Page last updated: 2024-12-11
4,4'-dichlorochalcone
Description
Research Excerpts
Clinical Trials
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Study Profile
Bioassays
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Description
4,4'-dichlorochalcone: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
ID Source | ID |
---|---|
PubMed CID | 5377011 |
CHEMBL ID | 226715 |
SCHEMBL ID | 659210 |
MeSH ID | M0426874 |
Synonyms (24)
Synonym |
---|
1,3-bis(4-chlorophenyl)prop-2-en-1-one |
nsc-122588 |
nsc122588 |
19672-59-4 |
(e)-1,3-bis-(4-chloro-phenyl)-propenone |
(e)-1,3-bis(4-chlorophenyl)prop-2-en-1-one |
AKOS000282619 |
4',4-dichlorochalcone |
CHEMBL226715 |
1,3-bis(4-chlorophenyl)-2-propen-1-one |
4,4'-dichlorochalcone |
(2e)-1,3-bis(4-chlorophenyl)prop-2-en-1-one |
22966-30-9 |
2-propen-1-one, 1,3-bis(4-chlorophenyl)-, (2e)- |
SCHEMBL659210 |
trans-1,3-di-(4-chlorophenyl)-prop-2-en-1-one |
STL421306 |
mfcd00018704 |
(2e)-1,3-bis(4-chlorophenyl)-2-propen-1-one |
Z46033279 |
4'-chloro-2-(4-chlorobenzylidene)acetophenone |
D90338 |
CS-0116755 |
2-propen-1-one, 1,3-bis(4-chlorophenyl)- |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (51)
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID386984 | Antifungal activity against haploid Saccharomyces cerevisiae D3C by agar dilution method | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Antifungal activity of chalcones: a mechanistic study using various yeast strains. |
AID386978 | Antifungal activity against diploid Saccharomyces cerevisiae PV-3 by agar dilution method | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Antifungal activity of chalcones: a mechanistic study using various yeast strains. |
AID666993 | Cytotoxicity against human HepG2 cells assessed as cell viability at 3.13 uM after 48 hrs by MTT assay | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis and in vitro evaluation of novel tetrazole embedded 1,3,5-trisubstituted pyrazoline derivatives as Entamoeba histolytica growth inhibitors. |
AID372907 | Antibacterial activity against Staphylococcus aureus Rosenbach 209 after 48 hrs by agar well diffusion method | 2009 | European journal of medicinal chemistry, May, Volume: 44, Issue:5 | Examination of growth inhibitory properties of synthetic chalcones for which antibacterial activity was predicted. |
AID386977 | Antifungal activity against diploid Saccharomyces cerevisiae PV-2 by agar dilution method | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Antifungal activity of chalcones: a mechanistic study using various yeast strains. |
AID386981 | Antifungal activity against diploid Saccharomyces cerevisiae 1a by agar dilution method | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Antifungal activity of chalcones: a mechanistic study using various yeast strains. |
AID666991 | Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis and in vitro evaluation of novel tetrazole embedded 1,3,5-trisubstituted pyrazoline derivatives as Entamoeba histolytica growth inhibitors. |
AID372908 | Antibacterial activity against Staphylococcus aureus Rosenbach 209 after 24 hrs by serial dilution method | 2009 | European journal of medicinal chemistry, May, Volume: 44, Issue:5 | Examination of growth inhibitory properties of synthetic chalcones for which antibacterial activity was predicted. |
AID386983 | Antifungal activity against haploid Saccharomyces cerevisiae Sigma 1278b by agar dilution method | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Antifungal activity of chalcones: a mechanistic study using various yeast strains. |
AID386995 | Antifungal activity against Hansenula polymorpha 2a with arg1 leu2 ura3 cys1 genotype by agar dilution method | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Antifungal activity of chalcones: a mechanistic study using various yeast strains. |
AID386993 | Antifungal activity against Hansenula polymorpha CD3 with ade1 leu2 cds3 genotype by agar dilution method | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Antifungal activity of chalcones: a mechanistic study using various yeast strains. |
AID386979 | Antifungal activity against haploid Saccharomyces cerevisiae 1169 by agar dilution method | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Antifungal activity of chalcones: a mechanistic study using various yeast strains. |
AID386991 | Antifungal activity against Hansenula polymorpha CD1 with ade1 leu2 cds1 genotype by agar dilution method | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Antifungal activity of chalcones: a mechanistic study using various yeast strains. |
AID387004 | Antifungal activity against Hansenula polymorpha R3 with rgh3 genotype by agar dilution method | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Antifungal activity of chalcones: a mechanistic study using various yeast strains. |
AID386990 | Antifungal activity against Hansenula polymorpha WT2 with ade1 met6 genotype by agar dilution method | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Antifungal activity of chalcones: a mechanistic study using various yeast strains. |
