metronidazole has been researched along with Diabetes Mellitus, Type 2 in 30 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Diabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine the efficacy of clindamycin compared with amoxicillin-metronidazole after a 7-day regimen during nonsurgical treatment of periodontitis in patients with type 2 diabetes mellitus." | 9.34 | Efficacy of clindamycin compared with amoxicillin-metronidazole after a 7-day regimen in the treatment of periodontitis in patients with diabetes: a randomized clinical trial. ( Espinel-Bermudez, MC; Gómez-Sandoval, JR; Hernández-González, SO; Mariaud-Schmidt, R; Martínez-Rodríguez, V; Mercado-Sesma, AR; Morgado-Castillo, KC; Robles-Cervantes, JA, 2020) |
| "Systemic amoxicillin-metronidazole was proven to be effective in managing periodontitis in systemically healthy patients." | 9.22 | Efficacy of Systemic Amoxicillin-Metronidazole in Periodontitis Patients with Diabetes Mellitus: A Systematic Review of Randomized Clinical Trials. ( Mugri, MH, 2022) |
| "The aim of this study was to assess the changes occurring in subgingival biofilm composition and in the periodontal clinical parameters of subjects with periodontitis and type 2 diabetes mellitus (DM) treated by means of scaling and root planing (SRP) only or combined with systemic metronidazole (MTZ) and amoxicillin (AMX)." | 9.22 | Amoxicillin Plus Metronidazole Therapy for Patients with Periodontitis and Type 2 Diabetes: A 2-year Randomized Controlled Trial. ( Duarte, PM; Faveri, M; Feres, M; Figueiredo, LC; Maciel, SS; Miranda, TS; Tamashiro, NS, 2016) |
| "To evaluate if non-diabetic subjects with periodontitis respond better than subjects with type 2 diabetes to the treatment protocol of scaling and root planing (SRP), metronidazole (MTZ) and amoxicillin (AMX)." | 7.88 | Clinical and microbiological effects of scaling and root planing, metronidazole and amoxicillin in the treatment of diabetic and non-diabetic subjects with periodontitis: A cohort study. ( Duarte, PM; Faveri, M; Feres, M; Figueiredo, LC; Miranda, TS; Retamal-Valdes, B; Soares, GMS; Yassine, LLS, 2018) |
| "To determine the efficacy of clindamycin compared with amoxicillin-metronidazole after a 7-day regimen during nonsurgical treatment of periodontitis in patients with type 2 diabetes mellitus." | 5.34 | Efficacy of clindamycin compared with amoxicillin-metronidazole after a 7-day regimen in the treatment of periodontitis in patients with diabetes: a randomized clinical trial. ( Espinel-Bermudez, MC; Gómez-Sandoval, JR; Hernández-González, SO; Mariaud-Schmidt, R; Martínez-Rodríguez, V; Mercado-Sesma, AR; Morgado-Castillo, KC; Robles-Cervantes, JA, 2020) |
| "Systemic amoxicillin-metronidazole was proven to be effective in managing periodontitis in systemically healthy patients." | 5.22 | Efficacy of Systemic Amoxicillin-Metronidazole in Periodontitis Patients with Diabetes Mellitus: A Systematic Review of Randomized Clinical Trials. ( Mugri, MH, 2022) |
| "The aim of this study was to assess the changes occurring in subgingival biofilm composition and in the periodontal clinical parameters of subjects with periodontitis and type 2 diabetes mellitus (DM) treated by means of scaling and root planing (SRP) only or combined with systemic metronidazole (MTZ) and amoxicillin (AMX)." | 5.22 | Amoxicillin Plus Metronidazole Therapy for Patients with Periodontitis and Type 2 Diabetes: A 2-year Randomized Controlled Trial. ( Duarte, PM; Faveri, M; Feres, M; Figueiredo, LC; Maciel, SS; Miranda, TS; Tamashiro, NS, 2016) |
