metronidazole has been researched along with Gastritis, Atrophic in 16 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Gastritis, Atrophic: GASTRITIS with atrophy of the GASTRIC MUCOSA, the GASTRIC PARIETAL CELLS, and the mucosal glands leading to ACHLORHYDRIA. Atrophic gastritis usually progresses from chronic gastritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We used data from a randomized placebo-controlled clinical trial to examine the relationship between Helicobacter pylori and reflux symptoms in nonulcer dyspepsia patients randomly assigned anti-Helicobacter pylori triple therapy alone, calcium carbonate alone, or in combination with triple therapy, tetracycline, or placebo." | 5.10 | Increased reflux symptoms after calcium carbonate supplementation and successful anti-Helicobacter pylori treatment. ( Correa, P; Feldman, M; Fischbach, LA; Fontham, E; Goodman, KJ; Jain, R; Priest, E, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (25.00) | 18.2507 |
| 2000's | 8 (50.00) | 29.6817 |
| 2010's | 2 (12.50) | 24.3611 |
| 2020's | 2 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Valencia, ME | 1 |
| Montejano, R | 1 |
| Moreno, V | 1 |
| Martín Carbonero, L | 1 |
| Bernardino, JI | 1 |
| Serrano, L | 1 |
| Kodama, M | 2 |
| Okimoto, T | 2 |
| Mizukami, K | 1 |
| Hirashita, Y | 1 |
| Wada, Y | 1 |
| Fukuda, M | 1 |
| Matsunari, O | 1 |
| Okamoto, K | 1 |
| Ogawa, R | 1 |
| Fukuda, K | 1 |
| Kudo, Y | 1 |
| Kawahara, Y | 1 |
| Murakami, K | 3 |
| Deguchi, R | 1 |
| Shiraishi, K | 1 |
| Arase, Y | 1 |
| Dekiden, M | 1 |
| Shimada, H | 1 |
| Miyakita, H | 1 |
| Ogimi, T | 1 |
| Myojin, K | 1 |
| Mine, T | 1 |
| Fischbach, LA | 2 |
| Bravo, LE | 3 |
| Zarama, GR | 1 |
| Bravo, JC | 3 |
| Ojha, RP | 1 |
| Ojha, PR | 1 |
| Priest, EL | 1 |
| Collazos, T | 1 |
| Casabon, AL | 1 |
| Casabon, LA | 1 |
| Guerrero, LZ | 1 |
| Singh, KP | 1 |
| Singh, PK | 1 |
| Correa, P | 4 |
| Sato, R | 2 |
| Watanabe, K | 1 |
| Fujioka, T | 2 |
| Schuster, MJ | 1 |
| Feldman, M | 1 |
| Fontham, E | 1 |
| Priest, E | 1 |
| Goodman, KJ | 1 |
| Jain, R | 1 |
| Malfertheiner, P | 1 |
| Schuster, M | 1 |
| Camargo, MC | 1 |
| Piazuelo, MB | 1 |
| Mera, RM | 1 |
| Fontham, ET | 1 |
| Delgado, AG | 1 |
| Yepez, MC | 1 |
| Ceron, C | 1 |
| Borody, TJ | 1 |
| Andrews, P | 1 |
| Jankiewicz, E | 1 |
| Ferch, N | 1 |
| Carroll, M | 1 |
| Tucci, A | 1 |
| Biasco, G | 1 |
| Paparo, GF | 1 |
| Kubota, T | 1 |
| Brieva, L | 1 |
| Ara, JR | 1 |
| Bertol, V | 1 |
| Canellas, A | 1 |
| del Agua, C | 1 |
| van Doorn, LJ | 1 |
| Ruiz, B | 1 |
| Realpe, JL | 1 |
| Kokkola, A | 1 |
| Sipponen, P | 1 |
| Rautelin, H | 1 |
| Härkönen, M | 1 |
| Kosunen, TU | 1 |
| Haapiainen, R | 1 |
| Puolakkainen, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Clinical Trial to Examine the Efficacy of a Clarithromycin-, Amoxicillin-, and Metronidazole-Based Regimen to Eradicate Helicobacter Pylori Infections in Pasto, Colombia[NCT00719420] | Phase 3 | 151 participants (Actual) | Interventional | 2006-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for metronidazole and Gastritis, Atrophic
| Article | Year |
|---|---|
[Helicobacter pylori. Update 2002].
