metronidazole has been researched along with Delayed Effects, Prenatal Exposure in 8 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess whether treatment with metronidazole during pregnancy is associated with preterm birth, low birth weight, or major congenital anomalies, we conducted chart reviews and an analysis of electronic data from a cohort of women delivering at an urban New York State hospital." | 7.78 | Investigation of metronidazole use during pregnancy and adverse birth outcomes. ( Aubry, R; Baras, DC; Koss, CA; Koumans, EH; Lane, SD; Marcus, M; Markowitz, LE, 2012) |
| "To assess whether treatment with metronidazole during pregnancy is associated with preterm birth, low birth weight, or major congenital anomalies, we conducted chart reviews and an analysis of electronic data from a cohort of women delivering at an urban New York State hospital." | 3.78 | Investigation of metronidazole use during pregnancy and adverse birth outcomes. ( Aubry, R; Baras, DC; Koss, CA; Koumans, EH; Lane, SD; Marcus, M; Markowitz, LE, 2012) |
| "The authors conclude that although there was no increase in risk for all cancers associated with in utero exposure to metronidazole, the observed increased risk for neuroblastomas, although not significant, requires further evaluation." | 3.70 | Prenatal exposure to metronidazole and risk of childhood cancer: a retrospective cohort study of children younger than 5 years. ( Brockman Worrell, KG; Gideon, P; Mitchel, EF; Pais, R; Ray, WA; Roberson, P; Thapa, PB; Whitlock, JA, 1998) |
| " Elimination half-life was inversely related to gestational age, and ranged from 22." | 1.26 | Pharmacokinetics and tissue distribution of metronidazole in the new born infant. ( Baird-Lambert, J; Buchanan, N; Cvejic, M; Doyle, PE; Jager-Roman, E, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (25.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| O'Connor, R | 1 |
| Moloney, GM | 1 |
| Fulling, C | 1 |
| O'Riordan, KJ | 1 |
| Fitzgerald, P | 1 |
| Bastiaanssen, TFS | 1 |
| Schellekens, H | 1 |
| Dinan, TG | 1 |
| Cryan, JF | 1 |
| Bates, JE | 1 |
| Almast, J | 1 |
| Augustine, EF | 1 |
| Mann, JR | 1 |
| McDermott, S | 1 |
| Barnes, TL | 1 |
| Hardin, J | 1 |
| Bao, H | 1 |
| Zhou, L | 1 |
| Koss, CA | 1 |
| Baras, DC | 1 |
| Lane, SD | 1 |
| Aubry, R | 1 |
| Marcus, M | 1 |
| Markowitz, LE | 1 |
| Koumans, EH | 1 |
| Jager-Roman, E | 1 |
| Doyle, PE | 1 |
| Baird-Lambert, J | 1 |
| Cvejic, M | 1 |
| Buchanan, N | 1 |
| Thapa, PB | 1 |
| Whitlock, JA | 1 |
| Brockman Worrell, KG | 1 |
| Gideon, P | 1 |
| Mitchel, EF | 1 |
| Roberson, P | 1 |
| Pais, R | 1 |
| Ray, WA | 1 |
| Berbel-Tornero, O | 1 |
| López-Andreu, JA | 1 |
| Ferris-Tortajada, J | 1 |
| Boiadzhieva, N | 1 |
8 other studies available for metronidazole and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
Maternal antibiotic administration during a critical developmental window has enduring neurobehavioural effects in offspring mice.
Topics: Ampicillin; Animals; Anti-Bacterial Agents; Anxiety; Ciprofloxacin; Cognition; Female; Homing Behavi | 2021 |
Neonatal dentate nucleus T2 hyperintensity after in utero metronidazole exposure.
Topics: Brain; Cerebellar Nuclei; Female; Humans; Infant; Magnetic Resonance Imaging; Male; Metronidazole; P | 2015 |
Trichomoniasis in pregnancy and mental retardation in children.
Topics: Adolescent; Child; Child, Preschool; Female; Humans; Incidence; Infant; Infant, Newborn; Intellectua | 2009 |
Investigation of metronidazole use during pregnancy and adverse birth outcomes.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Antifungal Agents; Cohort Studies; Female; Fungi; Hu | 2012 |
Pharmacokinetics and tissue distribution of metronidazole in the new born infant.
Topics: Bacterial Infections; Betamethasone; Female; Gestational Age; Half-Life; Humans; Infant, Newborn; In | 1982 |
Prenatal exposure to metronidazole and risk of childhood cancer: a retrospective cohort study of children younger than 5 years.
Topics: Adolescent; Adult; Carcinogens; Child, Preschool; Cohort Studies; Databases, Factual; Female; Humans | 1998 |
Prenatal exposure to metronidazole and risk of childhood cancer: a retrospective cohort study of children younger than 5 years.
Topics: Carcinogens; Child, Preschool; Female; Humans; Metronidazole; Neoplasms; Pregnancy; Prenatal Exposur | 1999 |
[Effect of the combined use of metronidazole and alcohol on fetal development in rats].
Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Drug Interactions; Embryo Loss; Embryonic an | 1988 |