability in plasma compared with other topoisomerase I inhibitors. | diflomotecan |
homocamptothecin | An organic heteropentacyclic compound that is (5R)-5-ethyl-5-hydroxy-8-(quinolin-3-ylmethyl)-1,4,5,8-tetrahydrooxepino[3,4-c]pyridine-3,9-dione in which position 7 of the oxepinopyridine group has been joined to position 2 of the quinoline ring by a single bond. A semisynthetic analogue of camptothecin, it is an inhibitor of topoisomerase I. | (R)-homocamptothecin |
Research
Studies (791)
Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
---|---|---|
pre-1990 | 1 (0.13) | 18.7374 |
1990's | 11 (1.39) | 18.2507 |
2000's | 226 (28.57) | 29.6817 |
2010's | 378 (47.79) | 24.3611 |
2020's | 175 (22.12) | 2.80 |
Study Types
Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
---|---|---|
Trials | 6 (0.73%) | 5.53% |
Reviews | 18 (2.18%) | 6.00% |
Case Studies | 2 (0.24%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 800 (96.85%) | 84.16% |