AID666994 | Cytotoxicity against human HepG2 cells assessed as cell viability at 25 uM after 48 hrs by MTT assay | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis and in vitro evaluation of novel tetrazole embedded 1,3,5-trisubstituted pyrazoline derivatives as Entamoeba histolytica growth inhibitors. |
AID1272515 | Antiplasmodial activity against chloroquine, quinine and pyrimethamine-resistant Plasmodium falciparum W2 assessed as inhibition of [3H]-hypoxanthine uptake after 48 hrs by liquid scintillation counting analysis | 2016 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3 | In vitro efficacy of 2,N-bisarylated 2-ethoxyacetamides against Plasmodium falciparum. |
AID386999 | Antifungal activity against Hansenula polymorpha MC1 with met2 cys1 genotype by agar dilution method | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Antifungal activity of chalcones: a mechanistic study using various yeast strains. |
AID386987 | Antifungal activity against haploid Saccharomyces cerevisiae YSH1170 by agar dilution method | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Antifungal activity of chalcones: a mechanistic study using various yeast strains. |
AID386985 | Antifungal activity against haploid Saccharomyces cerevisiae FY4 by agar dilution method | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Antifungal activity of chalcones: a mechanistic study using various yeast strains. |
AID387000 | Antifungal activity against Hansenula polymorpha AS1 with arg1 gsh2delta genotype by agar dilution method | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Antifungal activity of chalcones: a mechanistic study using various yeast strains. |
AID666992 | Selectivity index, ratio of IC50 for human HepG2 cells to IC50 for Entamoeba histolytica HM1:IMSS | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis and in vitro evaluation of novel tetrazole embedded 1,3,5-trisubstituted pyrazoline derivatives as Entamoeba histolytica growth inhibitors. |
AID386997 | Antifungal activity against Hansenula polymorpha D22 with arg1/arg1 ade1/ADE1 leu2/leu2 URA3/ura3 CYS1/cys1 genotype by agar dilution method | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Antifungal activity of chalcones: a mechanistic study using various yeast strains. |
AID387002 | Antifungal activity against Hansenula polymorpha AU05 with ade3 ura3 genotype by agar dilution method | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Antifungal activity of chalcones: a mechanistic study using various yeast strains. |
AID387003 | Antifungal activity against Hansenula polymorpha CTA1 with leu2 cat1 genotype by agar dilution method | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Antifungal activity of chalcones: a mechanistic study using various yeast strains. |
AID386988 | Antifungal activity against haploid Saccharomyces cerevisiae YSH1171 by agar dilution method | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Antifungal activity of chalcones: a mechanistic study using various yeast strains. |
AID283847 | Antifungal activity against Candida albicans Berhaut 62I after 24 hrs | 2007 | European journal of medicinal chemistry, Jan, Volume: 42, Issue:1 | Study on the substituents' effects of a series of synthetic chalcones against the yeast Candida albicans. |
AID372906 | Antibacterial activity against Escherichia coli WF+ | 2009 | European journal of medicinal chemistry, May, Volume: 44, Issue:5 | Examination of growth inhibitory properties of synthetic chalcones for which antibacterial activity was predicted. |
AID386976 | Antifungal activity against haploid Saccharomyces cerevisiae 1S by agar dilution method | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Antifungal activity of chalcones: a mechanistic study using various yeast strains. |
AID386986 | Antifungal activity against haploid Saccharomyces cerevisiae 10560-6B by agar dilution method | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Antifungal activity of chalcones: a mechanistic study using various yeast strains. |
AID538324 | Inhibition of Plasmodium falciparum-mediated human hemoglobin degradation at 100 uM | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Reinvestigation of structure-activity relationship of methoxylated chalcones as antimalarials: synthesis and evaluation of 2,4,5-trimethoxy substituted patterns as lead candidates derived from abundantly available natural β-asarone. |
AID283848 | Growth inhibition of Candida albicans Berhaut 62I by agar cup method | 2007 | European journal of medicinal chemistry, Jan, Volume: 42, Issue:1 | Study on the substituents' effects of a series of synthetic chalcones against the yeast Candida albicans. |
AID387006 | Antifungal activity against Kluyveromyces lactis 2-18B with MATalpha metA1 ura3 leu2 genotype by agar dilution method | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Antifungal activity of chalcones: a mechanistic study using various yeast strains. |
AID666995 | Cytotoxicity against human HepG2 cells assessed as cell viability at 50 to 100 uM after 48 hrs by MTT assay | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis and in vitro evaluation of novel tetrazole embedded 1,3,5-trisubstituted pyrazoline derivatives as Entamoeba histolytica growth inhibitors. |
