metronidazole has been researched along with Candida Infection in 30 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the recommended dosage nitrimidazine is inferior to metronidazole, but is sufficiently effective to be useful in cases of intolerance to metronidazole." | 2.64 | Nitrimidazine compared with metronidazole in the treatment of vaginal trichomoniasis. ( Catterall, RD; Evans, BA, 1971) |
| "Other causes of vaginitis are also discussed." | 2.37 | Vaginitis: current microbiologic and clinical concepts. ( Embil, JA; Hill, LV, 1986) |
| "Anidulafungin was used to treat invasive candidiasis in seven patients (20%) and candidemia in 10 patients (29%); Candida albicans or Candida glabrata was isolated most frequently in these two infections combined (7 isolates each [41%]/17 infections)." | 1.35 | Early clinical experience with anidulafungin at a large tertiary care medical center. ( Brielmaier, BD; Casabar, E; Kurtzeborn, CM; McKinnon, PS; Ritchie, DJ, 2008) |
| "Necrotizing fasciitis is a potentially fatal, acute bacterial infection characterized by extensive fascial and subcutaneous tissue necrosis." | 1.28 | Fatal necrotizing fasciitis of dental origin. ( Beecroft, WA; Cogan, AG; Stoykewych, AA, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (60.00) | 18.7374 |
| 1990's | 2 (6.67) | 18.2507 |
| 2000's | 5 (16.67) | 29.6817 |
| 2010's | 4 (13.33) | 24.3611 |
| 2020's | 1 (3.33) | 2.80 |
| Authors | Studies |
|---|---|
| Dhanasekaran, S | 3 |
| Selvadoss, PP | 3 |
| Manoharan, SS | 3 |
| Smith, S | 1 |
| Bagshaw, RJ | 1 |
| Hanson, J | 1 |
| Bastianpillai, J | 1 |
| Chaudhry, S | 1 |
| Vijendren, A | 1 |
| Falcone, M | 1 |
| Russo, A | 1 |
| Iraci, F | 1 |
| Carfagna, P | 1 |
| Goldoni, P | 1 |
| Vullo, V | 1 |
| Venditti, M | 1 |
| Sheikh, Z | 1 |
| Khan, AS | 1 |
| Khan, S | 1 |
| USHIJIMA, Y | 1 |
| SHIMOJI, T | 1 |
| SATO, T | 1 |
| BEVERIDGE, MM | 1 |
| BOURG, R | 2 |
| Brielmaier, BD | 1 |
| Casabar, E | 1 |
| Kurtzeborn, CM | 1 |
| McKinnon, PS | 1 |
| Ritchie, DJ | 1 |
| Schneider, GT | 1 |
| McEvoy, B | 1 |
| Ross, SM | 2 |
| Hoosen, AA | 1 |
| Sheik, AI | 1 |
| Zingman, BS | 1 |
| Piotrowski, S | 1 |
| Wojciechowski, I | 1 |
| Zaniewska-Kulesza, I | 1 |
| Bojarski, P | 1 |
| Trenschel, R | 1 |
| Peceny, R | 1 |
| Runde, V | 1 |
| Elmaagacli, A | 1 |
| Dermoumi, H | 1 |
| Heintschel von Heinegg, E | 1 |
| Müller, KD | 1 |
| Schaefer, UW | 1 |
| Beelen, DW | 1 |
| Wang, CC | 1 |
| McClelland, RS | 1 |
| Reilly, M | 1 |
| Overbaugh, J | 1 |
| Emery, SR | 1 |
| Mandaliya, K | 1 |
| Chohan, B | 1 |
| Ndinya-Achola, J | 1 |
| Bwayo, J | 1 |
| Kreiss, JK | 1 |
| Rouquette-Vincenti, I | 1 |
| Petitjeans, F | 1 |
| Villevieille, T | 1 |
| Szymczyszyn, P | 1 |
| Fangio, P | 1 |
| Baranger, B | 1 |
| Brinquin, L | 1 |
| McCormack, WM | 1 |
| Hauser, GA | 1 |
| Stoykewych, AA | 1 |
| Beecroft, WA | 1 |
| Cogan, AG | 1 |
| Hill, LV | 1 |
| Embil, JA | 1 |
| Korte, W | 1 |
| Dennerstein, GJ | 1 |
| Davidson, F | 1 |
| Evans, BA | 1 |
| Catterall, RD | 1 |
| Oller, LZ | 1 |
| Landes, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Assessment Of Changes In Gut Microbiota Of Patients With Recurrent Clostridioides Difficile Infection After Fecal Microbiota Transplantation: Prospective Study[NCT05739825] | 20 participants (Anticipated) | Observational | 2023-02-13 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for metronidazole and Candida Infection
| Article | Year |
|---|---|
Management of sexually transmissible infections during pregnancy.
Topics: Anti-Bacterial Agents; Candidiasis; Chlamydia Infections; Coitus; Condylomata Acuminata; Corynebacte | 1975 |
Vaginitis: current microbiologic and clinical concepts.
