metronidazole has been researched along with Tetanus in 37 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Tetanus: A disease caused by tetanospasmin, a powerful protein toxin produced by CLOSTRIDIUM TETANI. Tetanus usually occurs after an acute injury, such as a puncture wound or laceration. Generalized tetanus, the most common form, is characterized by tetanic muscular contractions and hyperreflexia. Localized tetanus presents itself as a mild condition with manifestations restricted to muscles near the wound. It may progress to the generalized form.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A prospective, open, non-randomised clinical trial was carried out to compare the efficacy of procaine penicillin with metronidazole in the treatment of moderate tetanus among 173 patients." | 9.05 | Treatment of tetanus: an open study to compare the efficacy of procaine penicillin and metronidazole. ( Ahmadsyah, I; Salim, A, 1985) |
| "An 83-year-old man presented to the acute cardiac care unit with a painful left arm and jaw." | 7.96 | [An unvaccinated man with a painful arm and jaw]. ( de Vries, PJ; Herderscheê, D; Lionarons, DA; Röttgering, JG, 2020) |
| "Metronidazole has therefore been suggested as an alternative." | 6.71 | Benzathine penicillin, metronidazole and benzyl penicillin in the treatment of tetanus: a randomized, controlled trial. ( Ganesh Kumar, AV; Karnad, DR; Kothari, VM; Krishnan, A, 2004) |
| "A prospective, open, non-randomised clinical trial was carried out to compare the efficacy of procaine penicillin with metronidazole in the treatment of moderate tetanus among 173 patients." | 5.05 | Treatment of tetanus: an open study to compare the efficacy of procaine penicillin and metronidazole. ( Ahmadsyah, I; Salim, A, 1985) |
| "An 83-year-old man presented to the acute cardiac care unit with a painful left arm and jaw." | 3.96 | [An unvaccinated man with a painful arm and jaw]. ( de Vries, PJ; Herderscheê, D; Lionarons, DA; Röttgering, JG, 2020) |
| "The assessment of modifications in the tetanus treatment, which included using metronidazol and midazolam instead penicillin and diazepam, was presented." | 3.70 | [Modifications in treatment of tetanus and prognosis--observations from the Cracow Department of Infectious Diseases]. ( Bociaga-Jasik, M; Caban, J; Garlicki, A; Kluba-Wojewoda, U; Krukowiecki, J, 1999) |
| "The patient received treatment with anti-tetanus globulin and metronidazole; sound insulation and shielding were also performed in a dark room." | 2.72 | Non-surgical treatment of tetanus infection associated with breast cancer skin ulcer: a case report and literature review. ( Aisaka, W; Narimatsu, E; Nomura, K; Okamoto, H; Sakawaki, E; Sakawaki, S; Takeyama, Y; Uemura, S; Yamaoka, A, 2021) |
| "Metronidazole has therefore been suggested as an alternative." | 2.71 | Benzathine penicillin, metronidazole and benzyl penicillin in the treatment of tetanus: a randomized, controlled trial. ( Ganesh Kumar, AV; Karnad, DR; Kothari, VM; Krishnan, A, 2004) |
| "Successful treatment of tetanus depends on prompt diagnosis of clinical tetanus, treatment to ensure neutralization of circulating toxin and elimination of C." | 2.47 | Narrative review: tetanus-a health threat after natural disasters in developing countries. ( Afshar, M; Ansell, D; Bleck, TP; Raju, M, 2011) |