AID538331 | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O+ erythrocytes after 72 hrs by SYBR Green-1 fluorescence based assay | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Reinvestigation of structure-activity relationship of methoxylated chalcones as antimalarials: synthesis and evaluation of 2,4,5-trimethoxy substituted patterns as lead candidates derived from abundantly available natural β-asarone. |
AID386998 | Antifungal activity against Hansenula polymorpha M2 with met2 genotype by agar dilution method | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Antifungal activity of chalcones: a mechanistic study using various yeast strains. |
AID386996 | Antifungal activity against Hansenula polymorpha 2b with arg1 ade1 leu2 genotype by agar dilution method | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Antifungal activity of chalcones: a mechanistic study using various yeast strains. |
AID1272514 | Antiplasmodial activity against mefloquine-resistant Plasmodium falciparum D6 assessed as inhibition of [3H]-hypoxanthine uptake after 48 hrs by liquid scintillation counting analysis | 2016 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3 | In vitro efficacy of 2,N-bisarylated 2-ethoxyacetamides against Plasmodium falciparum. |
AID387008 | Antifungal activity against Kluyveromyces lactis 2-19B with MATalpha ura lys arg genotype by agar dilution method | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Antifungal activity of chalcones: a mechanistic study using various yeast strains. |
AID386989 | Antifungal activity against Hansenula polymorpha WT1 with ade1 ura3 genotype by agar dilution method | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Antifungal activity of chalcones: a mechanistic study using various yeast strains. |
AID386980 | Antifungal activity against haploid Saccharomyces cerevisiae 2180 by agar dilution method | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Antifungal activity of chalcones: a mechanistic study using various yeast strains. |
AID386992 | Antifungal activity against Hansenula polymorpha CD2 with ade1 leu2 cds2 genotype by agar dilution method | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Antifungal activity of chalcones: a mechanistic study using various yeast strains. |
AID386982 | Antifungal activity against diploid Saccharomyces cerevisiae 29a by agar dilution method | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Antifungal activity of chalcones: a mechanistic study using various yeast strains. |
AID386994 | Antifungal activity against Hansenula polymorpha WA1 with ade1 leu2 gsh1 genotype by agar dilution method | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Antifungal activity of chalcones: a mechanistic study using various yeast strains. |
AID1272517 | Bio-transformation in human liver microsomes at 25 uM after 30 mins by LC-MS analysis | 2016 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3 | In vitro efficacy of 2,N-bisarylated 2-ethoxyacetamides against Plasmodium falciparum. |
AID1272516 | Resistant index, ratio of IC50 for chloroquine, quinine and pyrimethamine-resistant Plasmodium falciparum W2 to IC50 for mefloquine-resistant Plasmodium falciparum D6 | 2016 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3 | In vitro efficacy of 2,N-bisarylated 2-ethoxyacetamides against Plasmodium falciparum. |
AID283849 | Antifungal activity against Candida albicans Berhaut 62I in meat-pepton broth | 2007 | European journal of medicinal chemistry, Jan, Volume: 42, Issue:1 | Study on the substituents' effects of a series of synthetic chalcones against the yeast Candida albicans. |
AID387005 | Antifungal activity against Hansenula polymorpha CRD2 with leu2 CDR2 genotype by agar dilution method | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Antifungal activity of chalcones: a mechanistic study using various yeast strains. |
AID666990 | Antiamnesic activity against Entamoeba histolytica HM1:IMSS after 72 hrs by microdilution method | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Synthesis and in vitro evaluation of novel tetrazole embedded 1,3,5-trisubstituted pyrazoline derivatives as Entamoeba histolytica growth inhibitors. |
AID387001 | Antifungal activity against Hansenula polymorpha M4 with met4 genotype by agar dilution method | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Antifungal activity of chalcones: a mechanistic study using various yeast strains. |
AID387007 | Antifungal activity against Kluyveromyces lactis 1-6A with MATalpha uraA lys arg genotype by agar dilution method | 2008 | European journal of medicinal chemistry, Oct, Volume: 43, Issue:10 | Antifungal activity of chalcones: a mechanistic study using various yeast strains. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (8)
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 5 (62.50) | 29.6817 |
2010's | 3 (37.50) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.13
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.13) All Compounds (24.57) |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 8 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |