metronidazole has been researched along with Bone Marrow Neoplasms in 1 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Bone Marrow Neoplasms: Neoplasms located in the bone marrow. They are differentiated from neoplasms composed of bone marrow cells, such as MULTIPLE MYELOMA. Most bone marrow neoplasms are metastatic.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with metronidazole successfully eliminated the protozoa and cured the pyothorax." | 1.30 | Trichomonas tenax empyema in an immunocompromised patient with advanced cancer. ( Arizono, N; Morimoto, T; Nakao, K; Shimatsu, A; Shiota, T, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shiota, T | 1 |
| Arizono, N | 1 |
| Morimoto, T | 1 |
| Shimatsu, A | 1 |
| Nakao, K | 1 |
1 other study available for metronidazole and Bone Marrow Neoplasms
| Article | Year |
|---|---|
Trichomonas tenax empyema in an immunocompromised patient with advanced cancer.
Topics: Acromegaly; Adenocarcinoma; Animals; Antitrichomonal Agents; Bone Marrow Neoplasms; Brain Neoplasms; | 1998 |