mbx 1066 profile

MBX 1066: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	439135
CHEMBL ID	1097945
SCHEMBL ID	8238119
MeSH ID	M000598082

Synonym
6-(4,5-dihydro-1h-imidazol-2-yl)-2-[4-[6-(4,5-dihydro-1h-imidazol-2-yl)-1h-indol-2-yl]phenyl]-1h-indole
CHEMBL1097945
mbx-1066
mbx 1066
mbx1066
SCHEMBL8238119
868971-24-8 (free base)
868971-24-8

Bioassays (115)

Assay ID	Title	Year	Journal	Article
AID575279	Antimicrobial activity against Serratia marcescens by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9	Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates.
AID575188	Antimicrobial activity against methicillin-susceptible Staphylococcus aureus by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9	Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates.
AID477441	Upregulation of conventional hypothetical protein mRNA expression in MBX-1090-resistant Staphylococcus aureus isolate d20A1 at 0.4 ug/ml by RT-PCR analysis relative to wild type	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR.
AID580539	Antimicrobial activity against Bacillus licheniformis clinical isolate by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID575277	Antimicrobial activity against Klebsiella pneumoniae by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9	Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates.
AID477417	Antibacterial activity against Staphylococcus aureus NCTC 8325 carrying expression vector pG154 with mepA gene after 16 to 20 hrs by broth microdilution method	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR.
AID477446	Modulation of ribD gene expression in MBX-1090-resistant Staphylococcus aureus isolate d20A1 at 0.4 ug/ml by RT-PCR analysis relative to wild type	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR.
AID575271	Antimicrobial activity against penicillin-susceptible Streptococcus pneumoniae by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9	Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates.
AID580540	Antimicrobial activity against Bacillus megaterium clinical isolate by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID580547	Antimicrobial activity against Enterococcus faecalis clinical isolate by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID580538	Antimicrobial activity against Bacillus brevis clinical isolate by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID477421	Antibacterial activity against Staphylococcus aureus NCTC 8325 harboring genetic deletion of mepRA gene and carrying expression vector pG154 with mepA gene after 16 to 20 hrs by broth microdilution method	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR.
AID580633	Effect on cell membrane integrity in human HeLa cells assessed as lactate dehydrogenase release at 32 times MIC against Staphylococcus aureus by CytoTox ONE homogenous membrane integrity assay	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID477416	Antibacterial activity against Staphylococcus aureus NCTC 8325 carrying expression vector pG154 after 16 to 20 hrs by broth microdilution method in presence of anhydrous tetracycline	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR.
AID580613	Cytotoxicity against human HeLa cells after 3 days by MTS assay in presence of 10% fetal calf serum	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID477410	Antibacterial activity against Staphylococcus aureus NCTC 8325 after 16 to 20 hrs by broth microdilution method in presence of efflux pump inhibitor reserpine	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR.
AID575272	Antimicrobial activity against penicillin-intermediate Streptococcus pneumoniae by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9	Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates.
AID580620	Effect on bacterial membrane permeability in Bacillus subtilis BD54 upto 10 times MIC using DiSC3 fluorescent dye staining based fluorimetric assay	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID1196716	Inhibition of Escherichia coli UPPS using FPP/IPP as substrate by spectrophotometry	2015	Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3	Antibacterial drug leads: DNA and enzyme multitargeting.
AID575287	Protein binding to serum	2010	Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9	Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates.
AID580541	Antimicrobial activity against Bacillus pumilus clinical isolate by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID575285	Antimicrobial activity against Haemophilus influenzae by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9	Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates.
AID575267	Antimicrobial activity against vancomycin-susceptible Enterococcus faecalis by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9	Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates.
AID575264	Antimicrobial activity against methicillin-resistant Staphylococcus aureus by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9	Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates.