| "Since many of the wounds from which tetanus arises are minor, patients may not bring them to medical attention." | 2.38 | Tetanus. A threat to elderly patients. ( Kellerman, RD; Lichtenhan, JB; Richards, JF, 1992) |
| "Tetanus is a life-threatening infectious neurological condition that has become uncommon due to large-scale immunization campaigns." | 1.91 | Case Report: A Challenging Case of Tetanus Presenting with Headache. ( Azlan, EAM; Ismail, M; Pathi, NM; Rahim, AIA; Rahman, MR; Sulaiman, WAW, 2023) |
| "He was successfully treated with tetanus antitoxin without any adverse events." | 1.62 | Cephalic tetanus manifesting as isolated facial nerve palsy- a case report from rural Armenia. ( Acharya, D; Arakelyan, A; Gautam, J; Kishmiryan, A; Ohanyan, A; Shoura, S; Singh, BM; Vahanyan, A, 2021) |
| "Tetanus is a preventable infectious disease with vaccination." | 1.56 | Cephalic Tetanus: A Rare Case Report. ( Bağcı, Z, 2020) |
| "She quickly developed dysphagia and odynophagia with subsequent generalised spasms and profound hypoxic respiratory failure requiring nasotracheal intubation." | 1.51 | Return of the old guard: a case of tetanus in an unvaccinated patient. ( Gega, A; Ibe, U; Jiwa, N; Rehmani, S, 2019) |
| "Tetanus is a severe infectious disease that can lead to death." | 1.46 | An unusual complication of the traditional treatment of a closed fracture - generalized tetanus: a case report. ( Danwang, C; Essomba, A; Guifo, ML; Kalla, GC; Ndame, EK; Tchuenkam, LW, 2017) |
| "Tetanus is a rare diagnosis in the developed world but sporadic cases do occur." | 1.40 | Cephalic tetanus complicating geriatric fall. ( La Varis, T; Mason, D; McCabe, J, 2014) |
| "Tetanus is a neuromuscular disease in which Clostridium tetani exotoxin (tetanospasmin) produces muscle spasms, incapacitating its host." | 1.39 | Clostridium tetani bacteraemia. ( Afridi, M; Boghossian, J; Hallit, RR; Salem, E; Sison, R; Slim, J, 2013) |
| "On examination he was noted to have trismus, generalised muscle spasms, diaphoresis and emotional lability and he was diagnosed with generalised tetanus." | 1.36 | Generalised tetanus in an unvaccinated adult. ( Cavanagh, S; Fleming, C; Muldoon, EG, 2010) |
| " Treatment with penicillin G was very effective in the acute stage, and chronic administration of metronidazole prevented relapse of the disease." | 1.35 | An unusual case of chronic relapsing tetanus associated with mandibular osteomyelitis. ( Fujimuro, M; Jackson, M; Kawarabayashi, T; Kimura, T; Matsubara, E; Nakahata, N; Seino, Y; Shirahama, I; Shoji, M; Suzuki, C; Takamura, A; Tomiyama, M; Wakasaya, Y; Watanabe, M; Yamamoto-Watanabe, Y, 2009) |
| "The patient was initially treated for tetanus and aspiration pneumonia with a guarded prognosis." | 1.33 | Tetanus, pneumonia, and malaria in a tsunami victim in Banda Aceh, Indonesia. ( Hanley, MR; O'Regan, W; Squires, S; Tate, C, 2006) |
| "Metronidazole was used in addition to benzyl penicillin in 9 patients." | 1.32 | Tetanus experience in a public hospital in Western Saudi Arabia. ( Ayyub, M; Khazindar, AM; Lubbad, EH, 2003) |
| "The patient was successfully treated for Tetanus with complete recovery." | 1.32 | Case report of tetanus in an immunized, healthy adult and no point of entry. ( Erogul, M; Hahn, BJ; Sinert, R, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (8.11) | 18.7374 |
