| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
dinitrochlorobenzene
Dinitrochlorobenzene: A skin irritant that may cause dermatitis of both primary and allergic types. Contact sensitization with DNCB has been used as a measure of cellular immunity. DNCB is also used as a reagent for the detection and determination of pyridine compounds.. 1-chloro-2,4-dinitrobenzene : A C-nitro compound that is chlorobenzene carrying a nitro substituent at each of the 2- and 4-positions. | 3.07 | 1 | 0 | C-nitro compound;
monochlorobenzenes | allergen;
epitope;
sensitiser |
4-nitrobenzaldehyde
4-nitrobenzaldehyde: RN given refers to parent cpd. 4-nitrobenzaldehyde : A C-nitro compound that is benzaldehyde substituted at the para-position with a nitro group. | 3.07 | 1 | 0 | benzaldehydes;
C-nitro compound | |
indole
[no description available] | 2.03 | 1 | 0 | indole;
polycyclic heteroarene | Escherichia coli metabolite |
7-nitroindazole
7-nitroindazole: an inhibitor of nitric oxide synthase; exhibits anti-nociceptive activity without increasing blood pressure | 3.07 | 1 | 0 | | |
bisindolylmaleimide i
bisindolylmaleimide I: a bis(indolyl)maleimide | 2.02 | 1 | 0 | | |
chloroquine
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis. | 2.02 | 1 | 0 | aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound | anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug |
indirubin-3'-monoxime
indirubin-3'-monoxime: has antiangiogenic activity. indirubin-3'-monoxime : A member of the class of biindoles that is indirubin in which the keto group at position 3' has undergone condensation with hydroxylamine to form the corresponding oxime. | 2.02 | 1 | 0 | | |
nsc 664704
kenpaullone: inhibits CDK1/cyclin B; structure in first source. kenpaullone : An indolobenzazepine that is paullone in which the hydrogen at position 9 is replaced by a bromo substituent. It is an ATP-competitive inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3beta (GSK3beta). | 2.02 | 1 | 0 | indolobenzazepine;
lactam;
organobromine compound | cardioprotective agent;
EC 2.7.11.22 (cyclin-dependent kinase) inhibitor;
EC 2.7.11.26 (tau-protein kinase) inhibitor;
geroprotector |
mefloquine hydrochloride
[2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol : An organofluorine compound that consists of quinoline bearing trifluoromethyl substituents at positions 2 and 8 as well as a (2-piperidinyl)hydroxymethyl substituent at position 4. | 2.02 | 1 | 0 | organofluorine compound;
piperidines;
quinolines;
secondary alcohol | |
metronidazole
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.. metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death. | 3.07 | 1 | 0 | C-nitro compound;
imidazoles;
primary alcohol | antiamoebic agent;
antibacterial drug;
antimicrobial agent;
antiparasitic agent;
antitrichomonal drug;
environmental contaminant;
prodrug;
radiosensitizing agent;
xenobiotic |
olomoucine
olomoucine: inhibits protein P34CDC2. olomoucine : A 9H-purine that is substituted by a (2-hydroxyethyl)nitrilo, benzylnitrilo and a methyl group at positions 2,6 and 9, respectively. It is a cyclin-dependent kinase inhibitor. | 2.02 | 1 | 0 | 2,6-diaminopurines;
ethanolamines | EC 2.7.11.22 (cyclin-dependent kinase) inhibitor |
vorinostat
Vorinostat: A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.. vorinostat : A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL). | 2.08 | 1 | 0 | dicarboxylic acid diamide;
hydroxamic acid | antineoplastic agent;
apoptosis inducer;
EC 3.5.1.98 (histone deacetylase) inhibitor |
niridazole