AID477430	Induction of mepA gene expression in Staphylococcus aureus NCTC 8325 at 0.4 ug/ml by RT-PCR analysis	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR.
AID580552	Antimicrobial activity against ciprofloxacin-resistant Bacillus anthracis Ames 105-6 by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID477438	Upregulation of mepR gene expression in MBX-1090-resistant Staphylococcus aureus isolate d20A1 at 0.4 ug/ml by RT-PCR analysis relative to wild type	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR.
AID580607	Antimicrobial activity against Burkholderia mallei ATCC 23344 by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID575281	Antimicrobial activity against Acinetobacter baumannii by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9	Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates.
AID575268	Antimicrobial activity against vancomycin-resistant Enterococcus faecalis by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9	Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates.
AID580544	Antimicrobial activity against Bacillus anthracis Ames spores by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID477411	Antibacterial activity against MBX-1090-resistant Staphylococcus aureus isolate d20A1 after 16 to 20 hrs by broth microdilution method	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR.
AID575280	Antimicrobial activity against Proteus mirabilis by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9	Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates.
AID575278	Antimicrobial activity against ESBL-production Klebsiella pneumoniae by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9	Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates.
AID580625	Antibacterial activity against Staphylococcus aureus Smith infected in Swiss Webster mouse assessed as assessed as protection against microbe-induced mortality at 10 mg/kg, iv administered as single dose 15 mins post bacterial challenge measured 48 hrs po	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID580629	Cytotoxicity against mouse J774A1 cells assessed as live viable cells at 10 uM by Sytox green dye staining assay relative to untreated control	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID580554	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 1094 by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID580551	Antimicrobial activity against Mycobacterium smegmatis 700009 by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID477420	Antibacterial activity against Staphylococcus aureus NCTC 8325 harboring genetic deletion of mepRA gene and carrying expression vector pG154 after 16 to 20 hrs by broth microdilution method in presence of anhydrous tetracycline	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR.
AID477415	Antibacterial activity against Staphylococcus aureus NCTC 8325 carrying expression vector pG154 after 16 to 20 hrs by broth microdilution method	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR.
AID580608	Antimicrobial activity against Burkholderia pseudomallei DD503 by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID477418	Antibacterial activity against Staphylococcus aureus NCTC 8325 carrying expression vector pG154 with mepA gene after 16 to 20 hrs by broth microdilution method in presence of anhydrous tetracycline	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR.
AID580537	Antimicrobial activity against Bacillus anthracis Ames by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID477444	Modulation of ribA gene expression in MBX-1090-resistant Staphylococcus aureus isolate d20A1 at 0.4 ug/ml by RT-PCR analysis relative to wild type	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR.
AID575284	Antimicrobial activity against Burkholderia cepacia by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9	Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates.
AID1181202	Antimicrobial activity against TolC+ Escherichia coli 700 by CLSI method	2014	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15	Synthesis and antibacterial evaluation of new, unsymmetrical triaryl bisamidine compounds.
AID477409	Antibacterial activity against Staphylococcus aureus NCTC 8325 after 16 to 20 hrs by broth microdilution method	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR.
AID575275	Antimicrobial activity against Clostridium difficile by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9	Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates.
AID1181208	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 1094 by CLSI method	2014	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15	Synthesis and antibacterial evaluation of new, unsymmetrical triaryl bisamidine compounds.
AID1196719	Antimicrobial activity against Staphylococcus aureus Newman after 9 hrs by spectrophotometry	2015	Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3	Antibacterial drug leads: DNA and enzyme multitargeting.
