metronidazole has been researched along with Anus Diseases in 19 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Anus Diseases: Diseases involving the ANUS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate, in a prospective, open-label study, the influence of antibiotics and azathioprine on the clinical outcome of perianal fistulas in patients with Crohn's disease." | 9.10 | Antibiotics and azathioprine for the treatment of perianal fistulas in Crohn's disease. ( Dejaco, C; Harrer, M; Miehsler, W; Reinisch, W; Vogelsang, H; Waldhoer, T, 2003) |
| "88 Patients who had previously been in a prospective random control trial of two regimens of antibiotic treatment (ampicillin and metronidazole for one compared with four days) before incision, curettage, and primary closure of perianal abscess or pilonidal sinus." | 9.07 | Outcome at three to five years of primary closure of perianal and pilonidal abscess. A randomised, double-blind clinical trial with a complete three-year followup of one compared with four days' treatment with ampicillin and metronidazole. ( Gottrup, F; Lundhus, E, 1993) |
| "To evaluate, in a prospective, open-label study, the influence of antibiotics and azathioprine on the clinical outcome of perianal fistulas in patients with Crohn's disease." | 5.10 | Antibiotics and azathioprine for the treatment of perianal fistulas in Crohn's disease. ( Dejaco, C; Harrer, M; Miehsler, W; Reinisch, W; Vogelsang, H; Waldhoer, T, 2003) |
| "88 Patients who had previously been in a prospective random control trial of two regimens of antibiotic treatment (ampicillin and metronidazole for one compared with four days) before incision, curettage, and primary closure of perianal abscess or pilonidal sinus." | 5.07 | Outcome at three to five years of primary closure of perianal and pilonidal abscess. A randomised, double-blind clinical trial with a complete three-year followup of one compared with four days' treatment with ampicillin and metronidazole. ( Gottrup, F; Lundhus, E, 1993) |
| "Perianal pain was assessed on a visual analogue scale." | 2.75 | Randomized clinical trial of metronidazole ointment versus placebo in perianal Crohn's disease. ( Burt, C; Carapeti, E; Durdey, P; Maeda, Y; Mayberry, J; Moshkovska, T; Ng, SC; Rao, PK; Stone, CD; Torkington, J; Vaizey, CJ, 2010) |
| "Management of perianal Crohn's disease is still controversial, and reports on large series are very few in the literature." | 2.68 | Management of perianal Crohn's disease. Results of a multicenter study in Italy. ( Arcanà , F; Basso, L; Buffatti, P; Di Bella, F; Doldi, A; Forcheri, V; Gaetini, R; Interisano, A; Pera, A; Pescatori, M, 1995) |
| "Many patients with Crohn's disease present with the complications of infection." | 2.65 | Infection and the use of antibiotics in Crohn's disease. ( Keighley, MR, 1984) |
| "Perianal involvement in Crohn's disease is common but often mild and asymptomatic." | 2.40 | Perianal Crohn's disease. ( Hyland, JM; O'Donoghue, DP, 1997) |
| "Appropriate treatment of perianal fistulas in Crohn's disease (CD) involves accurate anatomic evaluation." | 1.38 | Endoscopic ultrasound for perianal Crohn's disease: disease and fistula characteristics, and impact on therapy. ( Assulin, Y; Beer-Gabel, M; Chowers, Y; Lahat, A, 2012) |
| "Patients with symptomatic anorectal Crohn's disease were studied in a prospective, nonblinded, nonrandomized study to evaluate the efficacy of topical 10 percent metronidazole." | 1.33 | Efficacy of topical metronidazole (10 percent) in the treatment of anorectal Crohn's disease. ( Armstrong, D; Nicholson, TJ; Stringer, EE, 2005) |
| "Four cases of perianal group A streptococcal infection presented with typical features of this condition; but because of lack of recognition appropriate therapy was delayed." | 1.29 | Perianal group A streptococcal infection. ( Guppy, DH, 1993) |
