metronidazole has been researched along with Proteinuria in 2 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Proteinuria: The presence of proteins in the urine, an indicator of KIDNEY DISEASES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Triptolide is a major active component of Tripterygium wilfordii Hook F that exhibits potent antiproteinuric effects." | 5.48 | Triptolide attenuates proteinuria and podocyte apoptosis via inhibition of NF-κB/GADD45B. ( Chen, Z; Hou, Q; Liu, Z; Wang, L; Zhang, L; Zhu, X, 2018) |
| "Triptolide is a major active component of Tripterygium wilfordii Hook F that exhibits potent antiproteinuric effects." | 1.48 | Triptolide attenuates proteinuria and podocyte apoptosis via inhibition of NF-κB/GADD45B. ( Chen, Z; Hou, Q; Liu, Z; Wang, L; Zhang, L; Zhu, X, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, L | 1 |
| Zhang, L | 1 |
| Hou, Q | 1 |
| Zhu, X | 1 |
| Chen, Z | 1 |
| Liu, Z | 1 |
| Zhou, W | 1 |
| Hildebrandt, F | 1 |
2 other studies available for metronidazole and Proteinuria
| Article | Year |
|---|---|
Triptolide attenuates proteinuria and podocyte apoptosis via inhibition of NF-κB/GADD45B.
Topics: Animals; Animals, Genetically Modified; Anti-Infective Agents; Antigens, Differentiation; Apoptosis; | 2018 |
Inducible podocyte injury and proteinuria in transgenic zebrafish.
Topics: Animals; Animals, Genetically Modified; Disease Models, Animal; Glomerular Filtration Barrier; Immun | 2012 |