AID575282	Antimicrobial activity against multiple dug-resistant Acinetobacter baumannii by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9	Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates.
AID580542	Antimicrobial activity against Bacillus anthracis Vollum clinical isolate by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID580623	Antibacterial activity against Bacillus anthracis Ames spores infected in C57BL/6 mouse assessed as protection against microbe-induced mortality at 10 mg/kg, ip for 5 days every 6 hrs administered 18 to 24 hrs postinfection and measured upto 20 days posti	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID580533	Antimicrobial activity against Bacillus anthracis Sterne spores by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID1181207	Antimicrobial activity against Bacillus subtilis BD54 by CLSI method	2014	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15	Synthesis and antibacterial evaluation of new, unsymmetrical triaryl bisamidine compounds.
AID575283	Antimicrobial activity against Pseudomonas aeruginosa by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9	Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates.
AID575274	Antimicrobial activity against Streptococcus agalactiae by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9	Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates.
AID575273	Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9	Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates.
AID575266	Antimicrobial activity against methicillin-resistant Staphylococcus epidermidis by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9	Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates.
AID575270	Antimicrobial activity against vancomycin-resistant Enterococcus faecium by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9	Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates.
AID580609	Antimicrobial activity against Burkholderia thailandensis by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID580624	Antibacterial activity against Yersinia pestis CO92 infected in C57BL/6 mouse assessed as protection against microbe-induced mortality at 10 mg/kg, ip for 5 days every 6 hrs administered 6 hrs post bacterial challenge measured after 15 days post infection	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID477445	Modulation of ribE gene expression in MBX-1090-resistant Staphylococcus aureus isolate d20A1 at 0.4 ug/ml by RT-PCR analysis relative to wild type	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR.
AID1181205	Antimicrobial activity against mexAB-oprM deficient Pseudomonas aeruginosa PAO1 harboring by CLSI method	2014	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15	Synthesis and antibacterial evaluation of new, unsymmetrical triaryl bisamidine compounds.
AID477443	Modulation of ribH gene expression in MBX-1090-resistant Staphylococcus aureus isolate d20A1 at 0.4 ug/ml by RT-PCR analysis relative to wild type	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR.
AID580543	Antimicrobial activity against Bacillus subtilis clinical isolate by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID580606	Antimicrobial activity against Yersinia pestis by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID575276	Antimicrobial activity against Escherichia coli by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9	Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates.
AID580553	Antimicrobial activity against methicillin-resistant Staphylococcus aureus clinical isolate by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID580630	Cytotoxicity against mouse J774A1 cells assessed as dead cells at 10 uM by Sytox green dye staining assay relative to untreated control	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID580615	Selective index, ratio of CC50 for human HeLa cells to MIC for Bacillus anthracis Ames in presence of 10% fetal calf serum	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID477440	Upregulation of mepB gene expression in MBX-1090-resistant Staphylococcus aureus isolate d20A1 at 0.4 ug/ml by RT-PCR analysis relative to wild type	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR.
AID580546	Antimicrobial activity against Staphylococcus aureus by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID575265	Antimicrobial activity against methicillin-susceptible Staphylococcus epidermidis by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9	Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates.
AID575269	Antimicrobial activity against vancomycin-susceptible Enterococcus faecium by broth microdilution method	2010	Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9	Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates.
AID477413	Antibacterial activity against Staphylococcus aureus NCTC 8325 harboring genetic deletion of mepRA gene after 16 to 20 hrs by broth microdilution method	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR.
