metronidazole has been researched along with Infant, Premature, Diseases in 10 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Infant, Premature, Diseases: Diseases that occur in PREMATURE INFANTS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Four patients with Bacteroides fragilis bacteremia, one patient with a brain abscess due to Bacteroides species, Fusobacterium naviforme, and Peptostreptococcus species, and an infant with Bacteroides species ventriculitis and meningitis were treated with metronidazole." | 7.66 | Metronidazole therapy of anaerobic bacteremia, meningitis, and brain abscess. ( Cordero, L; Perkins, RL; Warner, JF, 1979) |
| "Four patients with Bacteroides fragilis bacteremia, one patient with a brain abscess due to Bacteroides species, Fusobacterium naviforme, and Peptostreptococcus species, and an infant with Bacteroides species ventriculitis and meningitis were treated with metronidazole." | 3.66 | Metronidazole therapy of anaerobic bacteremia, meningitis, and brain abscess. ( Cordero, L; Perkins, RL; Warner, JF, 1979) |
| "Bacterial meningitis is not considered a separate disease entity but a complication of bacteremia and sepsis." | 1.27 | [Chemotherapy of severe bacterial infections in pediatrics]. ( Guggenbichler, JP, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (60.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sampson, MR | 1 |
| Bloom, BT | 1 |
| Arrieta, A | 1 |
| Capparelli, E | 1 |
| Benjamin, DK | 1 |
| Smith, PB | 1 |
| Kearns, GL | 1 |
| van den Anker, J | 1 |
| Cohen-Wolkowiez, M | 1 |
| Montaruli, E | 1 |
| Pfister, RE | 1 |
| Wildhaber, BE | 1 |
| Guggenbichler, JP | 1 |
| Khan, Z | 1 |
| Lentelink, MB | 1 |
| de Vries, TW | 1 |
| van Dijk, KN | 1 |
| Warner, JF | 1 |
| Perkins, RL | 1 |
| Cordero, L | 1 |
| de Louvois, J | 1 |
| Webber, SA | 1 |
| Tuohy, P | 1 |
| Vermeylen, D | 1 |
| De Laet, MH | 1 |
| Pardou, A | 1 |
| Govaerts, MJ | 1 |
| Bouton, JM | 1 |
| Metze, H | 1 |
| van Bergen, A | 1 |
1 review available for metronidazole and Infant, Premature, Diseases
| Article | Year |
|---|---|
Necrotising enterocolitis.
Topics: Age Factors; Animals; Anti-Bacterial Agents; Bacterial Infections; Bottle Feeding; Cross Infection; | 1986 |
1 trial available for metronidazole and Infant, Premature, Diseases
| Article | Year |
|---|---|
Intestinal fatty-acid binding protein and metronidazole response in premature infants.
Topics: Anti-Infective Agents; Biomarkers; Enterocolitis, Necrotizing; Fatty Acid-Binding Proteins; Female; | 2014 |
8 other studies available for metronidazole and Infant, Premature, Diseases
| Article | Year |
|---|---|
Sterile hepatic abscess secondary to administration of parenteral fluids via an umbilical venous catheter in a premature baby.
Topics: Catheterization; Female; Follow-Up Studies; Humans; Infant; Infant, Newborn; Infant, Premature; Infa | 2011 |
[Chemotherapy of severe bacterial infections in pediatrics].
Topics: Aminoglycosides; Anti-Bacterial Agents; Bacterial Infections; Cefotaxime; Cephalosporins; Clindamyci | 1983 |
Active management of preterm labour and preterm prelabour rupture of membranes.
Topics: Analgesics; Anti-Bacterial Agents; Embryonic and Fetal Development; Female; Fetal Membranes, Prematu | 1994 |
Accidental metronidazole overdose in a preterm newborn.
Topics: Antitrichomonal Agents; Drug Overdose; Enterocolitis; Female; Humans; Infant, Newborn; Infant, Prema | 1997 |
Metronidazole therapy of anaerobic bacteremia, meningitis, and brain abscess.
Topics: Adult; Anaerobiosis; Bacterial Infections; Bacteroides fragilis; Bacteroides Infections; Brain Absce | 1979 |
Bacteroides fragilis meningitis in a premature infant successfully treated with metronidazole.
Topics: Bacteroides fragilis; Bacteroides Infections; Cefotaxime; Drug Therapy, Combination; Female; Humans; | 1988 |
Neonatal necrotizing enterocolitis: from reduction of mortality to reduction of morbidity.
Topics: Anesthesia, General; Combined Modality Therapy; Critical Care; Enterocolitis, Pseudomembranous; Huma | 1985 |
[Trichomonas infections in premature infants].
Topics: Adult; Diseases in Twins; Female; Hematuria; Humans; Infant, Newborn; Infant, Premature, Diseases; M | 1971 |