| "To evaluate if non-diabetic subjects with periodontitis respond better than subjects with type 2 diabetes to the treatment protocol of scaling and root planing (SRP), metronidazole (MTZ) and amoxicillin (AMX)." | 3.88 | Clinical and microbiological effects of scaling and root planing, metronidazole and amoxicillin in the treatment of diabetic and non-diabetic subjects with periodontitis: A cohort study. ( Duarte, PM; Faveri, M; Feres, M; Figueiredo, LC; Miranda, TS; Retamal-Valdes, B; Soares, GMS; Yassine, LLS, 2018) |
| "After receiving different broad-spectrum antibiotics over seven weeks the patient developed Clostridium difficile toxin-positive diarrhea that resolved after administration of oral metronidazole and Saccharomyces boulardii (Perenterol ((R)))." | 3.72 | [Fungemia after oral treatment with Saccharomyces boulardii in a patient with multiple comorbidities]. ( Lestin, F; Pertschy, A; Rimek, D, 2003) |
| "pylori eradication in patients with type 2 diabetes." | 2.84 | Ten days of levofloxacin-containing concomitant therapy can achieve effective Helicobacter pylori eradication in patients with type 2 diabetes. ( Chang, WL; Chen, WY; Cheng, HC; Lin, CH; Lu, CC; Ou, HY; Sheu, BS; Wu, CT; Yang, HB; Yang, YJ, 2017) |
| "Here metformin hydrochloride was suggested to be useful for the treatment of recurrent CDI with type 2 diabetes mellitus." | 1.91 | [A case of recurrent Clostridium difficile infection with type 2 diabetes mellitus indicating the usefulness of metformin hydrochloride]. ( Obata, K; Yamashita, S, 2023) |
| "difficile infection in subjects with type 2 diabetes mellitus admitted into acute medical wards." | 1.39 | Hospital-acquired Clostridium difficile infection among patients with type 2 diabetes mellitus in acute medical wards. ( Hassan, SA; Huda, N; Lee, YY; Rahman, RA; Wan Bebakar, WM, 2013) |
| "Leukocytosis is a sign of severe CDI and is predictive for a complicated course." | 1.39 | [Case report. Leukocytosis in the course of Clostridium difficile infection]. ( Defosse, JM; Sakka, SG; Wappler, F; Weber, KS, 2013) |
| "Emphysematous gastritis is a rare form of gastritis characterized by gaseous dissection of the stomach wall usually secondary to invasion by gas forming organisms, corrosive ingestion, trauma, or gastric infarction." | 1.37 | Emphysematous gastritis associated with ulcerative esophagitis. ( Abbass, K; Akram, S; Hassan, S; Markert, R, 2011) |
| "loss of attachment." | 1.33 | Studies on periodontitis and analyses of individuals at risk for periodontal diseases. ( Jansson, H, 2006) |
| "Wounds with necrotising fasciitis are often malodorous and produce copious exudate." | 1.31 | Management of a heavily exuding, painful wound with necrotising subcutaneous infection. ( Fairhurst, J; Ovens, N, 2002) |
| "To report a case of necrotizing fasciitis after cosmetic blepharoplasty." | 1.30 | Necrotizing fasciitis after cosmetic blepharoplasty. ( Johnson, TE; Meldrum, ML; Suñer, IJ; Tse, DT, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.33) | 18.7374 |
| 1990's | 2 (6.67) | 18.2507 |
| 2000's | 4 (13.33) | 29.6817 |
| 2010's | 19 (63.33) | 24.3611 |
| 2020's | 4 (13.33) | 2.80 |
| Authors | Studies |
|---|---|
| Mugri, MH | 1 |
| Obata, K | 1 |
| Yamashita, S | 1 |
| El-Makaky, Y | 1 |
| Shalaby, HK | 1 |
| Gómez-Sandoval, JR | 1 |
| Robles-Cervantes, JA | 1 |
| Hernández-González, SO | 1 |
| Espinel-Bermudez, MC | 1 |
| Mariaud-Schmidt, R | 1 |
| Martínez-Rodríguez, V | 1 |
| Morgado-Castillo, KC | 1 |
| Mercado-Sesma, AR | 1 |
| Duarte, PM | 4 |
| Feres, M | 4 |