AID1181211	Cytotoxicity against human HeLa cells by MTS assay	2014	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15	Synthesis and antibacterial evaluation of new, unsymmetrical triaryl bisamidine compounds.
AID1181209	Antimicrobial activity against vancomycin-resistant Enterococcus faecalis ATCC 51575 by CLSI method	2014	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15	Synthesis and antibacterial evaluation of new, unsymmetrical triaryl bisamidine compounds.
AID477419	Antibacterial activity against Staphylococcus aureus NCTC 8325 harboring genetic deletion of mepRA gene and carrying expression vector pG154 after 16 to 20 hrs by broth microdilution method	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR.
AID1196718	Antimicrobial activity against Escherichia coli K-12 after 3 hrs by broth microdilution method	2015	Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3	Antibacterial drug leads: DNA and enzyme multitargeting.
AID580627	Protection against Bacillus anthracis Sterne spores induced cell death in mouse J774A1 cells assessed as live viable cells at 10 uM by Sytox green dye staining assay relative to untreated control	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID580605	Antimicrobial activity against Pseudomonas aeruginosa PAO1 by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID580604	Antimicrobial activity against Klebsiella pneumoniae 5657 by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID580545	Antimicrobial activity against Staphylococcus aureus ATCC 25923 by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID580614	Antimicrobial activity against Bacillus anthracis Ames by broth microdilution method in presence of 10% fetal calf serum	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID1181206	Antimicrobial activity against Klebsiella pneumoniae 13882 by CLSI method	2014	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15	Synthesis and antibacterial evaluation of new, unsymmetrical triaryl bisamidine compounds.
AID477439	Upregulation of mepA gene expression in MBX-1090-resistant Staphylococcus aureus isolate d20A1 at 0.4 ug/ml by RT-PCR analysis relative to wild type	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR.
AID580557	Antimicrobial activity against Escherichia coli J53 clinical isolate by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID575286	Cytotoxicity against HeLa cells after 3 days by MTS assay	2010	Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9	Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates.
AID580616	Inhibition of DNA synthesis in Bacillus subtilis BD54 at 5 X MIC by [3H]thymidine incorporation assay	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID477442	Downregulation of protein A gene expression in MBX-1090-resistant Staphylococcus aureus isolate d20A1 at 0.4 ug/ml by RT-PCR analysis relative to wild type	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR.
AID580555	Antimicrobial activity against vancomycin-resistant Enterococcus faecium B42762 by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID580621	Antibacterial activity against Bacillus anthracis Ames spores infected in C57BL/6 mouse assessed as mouse survival rate at 10 mg/kg, ip for 5 days every 6 hrs administered 6 hrs post bacterial challenge measured up to 20 days post infection	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID1181203	Antimicrobial activity against TolC-deficient Escherichia coli by CLSI method	2014	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15	Synthesis and antibacterial evaluation of new, unsymmetrical triaryl bisamidine compounds.
AID477422	Antibacterial activity against Staphylococcus aureus NCTC 8325 harboring genetic deletion of mepRA gene and carrying expression vector pG154 with mepA gene after 16 to 20 hrs by broth microdilution method in presence of anhydrous tetracycline	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR.
AID1196720	Binding affinity to DNA dodecamer complex (CGCGAATTCGCG)2 (unknown origin) assessed as change in melting temperature by differential scanning calorimetry	2015	Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3	Antibacterial drug leads: DNA and enzyme multitargeting.
AID580611	Bactericidal activity against Bacillus anthracis Sterne vegetative forms assessed as reduction in bacterial CFU at 4 X MIC after 24 hrs by time-kill analysis relative to untreated control	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID580628	Protection against Bacillus anthracis Sterne spores induced cell death in mouse J774A1 cells assessed as dead cells at 10 uM by Sytox green dye staining assay relative to untreated control	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID580610	Antimicrobial activity against Burkholderia cepacia clinical isolate by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID580550	Antimicrobial activity against Mycobacterium smegmatis 35798 by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID580535	Inhibition of spore outgrowth in Bacillus anthracis Sterne spores assessed as reduction in bacterial CFU count at MIC after 4 hrs relative to untreated control	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID580549	Antimicrobial activity against Mycobacterium smegmatis 19420 by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID477431	Induction of mepR gene expression in Staphylococcus aureus NCTC 8325 at 0.4 ug/ml by RT-PCR analysis	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR.
