metronidazole has been researched along with Inflammation, Endodontic in 4 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Amoxicillin was the most frequently prescribed antibiotic used for most clinical conditions apart from pericoronitis, acute ulcerative gingivitis and dry sockets where metronidazole was the drug of choice." | 3.70 | A study of therapeutic antibiotic prescribing in National Health Service general dental practice in England. ( Ireland, RS; Martin, MV; Palmer, NA; Pealing, R, 2000) |
| "Caries/pulpitis was the most common diagnosis (n = 222; 31% of cases), of which 48 (21%) were prescribed antibiotics." | 1.42 | Diagnosis and prescribing pattern of antibiotics and painkillers among dentists. ( Lundborg, CS; Marrone, G; Tanwir, F; Tariq, A, 2015) |
| "Bacteria taken from carious dentine (25 cases) and infected pulps (12 cases) were also sensitive to the drug combination." | 1.29 | In-vitro antibacterial susceptibility of bacteria taken from infected root dentine to a mixture of ciprofloxacin, metronidazole and minocycline. ( Hoshino, E; Iwaku, M; Kota, K; Kurihara-Ando, N; Sato, I; Sato, M; Uematsu, H, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tanwir, F | 1 |
| Marrone, G | 1 |
| Tariq, A | 1 |
| Lundborg, CS | 1 |
| Hoshino, E | 1 |
| Kurihara-Ando, N | 1 |
| Sato, I | 1 |
| Uematsu, H | 1 |
| Sato, M | 1 |
| Kota, K | 1 |
| Iwaku, M | 1 |
| Palmer, NA | 1 |
| Pealing, R | 1 |
| Ireland, RS | 1 |
| Martin, MV | 1 |
| Chomarat, M | 1 |
| Dubost, J | 1 |
| Kalfon, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Controlled Trial Comparing the Clinical and Radiographic Success of 3Mixtatin Versus Modified 3Mix in Lesion Sterilization and Tissue Repair (LSTR) for The Treatment of Necrotic Primary Molars[NCT05677945] | 24 participants (Anticipated) | Interventional | 2023-03-31 | Not yet recruiting | |||
| Efficacy of the Application of Moxifloxacin and Cefixime in Reduction of Inflammatory Sequelae and Complications After Mandibular Third Molar Surgery[NCT05027893] | 157 participants (Actual) | Interventional | 2019-06-07 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for metronidazole and Inflammation, Endodontic
| Article | Year |
|---|---|
[Randomized study of amoxicillin-clavulanic acid versus amoxicillin-metronidazole combinations in pyogenic infections of dental origin].
Topics: Adolescent; Adult; Amoxicillin; Anti-Bacterial Agents; Bacterial Infections; Clavulanic Acid; Clavul | 1991 |
3 other studies available for metronidazole and Inflammation, Endodontic
| Article | Year |
|---|---|
Diagnosis and prescribing pattern of antibiotics and painkillers among dentists.
Topics: Adolescent; Adult; Amoxicillin; Analgesics; Anti-Bacterial Agents; Child; Child, Preschool; Cross-Se | 2015 |
In-vitro antibacterial susceptibility of bacteria taken from infected root dentine to a mixture of ciprofloxacin, metronidazole and minocycline.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Local; Bacteria, Anaerobic; Cip | 1996 |
A study of therapeutic antibiotic prescribing in National Health Service general dental practice in England.
Topics: Abscess; Acute Disease; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Bacterial Infecti | 2000 |