| 1990's | 4 (10.81) | 18.2507 |
| 2000's | 9 (24.32) | 29.6817 |
| 2010's | 15 (40.54) | 24.3611 |
| 2020's | 6 (16.22) | 2.80 |
| Authors | Studies |
|---|---|
| Kishmiryan, A | 1 |
| Gautam, J | 1 |
| Acharya, D | 1 |
| Singh, BM | 1 |
| Ohanyan, A | 1 |
| Arakelyan, A | 1 |
| Vahanyan, A | 1 |
| Shoura, S | 1 |
| Rahim, AIA | 1 |
| Azlan, EAM | 1 |
| Rahman, MR | 1 |
| Pathi, NM | 1 |
| Ismail, M | 1 |
| Sulaiman, WAW | 1 |
| Niu, KY | 1 |
| Lin, YK | 1 |
| Nascimento, FA | 1 |
| Hammoud, N | 1 |
| Augusto, FD | 1 |
| Bağcı, Z | 1 |
| Röttgering, JG | 1 |
| Herderscheê, D | 1 |
| Lionarons, DA | 1 |
| de Vries, PJ | 1 |
| Nomura, K | 1 |
| Sakawaki, E | 1 |
| Sakawaki, S | 1 |
| Yamaoka, A | 1 |
| Aisaka, W | 1 |
| Okamoto, H | 1 |
| Takeyama, Y | 1 |
| Uemura, S | 1 |
| Narimatsu, E | 1 |
| Papageorgiou, V | 1 |
| Kazakos, G | 2 |
| Anagnostou, T | 1 |
| Polizopoulou, Z | 1 |
| Carter, C | 1 |
| Viveash, S | 1 |
| Tchuenkam, LW | 1 |
| Ndame, EK | 1 |
| Guifo, ML | 1 |
| Danwang, C | 1 |
| Kalla, GC | 1 |
| Essomba, A | 1 |
| Gelbart, D | 1 |
| Ibe, U | 1 |
| Rehmani, S | 1 |
| Jiwa, N | 1 |
| Gega, A | 1 |
| Cohen, R | 1 |
| McCabe, J | 1 |
| La Varis, T | 1 |
| Mason, D | 1 |
| Mitchell, L | 1 |
| Adams, W | 1 |
| Aspesberro, F | 1 |
| Muldoon, EG | 1 |
| Cavanagh, S | 1 |
| Fleming, C | 1 |
| Wakasaya, Y | 1 |
| Watanabe, M | 1 |
| Tomiyama, M | 1 |
| Suzuki, C | 1 |
| Jackson, M | 1 |
| Fujimuro, M | 1 |
| Kimura, T | 1 |
| Seino, Y | 1 |
| Kawarabayashi, T | 1 |
| Yamamoto-Watanabe, Y | 1 |
| Matsubara, E | 1 |
| Shirahama, I | 1 |
| Takamura, A | 1 |
| Nakahata, N | 1 |
| Shoji, M | 1 |
| Livorsi, DJ | 1 |
| Eaton, M | 1 |
| Glass, J | 1 |
| Afshar, M | 1 |
| Raju, M | 1 |
| Ansell, D | 1 |
| Bleck, TP | 1 |
| Montes, MI | 1 |
| Hernández Ortiz, OH | 1 |
| Guerra Palacio, A | 1 |
| Langner, KF | 1 |
| Schenk, HC | 1 |
| Leithaeuser, C | 1 |
| Tholen, H | 1 |
| Simon, D | 1 |
| Hallit, RR | 1 |
| Afridi, M | 1 |
| Sison, R | 1 |
| Salem, E | 1 |
| Boghossian, J | 1 |
| Slim, J | 1 |
| Polizopoulou, ZS | 1 |
| Georgiadis, G | 1 |
| Soubasis, N | 1 |
| Koutinas, Ch | 1 |
| Koutinas, AF | 1 |
| Baral, RM | 1 |
| Catt, MJ | 1 |
| Malik, R | 1 |
| Lubbad, EH | 1 |
| Khazindar, AM | 1 |
| Ayyub, M | 1 |
| Ganesh Kumar, AV | 1 |
| Kothari, VM | 1 |
| Krishnan, A | 1 |
| Karnad, DR | 1 |
| Hahn, BJ | 1 |
| Erogul, M | 1 |
| Sinert, R | 1 |
| Blaich, A | 1 |
| Hellwig, B | 1 |
| Bogdan, C | 1 |
| Hanley, MR | 1 |
| O'Regan, W | 1 |
| Squires, S | 1 |
| Tate, C | 1 |
| Herrman, H | 1 |
| Braekhus, A | 1 |
| Aaserud, O | 1 |
| Aukrust, P | 1 |
| Stubhaug, A | 1 |
| Hassel, B | 1 |
| Willis, AT | 1 |
| Golledge, C | 1 |
| Rüttimann, S | 1 |
| Garlicki, A | 1 |
| Caban, J | 1 |
| Bociaga-Jasik, M | 1 |
| Kluba-Wojewoda, U | 1 |
| Krukowiecki, J | 1 |
| Lichtenhan, JB | 1 |
| Kellerman, RD | 1 |
| Richards, JF | 1 |
| Ahmadsyah, I | 1 |
| Salim, A | 1 |
| Freeman, WA | 1 |
| McFadzean, JA | 1 |
| Whelan, JP | 1 |
3 reviews available for metronidazole and Tetanus
| Article | Year |
|---|---|
Non-surgical treatment of tetanus infection associated with breast cancer skin ulcer: a case report and literature review.