Topics: Antibody Formation; Antifungal Agents; Candidiasis; Candidiasis, Vulvovaginal; Carrier State; Female | 1986 |
Vaginitis: diagnosis and treatment.
Topics: Adult; Candidiasis; Clinical Laboratory Techniques; Diagnosis, Differential; Female; Haemophilus Inf | 1972 |
5 trials available for metronidazole and Candida Infection
| Article | Year |
|---|---|
Fungal colonization and invasive fungal infections following allogeneic BMT using metronidazole, ciprofloxacin and fluconazole or ciprofloxacin and fluconazole as intestinal decontamination.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Antibiotic Prophylaxis; Antifungal Agents; Aspergillosis; | 2000 |
The effect of treatment of vaginal infections on shedding of human immunodeficiency virus type 1.
Topics: Adult; Anti-Bacterial Agents; Antitrichomonal Agents; Candidiasis; DNA, Viral; Down-Regulation; Fema | 2001 |
[A new treatment of mycotic and prozoal vaginitis (author's transl)].
Topics: Candidiasis; Female; Humans; Mepartricin; Metronidazole; Polyenes; Trichomonas Vaginitis; Vaginitis | 1975 |
Single and triple dose treatment of Trichomonas infection of the vagina.
Topics: Administration, Oral; Adult; Antitrichomonal Agents; Candidiasis; Clinical Trials as Topic; Costs an | 1973 |
Nitrimidazine compared with metronidazole in the treatment of vaginal trichomoniasis.
Topics: Administration, Oral; Adolescent; Adult; Candidiasis; Clinical Trials as Topic; Female; Gonorrhea; H | 1971 |
22 other studies available for metronidazole and Candida Infection
| Article | Year |
|---|---|
Anti-Fungal Potential of Structurally Diverse FDA-Approved Therapeutics Targeting Secreted Aspartyl Proteinase (SAP) of Candida albicans: an In Silico Drug Repurposing Approach.
Topics: Anti-Bacterial Agents; Aspartic Acid Endopeptidases; Aspartic Acid Proteases; Aztreonam; Candida alb | 2023 |
Anti-Fungal Potential of Structurally Diverse FDA-Approved Therapeutics Targeting Secreted Aspartyl Proteinase (SAP) of Candida albicans: an In Silico Drug Repurposing Approach.
Topics: Anti-Bacterial Agents; Aspartic Acid Endopeptidases; Aspartic Acid Proteases; Aztreonam; Candida alb | 2023 |
Anti-Fungal Potential of Structurally Diverse FDA-Approved Therapeutics Targeting Secreted Aspartyl Proteinase (SAP) of Candida albicans: an In Silico Drug Repurposing Approach.
Topics: Anti-Bacterial Agents; Aspartic Acid Endopeptidases; Aspartic Acid Proteases; Aztreonam; Candida alb | 2023 |
Anti-Fungal Potential of Structurally Diverse FDA-Approved Therapeutics Targeting Secreted Aspartyl Proteinase (SAP) of Candida albicans: an In Silico Drug Repurposing Approach.
Topics: Anti-Bacterial Agents; Aspartic Acid Endopeptidases; Aspartic Acid Proteases; Aztreonam; Candida alb | 2023 |
Anti-Fungal Potential of Structurally Diverse FDA-Approved Therapeutics Targeting Secreted Aspartyl Proteinase (SAP) of Candida albicans: an In Silico Drug Repurposing Approach.
Topics: Anti-Bacterial Agents; Aspartic Acid Endopeptidases; Aspartic Acid Proteases; Aztreonam; Candida alb | 2023 |
Anti-Fungal Potential of Structurally Diverse FDA-Approved Therapeutics Targeting Secreted Aspartyl Proteinase (SAP) of Candida albicans: an In Silico Drug Repurposing Approach.
Topics: Anti-Bacterial Agents; Aspartic Acid Endopeptidases; Aspartic Acid Proteases; Aztreonam; Candida alb | 2023 |
Anti-Fungal Potential of Structurally Diverse FDA-Approved Therapeutics Targeting Secreted Aspartyl Proteinase (SAP) of Candida albicans: an In Silico Drug Repurposing Approach.
Topics: Anti-Bacterial Agents; Aspartic Acid Endopeptidases; Aspartic Acid Proteases; Aztreonam; Candida alb | 2023 |
Anti-Fungal Potential of Structurally Diverse FDA-Approved Therapeutics Targeting Secreted Aspartyl Proteinase (SAP) of Candida albicans: an In Silico Drug Repurposing Approach.
Topics: Anti-Bacterial Agents; Aspartic Acid Endopeptidases; Aspartic Acid Proteases; Aztreonam; Candida alb | 2023 |
Anti-Fungal Potential of Structurally Diverse FDA-Approved Therapeutics Targeting Secreted Aspartyl Proteinase (SAP) of Candida albicans: an In Silico Drug Repurposing Approach.
