metronidazole has been researched along with Allergy, Drug in 31 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our purpose was to develop and test an incremental dosing protocol for women with adverse reaction to metronidazole and severe symptomatic Trichomonas vaginitis." | 3.69 | An incremental dosing protocol for women with severe vaginal trichomoniasis and adverse reaction to metronidazole. ( Ernst, S; Pearlman, MD; Solomon, W; Yashar, C, 1996) |
| "Secnidazole was subsequently used for treatment, which resulted in clinical and microbiological cure without observation of cross-reactivity." | 1.62 | Successful treatment with secnidazole for trichomoniasis in the setting of metronidazole hypersensitivity. ( Asiago-Reddy, EA; Coyne, JL; Kufel, WD; Parsels, KA; Sanyal, S, 2021) |
| "We describe a pediatric case of Sweet syndrome presenting 10 days after treatment with azathioprine." | 1.37 | Azathioprine hypersensitivity presenting as sweet syndrome in a child with ulcerative colitis. ( Choe, YH; Jang, KT; Kim, MJ, 2011) |
| " The patient's vaginitis was treated with gentian violet and she was discharged on a tapering dosage of prednisone." | 1.29 | Metronidazole hypersensitivity. ( Choudhury, T; Knowles, S; Shear, NH, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (16.13) | 18.7374 |
| 1990's | 5 (16.13) | 18.2507 |
| 2000's | 5 (16.13) | 29.6817 |
| 2010's | 9 (29.03) | 24.3611 |
| 2020's | 7 (22.58) | 2.80 |
| Authors | Studies |
|---|---|
| Dutta, AK | 1 |
| Phull, PS | 1 |
| Dilley, M | 1 |
| Geng, B | 1 |
| Muzny, CA | 2 |
| Van Gerwen, OT | 1 |
| Kissinger, P | 1 |
| Nyssen, OP | 1 |
| Pérez-Aisa, Á | 2 |
| Tepes, B | 1 |
| Rodrigo-Sáez, L | 1 |
| Romero, PM | 1 |
| Lucendo, A | 1 |
| Castro-Fernández, M | 3 |
| Phull, P | 1 |
| Barrio, J | 3 |
| Bujanda, L | 1 |
| Ortuño, J | 1 |
| Areia, M | 1 |
| Brglez Jurecic, N | 1 |
| Huguet, JM | 1 |
| Alcaide, N | 1 |
| Voynovan, I | 1 |
| María Botargues Bote, J | 1 |
| Modolell, I | 2 |
| Pérez Lasala, J | 1 |
| Ariño, I | 1 |
| Jonaitis, L | 1 |
| Dominguez-Cajal, M | 1 |
| Buzas, G | 1 |
| Lerang, F | 1 |
| Perona, M | 1 |
| Bordin, D | 1 |
| Axon, T | 1 |
| Gasbarrini, A | 1 |
| Marcos Pinto, R | 1 |
| Niv, Y | 1 |
| Kupcinskas, L | 1 |
| Tonkic, A | 1 |
| Leja, M | 1 |
| Rokkas, T | 1 |
| Boyanova, L | 1 |
| Shvets, O | 1 |
| Venerito, M | 1 |
| Bytzer, P | 1 |
| Goldis, A | 1 |
| Simsek, I | 1 |
| Lamy, V | 1 |
| Przytulski, K | 1 |
| Kunovský, L | 1 |
| Capelle, L | 1 |
| Milosavljevic, T | 1 |
| Caldas, M | 1 |
| Garre, A | 1 |
| Mégraud, F | 1 |
| O'Morain, C | 1 |
| Gisbert, JP | 3 |
| Zhou, Y | 1 |
| Ye, Z | 1 |
| Lu, J | 1 |
| Miao, S | 1 |
| Lu, X | 1 |
| Sun, H | 1 |
| Wu, J | 1 |
| Wang, Y | 1 |
| Huang, Y | 1 |
| Beyaz, Ş | 1 |
| Akdeniz, N | 1 |
| Yılmaz, A | 1 |
| Demir, S | 1 |
| Öztop, N | 1 |
| Çolakoğlu, B | 1 |
| Büyüköztürk, S | 1 |
| Deniz, G | 1 |
| Gelincik, A | 1 |
| Kufel, WD | 1 |
| Asiago-Reddy, EA | 1 |
| Parsels, KA | 1 |
| Sanyal, S | 1 |
| Coyne, JL | 1 |
| Furuta, T | 1 |
| Sugimoto, M | 1 |
| Yamade, M | 1 |
| Uotani, T | 1 |
| Sahara, S | 1 |
| Ichikawa, H | 1 |
| Kagami, T | 1 |
| Yamada, T | 1 |
| Osawa, S | 1 |
| Sugimoto, K | 1 |
| Watanabe, H | 1 |
| Umemura, K | 1 |
| Molina-Infante, J | 1 |
| Aisa, AP | 1 |
| Rodrigo, L | 2 |
| Cosme, A | 2 |
| Gisbert, JL | 2 |
| Fernández-Bermejo, M | 1 |
| Marcos, S | 2 |
| Marín, AC | 1 |
| McNicholl, AG | 1 |
| Graham, DY | 1 |
| Lee, SY | 1 |
| Backus, KV | 1 |
| Beauchamps, LS | 1 |
| Steurer, J | 1 |
| Moreno-Otero, R | 1 |
| Mombelli, A | 1 |
| Cionca, N | 1 |