Topics: Breast Neoplasms; Female; Humans; Lymphatic Metastasis; Metronidazole; Middle Aged; Neoplasm Recurre | 2021 |
Narrative review: tetanus-a health threat after natural disasters in developing countries.
Topics: Anti-Infective Agents; Clostridium tetani; Developing Countries; Disasters; Disease Outbreaks; Endem | 2011 |
Tetanus. A threat to elderly patients.
Topics: Age Factors; Aged; Child; Clinical Protocols; Diagnosis, Differential; Female; Geriatrics; Humans; I | 1992 |
2 trials available for metronidazole and Tetanus
| Article | Year |
|---|---|
Benzathine penicillin, metronidazole and benzyl penicillin in the treatment of tetanus: a randomized, controlled trial.
Topics: Adult; Anti-Bacterial Agents; Anti-Infective Agents; Central Nervous System; Female; Humans; Length | 2004 |
Treatment of tetanus: an open study to compare the efficacy of procaine penicillin and metronidazole.
Topics: Clinical Trials as Topic; Clostridium tetani; Female; Humans; Length of Stay; Male; Metronidazole; P | 1985 |
32 other studies available for metronidazole and Tetanus
| Article | Year |
|---|---|
Cephalic tetanus manifesting as isolated facial nerve palsy- a case report from rural Armenia.
Topics: Aged; Anti-Bacterial Agents; Armenia; Bell Palsy; Diagnosis, Differential; Facial Paralysis; Humans; | 2021 |
Case Report: A Challenging Case of Tetanus Presenting with Headache.
Topics: Adult; Female; Headache; Humans; Metronidazole; Tetanus; Tetanus Toxoid; Trismus | 2023 |
Generalized tetanus.
Topics: Anti-Bacterial Agents; Ceftriaxone; Critical Care; Debridement; Humans; Male; Metronidazole; Middle | 2019 |
Teaching Video NeuroImages: Cephalic tetanus: Not every facial weakness is Bell palsy.
Topics: Anti-Bacterial Agents; Bell Palsy; Debridement; Diagnosis, Differential; Facial Injuries; Facial Mus | 2019 |
Cephalic Tetanus: A Rare Case Report.
Topics: Administration, Intravenous; Cranial Nerves; Female; Humans; Infant; Injections, Intramuscular; Metr | 2020 |
[An unvaccinated man with a painful arm and jaw].
Topics: Aged, 80 and over; Anti-Bacterial Agents; Arm; Clostridium tetani; Humans; Jaw; Male; Metronidazole; | 2020 |
The Role of Magnesium in the Management of Acute and Long-Term Symptoms Caused by Tetanus in Two Dogs.
Topics: Animals; Clostridium tetani; Dog Diseases; Dogs; Female; Magnesium; Magnesium Sulfate; Male; Metroni | 2021 |
Nursing a critically ill tetanus patient in an intensive care unit in Zambia.
Topics: Analgesics, Opioid; Anti-Infective Agents; Anticonvulsants; Back Pain; Critical Care Nursing; Critic | 2017 |
An unusual complication of the traditional treatment of a closed fracture - generalized tetanus: a case report.
Topics: Adolescent; Anti-Infective Agents; Fatal Outcome; Fractures, Closed; Humans; Male; Metronidazole; Te | 2017 |
Tetanus.
Topics: Airway Management; Bacterial Translocation; Brain; Clostridium tetani; gamma-Aminobutyric Acid; Huma | 2017 |
Return of the old guard: a case of tetanus in an unvaccinated patient.
Topics: Aged; Anti-Bacterial Agents; Deglutition Disorders; Female; Gastrostomy; Humans; Metronidazole; Resp | 2019 |
Risus sardonicus.
Topics: Adrenal Cortex Hormones; Aged, 80 and over; Benzodiazepines; Bronchodilator Agents; Female; Hospital | 2014 |
Cephalic tetanus complicating geriatric fall.