Niridazole: An antischistosomal agent that has become obsolete. | 3.07 | 1 | 0 | 1,3-thiazoles;
C-nitro compound | |
dinitrofluorobenzene
Dinitrofluorobenzene: Irritants and reagents for labeling terminal amino acid groups.. 1-fluoro-2,4-dinitrobenzene : The organofluorine compound that is benzene with a fluoro substituent at the 1-position and two nitro substituents in the 2- and 4-positions. | 3.07 | 1 | 0 | C-nitro compound;
organofluorine compound | agrochemical;
allergen;
chromatographic reagent;
EC 2.7.3.2 (creatine kinase) inhibitor;
protein-sequencing agent;
spectrophotometric reagent |
phthalimide
phthalimide: RN given refers to parent cpd. phthalimide : A dicarboximide that is 2,3-dihydro-1H-isoindole substituted by oxo groups at positions 1 and 3. | 2.03 | 1 | 0 | phthalimides | |
1-nitronaphthalene
1-nitronaphthalene: RN given refers to cpd with locant for nitro moiety in 1 position. 1-nitronaphthalene : A mononitronaphthalene substituted by a nitro group at position 1.. mononitronaphthalene : A nitronaphthalene carrying a single nitro group at unspecified position.. nitronaphthalene : A nitroarene that is naphthalene substituted by at least one nitro group. | 3.07 | 1 | 0 | mononitronaphthalene | environmental contaminant;
mouse metabolite |
5-bromoisatin
[no description available] | 3.3 | 6 | 0 | indoles | anticoronaviral agent |
1-chloro-2-nitrobenzene
[no description available] | 3.07 | 1 | 0 | C-nitro compound;
monochlorobenzenes | |
2,5-dichloronitrobenzene
[no description available] | 3.07 | 1 | 0 | | |
2-nitroanisole
2-nitroanisole : A member of the class of 2-nitroanisoles that is anisole in which one of the hydrogens ortho to the methoxy group is replaced by a nitro group. | 3.07 | 1 | 0 | 2-nitroanisoles | carcinogenic agent |
isatin
tribulin: endogenous MONOAMINE OXIDASE inhibitory activity extractable into ethyl acetate found in brain and many mammalian tissues and fluids; ISATIN is a major component; produced in excess following alcohol withdrawal; | 3.3 | 6 | 0 | indoledione | EC 1.4.3.4 (monoamine oxidase) inhibitor;
plant metabolite |
4-nitrobiphenyl
4-nitrobiphenyl: structure given in first source | 3.07 | 1 | 0 | biphenyls | |
indene
indene: structure in first source. 1H-indene : An ortho-fused bicyclic arene comprising of benzene and cyclopentene rings. | 2.03 | 1 | 0 | indene;
ortho-fused bicyclic arene | |
2,4-dinitroaniline
2,4-dinitroaniline : A nitroaniline consisting of an aniline core having two nitro substituents located at the 2- and 4-positions. | 3.07 | 1 | 0 | nitroaniline | |
nitrobenzene
nitrobenzene : A nitroarene consisting of benzene carrying a single nitro substituent. An industrial chemical used widely in the production of aniline. | 3.07 | 1 | 0 | nitroarene;
nitrobenzenes | |
1,2-dichloro-4-nitrobenzene
[no description available] | 3.07 | 1 | 0 | | |
3-dinitrobenzene
dinitrobenzene : Any member of the class of nitrobenzenes that consists of a benzene ring substituted by two nitro groups. A closed class.. 1,3-dinitrobenzene : A dinitrobenzene that is benzene disubstituted at positions 1 and 3 with nitro groups. | 3.07 | 1 | 0 | dinitrobenzene | neurotoxin |
4-chloronitrobenzene
[no description available] | 3.07 | 1 | 0 | C-nitro compound | |
4-nitroanisole
4-nitroanisole: dye intermediate; organic synthesis; structure. 4-nitroanisole : A member of the class of 4-nitroanisoles that is anisole in which one the hydrogen meta to the methoxy group is replaced by a nitro group. | 3.07 | 1 | 0 | 4-nitroanisoles | |
4-nitroacetophenone