| "The outcome of treatment of perianal Crohn's disease was assessed in 127 patients." | 1.29 | Perianal Crohn's disease--is it all bad news? ( Keenan, RA; McKee, RF, 1996) |
| "The mean age at diagnosis of Crohn's disease was 11." | 1.28 | Perianal complications of pediatric Crohn's disease. ( Bilik, R; Griffiths, AM; Palder, SB; Shandling, B; Sherman, P, 1991) |
| "Metastatic Crohn's disease is a rare cutaneous manifestation of intestinal Crohn's disease, for which existing treatment is unsatisfactory." | 1.27 | Metastatic Crohn's disease responding to metronidazole. ( Duhra, P; Paul, CJ, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (15.79) | 18.7374 |
| 1990's | 7 (36.84) | 18.2507 |
| 2000's | 5 (26.32) | 29.6817 |
| 2010's | 4 (21.05) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ghahramani, L | 1 |
| Minaie, MR | 1 |
| Arasteh, P | 1 |
| Hosseini, SV | 1 |
| Izadpanah, A | 1 |
| Bananzadeh, AM | 1 |
| Ahmadbeigi, M | 1 |
| Hooshanginejad, Z | 1 |
| Kiyak, G | 1 |
| Ergul, E | 1 |
| Celik, A | 1 |
| Maeda, Y | 1 |
| Ng, SC | 1 |
| Durdey, P | 1 |
| Burt, C | 1 |
| Torkington, J | 1 |
| Rao, PK | 1 |
| Mayberry, J | 1 |
| Moshkovska, T | 1 |
| Stone, CD | 1 |
| Carapeti, E | 1 |
| Vaizey, CJ | 1 |
| Brueseke, TJ | 1 |
| Lane, FL | 1 |
| Lahat, A | 1 |
| Assulin, Y | 1 |
| Beer-Gabel, M | 1 |
| Chowers, Y | 1 |
| Dejaco, C | 1 |
| Harrer, M | 1 |
| Waldhoer, T | 1 |
| Miehsler, W | 1 |
| Vogelsang, H | 1 |
| Reinisch, W | 1 |
| Stringer, EE | 1 |
| Nicholson, TJ | 1 |
| Armstrong, D | 1 |
| Singleton, JW | 1 |
| Keighley, MR | 1 |
| Pescatori, M | 1 |
| Interisano, A | 1 |
| Basso, L | 1 |
| Arcanà , F | 1 |
| Buffatti, P | 1 |
| Di Bella, F | 1 |
| Doldi, A | 1 |
| Forcheri, V | 1 |
| Gaetini, R | 1 |
| Pera, A | 1 |
| Lundhus, E | 1 |
| Gottrup, F | 1 |
| Guppy, DH | 1 |
| McKee, RF | 1 |
| Keenan, RA | 1 |
| O'Donoghue, DP | 1 |
| Hyland, JM | 1 |
| Shetty, AK | 1 |
| Udall, J | 1 |
| Schmidt-Sommerfeld, E | 1 |
| Yar'mov, N | 1 |
| Gachev, N | 1 |
| Petkov, K | 1 |
| Rouquette-Vincenti, I | 1 |
| Petitjeans, F | 1 |
| Villevieille, T | 1 |
| Szymczyszyn, P | 1 |
| Fangio, P | 1 |
| Baranger, B | 1 |
| Brinquin, L | 1 |
| Palder, SB | 1 |
| Shandling, B | 1 |
| Bilik, R | 1 |
| Griffiths, AM | 1 |
| Sherman, P | 1 |
| Duhra, P | 1 |
| Paul, CJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomised, Double-blind, Placebo-controlled Trial Evaluating the Effects of Metronidazole Ointment in Facilitating Resolution of Non-healing Pilonidal Sinus Wounds.[NCT04273997] | Phase 2 | 80 participants (Anticipated) | Interventional | 2021-10-01 | Not yet recruiting | ||
| Phase III Study to Evaluate the Effect of 10% Metronidazole Ointment, Applied Topically Three Times a Day in and Around the Anus and the Change in Perianal Crohn's Disease Activity[NCT00509639] | Phase 3 | 74 participants (Actual) | Interventional | 2005-05-31 | Completed | ||
| Investigation of Sexual Function in Crohn's Disease Patients With Perianal Fistulas[NCT01635543] | 0 participants (Actual) | Observational | 2011-10-31 | Withdrawn (stopped due to This study was terminated due to some challenges in recruitment process) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for metronidazole and Anus Diseases
| Article | Year |
|---|---|
Perianal Crohn's disease.
Topics: Anus Diseases; Crohn Disease; Fissure in Ano; Humans; Hyperbaric Oxygenation; Immunosuppressive Agen | 1997 |
6 trials available for metronidazole and Anus Diseases
| Article | Year |
|---|---|
Antibiotic therapy for prevention of fistula in-ano after incision and drainage of simple perianal abscess: A randomized single blind clinical trial.
Topics: Abscess; Anti-Bacterial Agents; Antibiotic Prophylaxis; Anus Diseases; Ciprofloxacin; Drainage; Huma | 2017 |
Randomized clinical trial of metronidazole ointment versus placebo in perianal Crohn's disease.