Topics: Adenocarcinoma; Amoxicillin; Anti-Bacterial Agents; Clarithromycin; Drug Therapy, Combination; Duode | 2002 |
[Guidelines for the diagnosis and treatment of H. pylori infection].
Topics: Adult; Anti-Bacterial Agents; Anti-Infective Agents; Drug Therapy, Combination; Duodenal Ulcer; Dysp | 2003 |
[Helicobacter pylori: reasons for eradication].
Topics: Adenocarcinoma; Amoxicillin; Anti-Ulcer Agents; Clarithromycin; Drug Therapy, Combination; Gastritis | 2004 |
[Problems following antibiotic therapy for eradication of Helicobacter pylori].
Topics: Amoxicillin; Anti-Bacterial Agents; Antitrichomonal Agents; Clarithromycin; Drug Resistance, Microbi | 1998 |
2 trials available for metronidazole and Gastritis, Atrophic
| Article | Year |
|---|---|
A randomized clinical trial to determine the efficacy of regimens containing clarithromycin, metronidazole, and amoxicillin among histologic subgroups for Helicobacter pylori eradication in a developing country.
Topics: Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Clarithromycin; Cohort Studies; Colombia; Developin | 2009 |
Increased reflux symptoms after calcium carbonate supplementation and successful anti-Helicobacter pylori treatment.
Topics: Adult; Amoxicillin; Antacids; Bismuth; Calcium Carbonate; Drug Therapy, Combination; Dyspepsia; Fema | 2003 |
10 other studies available for metronidazole and Gastritis, Atrophic
| Article | Year |
|---|---|
[Helicobacter pylori infection in the HIV + population: a comorbidity to think about].
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Anti-HIV Agents; Anti-Ulcer Agents; Clarithromycin; Comor | 2020 |
Gastric mucosal changes, and sex differences therein, after Helicobacter pylori eradication: A long-term prospective follow-up study.
Topics: Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Atrophy; Clarithromycin; Female; Follow-Up Studies; | 2021 |
Successful Eradication Therapy for Helicobacter pylori-positive Atrophic Gastritis at the Sixth Attempt: A Case Report.
Topics: Aged; Drug Therapy, Combination; Female; Fluoroquinolones; Gastritis, Atrophic; Helicobacter Infecti | 2016 |
Development of corpus atrophic gastritis may be associated with Helicobacter pylori-related idiopathic thrombocytopenic purpura.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Clarithrom | 2011 |
Effect of smoking on failure of H. pylori therapy and gastric histology in a high gastric cancer risk area of Colombia.
Topics: Amoxicillin; Anti-Infective Agents; Bismuth; Colombia; Drug Therapy, Combination; Female; Follow-Up | 2007 |
Apparent reversal of early gastric mucosal atrophy after triple therapy for Helicobacter pylori.
Topics: Anti-Bacterial Agents; Antibodies, Bacterial; Bismuth; Drug Therapy, Combination; Gastric Mucosa; Ga | 1993 |
Effect of eradication of Helicobacter pylori in patients with fundic atrophic gastritis.
Topics: Amoxicillin; Bismuth; Female; Gastritis, Atrophic; Helicobacter Infections; Helicobacter pylori; Hum | 1997 |
[Polyneuropathy caused by vitamin B12 deficiency secondary to chronic atrophic gastritis and giardiasis].
Topics: Amoxicillin; Anemia, Pernicious; Anti-Bacterial Agents; Antiprotozoal Agents; Bismuth; Duodenitis; E | 1998 |
Unsuccessful treatment results in survival of less virulent genotypes of Helicobacter pylori in Colombian patients.
Topics: Amoxicillin; Antacids; Anti-Bacterial Agents; Bismuth; Chemoprevention; Colombia; Follow-Up Studies; | 2000 |
The effect of Helicobacter pylori eradication on the natural course of atrophic gastritis with dysplasia.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Amoxicillin; Anti-Bacterial Agents; Drug Combinations | 2002 |