metronidazole has been researched along with Osteogenic Sarcoma in 4 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A study was made of the time course of the level of metronidazole in the blood and tissues of 97 patients with localized osteogenic sarcoma in several modes of the drug administration (per os, using an enema and their combinations)." | 7.67 | [Metronidazole content of normal and tumor tissues in the combined treatment of patients with osteogenic sarcoma]. ( Bizer, VA; Grigor'ev, AN; Konopliannikov, AG; Polonskaia, NIu, 1987) |
| "A study was made of the time course of the level of metronidazole in the blood and tissues of 97 patients with localized osteogenic sarcoma in several modes of the drug administration (per os, using an enema and their combinations)." | 3.67 | [Metronidazole content of normal and tumor tissues in the combined treatment of patients with osteogenic sarcoma]. ( Bizer, VA; Grigor'ev, AN; Konopliannikov, AG; Polonskaia, NIu, 1987) |
| "Recently the resection of pulmonary metastases combined with chemotherapy has increased the survival rate." | 1.26 | Radiation treatment of Ewing's sarcoma and osteogenic sarcoma. ( Jenkin, RD, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tsyb, AF | 1 |
| Konopliannikov, AG | 2 |
| Kudriavtseva, GT | 1 |
| Goldobenko, GV | 1 |
| Kherkheulidze, ZSh | 1 |
| Shchebetenko, IuE | 1 |
| Polotskiĭ, BE | 1 |
| Jenkin, RD | 1 |
| Bizer, VA | 1 |
| Polonskaia, NIu | 1 |
| Grigor'ev, AN | 1 |
1 review available for metronidazole and Osteogenic Sarcoma
| Article | Year |
|---|---|
[Analysis of clinical experience in the use of metronidazole as a radiosensitizer of tumors].
Topics: Brain Neoplasms; Clinical Trials as Topic; Esophageal Neoplasms; Female; Genital Neoplasms, Female; | 1983 |
2 trials available for metronidazole and Osteogenic Sarcoma
| Article | Year |
|---|---|
[Use of electron acceptor compounds in radiotherapy].
Topics: Clinical Trials as Topic; Esophageal Neoplasms; Female; Humans; Laryngeal Neoplasms; Metronidazole; | 1983 |
[Analysis of clinical experience in the use of metronidazole as a radiosensitizer of tumors].
Topics: Brain Neoplasms; Clinical Trials as Topic; Esophageal Neoplasms; Female; Genital Neoplasms, Female; | 1983 |
2 other studies available for metronidazole and Osteogenic Sarcoma
| Article | Year |
|---|---|
Radiation treatment of Ewing's sarcoma and osteogenic sarcoma.
Topics: Adolescent; Adult; Bone Neoplasms; Child; Doxorubicin; Female; Humans; Lung Neoplasms; Methotrexate; | 1977 |
[Metronidazole content of normal and tumor tissues in the combined treatment of patients with osteogenic sarcoma].
Topics: Adolescent; Adult; Child; Combined Modality Therapy; Humans; Kinetics; Metronidazole; Middle Aged; O | 1987 |