metronidazole has been researched along with Middle Ear Inflammation in 20 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We reported a case of Gradenigo's syndrome in a child with an abscess of the left petrous apex and initial involvement of the carotid artery." | 1.51 | Gradenigo's syndrome with abscess of the petrous apex in pediatric patients: what is the best treatment? ( Aprile, F; Benazzo, M; Canzi, P; Foiadelli, T; Manfrin, M; Michev, A; Savasta, S, 2019) |
| "Lemierre syndrome is a disease that every pediatrician must know." | 1.35 | [Lemierre syndrome: a complication of an oropharyngeal infection]. ( Bailly, C; Berlioz, M; Boutté, P; Passalidou, P, 2008) |
| "The changes in management of intradural brain abscess at Groote Schuur Hospital for the 35 years 1952-1986 are reviewed." | 1.28 | Cranial intradural abscess management of 641 patients during the 35 years from 1952 to 1986. ( Keet, PC, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (45.00) | 18.7374 |
| 1990's | 3 (15.00) | 18.2507 |
| 2000's | 6 (30.00) | 29.6817 |
| 2010's | 2 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Savasta, S | 1 |
| Canzi, P | 1 |
| Aprile, F | 1 |
| Michev, A | 1 |
| Foiadelli, T | 1 |
| Manfrin, M | 1 |
| Benazzo, M | 1 |
| Deng, R | 1 |
| Fang, Y | 1 |
| Shen, J | 1 |
| Ou, X | 1 |
| Liuyan, W | 1 |
| Wan, B | 1 |
| Yuan, Y | 1 |
| Cheng, X | 1 |
| Shu, Y | 1 |
| Chen, B | 1 |
| Passalidou, P | 1 |
| Berlioz, M | 1 |
| Bailly, C | 1 |
| Boutté, P | 1 |
| Valla, F | 1 |
| Berchiche, C | 1 |
| Floret, D | 1 |
| Spitzer, C | 1 |
| Foltys, H | 1 |
| Lemmen, SW | 1 |
| Block, F | 1 |
| Giridharan, W | 1 |
| De, S | 1 |
| Osman, EZ | 1 |
| Amma, L | 1 |
| Hughes, J | 1 |
| McCormick, MS | 1 |
| Píno Rivero, V | 1 |
| Keituqwa Yáñez, T | 1 |
| Marcos García, M | 1 |
| Trinidad Ruiz, G | 1 |
| Pardo Romero, G | 1 |
| González Palomino, A | 1 |
| Blasco Huelva, A | 1 |
| Alonso-Ojembarrena, A | 1 |
| Amigo Bello, C | 1 |
| Martínez-Pérez, J | 1 |
| Rubio de Villanueva, JL | 1 |
| Browning, GG | 1 |
| Picozzi, G | 1 |
| Sweeney, G | 1 |
| Calder, IT | 1 |
| Jokipii, AM | 2 |
| Jokipii, L | 2 |
| Mann, W | 1 |
| Pelz, K | 1 |
| Beeden, AG | 1 |
| Willis, AT | 1 |
| Weiner, GM | 1 |
| Williams, B | 1 |
| Egelund, E | 1 |
| Bak-Pedersen, K | 1 |
| Karma, P | 1 |
| Ingham, HR | 1 |
| Selkon, JB | 1 |
| Roxby, CM | 1 |
| O'Grady, FW | 1 |
| Lambert, HP | 1 |
| Begent, RH | 1 |
| Keet, PC | 1 |
| Kristensen, S | 1 |
| Juul, A | 1 |
| Rosetzsky, A | 1 |
| Reynolds, MA | 1 |
| Hart, CA | 1 |
| Harris, F | 1 |
| Taitz, LS | 1 |
2 reviews available for metronidazole and Middle Ear Inflammation
| Article | Year |
|---|---|
[Bacterial meningitis as a complication of Fusobacterium necroforum infection in adults].
Topics: Adult; Anti-Bacterial Agents; Blood Glucose; Cerebrospinal Fluid Proteins; Diagnosis, Differential; | 2003 |
[Anerobic infections in otolaryngology (author's transl)].