4-nitroacetophenone : A member of the class of acetophenones that is acetophenone substituted at the para-position by a nitro group. | 3.07 | 1 | 0 | acetophenones;
C-nitro compound | |
1,4-dinitrobenzene
1,4-dinitrobenzene : A dinitrobenzene carrying nitro groups at positions 1 and 4. | 3.07 | 1 | 0 | dinitrobenzene | |
2,4-dinitroanisole
2,4-dinitroanisole : A member of the class of dinitroanisoles that is 2-nitroanisole in which the hydrogen para to the methoxy group is replaced by a second nitro group. | 3.07 | 1 | 0 | dinitroanisoles | explosive |
2,4,7-trinitrofluorenone
2,4,7-trinitrofluorenone: structure | 3.07 | 1 | 0 | | |
indan
indan: structure in first source. indane : An ortho-fused bicyclic hydrocarbon consisting of a benzene ring fused to a cyclopentane ring; a high-boiling (176 (o)C) colourless liquid. | 2.03 | 1 | 0 | indanes;
ortho-fused bicyclic hydrocarbon | |
indoline
indoline: structure given in first source | 2.03 | 1 | 0 | indoles | |
1,2-dinitrobenzene
[no description available] | 3.07 | 1 | 0 | dinitrobenzene | |
2-nitrobenzaldehyde
2-nitrobenzaldehyde: structure given in first source. 2-nitrobenzaldehyde : Benzaldehyde substituted at the ortho-position with a nitro group. | 3.07 | 1 | 0 | benzaldehydes;
C-nitro compound | |
1-acetylisatin
1-acetylisatin: structure in first source | 2.03 | 1 | 0 | indoledione | |
2-nitronaphthalene
2-nitronaphthalene : A mononitronaphthalene carrying a nitro group at position 2. | 3.07 | 1 | 0 | mononitronaphthalene | |
9-nitroanthracene
9-nitroanthracene: RN given refers to cpd with locant for nitro moiety in 5 position | 3.07 | 1 | 0 | anthracenes | |
5-nitroacenaphthene
[no description available] | 3.07 | 1 | 0 | nitronaphthalene | |
erythropoietin
1,5-dinitronaphthalene: structure in first source. 1,5-dinitronaphthalene : A dinitronaphthalene carrying nitro groups at positions 1 and 5. | 3.07 | 1 | 0 | dinitronaphthalene | genotoxin |
1,3-indandione
1,3-indandione : A member of the class of indanones that is indane in which the hydrogens at positions 2 and 4 have been replaced by oxo groups. | 2.03 | 1 | 0 | aromatic ketone;
beta-diketone;
indanones | |
1,3-dinitronaphthalene
1,3-dinitronaphthalene: structure given in first source | 3.07 | 1 | 0 | dinitronaphthalene | |
5-nitroquinoline
[no description available] | 3.07 | 1 | 0 | | |
2-nitrofluorene
2-nitrofluorene: RN given refers to cpd with locant with nitro moiety in 2 position. 2-nitrofluorene : A nitroarene that is fluorene substituted by a nitro group at position 2. | 3.07 | 1 | 0 | nitroarene | carcinogenic agent;
mutagen |
5-methylisatin
5-methylisatin: structure in first source | 2.96 | 4 | 0 | | |
2,4-dichloro-1-nitrobenzene
[no description available] | 3.07 | 1 | 0 | | |
5-nitro-2-furaldehyde
[no description available] | 3.07 | 1 | 0 | C-nitro compound;
furans | |
2-nitropyrene
[no description available] | 3.07 | 1 | 0 | pyrenes | |
3-nitrofluoranthene
3-nitrofluoranthene: environmental carcinogen from diesel exhaust | 3.07 | 1 | 0 | nitronaphthalene | |
2-amino-7-nitrofluorene
2-amino-7-nitrofluorene: structure in first source | 3.07 | 1 | 0 | | |
2-bromo-4,6-dinitroaniline
2-bromo-4,6-dinitroaniline: used in synthesis of commercially significant monoazo dyes | 3.07 | 1 | 0 | | |
n-methylisatin
N-methylisatin: structure given in first source | 3.28 | 6 | 0 | | |
5-nitroindazole
[no description available] | 3.07 | 1 | 0 | | |
2,7-dinitrofluorene
[no description available] | 3.07 | 1 | 0 | | |
1-nitropyrene
[no description available] | 3.07 | 1 | 0 | nitroarene | carcinogenic agent |
nsc 520594