| Almaghlouth, A | 1 |
| Kim, MJ | 1 |
| Jang, KT | 1 |
| Choe, YH | 1 |
| Seto, K | 1 |
| Knowles, SR | 1 |
| Weber, EA | 1 |
| Lomax, NJ | 1 |
| Estcourt, C | 1 |
| Mirakian, R | 1 |
| Rodríguez-Torres, M | 1 |
| Salgado-Mercado, R | 1 |
| Ríos-Bedoya, CF | 1 |
| Aponte-Rivera, E | 1 |
| Marxuach-Cuétara, AM | 1 |
| Rodríguez-Orengo, JF | 1 |
| Fernández-Carbia, A | 1 |
| Girardi, M | 1 |
| Duncan, KO | 1 |
| Tigelaar, RE | 1 |
| Imaeda, S | 1 |
| Watsky, KL | 1 |
| McNiff, JM | 1 |
| Helms, DJ | 1 |
| Mosure, DJ | 1 |
| Secor, WE | 1 |
| Workowski, KA | 1 |
| Asensio Sánchez, T | 1 |
| Dávila, I | 1 |
| Moreno, E | 1 |
| Laffond, E | 1 |
| Macías, E | 1 |
| Ruiz, A | 1 |
| Lorente, F | 1 |
| Rockwell, S | 1 |
| Irvin, CG | 1 |
| Neaderland, MH | 1 |
| Knowles, S | 1 |
| Choudhury, T | 1 |
| Shear, NH | 1 |
| Pearlman, MD | 1 |
| Yashar, C | 1 |
| Ernst, S | 1 |
| Solomon, W | 1 |
| Bhaduri, S | 1 |
| Riley, VC | 1 |
| Mani, V | 1 |
| Cartwright, K | 1 |
| Dooley, J | 1 |
| Swarbrick, E | 1 |
| Fairclough, P | 1 |
| Oakley, C | 1 |
| Guerre, J | 1 |
| Gaudric, M | 1 |
| Tual, JL | 1 |
| Kurohara, ML | 1 |
| Kwong, FK | 1 |
| Lebherz, TB | 1 |
| Klaustermeyer, WB | 1 |
| Danilov, LN | 1 |
| Evans, BA | 1 |
| Catterall, RD | 1 |
5 reviews available for metronidazole and Allergy, Drug
| Article | Year |
|---|---|
Treatment of
Topics: Amoxicillin; Anti-Bacterial Agents; Bismuth; Drug Hypersensitivity; Drug Therapy, Combination; Helic | 2021 |
Immediate and Delayed Hypersensitivity Reactions to Antibiotics: Aminoglycosides, Clindamycin, Linezolid, and Metronidazole.
Topics: Aminoglycosides; Anaphylaxis; Angioedema; Anti-Bacterial Agents; Clindamycin; Dermatitis, Allergic C | 2022 |
Updates in trichomonas treatment including persistent infection and 5-nitroimidazole hypersensitivity.
Topics: Antiprotozoal Agents; Dose-Response Relationship, Drug; Drug Hypersensitivity; Female; Humans; Male; | 2020 |
How to Effectively Use Bismuth Quadruple Therapy: The Good, the Bad, and the Ugly.
Topics: Antacids; Anti-Bacterial Agents; Bismuth; Drug Administration Schedule; Drug Hypersensitivity; Drug | 2015 |
Does adjunctive antimicrobial therapy reduce the perceived need for periodontal surgery?
Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents, Local; Chemotherapy, Adjuvant; Drug Combi | 2011 |
4 trials available for metronidazole and Allergy, Drug
| Article | Year |
|---|---|
Diagnostic workup including CD203c-based basophil activation test in immediate hypersensitivity due to metronidazole and ornidazole and evaluation of cross-reactivity in between.
Topics: Basophil Degranulation Test; Basophils; Drug Hypersensitivity; Humans; Hypersensitivity, Immediate; | 2021 |
Topics: Acute Disease; Administration, Oral; Amoxicillin-Potassium Clavulanate Combination; Ciprofloxacin; C | 2017 |
High eradication rates of Helicobacter pylori infection with first- and second-line combination of esomeprazole, tetracycline, and metronidazole in patients allergic to penicillin.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Anti-Ulcer Agents; Drug Hypersensitivity; Drug Therapy | 2005 |
Nifuratel compared with metronidazole in the treatment of trichomonal vaginitis.
Topics: Adolescent; Adult; Clinical Trials as Topic; Drug Hypersensitivity; Female; Gonorrhea; Humans; Metro | 1970 |
22 other studies available for metronidazole and Allergy, Drug
| Article | Year |
|---|---|
Helicobacter pylori first-line and rescue treatments in patients allergic to penicillin: Experience from the European Registry on H pylori management (Hp-EuReg).
