Page last updated: 2024-10-31

metronidazole and Hyperesthesia

metronidazole has been researched along with Hyperesthesia in 1 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Hyperesthesia: Increased sensitivity to cutaneous stimulation due to a diminished threshold or an increased response to stimuli.

Research Excerpts

ExcerptRelevanceReference
"Five patients with Crohn's disease for 4 months to 12 years were treated with metronidazole."1.25Metronidazole for Crohn's disease. ( Kamme, C; Ursing, B, 1975)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19901 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ursing, B1
Kamme, C1

Other Studies

1 other study available for metronidazole and Hyperesthesia

ArticleYear
Metronidazole for Crohn's disease.
    Lancet (London, England), 1975, Apr-05, Volume: 1, Issue:7910

    Topics: Adult; Child; Crohn Disease; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Hu

1975