AID580632	Antibacterial activity against MBX 1090 resistant Staphylococcus aureus NCTC8325 isolates selected on 10 to 12 days of serial passage through MBX 1090	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID580548	Antimicrobial activity against Enterococcus faecalis 29212 clinical isolate by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID477816	Dissociation constant, pKa of the compound	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR.
AID477414	Antibacterial activity against Staphylococcus aureus NCTC 8325 harboring genetic deletion of mepRAB gene after 16 to 20 hrs by broth microdilution method	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR.
AID580534	Antimicrobial activity against Bacillus anthracis Sterne vegetative cells by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID1181210	Antimicrobial activity against Bacillus anthracis Sterne by CLSI method	2014	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15	Synthesis and antibacterial evaluation of new, unsymmetrical triaryl bisamidine compounds.
AID477412	Antibacterial activity against Staphylococcus aureus NCTC 8325 harboring genetic deletion of mepR gene after 16 to 20 hrs by broth microdilution method	2010	Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6	Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR.
AID580631	Inhibition of spore germination in Bacillus anthracis Sterne spores at MIC after 4 hrs	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID1196717	Inhibition of Staphylococcus aureus UPPS using FPP/IPP as substrate by spectrophotometry	2015	Journal of medicinal chemistry, Feb-12, Volume: 58, Issue:3	Antibacterial drug leads: DNA and enzyme multitargeting.
AID580612	Bactericidal activity against pgm, pCD1 gene-deficient Yersinia pestis KIM assessed as reduction in bacterial CFU at 4 X MIC after 24 hrs by time-kill analysis relative to untreated control	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID580556	Antimicrobial activity against vancomycin-resistant Enterococcus faecalis ATCC 51575 by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.
AID1181204	Antimicrobial activity against Pseudomonas aeruginosa PAO1 by CLSI method	2014	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15	Synthesis and antibacterial evaluation of new, unsymmetrical triaryl bisamidine compounds.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (14.29)	29.6817
2010's	6 (85.71)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
indole [no description available]	7.08	1	indole; polycyclic heteroarene	Escherichia coli metabolite
2,4-dinitrophenol 2,4-Dinitrophenol: A toxic dye, chemically related to trinitrophenol (picric acid), used in biochemical studies of oxidative processes where it uncouples oxidative phosphorylation. It is also used as a metabolic stimulant. (Stedman, 26th ed). dinitrophenol : Members of the class of nitrophenol carrying two nitro substituents.. 2,4-dinitrophenol : A dinitrophenol having the nitro groups at the 2- and 4-positions.	2.05	1	dinitrophenol	allergen; antiseptic drug; bacterial xenobiotic metabolite; geroprotector; oxidative phosphorylation inhibitor
ciprofloxacin Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.. ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.	2.74	3	aminoquinoline; cyclopropanes; fluoroquinolone antibiotic; N-arylpiperazine; quinolinemonocarboxylic acid; quinolone antibiotic; quinolone; zwitterion	antibacterial drug; antiinfective agent; antimicrobial agent; DNA synthesis inhibitor; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; environmental contaminant; topoisomerase IV inhibitor; xenobiotic
dapi DAPI: RN given refers to parent cpd.	2.05	1	indoles	fluorochrome
stallimycin [no description available]	2.05	1
metronidazole Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.. metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.	2.05	1	C-nitro compound; imidazoles; primary alcohol	antiamoebic agent; antibacterial drug; antimicrobial agent; antiparasitic agent; antitrichomonal drug; environmental contaminant; prodrug; radiosensitizing agent; xenobiotic
nalidixic acid [no description available]	2.05	1	1,8-naphthyridine derivative; monocarboxylic acid; quinolone antibiotic	antibacterial drug; antimicrobial agent; DNA synthesis inhibitor
netropsin Netropsin: A basic polypeptide isolated from Streptomyces netropsis. It is cytotoxic and its strong, specific binding to A-T areas of DNA is useful to genetics research.	2.11	1