| Yassine, LLS | 1 |
| Soares, GMS | 1 |
| Miranda, TS | 4 |
| Faveri, M | 3 |
| Retamal-Valdes, B | 1 |
| Figueiredo, LC | 3 |
| Lipton, G | 1 |
| Tikka, T | 1 |
| Soulsby, H | 1 |
| Keh, S | 1 |
| Hassan, SA | 1 |
| Rahman, RA | 1 |
| Huda, N | 1 |
| Wan Bebakar, WM | 1 |
| Lee, YY | 1 |
| Weber, KS | 1 |
| Defosse, JM | 1 |
| Wappler, F | 1 |
| Sakka, SG | 1 |
| Denes, E | 1 |
| Cypierre, A | 1 |
| Vacquier, J | 1 |
| Matt, M | 1 |
| Weinbreck, P | 1 |
| Perez-Chaparro, PJ | 1 |
| Tamashiro, NS | 2 |
| Bastos, MF | 1 |
| Pollett, S | 1 |
| McMullan, B | 1 |
| Lam, VW | 1 |
| Qureshi, C | 1 |
| Kok, J | 1 |
| Sapmaz, F | 1 |
| Kalkan, IH | 1 |
| Suslu, I | 1 |
| Demirci, H | 1 |
| Atasoy, P | 1 |
| Guliter, S | 1 |
| Vivas, LLY | 1 |
| Gold, WL | 1 |
| Mandell, DM | 1 |
| Wu, PE | 1 |
| von Hallern, B | 1 |
| Maciel, SS | 1 |
| Kuriyama, A | 1 |
| Kim, SE | 1 |
| Park, MI | 1 |
| Park, SJ | 1 |
| Moon, W | 1 |
| Kim, JH | 1 |
| Jung, K | 1 |
| Kim, HK | 1 |
| Lee, YD | 1 |
| Yang, YJ | 1 |
| Wu, CT | 1 |
| Ou, HY | 1 |
| Lin, CH | 1 |
| Cheng, HC | 1 |
| Chang, WL | 1 |
| Chen, WY | 1 |
| Yang, HB | 1 |
| Lu, CC | 1 |
| Sheu, BS | 1 |
| Demir, M | 2 |
| Göktürk, S | 1 |
| Oztürk, NA | 1 |
| Serin, E | 1 |
| Yilmaz, U | 1 |
| Ataseven, H | 1 |
| Gen, R | 1 |
| Gupta, P | 1 |
| Gupta, R | 2 |
| Jandial, K | 1 |
| Samotra, S | 1 |
| Rana, V | 1 |
| Gupta, S | 1 |
| Singh, J | 1 |
| Hassan, S | 1 |
| Abbass, K | 1 |
| Markert, R | 1 |
| Akram, S | 1 |
| Mendonça, AC | 1 |
| Santos, VR | 1 |
| Ribeiro, FV | 1 |
| Lima, JA | 1 |
| Lestin, F | 1 |
| Pertschy, A | 1 |
| Rimek, D | 1 |
| Severi, C | 1 |
| Zippi, M | 1 |
| Baccini, F | 1 |
| Gentile, G | 1 |
| Bezzi, M | 1 |
| Fiocca, F | 1 |
| Caprilli, R | 1 |
| Jansson, H | 1 |
| Miyahara, T | 1 |
| Kubokawa, M | 1 |
| Koyanagi, S | 1 |
| Migita, Y | 1 |
| Oogoshi, K | 1 |
| Sakai, H | 1 |
| Ito, T | 1 |
| Nakano, I | 1 |
| Nawata, H | 1 |
| Suñer, IJ | 1 |
| Meldrum, ML | 1 |
| Johnson, TE | 1 |
| Tse, DT | 1 |
| Ovens, N | 1 |
| Fairhurst, J | 1 |
| Duran, D | 1 |
| Lagarrigue, J | 1 |
| Blazy-Maugen, F | 1 |
| Michel, G | 1 |
| Ziane, M | 1 |
| Bouziane, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Impact of Different Dosages and Time of Administration of Metronidazole and Amoxicillin in the Treatment of Generalized Chronic Periodontitis: A Randomized Clinical Trial[NCT02735395] | Phase 4 | 110 participants (Actual) | Interventional | 2011-07-31 | Active, not recruiting | ||
| Clinical and Microbiological Effects of Surgical Access Combined With Systematically Administered Antibiotics in the Treatment of Peri-implantitis: 1-year Randomized Double-blinded Controlled Clinical Trial[NCT05444218] | 94 participants (Anticipated) | Interventional | 2021-05-01 | Recruiting | |||
| Metronidazole and Amoxicillin as Adjuncts to Scaling and Root Planing for the Treatment of Type 2 Diabetic Subjects With Periodontitis: a Randomized Placebo-controlled Clinical Trial[NCT02135952] | Phase 4 | 58 participants (Actual) | Interventional | 2011-09-30 | Active, not recruiting | ||
| Strategy on the Increment of H. Pylori Eradication Rate and Investigating the Gastric Pathology and Antimicrobial Resistance in Diabetic Patients[NCT02466919] | Phase 4 | 114 participants (Actual) | Interventional | 2014-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for metronidazole and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Efficacy of Systemic Amoxicillin-Metronidazole in Periodontitis Patients with Diabetes Mellitus: A Systematic Review of Randomized Clinical Trials.
