metronidazole has been researched along with Acute Febrile Neutrophilic Dermatosis in 2 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 39-year-old woman with chronic, recurrent Sweet's syndrome (acute febrile neutrophilic dermatosis) and possible Crohn's disease was successfully treated with oral metronidazole." | 3.69 | Oral metronidazole, an effective treatment for Sweet's syndrome in a patient with associated inflammatory bowel disease. ( Banet, DE; Callen, JP; McClave, SA, 1994) |
| "We describe a pediatric case of Sweet syndrome presenting 10 days after treatment with azathioprine." | 1.37 | Azathioprine hypersensitivity presenting as sweet syndrome in a child with ulcerative colitis. ( Choe, YH; Jang, KT; Kim, MJ, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, MJ | 1 |
| Jang, KT | 1 |
| Choe, YH | 1 |
| Banet, DE | 1 |
| McClave, SA | 1 |
| Callen, JP | 1 |
2 other studies available for metronidazole and Acute Febrile Neutrophilic Dermatosis
| Article | Year |
|---|---|
Azathioprine hypersensitivity presenting as sweet syndrome in a child with ulcerative colitis.
Topics: Azathioprine; Child; Colitis, Ulcerative; Drug Hypersensitivity; Female; Humans; Immunosuppressive A | 2011 |
Oral metronidazole, an effective treatment for Sweet's syndrome in a patient with associated inflammatory bowel disease.
Topics: Administration, Oral; Adult; Crohn Disease; Female; Humans; Metronidazole; Sweet Syndrome | 1994 |