Topics: Accidental Falls; Aged, 80 and over; Anti-Infective Agents; Debridement; Facial Muscles; Female; For | 2014 |
Case 6: Episodic Stiffness in a 30-month-old Girl.
Topics: Anti-Infective Agents; Child, Preschool; Diagnosis, Differential; Female; Humans; Metronidazole; Mus | 2017 |
Generalised tetanus in an unvaccinated adult.
Topics: Aged; Anti-Bacterial Agents; Anti-Infective Agents; Clostridium tetani; Diazepam; Humans; Magnesium | 2010 |
An unusual case of chronic relapsing tetanus associated with mandibular osteomyelitis.
Topics: Anti-Bacterial Agents; Chronic Disease; Gallium Radioisotopes; Head and Neck Neoplasms; Humans; Lymp | 2009 |
Generalized tetanus despite prior vaccination and a protective level of anti-tetanus antibodies.
Topics: Adult; Anti-Bacterial Agents; Antibodies; Baclofen; Benzodiazepines; Humans; Immunoglobulins; Male; | 2010 |
[Electroencephalographic burst-suppression pattern due to baclofen intoxication].
Topics: Baclofen; Coma; Drug Overdose; Electroencephalography; Emergencies; Fatal Outcome; Female; Humans; I | 2011 |
Localised tetanus in a cat.
Topics: Animals; Anti-Bacterial Agents; Cat Diseases; Cats; Clostridium tetani; Debridement; Electromyograph | 2011 |
Clostridium tetani bacteraemia.
Topics: Aged, 80 and over; Anti-Bacterial Agents; Bacteremia; Clostridium tetani; Diphtheria-Tetanus Vaccine | 2013 |
Presumed localized tetanus in two cats.
Topics: Animals; Cat Diseases; Cats; Diagnosis, Differential; Diazepam; Electromyography; Forelimb; Male; Me | 2002 |
What is your diagnosis? Localised tetanus in a cat.
Topics: Animals; Anti-Bacterial Agents; Cat Diseases; Cats; Clostridium tetani; Diagnosis, Differential; Ele | 2002 |
Tetanus experience in a public hospital in Western Saudi Arabia.
Topics: Adult; Age Distribution; Aged; Anti-Bacterial Agents; Developing Countries; Drug Therapy, Combinatio | 2003 |
Case report of tetanus in an immunized, healthy adult and no point of entry.
Topics: Anti-Infective Agents; Anticonvulsants; Emergency Medical Services; Humans; Immunization; Infusions, | 2004 |
[Tetanus following an abrasion injury].
Topics: Aged, 80 and over; Animals; Anti-Infective Agents; Debridement; Female; Forearm Injuries; Hand; Huma | 2006 |
Tetanus, pneumonia, and malaria in a tsunami victim in Banda Aceh, Indonesia.
Topics: Adult; Ceftriaxone; Diazepam; Disasters; Female; Humans; Indonesia; Malaria; Metronidazole; Pneumoni | 2006 |
Early treatment of tetanus-induced trismus with botulinum toxin A.
Topics: Aged, 80 and over; Anti-Infective Agents; Antidotes; Botulinum Toxins, Type A; Drug Administration S | 2008 |
Treatment of anaerobic infections.
Topics: Anti-Bacterial Agents; Bacteria, Anaerobic; Bacterial Infections; Clostridium Infections; Clostridiu | 1984 |
The misplaced left hook.
Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Bites, Human; Ceftriaxone; Debridement; Drug T | 1998 |
[Lockjaw].
Topics: Aged; Anti-Bacterial Agents; Clostridium tetani; Female; Humans; Metronidazole; Tetanus; Trismus | 1999 |
[Modifications in treatment of tetanus and prognosis--observations from the Cracow Department of Infectious Diseases].
Topics: Aged; Aged, 80 and over; Diazepam; Drug Therapy, Combination; Female; Humans; Length of Stay; Male; | 1999 |
Activity of metronidazole against experimental tetanus and gas gangrene.
Topics: Animals; Clostridium; Clostridium perfringens; Clostridium tetani; Gas Gangrene; Metronidazole; Mice | 1968 |