Topics: Amoxicillin; Anti-Bacterial Agents; Clindamycin; Diabetes Mellitus, Type 2; Humans; Metronidazole; P | 2022 |
Prevertebral neck abscess with
Topics: Abscess; Ceftriaxone; Ciprofloxacin; Diabetes Mellitus, Type 2; Drainage; Humans; Male; Metronidazol | 2019 |
8 trials available for metronidazole and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
The effects of non-surgical periodontal therapy on glycemic control in diabetic patients: A randomized controlled trial.
Topics: Amoxicillin; Anti-Bacterial Agents; Blood Glucose; Chronic Periodontitis; Dental Scaling; Diabetes M | 2020 |
Efficacy of clindamycin compared with amoxicillin-metronidazole after a 7-day regimen in the treatment of periodontitis in patients with diabetes: a randomized clinical trial.
Topics: Adolescent; Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Clindamycin; Diabetes Mellitus, Type 2; | 2020 |
Metronidazole and amoxicillin as adjuncts to scaling and root planing for the treatment of type 2 diabetic subjects with periodontitis: 1-year outcomes of a randomized placebo-controlled clinical trial.
Topics: Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Biofilms; Chronic Periodonti | 2014 |
Amoxicillin Plus Metronidazole Therapy for Patients with Periodontitis and Type 2 Diabetes: A 2-year Randomized Controlled Trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Biofilms; Dental Plaque; Dental Sc | 2016 |
Amoxicillin Plus Metronidazole Therapy for Patients with Periodontitis and Type 2 Diabetes: A 2-year Randomized Controlled Trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Biofilms; Dental Plaque; Dental Sc | 2016 |
Amoxicillin Plus Metronidazole Therapy for Patients with Periodontitis and Type 2 Diabetes: A 2-year Randomized Controlled Trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Biofilms; Dental Plaque; Dental Sc | 2016 |
Amoxicillin Plus Metronidazole Therapy for Patients with Periodontitis and Type 2 Diabetes: A 2-year Randomized Controlled Trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Biofilms; Dental Plaque; Dental Sc | 2016 |
Ten days of levofloxacin-containing concomitant therapy can achieve effective Helicobacter pylori eradication in patients with type 2 diabetes.
Topics: Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Clarithromycin; Diabetes Mellitus, Type 2; Drug Res | 2017 |
Bismuth-based first-line therapy for Helicobacter pylori eradication in type 2 diabetes mellitus patients.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Amoxicillin; Antacids; Anti-Bacterial Agents; Anti-Infectiv | 2010 |
Effect of sequential treatment as a first-line therapy for Helicobacter pylori eradication in patients with diabetes mellitus.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Amoxicillin; Anti-Bacterial Agents; Anti-Ulcer Agents; Diab | 2010 |
Surgical and non-surgical therapy with systemic antimicrobials for residual pockets in type 2 diabetics with chronic periodontitis: a pilot study.
Topics: Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Chronic Periodontitis; Cytokines; Dental Scaling; D | 2012 |
20 other studies available for metronidazole and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
[A case of recurrent Clostridium difficile infection with type 2 diabetes mellitus indicating the usefulness of metformin hydrochloride].
Topics: Aged; Anti-Bacterial Agents; Clostridioides difficile; Clostridium Infections; Diabetes Mellitus, Ty | 2023 |
Clinical and microbiological effects of scaling and root planing, metronidazole and amoxicillin in the treatment of diabetic and non-diabetic subjects with periodontitis: A cohort study.