Topics: Anti-Bacterial Agents; Bismuth; Clarithromycin; Drug Hypersensitivity; Drug Therapy, Combination; He | 2020 |
Long-term changes in the gut microbiota after 14-day bismuth quadruple therapy in penicillin-allergic children.
Topics: Adolescent; Anti-Bacterial Agents; Bismuth; Child; Clarithromycin; Cross-Sectional Studies; Drug Hyp | 2020 |
Successful treatment with secnidazole for trichomoniasis in the setting of metronidazole hypersensitivity.
Topics: Drug Hypersensitivity; Female; Humans; Metronidazole; Treatment Outcome; Trichomonas Infections; Tri | 2021 |
Eradication of H. pylori infection in patients allergic to penicillin using triple therapy with a PPI, metronidazole and sitafloxacin.
Topics: Anti-Bacterial Agents; Breath Tests; Cytochrome P-450 CYP2C19; Drug Administration Schedule; Drug Hy | 2014 |
Helicobacter pylori first-line and rescue treatments in the presence of penicillin allergy.
Topics: Antacids; Anti-Bacterial Agents; Bismuth; Breath Tests; Clarithromycin; Drug Administration Schedule | 2015 |
Trichomonas vaginalis Treated With Boric Acid in a Metronidazole Allergic Female.
Topics: Aged; Antiprotozoal Agents; Boric Acids; Drug Hypersensitivity; Drug-Related Side Effects and Advers | 2017 |
Helicobacter pylori first-line treatment and rescue option containing levofloxacin in patients allergic to penicillin.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Anti-Ulcer Agents; Clarithromycin; Drug Administration | 2010 |
Azathioprine hypersensitivity presenting as sweet syndrome in a child with ulcerative colitis.
Topics: Azathioprine; Child; Colitis, Ulcerative; Drug Hypersensitivity; Female; Humans; Immunosuppressive A | 2011 |
Immediate hypersensitivity reaction induced by metronidazole.
Topics: Aged; Anti-Infective Agents; Drug Hypersensitivity; Female; Humans; Hypersensitivity, Immediate; Met | 2012 |
Symptomatic trichomoniasis, metronidazole allergic and pregnant--a management dilemma.
Topics: Adult; Animals; Anti-Infective Agents, Local; Antitrichomonal Agents; Clotrimazole; Drug Hypersensit | 2004 |
Cross-comparison of patch test and lymphocyte proliferation responses in patients with a history of acute generalized exanthematous pustulosis.
Topics: Adult; Aged; Anti-Infective Agents; Calcium Channel Blockers; Cell Proliferation; Diltiazem; Drug Er | 2005 |
Management of trichomonas vaginalis in women with suspected metronidazole hypersensitivity.
Topics: Adolescent; Adult; Aged; Animals; Antiprotozoal Agents; Desensitization, Immunologic; Drug Hypersens | 2008 |
Anaphylaxis due to metronidazole with positive skin prick test.
Topics: Anaphylaxis; Angioedema; Drug Hypersensitivity; Female; Humans; Metronidazole; Middle Aged; Skin Tes | 2008 |
Inhibition of delayed hypersensitivity by metronidazole and misonidazole.
Topics: Animals; Dinitrofluorobenzene; Drug Hypersensitivity; Female; Hypersensitivity, Delayed; Male; Metro | 1983 |
Metronidazole hypersensitivity.
Topics: Adult; Biological Availability; Candidiasis, Vulvovaginal; Drug Hypersensitivity; Drug Therapy, Comb | 1994 |
An incremental dosing protocol for women with severe vaginal trichomoniasis and adverse reaction to metronidazole.
Topics: Antitrichomonal Agents; Clinical Protocols; Drug Hypersensitivity; Female; Humans; Infusions, Intrav | 1996 |
Metronidazole hypersensitivity in a patient with bacterial vaginosis.
Topics: Adult; Antitrichomonal Agents; Drug Hypersensitivity; Female; Humans; Metronidazole; Vaginosis, Bact | 1997 |
Antibiotic prophylaxis in gastrointestinal endoscopy: a report by a Working Party for the British Society of Gastroenterology Endoscopy Committee.
Topics: Administration, Oral; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Antibiotic Prophyla | 1997 |
[Early neutropenia during treatment by metronidazole].
Topics: Adult; Agranulocytosis; Drug Hypersensitivity; Female; Humans; Metronidazole; Neutropenia | 1979 |
Metronidazole hypersensitivity and oral desensitization.
Topics: Adult; Desensitization, Immunologic; Drug Hypersensitivity; Female; Humans; Metronidazole | 1991 |
Gas gangrene.
Topics: Drug Hypersensitivity; Gas Gangrene; Humans; Metronidazole; Penicillins | 1988 |
[A case of allergic reaction to trichopol in the treatment of urogenital trichomoniasis].
Topics: Adult; Drug Hypersensitivity; Female; Humans; Metronidazole; Trichomonas Vaginitis | 1973 |