[no description available] | 3.07 | 1 | 0 | | |
2-hydroxy-7-nitrofluorene
2-hydroxy-7-nitrofluorene: structure in first source | 3.07 | 1 | 0 | | |
6-nitrochrysene
6-nitrochrysene: RN given refers to cpd with locant for nitro group in position 6 | 3.07 | 1 | 0 | carbopolycyclic compound | |
6-nitroindazole
[no description available] | 3.07 | 1 | 0 | | |
2-nitrofluoranthene
[no description available] | 3.07 | 1 | 0 | | |
7-nitrobenzanthracene
[no description available] | 3.07 | 1 | 0 | phenanthrenes | |
3,9-dinitrofluoranthene
[no description available] | 3.07 | 1 | 0 | nitronaphthalene | |
2,7-dinitrofluorenone
2,7-dinitrofluorenone: structure given in first source | 3.07 | 1 | 0 | | |
5-Methoxyisatin
[no description available] | 3.15 | 5 | 0 | indoles | anticoronaviral agent |
1,6-dinitropyrene
[no description available] | 3.07 | 1 | 0 | pyrenes | |
1,8-dinitropyrene
[no description available] | 3.07 | 1 | 0 | pyrenes | |
staurosporine
[no description available] | 2.43 | 2 | 0 | indolocarbazole alkaloid;
organic heterooctacyclic compound | apoptosis inducer;
bacterial metabolite;
EC 2.7.11.13 (protein kinase C) inhibitor;
geroprotector |
6-nitrobenzo(a)pyrene
[no description available] | 3.07 | 1 | 0 | ortho- and peri-fused polycyclic arene | |
1-nitrobenzo(a)pyrene
[no description available] | 3.07 | 1 | 0 | | |
3-nitrobenzo(a)pyrene
[no description available] | 3.07 | 1 | 0 | | |
1,3-dinitropyrene
[no description available] | 3.07 | 1 | 0 | pyrenes | |
3,7-dinitrofluoranthene
[no description available] | 3.07 | 1 | 0 | nitronaphthalene | |
4-nitropyrene
[no description available] | 3.07 | 1 | 0 | pyrenes | |
3-nitroperylene
3-nitroperylene: RN given refers to cpd with nitro group in position 3 | 3.07 | 1 | 0 | phenanthrenes | |
1-nitro-2,4-difluorobenzene
1-nitro-2,4-difluorobenzene: standard antigen; structure | 3.07 | 1 | 0 | | |
n-phenylphthalimide
N-phenylphthalimide: structure given in first source | 2.03 | 1 | 0 | | |
5-nitroisoquinoline
[no description available] | 3.07 | 1 | 0 | | |
9-nitrophenanthrene
9-nitrophenanthrene: RN given refers to parent cpd; | 3.07 | 1 | 0 | | |
5-nitro-1,10-phenanthroline
5-nitro-1,10-phenanthroline: structure in first source | 3.07 | 1 | 0 | | |
1-fluoro-2-nitrobenzene
1-fluoro-2-nitrobenzene: structure given in first source | 3.07 | 1 | 0 | | |
2,3-dioxo-5-indolinesulfonic acid
2,3-dioxo-5-indolinesulfonic acid: reagent for modification of tryptophan residues in peptides & proteins | 2.06 | 1 | 0 | | |
5-Chloro-1H-indole-2,3-dione
[no description available] | 3.15 | 5 | 0 | indoles | anticoronaviral agent |
5-iodoisatin
5-iodoisatin: structure in first source | 3.3 | 6 | 0 | indoles | anticoronaviral agent |
6-bromoisatin
6-bromoisatin: anticancer compound from Dicathais orbita; structure in first source | 2.45 | 2 | 0 | | |
2-nitrobenzimidazole
2-nitrobenzimidazole: RN given refers to parent cpd | 3.07 | 1 | 0 | | |
5-Fluoroisatin
[no description available] | 3.43 | 7 | 0 | indoles | anticoronaviral agent |
isatin beta-thiosemicarbazone
isatin beta-thiosemicarbazone: isatizon believed to be Russian synonym | 2.01 | 1 | 0 | | |
1-[(3,4-dichlorophenyl)methyl]indole-2,3-dione
[no description available] | 2.03 | 1 | 0 | indoles | |
2,4-dinitrophenylhydrazine
2,4-dinitrophenylhydrazine: structure. 2,4-dinitrophenylhydrazine : A C-nitro compound that is phenylhydrazine substituted at the 2- and 4-positions by nitro groups. | 3.07 | 1 | 0 | C-nitro compound;
phenylhydrazines | reagent |
2-nitro-4-phenylenediamine