Topics: Administration, Topical; Adult; Anti-Bacterial Agents; Anus Diseases; Crohn Disease; Double-Blind Me | 2010 |
Randomized clinical trial of metronidazole ointment versus placebo in perianal Crohn's disease.
Topics: Administration, Topical; Adult; Anti-Bacterial Agents; Anus Diseases; Crohn Disease; Double-Blind Me | 2010 |
Randomized clinical trial of metronidazole ointment versus placebo in perianal Crohn's disease.
Topics: Administration, Topical; Adult; Anti-Bacterial Agents; Anus Diseases; Crohn Disease; Double-Blind Me | 2010 |
Randomized clinical trial of metronidazole ointment versus placebo in perianal Crohn's disease.
Topics: Administration, Topical; Adult; Anti-Bacterial Agents; Anus Diseases; Crohn Disease; Double-Blind Me | 2010 |
Antibiotics and azathioprine for the treatment of perianal fistulas in Crohn's disease.
Topics: Adjuvants, Immunologic; Adolescent; Adult; Aged; Anti-Bacterial Agents; Anus Diseases; Azathioprine; | 2003 |
Infection and the use of antibiotics in Crohn's disease.
Topics: Abscess; Anus Diseases; Bacterial Infections; Clinical Trials as Topic; Crohn Disease; Drug Combinat | 1984 |
Management of perianal Crohn's disease. Results of a multicenter study in Italy.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Aminosalicylic Acids; Anti-Bact | 1995 |
Outcome at three to five years of primary closure of perianal and pilonidal abscess. A randomised, double-blind clinical trial with a complete three-year followup of one compared with four days' treatment with ampicillin and metronidazole.
Topics: Abscess; Ampicillin; Anus Diseases; Chi-Square Distribution; Combined Modality Therapy; Double-Blind | 1993 |
12 other studies available for metronidazole and Anus Diseases
| Article | Year |
|---|---|
Spontaneous rupture of the rectum with evisceration of small intestine through the anus.
Topics: Aged; Anal Canal; Anti-Bacterial Agents; Anti-Infective Agents; Anus Diseases; Ceftriaxone; Female; | 2008 |
Ischiorectal fossa abscess after pelvic floor injection of botulinum toxin.
Topics: Abscess; Ampicillin; Anti-Bacterial Agents; Anti-Dyskinesia Agents; Anus Diseases; Botulinum Toxins; | 2012 |
Endoscopic ultrasound for perianal Crohn's disease: disease and fistula characteristics, and impact on therapy.
Topics: Abscess; Adolescent; Adrenal Cortex Hormones; Adult; Aged; Anti-Infective Agents; Anti-Inflammatory | 2012 |
Efficacy of topical metronidazole (10 percent) in the treatment of anorectal Crohn's disease.
Topics: Administration, Topical; Adult; Aged; Anti-Infective Agents; Anus Diseases; Crohn Disease; Female; H | 2005 |
Medical therapy of inflammatory bowel disease.
Topics: Acute Disease; Adjuvants, Immunologic; Anus Diseases; Azathioprine; Colitis, Ulcerative; Crohn Disea | 1980 |
Perianal group A streptococcal infection.
Topics: Anus Diseases; Child; Child, Preschool; Erythromycin Ethylsuccinate; Family Health; Humans; Male; Me | 1993 |
Perianal Crohn's disease--is it all bad news?
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Antimetabolites; Antitrichomona | 1996 |
Highly destructive perianal Crohn's disease.
Topics: Adolescent; Anti-Infective Agents; Anti-Inflammatory Agents; Anus Diseases; Ciprofloxacin; Colostomy | 1998 |
[Case of an HIV-patient with advanced form of perianal hidradenitis].
Topics: Adult; Anus Diseases; Hidradenitis; HIV Infections; Humans; Male; Metronidazole; Proctitis; Sigmoido | 2000 |
[Obesity, diabetes mellitus, and gas gangrene: a major therapeutic challenge].
Topics: Abscess; Amikacin; Anus Diseases; Buttocks; Candidiasis; Ceftazidime; Colostomy; Combined Modality T | 2001 |
Perianal complications of pediatric Crohn's disease.
Topics: Abscess; Adolescent; Anus Diseases; Child; Child, Preschool; Crohn Disease; Female; Fissure in Ano; | 1991 |
Metastatic Crohn's disease responding to metronidazole.
Topics: Anus Diseases; Crohn Disease; Female; Humans; Metronidazole; Middle Aged; Vulva; Vulvar Diseases | 1988 |