metronidazole has been researched along with Mouth Diseases in 31 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Mouth Diseases: Diseases involving the MOUTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The penicillin-metronidazole combination is well tried antibiotic therapy for the treatment of inflammations of dental origin." | 3.69 | [The role of dalacin C in the management of odontogenic inflammations]. ( Gyenes, V; Sülle, T, 1995) |
| "Histoplasmosis is a frequent complication of HIV infection and is usually the result of reactivation." | 2.39 | Oral histoplasmosis in a patient infected with HIV. A case report. ( Durham, T; Johansson, SL; Kaufman, L; Swindells, S, 1994) |
| "Metronidazole has important interactions with alcohol, disulfiram and warfarin and there are contraindications to its use." | 2.37 | Metronidazole: its use in clinical dentistry. ( Mitchell, DA, 1984) |
| "Metronidazole alone was ineffective against facultative anaerobic biofilms, but the presence of LL-37 and Lactoferricin led to a greater biofilm reduction." | 1.62 | Targeting antibiotic tolerance in anaerobic biofilms associated with oral diseases: Human antimicrobial peptides LL-37 and lactoferricin enhance the antibiotic efficacy of amoxicillin, clindamycin and metronidazole. ( Hickel, R; Huth, KC; Kollmuss, M; Wuersching, SN, 2021) |
| "Amoxicillin was the most frequently prescribed antibiotic." | 1.32 | Pattern of antibiotic prescription in the management of oral diseases among dentists in Kuwait. ( Adib, SM; Al-Mutawa, S; Rotimi, VO; Salako, NO, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (51.61) | 18.7374 |
| 1990's | 7 (22.58) | 18.2507 |
| 2000's | 4 (12.90) | 29.6817 |
| 2010's | 3 (9.68) | 24.3611 |
| 2020's | 1 (3.23) | 2.80 |
| Authors | Studies |
|---|---|
| Wuersching, SN | 1 |
| Huth, KC | 1 |
| Hickel, R | 1 |
| Kollmuss, M | 1 |
| Del Carmen Martínez-Herrero, M | 1 |
| González-González, F | 1 |
| López-Márquez, I | 1 |
| García-Peña, FJ | 1 |
| Sansano-Maestre, J | 1 |
| Martínez-Díaz, RA | 1 |
| Ponce-Gordo, F | 1 |
| Garijo-Toledo, MM | 1 |
| Gómez-Muñoz, MT | 1 |
| Bali, R | 1 |
| Sharma, P | 1 |
| Gaba, S | 1 |
| Bergquist, R | 1 |
| Rao, DD | 1 |
| Desai, A | 1 |
| Kulkarni, RD | 1 |
| Gopalkrishnan, K | 1 |
| Rao, CB | 1 |
| Salako, NO | 1 |
| Rotimi, VO | 1 |
| Adib, SM | 1 |
| Al-Mutawa, S | 1 |
| Mitchell, DA | 1 |
| Meyer, FU | 1 |
| Amon, I | 1 |
| Tandon, S | 1 |
| Guidicelli, J | 1 |
| Terestri, P | 1 |
| Miotti, A | 1 |
| Lewis, R | 1 |
| McKenzie, D | 1 |
| Bagg, J | 1 |
| Dickie, A | 1 |
| Barrett, AP | 1 |
| Schifter, M | 1 |
| Swindells, S | 1 |
| Durham, T | 1 |
| Johansson, SL | 1 |
| Kaufman, L | 1 |
| Karlowsky, J | 1 |
| Ferguson, J | 1 |
| Zhanel, G | 1 |
| Gyenes, V | 1 |
| Sülle, T | 1 |
| Segelman, AE | 1 |
| Reiss, M | 1 |
| Reiss, G | 1 |
| Weeda, LW | 1 |
| Miglani, DC | 2 |
| Subramanian, S | 2 |
| Paramasivan, CN | 2 |
| Jayanthi, S | 2 |
| Rajasekher, A | 1 |
| Coco, JW | 1 |
| Pankey, GA | 1 |
| Brook, I | 1 |
| Balogh, G | 1 |
| Cekić-Arambasin, A | 1 |
| Durcević-matić, A | 1 |
| Beltrami, T | 1 |
| Videau, D | 1 |
| Blanchard, JC | 1 |
| Sebald, M | 1 |
| Finegold, SM | 1 |
| Rosenblatt, JE | 1 |
| Dangy, J | 1 |
| Tosani, B | 1 |
| Palfer-Sollier, M | 1 |
| Chikhani, P | 1 |
7 reviews available for metronidazole and Mouth Diseases
| Article | Year |
|---|---|
Parasitic infections affecting the oral cavity.
Topics: Animals; Antiparasitic Agents; Entamoeba; Humans; Leishmaniasis; Metronidazole; Mouth Diseases; Para | 2009 |
Metronidazole: its use in clinical dentistry.
Topics: Aggressive Periodontitis; Bacteria, Anaerobic; Drug Interactions; Gingivitis; Humans; Kinetics; Metr | 1984 |
Oral histoplasmosis in a patient infected with HIV. A case report.
Topics: Adult; AIDS-Related Opportunistic Infections; Fluconazole; Histoplasmosis; Humans; Male; Metronidazo | 1994 |
A review of commonly prescribed oral antibiotics in general dentistry.
Topics: Administration, Oral; Anti-Bacterial Agents; Bacteria, Anaerobic; Bacterial Infections; Cephalospori | 1993 |
Review of metronidazole use in dentistry.
Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Clinical Trials as Topic; Humans; Metronidazol | 1997 |
[Bad breath--etiological, diagnostic and therapeutic problems].