pentamidine Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.. pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.	2.11	1	aromatic ether; carboxamidine; diether	anti-inflammatory agent; antifungal agent; calmodulin antagonist; chemokine receptor 5 antagonist; EC 2.3.1.48 (histone acetyltransferase) inhibitor; NMDA receptor antagonist; S100 calcium-binding protein B inhibitor; trypanocidal drug; xenobiotic
trimethoprim Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.. trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.	2.05	1	aminopyrimidine; methoxybenzenes	antibacterial drug; diuretic; drug allergen; EC 1.5.1.3 (dihydrofolate reductase) inhibitor; environmental contaminant; xenobiotic
chloramphenicol Amphenicol: Chloramphenicol and its derivatives.	2.46	2	C-nitro compound; carboxamide; diol; organochlorine compound	antibacterial drug; antimicrobial agent; Escherichia coli metabolite; geroprotector; Mycoplasma genitalium metabolite; protein synthesis inhibitor
kanamycin a Kanamycin: Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major component, and kanamycins B and C, the minor components.. kanamycin : Kanamycin is a naturally occurring antibiotic complex from Streptomyces kanamyceticus that consists of several components: kanamycin A, the major component (also usually designated as kanamycin), and kanamycins B, C, D and X the minor components.	2.05	1	kanamycins	bacterial metabolite
oxacillin Oxacillin: An antibiotic similar to FLUCLOXACILLIN used in resistant staphylococci infections.. oxacillin : A penicillin antibiotic carrying a 5-methyl-3-phenylisoxazole-4-carboxamide group at position 6beta.	2.05	1	penicillin	antibacterial agent; antibacterial drug
ampicillin Ampicillin: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.. ampicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group.	2.05	1	beta-lactam antibiotic; penicillin allergen; penicillin	antibacterial drug
erythromycin Erythromycin: A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.. erythromycin : Any of several wide-spectrum macrolide antibiotics obtained from actinomycete Saccharopolyspora erythraea (formerly known as Streptomyces erythraeus).. erythromycin A : An erythromycin that consists of erythronolide A having 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl and 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl residues attahced at positions 4 and 6 respectively.	2.05	1	cyclic ketone; erythromycin
vancomycin Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.. vancomycin : A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.	2.74	3	glycopeptide	antibacterial drug; antimicrobial agent; bacterial metabolite
spectinomycin Spectinomycin: An antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of GONORRHEA.. spectinomycin dihydrochloride : A hydrochloride obtained by combining spectinomycin with two molar equivalents of hydrochloric acid. An antibiotic that is active against gram-negative bacteria and used (as its pentahydrate) to treat gonorrhea.. spectinomycin : A pyranobenzodioxin and antibiotic that is active against gram-negative bacteria and used (as its dihydrochloride pentahydrate) to treat gonorrhea. It is produced by the bacterium Streptomyces spectabilis.	2.05	1	cyclic acetal; cyclic hemiketal; cyclic ketone; pyranobenzodioxin; secondary alcohol; secondary amino compound	antibacterial drug; antimicrobial agent; bacterial metabolite
streptomycin [no description available]	2.05	1	antibiotic antifungal drug; antibiotic fungicide; streptomycins	antibacterial drug; antifungal agrochemical; antimicrobial agent; antimicrobial drug; bacterial metabolite; protein synthesis inhibitor
carbenicillin Carbenicillin: Broad-spectrum semisynthetic penicillin derivative used parenterally. It is susceptible to gastric juice and penicillinase and may damage platelet function.. carbenicillin : A penicillin antibiotic having a 6beta-2-carboxy-2-phenylacetamido side-chain.	2.05	1	penicillin allergen; penicillin	antibacterial drug
4',6-bis(2'imidazolinyl-4',5'-h)-2-phenylindole 4',6-bis(2'imidazolinyl-4',5'-H)-2-phenylindole: used to produce distinct fluorescent bands in human chromosomes; structure	2.05	1
1,2-di(5-amidino-2-benzofuranyl)ethane 1,2-di(5-amidino-2-benzofuranyl)ethane: preferential inhibitor of bovine factor Xa; structure given in first source	2.05	1
aminoquinuride [no description available]	2.05	1
enrofloxacin Enrofloxacin: A fluoroquinolone antibacterial and antimycoplasma agent that is used in veterinary practice.. enrofloxacin : A quinolinemonocarboxylic acid that is 1,4-dihydroquinoline-3-carboxylic acid substituted by an oxo group at position 4, a fluoro group at position 6, a cyclopropyl group at position 1 and a 4-ethylpiperazin-1-yl group at position 7. It is a veterinary antibacterial agent used for the treatment of pets.	2.05	1	cyclopropanes; N-alkylpiperazine; N-arylpiperazine; organofluorine compound; quinolinemonocarboxylic acid; quinolone	antibacterial agent; antimicrobial agent; antineoplastic agent