Topics: Anti-Bacterial Agents; Aspartic Acid Endopeptidases; Aspartic Acid Proteases; Aztreonam; Candida alb | 2023 |
The microbiology of crocodile attacks in Far North Queensland: implications for empirical antimicrobial therapy.
Topics: Adolescent; Adult; Aged; Alligators and Crocodiles; Animals; Anti-Bacterial Agents; Bacillus cereus; | 2017 |
Rare case of a 3-year-old with
Topics: Administration, Intravenous; Anti-Bacterial Agents; Antifungal Agents; Candida albicans; Candidiasis | 2019 |
Risk Factors and Outcomes for Bloodstream Infections Secondary to Clostridium difficile Infection.
Topics: Aged; Anti-Infective Agents; Bacteremia; Candida; Candidiasis; Case-Control Studies; Clostridioides | 2016 |
Lingua villosa nigra.
Topics: Anti-Infective Agents; Antifungal Agents; Candidiasis; Clavulanic Acid; Female; Fluconazole; Humans; | 2011 |
[Metronidazole therapy of Trichomonas vaginitis and incidence of Candida vaginitis in the post-therapy].
Topics: Candida; Candidiasis; Candidiasis, Vulvovaginal; Female; Humans; Imidazoles; Incidence; Metronidazol | 1962 |
[A SIMPLE RAPID EXAMINATION METHOD FOR CANDIDIASIS AND THE TREATMENT OF VULVOVAGINAL MONILIASIS WITH METRONIDAZOLE (FLAGYL)].
Topics: Antiprotozoal Agents; Candidiasis; Candidiasis, Vulvovaginal; Coloring Agents; Drug Therapy; Female; | 1964 |
LOCAL FUNGICIDE USED CONCOMITANTLY WITH "FLAGYL" IN TRICHOMONAL INFECTION.
Topics: Adolescent; Candida; Candidiasis; Candidiasis, Vulvovaginal; Drug Therapy; Female; Fungicides, Indus | 1964 |
[DOES VAGINAL CANDIDIASIS HAVE AN HORMONAL ETIOLOGY?].
Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Candidiasis; Candidiasis, Vulvovaginal; Female; | 1964 |
Early clinical experience with anidulafungin at a large tertiary care medical center.
Topics: Academic Medical Centers; Alanine Transaminase; Anidulafungin; Antifungal Agents; Aspartate Aminotra | 2008 |
Vaginal infections. How to identify and treat them.
Topics: Adolescent; Adult; Candidiasis; Child; Chlamydia Infections; Female; Haemophilus Infections; Herpes | 1983 |
Transfer of bioactive substances in breast milk.
Topics: Amoxicillin; Breast Feeding; Candidiasis; Dermatitis, Atopic; Female; Humans; Infant; Intestinal Dis | 1984 |
Diagnosis and treatment of vaginal discharge in pregnancy.
Topics: Candidiasis; Female; Humans; Leukorrhea; Metronidazole; Pregnancy; Pregnancy Complications, Infectio | 1980 |
Fever after cytotoxic therapy of chronic lymphocytic leukemia.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Antineoplastic Agents; Aztreonam; Candidiasis; Female; | 1999 |
[Intracranial complication of sinusitis in a 18-year old patient].
Topics: Adolescent; Anti-Infective Agents; Brain Abscess; Candidiasis; Female; Humans; Maxillary Sinusitis; | 2000 |
[Obesity, diabetes mellitus, and gas gangrene: a major therapeutic challenge].
Topics: Abscess; Amikacin; Anus Diseases; Buttocks; Candidiasis; Ceftazidime; Colostomy; Combined Modality T | 2001 |
Fatal necrotizing fasciitis of dental origin.
Topics: Adult; Bacteroides Infections; Candidiasis; Cefotaxime; Clindamycin; Cloxacillin; Fasciitis; Female; | 1992 |
[Epidemiology, pathology and clinical aspects of trichomonas vaginalis infection].
Topics: Age Factors; Candidiasis; Carcinoma in Situ; Chronic Disease; Fallopian Tubes; Female; History, 19th | 1973 |
Short-term high-dose metronidazole for vaginal trichomoniasis.
Topics: Adolescent; Adult; Candidiasis; Contraceptives, Oral; Female; Gonorrhea; Humans; Male; Metronidazole | 1973 |
[Current aspects of vaginal trichomoniasis and candidiasis].
Topics: Candidiasis; Female; Humans; Metronidazole; Trichomonas Infections; Vaginitis | 1967 |
Prevention of post-metronidazole candidosis with amphotericin B pessaries.
Topics: Adolescent; Adult; Aged; Amphotericin B; Candida; Candidiasis; Female; Humans; Metronidazole; Middle | 1969 |
[Vulvitis and vaginitis].
Topics: Anti-Bacterial Agents; Candidiasis; Female; Humans; Metronidazole; Trichomonas Vaginitis; Vaginitis; | 1966 |