2-nitro-4-phenylenediamine: 2-nitro-1,4-benzenediamine; RN given refers to parent cpd. 2-nitro-p-phenylenediamine : A primary amino compound that is p-phenylenediamine in which one of the hydrogens attached to the benzene ring is replaced by a nitro group. It is a cosmetic hair dye intermediate that is used in permanent hair colouring products (diluted 1:1 with an oxidising agent prior to application). | 3.07 | 1 | 0 | C-nitro compound;
primary amino compound | |
2-amino-5-nitrophenol
2-amino-5-nitrophenol: RN & structure given in first source | 3.07 | 1 | 0 | 3-nitrophenols | |
alsterpaullone
alsterpaullone: structure in first source. alsterpaullone : An organic heterotetracyclic compound that is 1,3-dihydro-2H-1-benzazepin-2-one which shares its 4-5 bond with the 3-2 bond of 5-nitro-1H-indole. | 2.02 | 1 | 0 | C-nitro compound;
caprolactams;
organic heterotetracyclic compound | anti-HIV-1 agent;
antineoplastic agent;
apoptosis inducer;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
EC 2.7.11.22 (cyclin-dependent kinase) inhibitor;
EC 2.7.11.26 (tau-protein kinase) inhibitor |
1,2-diamino-4-nitrobenzene
1,2-diamino-4-nitrobenzene: reagent for determination of selenium in milk with gas chromatograph. 4-nitro-1,2-phenylenediamine : The primary amino compound that is 1,2-phenylenediamine (o-phenylenediamine) substituted at the 4- (para-) position by a nitro group. | 3.07 | 1 | 0 | C-nitro compound;
primary amino compound | |
apigenin
Chamomile: Common name for several daisy-like plants (MATRICARIA; TRIPLEUROSPERMUM; ANTHEMIS; CHAMAEMELUM) native to Europe and Western Asia, now naturalized in the United States and Australia. | 2.02 | 1 | 0 | trihydroxyflavone | antineoplastic agent;
metabolite |
genistein
[no description available] | 2.02 | 1 | 0 | 7-hydroxyisoflavones | antineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
human urinary metabolite;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor |
myricetin
[no description available] | 2.02 | 1 | 0 | 7-hydroxyflavonol;
hexahydroxyflavone | antineoplastic agent;
antioxidant;
cyclooxygenase 1 inhibitor;
food component;
geroprotector;
hypoglycemic agent;
plant metabolite |
furazolidone
[no description available] | 3.07 | 1 | 0 | | |
4'-acetamidochalcone
[no description available] | 2.02 | 1 | 0 | | |
nitrofurazone
Nitrofurazone: A topical anti-infective agent effective against gram-negative and gram-positive bacteria. It is used for superficial WOUNDS AND INJURIES and skin infections. Nitrofurazone has also been administered orally in the treatment of TRYPANOSOMIASIS.. nitrofurazone : A semicarbazone resulting from the formal condensation of semicarbazide with 5-nitrofuraldehyde. A broad spectrum antibacterial drug, although with little activity against Pseudomonas species, it is used as a local application for burns, ulcers, wounds and skin infections. | 3.07 | 1 | 0 | | |
nitrofurantoin
Nitrofurantoin: A urinary anti-infective agent effective against most gram-positive and gram-negative organisms. Although sulfonamides and antibiotics are usually the agents of choice for urinary tract infections, nitrofurantoin is widely used for prophylaxis and long-term suppression.. nitrofurantoin : An imidazolidine-2,4-dione that is hydantoin substituted at position 1 by a [(5-nitro-2-furyl)methylene]amino group. An antibiotic that damages bacterial DNA. | 3.07 | 1 | 0 | imidazolidine-2,4-dione;
nitrofuran antibiotic;
organonitrogen heterocyclic antibiotic;
organooxygen heterocyclic antibiotic | antibacterial drug;
antiinfective agent;
hepatotoxic agent |
monosulfuron
monosulfuron: structure in first source | 2.06 | 1 | 0 | | |