metronidazole has been researched along with Leishmaniasis, Visceral in 15 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Leishmaniasis, Visceral: A chronic disease caused by LEISHMANIA DONOVANI and transmitted by the bite of several sandflies of the genera Phlebotomus and Lutzomyia. It is commonly characterized by fever, chills, vomiting, anemia, hepatosplenomegaly, leukopenia, hypergammaglobulinemia, emaciation, and an earth-gray color of the skin. The disease is classified into three main types according to geographic distribution: Indian, Mediterranean (or infantile), and African.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metronidazole has been claimed in several earlier reports to be active in human cases of leishmaniasis and trypanosomiasis." | 3.66 | Inefficacy of metronidazole in experimental infections of Leishmania donovani, L. mexicana, and Trypanosoma brucei brucei. ( Keithly, JS; Langreth, SG, 1983) |
| "Seven cases of visceral leishmaniasis are reported, whose epidemiologic, clinical, laboratory, evolutive and therapeutical features are presented." | 2.37 | [Kala-azar. Presentation of 7 cases and review of the literature]. ( García de Miguel, MJ; García Hortelano, J; López-Herce Cid, J; Ramirez Balza, O; Vidal López, ML, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (53.33) | 18.7374 |
| 1990's | 5 (33.33) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 1 (6.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Upadhyay, A | 1 |
| Chandrakar, P | 1 |
| Gupta, S | 1 |
| Parmar, N | 1 |
| Singh, SK | 1 |
| Rashid, M | 1 |
| Kushwaha, P | 1 |
| Wahajuddin, M | 1 |
| Sashidhara, KV | 1 |
| Kar, S | 1 |
| Pennisi, MG | 1 |
| De Majo, M | 1 |
| Masucci, M | 1 |
| Britti, D | 1 |
| Vitale, F | 1 |
| Del Maso, R | 1 |
| Masramon, J | 1 |
| Aubia, J | 1 |
| Lloveras, J | 1 |
| Llorach, I | 1 |
| Llorach, M | 1 |
| Keithly, JS | 1 |
| Langreth, SG | 1 |
| García de Miguel, MJ | 1 |
| López-Herce Cid, J | 1 |
| Ramirez Balza, O | 1 |
| Vidal López, ML | 1 |
| García Hortelano, J | 1 |
| Aguado, JM | 1 |
| Gómez Berne, J | 1 |
| Figuera, A | 1 |
| de Villalobos, E | 1 |
| Fernández-Guerrero, ML | 1 |
| Sanchez Fayos, J | 1 |
| Bano, P | 1 |
| Shahab, SM | 1 |
| Laguna del Estal, P | 1 |
| Moya, MS | 1 |
| Martín, T | 1 |
| Lucero, MJ | 1 |
| Salgado, R | 1 |
| Arranz-Caso, JA | 1 |
| Albarrán-Hernández, F | 1 |
| Cuadrado-Gómez, LM | 1 |
| Gonzalez-Palacios, R | 1 |
| Laguna-del-Estal, P | 1 |
| Moya-Mir, MS | 1 |
| Arora, SK | 1 |
| Sinha, R | 1 |
| Sehgal, S | 1 |
| Thakur, CP | 1 |
| Sinha, PK | 1 |
| Mishra, M | 1 |
| Thakur, BD | 1 |
| Choudhary, M | 1 |
| Geddes, AM | 1 |
| Lapierre, J | 1 |
1 review available for metronidazole and Leishmaniasis, Visceral
| Article | Year |
|---|---|
[Kala-azar. Presentation of 7 cases and review of the literature].
Topics: Antimony; Child; Child, Preschool; Drug Combinations; Female; Humans; Infant; Leishmaniasis, Viscera | 1984 |
3 trials available for metronidazole and Leishmaniasis, Visceral
| Article | Year |
|---|---|
Efficacy of the treatment of dogs with leishmaniosis with a combination of metronidazole and spiramycin.
Topics: Allopurinol; Animals; Antiprotozoal Agents; Dog Diseases; Dogs; Drug Therapy, Combination; Female; F | 2005 |
Inefficacy of ethambutol, ethambutol plus isoniazid, INH plus rifampicin, co-trimoxazole and metronidazole in the treatment of kala-azar.
Topics: Antiprotozoal Agents; Drug Therapy, Combination; Ethambutol; Female; Follow-Up Studies; Humans; Ison | 1989 |
Metronidazole and Indian kala-azar: results of a clinical trial.
Topics: Adult; Clinical Trials as Topic; Female; Humans; India; Leishmaniasis, Visceral; Male; Metronidazole | 1985 |
11 other studies available for metronidazole and Leishmaniasis, Visceral
| Article | Year |
|---|---|
Synthesis, Biological Evaluation, Structure-Activity Relationship, and Mechanism of Action Studies of Quinoline-Metronidazole Derivatives Against Experimental Visceral Leishmaniasis.
Topics: Animals; Antiprotozoal Agents; Chemistry Techniques, Synthetic; Chlorocebus aethiops; Disease Models | 2019 |
Co-trimoxazole for leishmaniasis-or metronidazole?
Topics: Adult; Drug Combinations; Humans; Leishmaniasis, Visceral; Male; Metronidazole; Sulfamethoxazole; Tr | 1981 |
Inefficacy of metronidazole in experimental infections of Leishmania donovani, L. mexicana, and Trypanosoma brucei brucei.
Topics: Animals; Antimony Sodium Gluconate; Cricetinae; Leishmaniasis; Leishmaniasis, Visceral; Mesocricetus | 1983 |
Visceral leishmaniasis (kala-azar) complicating acute leukaemia.
Topics: Acute Disease; Adolescent; Humans; Leishmaniasis, Visceral; Leukemia; Male; Metronidazole | 1983 |
A combination of sulphadiazine, trimethoprim and metronidazole or tinidazole in kala-azar.
Topics: Adult; Animals; Drug Therapy, Combination; Female; Humans; Leishmania donovani; Leishmaniasis, Visce | 1994 |
Metronidazole therapy for visceral leishmaniasis.
Topics: Adult; Animals; Antibodies, Protozoan; Bone Marrow; Hodgkin Disease; Humans; Leishmania donovani; Le | 1994 |
Metronidazole treatment in a patient with AIDS and visceral leishmaniasis.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Humans; Leishmania | 1995 |
Prophylaxis of visceral leishmaniasis in human immunodeficiency virus-infected patients.
Topics: AIDS-Related Opportunistic Infections; Antiprotozoal Agents; Humans; Leishmaniasis, Visceral; Metron | 1997 |
Use of in vitro method to assess different brands of anti-leishmanial drugs.
Topics: Animals; Antiprotozoal Agents; Drug Evaluation, Preclinical; In Vitro Techniques; Leishmania donovan | 1991 |
Imported infections. Unexplained fever.
Topics: Africa; Asia; Brucellosis; Chloramphenicol; Chloroquine; Fever; Humans; Leishmaniasis, Visceral; Liv | 1974 |
[Leishmaniasis].
Topics: Amidines; Amphotericin B; Anemia; Animals; Antimony; Blood Protein Electrophoresis; Child, Preschool | 1969 |