Topics: Anti-Bacterial Agents; Diagnosis, Differential; Gastrointestinal Diseases; Halitosis; Humans; Lung D | 2000 |
The use of antimicrobials in dentistry.
Topics: Adolescent; Adult; Ambulatory Care; Amoxicillin; Anti-Bacterial Agents; Child; Dental Care; Doxycycl | 1989 |
5 trials available for metronidazole and Mouth Diseases
| Article | Year |
|---|---|
Use of metronidazole as part of an empirical antibiotic regimen after incision and drainage of infections of the odontogenic spaces.
Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Anti-Infective Agents; Bacteriological Techniq | 2015 |
Comparative study of the effectiveness of metronidazole, and spiramycin on the bacterial isolates in cases of ANUG and mixed oral infection.
Topics: Bacteria; Clinical Trials as Topic; Gingivitis, Necrotizing Ulcerative; Humans; Leucomycins; Metroni | 1975 |
Effect of metronidazole and spiramycin in cases of ANUG and mixed oral infection--a double blind clinical trial.
Topics: Clinical Trials as Topic; Double-Blind Method; Gingivitis, Necrotizing Ulcerative; Humans; Leucomyci | 1975 |
[Open, noncomparative multicenter study of the efficacy and tolerance of a spiramycin-metronidazole combination used in infectious oral pathology].
Topics: Bacterial Infections; Cellulitis; Drug Combinations; Dry Socket; Edema; Humans; Metronidazole; Mouth | 1991 |
[Bucco-dental flora. Sensitivity to antibiotics and value of the spiramycin-metronidazole combination].
Topics: Aerobiosis; Anaerobiosis; Bacteria; Bacterial Infections; Clinical Trials as Topic; Drug Synergism; | 1973 |
19 other studies available for metronidazole and Mouth Diseases
| Article | Year |
|---|---|
Targeting antibiotic tolerance in anaerobic biofilms associated with oral diseases: Human antimicrobial peptides LL-37 and lactoferricin enhance the antibiotic efficacy of amoxicillin, clindamycin and metronidazole.
Topics: Amoxicillin; Anti-Bacterial Agents; Antimicrobial Peptides; Bacteria, Anaerobic; Bacterial Infection | 2021 |
Oropharyngeal Trichomonosis Due to Trichomonas gypaetinii in a Cinereous Vulture ( Aegypius monachus) Fledgling in Spain.
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Falconiformes; Metronidazole; Mouth Diseases; | 2019 |
Comparison of maxillofacial space infection in diabetic and nondiabetic patients.
Topics: Adolescent; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Case-Control Studi | 2010 |
Pattern of antibiotic prescription in the management of oral diseases among dentists in Kuwait.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Bacterial Infections; Clinical Com | 2004 |
[The use of metronidazole (Vagimid) in odontogenic infections].
Topics: Bacterial Infections; Humans; Metronidazole; Mouth Diseases | 1983 |
Clinical experience with metronidazole in anaerobic oro-dental infections.
Topics: Adolescent; Adult; Anaerobiosis; Bacterial Infections; Child; Female; Humans; Male; Metronidazole; M | 1980 |
[Therapeutic properties of a specific antibiotic in diseases of the mouth. Apropos of 52 cases].
Topics: Adolescent; Adult; Aged; Drug Combinations; Drug Evaluation; Female; Humans; Leucomycins; Male; Metr | 1980 |
[Metronidazole in dentistry].
Topics: Gingivitis; Humans; Metronidazole; Mouth Diseases; Periodontal Diseases | 1982 |
Experience with a novel selective medium for isolation of Actinomyces spp. from medical and dental specimens.
Topics: Actinomyces; Actinomycosis; Bacterial Typing Techniques; Bacteriological Techniques; Culture Media; | 1995 |
Antibiotic strategy in orofacial/head and neck infections in severe neutropenia.
Topics: Adolescent; Adult; Aged; Aminoglycosides; Anti-Bacterial Agents; Bacterial Infections; Clinical Prot | 1994 |
[The role of dalacin C in the management of odontogenic inflammations].
Topics: Bacteria, Aerobic; Bacteria, Anaerobic; Clindamycin; Drug Resistance, Microbial; Humans; Inflammatio | 1995 |
Erythromycin and amoxicillin?
Topics: Amoxicillin; Anti-Bacterial Agents; Bacteria, Anaerobic; Bacterial Infections; Cephalosporins; Clind | 2001 |
Anaerobic infections in childhood.
Topics: Bacteria, Anaerobic; Bacterial Infections; Bacteroides fragilis; Brain Abscess; Cephalosporins; Chil | 1986 |
Examination of Kliostom in the prophylaxis of oral surgery cases and treatment of microbial diseases of the oral mucosa.
Topics: Administration, Topical; Adolescent; Adult; Aged; Bacterial Infections; Dentistry, Operative; Drug C | 1986 |
[The possibilities of drug therapy in oral lichen ruber].
Topics: Adrenal Cortex Hormones; Adult; Aged; Female; Humans; Lichen Planus; Male; Metronidazole; Middle Age | 1985 |
[Experimentation on the joint therapeutic action of spiramycin and metronidazole].
Topics: Dentistry; Leucomycins; Metronidazole; Mouth Diseases | 1972 |
Practical aspects of anaerobic sepsis.
Topics: Abscess; Anaerobiosis; Arthritis, Infectious; Bacterial Infections; Bacteroides; Bone Diseases; Brai | 1973 |
[A new anti-infective agent in dentistry].
Topics: Dentistry; Leucomycins; Metronidazole; Mouth Diseases | 1971 |
[A highly synergistic antibacterial combination].
Topics: Drug Synergism; Humans; Jaw Diseases; Leucomycins; Metronidazole; Mouth Diseases | 1971 |