Topics: Amoxicillin; Anti-Bacterial Agents; Cohort Studies; Combined Modality Therapy; Dental Plaque; Dental | 2018 |
Hospital-acquired Clostridium difficile infection among patients with type 2 diabetes mellitus in acute medical wards.
Topics: Abdominal Pain; Age Factors; Aged; Anti-Bacterial Agents; Bacterial Proteins; Bacterial Toxins; Clos | 2013 |
[Case report. Leukocytosis in the course of Clostridium difficile infection].
Topics: Aged; Anti-Bacterial Agents; Clostridioides difficile; Colon; Colonoscopy; Diabetes Mellitus, Type 2 | 2013 |
Meningitis due to Fusobacterium nucleatum after a kart crash.
Topics: Anti-Infective Agents; Athletic Injuries; Bacteremia; Bacterial Translocation; Bacterial Typing Tech | 2013 |
A 68-year-old type 2 diabetic man of Korean ethnicity with fever, abdominal pain, and right eye visual disturbance.
Topics: Abdominal Pain; Aged; Anti-Bacterial Agents; Bacteremia; Diabetes Mellitus, Type 2; Endophthalmitis; | 2015 |
Lower plasma pantoprazole level predicts Helicobacter pylori treatment failure in patients with type 2 diabetes mellitus.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Anti-Bacterial Agents; Anti-Ulcer Agents; Diabetes M | 2015 |
An 82-year-old man with ataxia and dysarthria.
Topics: Aged, 80 and over; Anti-Infective Agents; Ataxia; Brain; Cerebellar Nuclei; Diabetes Mellitus, Type | 2016 |
Case 7: highly infected post-surgical wound.
Topics: Aged; Anti-Bacterial Agents; Anti-Infective Agents, Local; Cefuroxime; Diabetes Mellitus, Type 2; Ex | 2016 |
Chestnut Sign: Metronidazole-Induced Encephalopathy.
Topics: Abdominal Abscess; Aged; Anti-Bacterial Agents; Ataxia; Brain Diseases; Ciprofloxacin; Depression; D | 2017 |
Second-line bismuth-containing quadruple therapy for
Topics: Adult; Aged; Antacids; Anti-Infective Agents; Bismuth; Breath Tests; Diabetes Mellitus, Type 2; Dise | 2017 |
Emphysematous pyelonephritis in the setting of diabetes mellitus.
Topics: Anti-Infective Agents; Diabetes Mellitus, Type 2; Diagnosis, Differential; Emphysema; Escherichia co | 2011 |
Emphysematous gastritis associated with ulcerative esophagitis.
Topics: Aged; Anti-Bacterial Agents; Bacterial Infections; Ciprofloxacin; Diabetes Mellitus, Type 2; Emphyse | 2011 |
[Fungemia after oral treatment with Saccharomyces boulardii in a patient with multiple comorbidities].
Topics: Administration, Oral; Amputation, Surgical; Clostridioides difficile; Diabetes Mellitus, Type 2; Dia | 2003 |
Amebic liver abscess, Mirizzi syndrome, and acute hepatic failure.
Topics: Anti-Infective Agents; Barium Radioisotopes; Cefoperazone; Cholecystectomy; Diabetes Mellitus, Type | 2004 |
Studies on periodontitis and analyses of individuals at risk for periodontal diseases.
Topics: Adult; Anti-Infective Agents; Chronic Disease; Diabetes Mellitus, Type 2; Female; Genetic Predisposi | 2006 |
A case of successfully treated giardiasis in pancreas.
Topics: Aged; Animals; Antiprotozoal Agents; Diabetes Mellitus, Type 2; Female; Giardiasis; Humans; Metronid | 1997 |
Necrotizing fasciitis after cosmetic blepharoplasty.
Topics: Aged; Blepharoplasty; Debridement; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Eyelids; Fa | 1999 |
Management of a heavily exuding, painful wound with necrotising subcutaneous infection.
Topics: Anti-Bacterial Agents; Ciprofloxacin; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Fasciiti | 2002 |
[Peripheral concentrations and distribution of a combination of anti-infective agents (spiramycin-metronidazole) in diabetics].
Topics: Anti-Infective Agents; Dentistry, Operative; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; D | 1985 |