metronidazole has been researched along with Fournier Disease in 4 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate Fournier's gangrene severity score index (FGSI) predictive value." | 1.37 | [Hyperbaric oxygen therapy adjunctive to surgical debridement in management of Fournier's gangrene: usefulness of a severity index score in predicting disease gravity and patient survival]. ( Abbar, M; Albouzidi, A; Ameur, A; Chafiqui, J; Ghadouane, M; Hajji, F; Ismail, TO; Janane, A, 2011) |
| "Fournier gangrene is a necrotizing fasciitis of the perineal and genital region, which almost exclusively affects men." | 1.33 | [Extensive Fournier gangrene. A dermatologic emergency]. ( Aschoff, R; Baldauf, A; Leike, S; Meurer, M; Wirth, MP, 2006) |
| "Fournier's gangrene is an aggressive form of necrotizing fasciitis of the perineal, perianal or genital regions, usually caused by a polymicrobial infection that includes virulent organisms." | 1.33 | The use of oxygen in Fournier's gangrene. ( Diab, AI; Safioleas, MC; Safioleas, PM; Stamatakos, MC, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Batista, N | 1 |
| Fernández, MP | 1 |
| Gambra, ML | 1 |
| RodrÃguez, L | 1 |
| Janane, A | 1 |
| Hajji, F | 1 |
| Ismail, TO | 1 |
| Chafiqui, J | 1 |
| Ghadouane, M | 1 |
| Ameur, A | 1 |
| Abbar, M | 1 |
| Albouzidi, A | 1 |
| Aschoff, R | 1 |
| Baldauf, A | 1 |
| Leike, S | 1 |
| Wirth, MP | 1 |
| Meurer, M | 1 |
| Safioleas, MC | 1 |
| Stamatakos, MC | 1 |
| Diab, AI | 1 |
| Safioleas, PM | 1 |
4 other studies available for metronidazole and Fournier Disease
| Article | Year |
|---|---|
[Fournier's gangrene caused by Streptococcus agalactiae in a non-pregnant woman].
Topics: Adult; Anti-Bacterial Agents; Clindamycin; Combined Modality Therapy; Debridement; Diabetes Mellitus | 2009 |
[Hyperbaric oxygen therapy adjunctive to surgical debridement in management of Fournier's gangrene: usefulness of a severity index score in predicting disease gravity and patient survival].
Topics: Adult; Aged; Anti-Bacterial Agents; Cephalosporins; Combined Modality Therapy; Debridement; Fournier | 2011 |
[Extensive Fournier gangrene. A dermatologic emergency].
Topics: Adult; Cefotaxime; Combined Modality Therapy; Drug Therapy, Combination; Emergencies; Follow-Up Stud | 2006 |
The use of oxygen in Fournier's gangrene.
Topics: Adolescent; Anti-Bacterial Agents; Anti-Infective Agents, Local; Bandages; Debridement; Fournier Gan | 2006 |