metronidazole has been researched along with Diffuse Mixed Small and Large Cell Lymphoma in 14 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "CT abdomen confirmed the diagnosis of typhlitis, demonstrating characteristic terminal ileum, caecal and right-sided colon involvement." | 1.39 | Concomitant typhlitis and Clostridium difficile colitis developed after first R-CHOP chemotherapy in a non-Hodgkin lymphoma patient. ( Buppajarntham, S; Junpaparp, P; Madueno, FV; Varadi, G, 2013) |
| "pylori treatment on MALT lymphoma and chronic gastritis at the histologic and molecular levels." | 1.31 | Mucosal change of the stomach with low-grade mucosa-associated lymphoid tissue lymphoma after eradication of Helicobacter pylori: follow-up study of 48 cases. ( Begum, S; Endo, H; Kawamata, H; Sano, T; Urakami, Y, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (28.57) | 18.7374 |
| 1990's | 3 (21.43) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 3 (21.43) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, JL | 1 |
| Cho, SJ | 1 |
| Chung, SJ | 1 |
| Lee, A | 1 |
| Choi, J | 1 |
| Chung, H | 1 |
| Kim, SG | 1 |
| van Atteveld, JE | 1 |
| Graaf, M | 1 |
| Grotel, MV | 1 |
| van den Heuvel-Eibrink, MM | 1 |
| Junpaparp, P | 1 |
| Buppajarntham, S | 1 |
| Madueno, FV | 1 |
| Varadi, G | 1 |
| Tu, S | 1 |
| Yang, H | 1 |
| Marshall, BJ | 1 |
| Stemmer, SM | 1 |
| Kinsman, K | 1 |
| Tellschow, S | 1 |
| Jones, RB | 1 |
| Martin, J | 1 |
| Boyle, S | 1 |
| Jacyna, M | 1 |
| Begum, S | 1 |
| Sano, T | 1 |
| Endo, H | 1 |
| Kawamata, H | 1 |
| Urakami, Y | 1 |
| Tankovic, J | 1 |
| Lamarque, D | 1 |
| Lascols, C | 1 |
| Soussy, CJ | 1 |
| Delchier, JC | 1 |
| Alpen, B | 1 |
| Röbbecke, J | 1 |
| Wündisch, T | 1 |
| Stolte, M | 1 |
| Neubauer, A | 1 |
| Efimov, ML | 3 |
| Koposova, RP | 2 |
| Seĭtkazina, GD | 3 |
| Vasil'eva, GS | 2 |
| Kovalenko, VR | 2 |
| Wishart, JM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Empirical and Genotypic Resistance Guided Tailored Therapy for Helicobacter Pylori Infection[NCT04006340] | 62 participants (Anticipated) | Interventional | 2019-01-04 | Enrolling by invitation | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for metronidazole and Diffuse Mixed Small and Large Cell Lymphoma
| Article | Year |
|---|---|
[Management of the peptic ulcer patient in the Helicobacter pylori age].
Topics: Algorithms; Antacids; Anti-Bacterial Agents; Biopsy; Bismuth; Breath Tests; Child; Drug Therapy, Com | 1994 |
2 trials available for metronidazole and Diffuse Mixed Small and Large Cell Lymphoma
| Article | Year |
|---|---|
Empiric Versus Clarithromycin Resistance-Guided Therapy for Helicobacter pylori Based on Polymerase Chain Reaction Results in Patients With Gastric Neoplasms or Gastric Mucosa-Associated Lymphoid Tissue Lymphoma: A Randomized Controlled Trial.
Topics: Aged; Amoxicillin; Anti-Bacterial Agents; Biopsy; Bismuth; Clarithromycin; DNA, Bacterial; Drug Resi | 2020 |
Helicobacter pylori eradication therapy in gastric high grade non Hodgkin's lymphoma (NHL).
Topics: Aged; Anti-Ulcer Agents; Clarithromycin; Combined Modality Therapy; Drug Therapy, Combination; Gastr | 2001 |
11 other studies available for metronidazole and Diffuse Mixed Small and Large Cell Lymphoma
| Article | Year |
|---|---|
Demodicosis in Pediatric Cancer.
Topics: Child; Humans; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell; Male; Metronidazole; Mite Infestations; Trea | 2017 |
Concomitant typhlitis and Clostridium difficile colitis developed after first R-CHOP chemotherapy in a non-Hodgkin lymphoma patient.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Antibodies, Monoclonal, Murine-Derived; Antineoplastic | 2013 |
[Progress in the treatment of Helicobacter pylori infection].
Topics: Anti-Bacterial Agents; Clarithromycin; Drug Therapy, Combination; Drugs, Chinese Herbal; Gastritis; | 2014 |
Fatal noncutaneous visceral infection with varicella-zoster virus in a patient with lymphoma after autologous bone marrow transplantation.
Topics: Acyclovir; Adult; Bone Marrow Transplantation; Gentamicins; Herpes Zoster; Humans; Immunocompromised | 1993 |
Regression of a large gastric MALT lymphoma with antibiotic treatment to eradicate Helicobacter pylori.
Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Ulcer Agents; Drug Therapy, Combination; Helicobacter Infec | 1997 |
Mucosal change of the stomach with low-grade mucosa-associated lymphoid tissue lymphoma after eradication of Helicobacter pylori: follow-up study of 48 cases.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Amoxicillin; Drug Therapy, Combination; Female | 2000 |
Clarithromycin resistance of Helicobacter pylori has a major impact on the efficacy of the omeprazole-amoxicillin-clarithromycin therapy.
Topics: Adolescent; Adult; Aged; Amoxicillin; Anti-Ulcer Agents; Biopsy; Clarithromycin; DNA, Bacterial; Dru | 2001 |
[Increasing the metronidazole content of tumors using pyrogenal hyperthermia].
Topics: Animals; Combined Modality Therapy; Female; Hyperthermia, Induced; Lipopolysaccharides; Lymphoma, No | 1987 |
[Potentiation of the radiosensitizing effect of metronidazole using whole-body drug-induced hyperthermia].
Topics: Animals; Combined Modality Therapy; Hyperthermia, Induced; Lymphoma, Non-Hodgkin; Metronidazole; Neo | 1985 |
[Accumulation of metronidazole in tumors during whole-body hyperthermia induced by Sulfazin].
Topics: Animals; Hyperthermia, Induced; Lymphoma, Non-Hodgkin; Metronidazole; Neoplasm Transplantation; Rats | 1985 |
Reticulosarcoma of the vulva complicating dermatomyositis treated by immunosuppression.
Topics: Adult; Azathioprine; Dermatomyositis; Erythema; Female; Humans; Immunosuppressive Agents; Lymphoma, | 1973 |