Page last updated: 2024-10-31

metronidazole and Osteogenic Sarcoma

metronidazole has been researched along with Osteogenic Sarcoma in 4 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Research Excerpts

ExcerptRelevanceReference
"A study was made of the time course of the level of metronidazole in the blood and tissues of 97 patients with localized osteogenic sarcoma in several modes of the drug administration (per os, using an enema and their combinations)."7.67[Metronidazole content of normal and tumor tissues in the combined treatment of patients with osteogenic sarcoma]. ( Bizer, VA; Grigor'ev, AN; Konopliannikov, AG; Polonskaia, NIu, 1987)
"A study was made of the time course of the level of metronidazole in the blood and tissues of 97 patients with localized osteogenic sarcoma in several modes of the drug administration (per os, using an enema and their combinations)."3.67[Metronidazole content of normal and tumor tissues in the combined treatment of patients with osteogenic sarcoma]. ( Bizer, VA; Grigor'ev, AN; Konopliannikov, AG; Polonskaia, NIu, 1987)
"Recently the resection of pulmonary metastases combined with chemotherapy has increased the survival rate."1.26Radiation treatment of Ewing's sarcoma and osteogenic sarcoma. ( Jenkin, RD, 1977)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19904 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Tsyb, AF1
Konopliannikov, AG2
Kudriavtseva, GT1
Goldobenko, GV1
Kherkheulidze, ZSh1
Shchebetenko, IuE1
Polotskiĭ, BE1
Jenkin, RD1
Bizer, VA1
Polonskaia, NIu1
Grigor'ev, AN1

Reviews

1 review available for metronidazole and Osteogenic Sarcoma

ArticleYear
[Analysis of clinical experience in the use of metronidazole as a radiosensitizer of tumors].
    Meditsinskaia radiologiia, 1983, Volume: 28, Issue:7

    Topics: Brain Neoplasms; Clinical Trials as Topic; Esophageal Neoplasms; Female; Genital Neoplasms, Female;

1983

Trials

2 trials available for metronidazole and Osteogenic Sarcoma

ArticleYear
[Use of electron acceptor compounds in radiotherapy].
    Meditsinskaia radiologiia, 1983, Volume: 28, Issue:7

    Topics: Clinical Trials as Topic; Esophageal Neoplasms; Female; Humans; Laryngeal Neoplasms; Metronidazole;

1983
[Analysis of clinical experience in the use of metronidazole as a radiosensitizer of tumors].
    Meditsinskaia radiologiia, 1983, Volume: 28, Issue:7

    Topics: Brain Neoplasms; Clinical Trials as Topic; Esophageal Neoplasms; Female; Genital Neoplasms, Female;

1983

Other Studies

2 other studies available for metronidazole and Osteogenic Sarcoma

ArticleYear
Radiation treatment of Ewing's sarcoma and osteogenic sarcoma.
    Canadian journal of surgery. Journal canadien de chirurgie, 1977, Volume: 20, Issue:6

    Topics: Adolescent; Adult; Bone Neoplasms; Child; Doxorubicin; Female; Humans; Lung Neoplasms; Methotrexate;

1977
[Metronidazole content of normal and tumor tissues in the combined treatment of patients with osteogenic sarcoma].
    Meditsinskaia radiologiia, 1987, Volume: 32, Issue:6

    Topics: Adolescent; Adult; Child; Combined Modality Therapy; Humans; Kinetics; Metronidazole; Middle Aged; O

1987