imipenem, anhydrous Imipenem: Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.. imipenem : A broad-spectrum, intravenous beta-lactam antibiotic of the carbapenem subgroup.	2.05	1	beta-lactam antibiotic allergen; carbapenems; zwitterion	antibacterial drug
2-(4-amidinophenyl)-1-benzofuran-5-carboxamidine 2-(4-amidinophenyl)-1-benzofuran-5-carboxamidine: structure given in first source	2.05	1
levofloxacin Levofloxacin: The L-isomer of Ofloxacin.. levofloxacin : An optically active form of ofloxacin having (S)-configuration; an inhibitor of bacterial topoisomerase IV and DNA gyrase.	2.05	1	9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid; fluoroquinolone antibiotic; quinolone antibiotic	antibacterial drug; DNA synthesis inhibitor; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; topoisomerase IV inhibitor
linezolid [no description available]	2.05	1	acetamides; morpholines; organofluorine compound; oxazolidinone	antibacterial drug; protein synthesis inhibitor
mupirocin Mupirocin: A topically used antibiotic from a strain of Pseudomonas fluorescens. It has shown excellent activity against gram-positive staphylococci and streptococci. The antibiotic is used primarily for the treatment of primary and secondary skin disorders, nasal infections, and wound healing.. mupirocin : An alpha,beta-unsaturated ester resulting from the formal condensation of the alcoholic hydroxy group of 9-hydroxynonanoic acid with the carboxy group of (2E)-4-[(2S)-tetrahydro-2H-pyran-2-yl]-3-methylbut-2-enoic acid in which the tetrahydropyranyl ring is substituted at positions 3 and 4 by hydroxy groups and at position 5 by a {(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl}methyl group. Originally isolated from the Gram-negative bacterium Pseudomonas fluorescens, it is used as a topical antibiotic for the treatment of Gram-positive bacterial infections.	2.05	1	alpha,beta-unsaturated carboxylic ester; epoxide; monocarboxylic acid; oxanes; secondary alcohol; triol	antibacterial drug; bacterial metabolite; protein synthesis inhibitor
clindamycin Clindamycin: An antibacterial agent that is a semisynthetic analog of LINCOMYCIN.. clindamycin : A carbohydrate-containing antibiotic that is the semisynthetic derivative of lincomycin, a natural antibiotic.	2.05	1
dactinomycin Dactinomycin: A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)	2.05	1	actinomycin	mutagen
fusidic acid Fusidic Acid: An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed). It acts by inhibiting translocation during protein synthesis.. fusidic acid : A steroid antibiotic that is isolated from the fermentation broth of Fusidium coccineum.	2.05	1	11alpha-hydroxy steroid; 3alpha-hydroxy steroid; alpha,beta-unsaturated monocarboxylic acid; steroid acid; steroid antibiotic; sterol ester	EC 2.7.1.33 (pantothenate kinase) inhibitor; Escherichia coli metabolite; protein synthesis inhibitor
mbx 1090 [no description available]	7.75	3
cefotaxime Cefotaxime: Semisynthetic broad-spectrum cephalosporin.. cefotaxime : A cephalosporin compound having acetoxymethyl and [2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side groups.	2.05	1	1,3-thiazoles; cephalosporin; oxime O-ether	antibacterial drug; drug allergen
gentamicin sulfate [no description available]	2.46	2
ly-146032 [no description available]	2.46	2	heterodetic cyclic peptide; lipopeptide antibiotic; lipopeptide; macrocycle; macrolide	antibacterial drug; bacterial metabolite; calcium-dependent antibiotics
novobiocin Novobiocin: An antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189). novobiocin : A coumarin-derived antibiotic obtained from Streptomyces niveus.	2.05	1	carbamate ester; ether; hexoside; hydroxycoumarin; monocarboxylic acid amide; monosaccharide derivative; phenols	antibacterial agent; antimicrobial agent; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; Escherichia coli metabolite; hepatoprotective agent
tetracycline Tetracycline: A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.. tetracycline : A broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria.	2.05	1
tigecycline [no description available]	2.05	1
rifampin Rifampin: A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)	2.46	2	cyclic ketal; hydrazone; N-iminopiperazine; N-methylpiperazine; rifamycins; semisynthetic derivative; zwitterion	angiogenesis inhibitor; antiamoebic agent; antineoplastic agent; antitubercular agent; DNA synthesis inhibitor; EC 2.7.7.6 (RNA polymerase) inhibitor; Escherichia coli metabolite; geroprotector; leprostatic drug; neuroprotective agent; pregnane X receptor agonist; protein synthesis inhibitor

mbx 1066

Description

Cross-References

Synonyms (8)

Bioassays (115)

Research

Studies (7)

Study Types

mbx 1066

Description

Cross-References

Synonyms (8)

Bioassays (115)

Research

Studies (7)

Study Types

Related Drugs (39)

Related Conditions (0)