metronidazole has been researched along with Diathesis in 13 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Both factors are modulated by bacterial vaginosis (BV) and, to some extent, by Lactobacillus iners, the genital Lactobacillus spp." | 1.51 | Impact of Standard Bacterial Vaginosis Treatment on the Genital Microbiota, Immune Milieu, and Ex Vivo Human Immunodeficiency Virus Susceptibility. ( Anzala, O; Dizzell, S; Gajer, P; Huibner, S; Humphrys, M; Joag, V; Kaul, R; Kaushic, C; Kimani, J; Mureithi, M; Obila, O; Oyugi, J; Ravel, J; Scott, MC; Shahabi, K; Shannon, B; Tharao, W, 2019) |
| "Cancrum oris is predominantly seen in children in underdeveloped countries where widespread malnutrition, dehydration and epidemic infections are present." | 1.28 | Cancrum oris-like lesions. ( Cheng, LH; Nash, ES; Smart, K, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (23.08) | 18.2507 |
| 2000's | 5 (38.46) | 29.6817 |
| 2010's | 5 (38.46) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Joag, V | 1 |
| Obila, O | 1 |
| Gajer, P | 1 |
| Scott, MC | 1 |
| Dizzell, S | 1 |
| Humphrys, M | 1 |
| Shahabi, K | 1 |
| Huibner, S | 1 |
| Shannon, B | 1 |
| Tharao, W | 1 |
| Mureithi, M | 1 |
| Oyugi, J | 1 |
| Kimani, J | 1 |
| Kaushic, C | 1 |
| Ravel, J | 1 |
| Anzala, O | 1 |
| Kaul, R | 1 |
| Alidjinou, EK | 1 |
| Bonnet, I | 1 |
| Canis, F | 1 |
| Dewulf, G | 1 |
| Mazars, E | 1 |
| Cattoen, C | 1 |
| Ogut, H | 1 |
| Parlak, R | 1 |
| Batista, N | 1 |
| Fernández, MP | 1 |
| Gambra, ML | 1 |
| Rodríguez, L | 1 |
| Leininger, M | 1 |
| Tenenbaum, H | 1 |
| Davideau, JL | 1 |
| Turnbull, IR | 1 |
| Wlzorek, JJ | 1 |
| Osborne, D | 1 |
| Hotchkiss, RS | 1 |
| Coopersmith, CM | 1 |
| Buchman, TG | 1 |
| Yahav, J | 1 |
| Samra, Z | 1 |
| Niv, Y | 1 |
| Evans, CT | 1 |
| Passaro, DJ | 1 |
| Dinari, G | 1 |
| Shmuely, H | 1 |
| Sharma, S | 1 |
| Prasad, KN | 1 |
| Chamoli, D | 1 |
| Ayyagari, A | 1 |
| Miyaji, H | 1 |
| Azuma, T | 1 |
| Ito, S | 1 |
| Suto, H | 1 |
| Ito, Y | 1 |
| Yamazaki, Y | 1 |
| Sato, F | 1 |
| Hirai, M | 1 |
| Kuriyama, M | 1 |
| Kato, T | 1 |
| Kohli, Y | 1 |
| Trenschel, R | 1 |
| Peceny, R | 1 |
| Runde, V | 1 |
| Elmaagacli, A | 1 |
| Dermoumi, H | 1 |
| Heintschel von Heinegg, E | 1 |
| Müller, KD | 1 |
| Schaefer, UW | 1 |
| Beelen, DW | 1 |
| Rouquette-Vincenti, I | 1 |
| Petitjeans, F | 1 |
| Villevieille, T | 1 |
| Szymczyszyn, P | 1 |
| Fangio, P | 1 |
| Baranger, B | 1 |
| Brinquin, L | 1 |
| Nash, ES | 1 |
| Cheng, LH | 1 |
| Smart, K | 1 |
3 trials available for metronidazole and Diathesis
| Article | Year |
|---|---|
Susceptibility-guided vs. empiric retreatment of Helicobacter pylori infection after treatment failure.
Topics: Anti-Bacterial Agents; Biopsy; Cells, Cultured; Clarithromycin; Cohort Studies; Disease Susceptibili | 2006 |
Susceptibility of Helicobacter pylori isolates to metronidazole, clarithromycin and amoxycillin in vitro and in clinical treatment in Japan.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amoxicillin; Clarithromycin; Disease Susceptibility; Dru | 1997 |
Fungal colonization and invasive fungal infections following allogeneic BMT using metronidazole, ciprofloxacin and fluconazole or ciprofloxacin and fluconazole as intestinal decontamination.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Antibiotic Prophylaxis; Antifungal Agents; Aspergillosis; | 2000 |
10 other studies available for metronidazole and Diathesis
| Article | Year |
|---|---|
Impact of Standard Bacterial Vaginosis Treatment on the Genital Microbiota, Immune Milieu, and Ex Vivo Human Immunodeficiency Virus Susceptibility.
Topics: Administration, Oral; Adult; CD4-Positive T-Lymphocytes; Cells, Cultured; Cervix Uteri; Cytokines; D | 2019 |
[Gardnerella vaginalis bacteremia in a male patient].
Topics: Adenocarcinoma; Amikacin; Anti-Bacterial Agents; Antineoplastic Combined Chemotherapy Protocols; Bac | 2013 |
Hexamitiasis leads to lower metabolic rates in rainbow trout Oncorhynchus mykiss (Walbaum) juveniles.
Topics: Animals; Antiparasitic Agents; Body Weight; Diplomonadida; Disease Susceptibility; Fish Diseases; In | 2014 |
[Fournier's gangrene caused by Streptococcus agalactiae in a non-pregnant woman].
Topics: Adult; Anti-Bacterial Agents; Clindamycin; Combined Modality Therapy; Debridement; Diabetes Mellitus | 2009 |
Modified periodontal risk assessment score: long-term predictive value of treatment outcomes. A retrospective study.
Topics: Aggressive Periodontitis; Anti-Infective Agents, Local; Chronic Periodontitis; Dental Scaling; Disea | 2010 |
[Update on current care guidelines: antimicrobials in acute dentistry].
Topics: Amoxicillin; Anti-Bacterial Agents; Antibiotic Prophylaxis; Clavulanic Acid; Disease Susceptibility; | 2011 |
Effects of age on mortality and antibiotic efficacy in cecal ligation and puncture.
Topics: Age Factors; Aging; Animals; Cecum; Ceftriaxone; Disease Susceptibility; Drug Therapy, Combination; | 2003 |
Antimicrobial susceptibility pattern & biotyping of Helicobacter pylori isolates from patients with peptic ulcer diseases.
Topics: Adolescent; Adult; Bacterial Typing Techniques; Child; Disease Susceptibility; Drug Resistance, Micr | 1995 |
[Obesity, diabetes mellitus, and gas gangrene: a major therapeutic challenge].
Topics: Abscess; Amikacin; Anus Diseases; Buttocks; Candidiasis; Ceftazidime; Colostomy; Combined Modality T | 2001 |
Cancrum oris-like lesions.
Topics: Ampicillin; Busulfan; Candida albicans; Chronic Disease; Diagnosis, Differential; Disease Susceptibi | 1991 |