Page last updated: 2024-10-31

metronidazole and Inflammation, Endodontic

metronidazole has been researched along with Inflammation, Endodontic in 4 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Research Excerpts

ExcerptRelevanceReference
" Amoxicillin was the most frequently prescribed antibiotic used for most clinical conditions apart from pericoronitis, acute ulcerative gingivitis and dry sockets where metronidazole was the drug of choice."3.70A study of therapeutic antibiotic prescribing in National Health Service general dental practice in England. ( Ireland, RS; Martin, MV; Palmer, NA; Pealing, R, 2000)
"Caries/pulpitis was the most common diagnosis (n = 222; 31% of cases), of which 48 (21%) were prescribed antibiotics."1.42Diagnosis and prescribing pattern of antibiotics and painkillers among dentists. ( Lundborg, CS; Marrone, G; Tanwir, F; Tariq, A, 2015)
"Bacteria taken from carious dentine (25 cases) and infected pulps (12 cases) were also sensitive to the drug combination."1.29In-vitro antibacterial susceptibility of bacteria taken from infected root dentine to a mixture of ciprofloxacin, metronidazole and minocycline. ( Hoshino, E; Iwaku, M; Kota, K; Kurihara-Ando, N; Sato, I; Sato, M; Uematsu, H, 1996)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (50.00)18.2507
2000's1 (25.00)29.6817
2010's1 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Tanwir, F1
Marrone, G1
Tariq, A1
Lundborg, CS1
Hoshino, E1
Kurihara-Ando, N1
Sato, I1
Uematsu, H1
Sato, M1
Kota, K1
Iwaku, M1
Palmer, NA1
Pealing, R1
Ireland, RS1
Martin, MV1
Chomarat, M1
Dubost, J1
Kalfon, F1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized Controlled Trial Comparing the Clinical and Radiographic Success of 3Mixtatin Versus Modified 3Mix in Lesion Sterilization and Tissue Repair (LSTR) for The Treatment of Necrotic Primary Molars[NCT05677945]24 participants (Anticipated)Interventional2023-03-31Not yet recruiting
Efficacy of the Application of Moxifloxacin and Cefixime in Reduction of Inflammatory Sequelae and Complications After Mandibular Third Molar Surgery[NCT05027893]157 participants (Actual)Interventional2019-06-07Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for metronidazole and Inflammation, Endodontic

ArticleYear
[Randomized study of amoxicillin-clavulanic acid versus amoxicillin-metronidazole combinations in pyogenic infections of dental origin].
    Pathologie-biologie, 1991, Volume: 39, Issue:5

    Topics: Adolescent; Adult; Amoxicillin; Anti-Bacterial Agents; Bacterial Infections; Clavulanic Acid; Clavul

1991

Other Studies

3 other studies available for metronidazole and Inflammation, Endodontic

ArticleYear
Diagnosis and prescribing pattern of antibiotics and painkillers among dentists.
    Oral health & preventive dentistry, 2015, Volume: 13, Issue:1

    Topics: Adolescent; Adult; Amoxicillin; Analgesics; Anti-Bacterial Agents; Child; Child, Preschool; Cross-Se

2015
In-vitro antibacterial susceptibility of bacteria taken from infected root dentine to a mixture of ciprofloxacin, metronidazole and minocycline.
    International endodontic journal, 1996, Volume: 29, Issue:2

    Topics: Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Local; Bacteria, Anaerobic; Cip

1996
A study of therapeutic antibiotic prescribing in National Health Service general dental practice in England.
    British dental journal, 2000, May-27, Volume: 188, Issue:10

    Topics: Abscess; Acute Disease; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Bacterial Infecti

2000