Topics: Adult; Anaerobiosis; Bacteria; Bacterial Infections; Carcinoma, Squamous Cell; Cephalosporins; Chron | 1981 |
2 trials available for metronidazole and Middle Ear Inflammation
| Article | Year |
|---|---|
Effect of esterified hyaluronic acid as middle ear packing in tympanoplasty for adhesive otitis media.
Topics: Adult; Anti-Infective Agents; Cartilage; Ear, Middle; Esters; Female; Hearing Loss, Conductive; Huma | 2018 |
Role of anaerobes in chronic otitis media.
Topics: Adult; Anti-Bacterial Agents; Bacterial Infections; Chronic Disease; Gram-Negative Aerobic Bacteria; | 1983 |
16 other studies available for metronidazole and Middle Ear Inflammation
| Article | Year |
|---|---|
Gradenigo's syndrome with abscess of the petrous apex in pediatric patients: what is the best treatment?
Topics: Abscess; Anti-Bacterial Agents; Anti-Inflammatory Agents; Ceftriaxone; Child; Drug Therapy, Combinat | 2019 |
[Lemierre syndrome: a complication of an oropharyngeal infection].
Topics: Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Anti-Infective Agents; Cefotax | 2008 |
[Necrobacillosis and Lemierre's syndrome: case report].
Topics: Amoxicillin; Anti-Infective Agents; Brain Diseases; Child, Preschool; Female; Fusobacterium Infectio | 2003 |
Complicated otitis media caused by Fusobacterium necrophorum.
Topics: Anti-Infective Agents; Child, Preschool; Female; Fusobacterium Infections; Fusobacterium necrophorum | 2004 |
[Otogenic intracranial abscesses. Description of 6 cases].
Topics: Adult; Aged; Anti-Bacterial Agents; Anti-Infective Agents; Brain Abscess; Cefotaxime; Cilastatin; Ci | 2004 |
[Sigmoid sinus thrombosis following otitis media].
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Cefotaxime; Child, Preschool; Drug Therapy, Combinatio | 2006 |
Metronidazole, tinidazole, ornidazole and anaerobic infections of the middle ear, maxillary sinus and central nervous system.
Topics: Bacterial Infections; Central Nervous System Diseases; Humans; Maxillary Sinus; Metronidazole; Nitro | 1981 |
A case of anaerobic middle ear infection with complications.
Topics: Bacterial Infections; Brain Abscess; Child; Humans; Male; Metronidazole; Otitis Media; Otitis Media, | 1980 |
Prevention of intracranial problems in ear and sinus surgery: a possible role for cefotaxime.
Topics: Bacteria; Brain Abscess; Cefotaxime; Chloramphenicol; Empyema, Subdural; Humans; Metronidazole; Micr | 1993 |
Suppurative labyrinthitis caused by anaerobic bacteria.
Topics: Aged; Bacteroides fragilis; Bacteroides Infections; Chronic Disease; Female; Gram-Positive Bacterial | 1994 |
Access of metronidazole into the chronically inflamed middle ear with reference to anaerobic bacterial infections.
Topics: Administration, Oral; Bacteroides; Exudates and Transudates; Humans; Metronidazole; Otitis Media | 1978 |
The bacteriology and chemotherapy of otogenic cerebral abscesses.
Topics: Adolescent; Adult; Anaerobiosis; Bacteroides fragilis; Bacteroides Infections; Brain Abscess; Chroni | 1978 |
Sensible prescribing. III. Acute otitis media and sore throat.
Topics: Amphotericin B; Ampicillin; Anti-Bacterial Agents; Aspirin; Cephalexin; Drug Prescriptions; Erythrom | 1975 |
Cranial intradural abscess management of 641 patients during the 35 years from 1952 to 1986.
Topics: Brain Abscess; Brain Injuries; Glasgow Coma Scale; Humans; Metronidazole; Otitis Media; Prognosis; T | 1990 |
Metronidazole uptake in the cholesteatomatous membrane in chronic otitis media.
Topics: Adult; Aged; Cholesteatoma; Chromatography, High Pressure Liquid; Ear Diseases; Ear, Middle; Female; | 1986 |
Anaerobes in acute otitis media.
Topics: Bacteria, Anaerobic; Bacteroides Infections; Child; Child, Preschool; Eikenella corrodens; Fusobacte | 1985 |