Compounds > 4,4'-dichlorochalcone
Page last updated: 2024-12-11

4,4'-dichlorochalcone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

4,4'-dichlorochalcone: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID5377011
CHEMBL ID226715
SCHEMBL ID659210
MeSH IDM0426874

Synonyms (24)

Synonym
1,3-bis(4-chlorophenyl)prop-2-en-1-one
nsc-122588
nsc122588
19672-59-4
(e)-1,3-bis-(4-chloro-phenyl)-propenone
(e)-1,3-bis(4-chlorophenyl)prop-2-en-1-one
AKOS000282619
4',4-dichlorochalcone
CHEMBL226715
1,3-bis(4-chlorophenyl)-2-propen-1-one
4,4'-dichlorochalcone
(2e)-1,3-bis(4-chlorophenyl)prop-2-en-1-one
22966-30-9
2-propen-1-one, 1,3-bis(4-chlorophenyl)-, (2e)-
SCHEMBL659210
trans-1,3-di-(4-chlorophenyl)-prop-2-en-1-one
STL421306
mfcd00018704
(2e)-1,3-bis(4-chlorophenyl)-2-propen-1-one
Z46033279
4'-chloro-2-(4-chlorobenzylidene)acetophenone
D90338
CS-0116755
2-propen-1-one, 1,3-bis(4-chlorophenyl)-
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (51)

Assay IDTitleYearJournalArticle
AID386984Antifungal activity against haploid Saccharomyces cerevisiae D3C by agar dilution method2008European journal of medicinal chemistry, Oct, Volume: 43, Issue:10
Antifungal activity of chalcones: a mechanistic study using various yeast strains.
AID386978Antifungal activity against diploid Saccharomyces cerevisiae PV-3 by agar dilution method2008European journal of medicinal chemistry, Oct, Volume: 43, Issue:10
Antifungal activity of chalcones: a mechanistic study using various yeast strains.
AID666993Cytotoxicity against human HepG2 cells assessed as cell viability at 3.13 uM after 48 hrs by MTT assay2012European journal of medicinal chemistry, Aug, Volume: 54Synthesis and in vitro evaluation of novel tetrazole embedded 1,3,5-trisubstituted pyrazoline derivatives as Entamoeba histolytica growth inhibitors.
AID372907Antibacterial activity against Staphylococcus aureus Rosenbach 209 after 48 hrs by agar well diffusion method2009European journal of medicinal chemistry, May, Volume: 44, Issue:5
Examination of growth inhibitory properties of synthetic chalcones for which antibacterial activity was predicted.
AID386977Antifungal activity against diploid Saccharomyces cerevisiae PV-2 by agar dilution method2008European journal of medicinal chemistry, Oct, Volume: 43, Issue:10
Antifungal activity of chalcones: a mechanistic study using various yeast strains.
AID386981Antifungal activity against diploid Saccharomyces cerevisiae 1a by agar dilution method2008European journal of medicinal chemistry, Oct, Volume: 43, Issue:10
Antifungal activity of chalcones: a mechanistic study using various yeast strains.
AID666991Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay2012European journal of medicinal chemistry, Aug, Volume: 54Synthesis and in vitro evaluation of novel tetrazole embedded 1,3,5-trisubstituted pyrazoline derivatives as Entamoeba histolytica growth inhibitors.
AID372908Antibacterial activity against Staphylococcus aureus Rosenbach 209 after 24 hrs by serial dilution method2009European journal of medicinal chemistry, May, Volume: 44, Issue:5
Examination of growth inhibitory properties of synthetic chalcones for which antibacterial activity was predicted.
AID386983Antifungal activity against haploid Saccharomyces cerevisiae Sigma 1278b by agar dilution method2008European journal of medicinal chemistry, Oct, Volume: 43, Issue:10
Antifungal activity of chalcones: a mechanistic study using various yeast strains.
AID386995Antifungal activity against Hansenula polymorpha 2a with arg1 leu2 ura3 cys1 genotype by agar dilution method2008European journal of medicinal chemistry, Oct, Volume: 43, Issue:10
Antifungal activity of chalcones: a mechanistic study using various yeast strains.
AID386993Antifungal activity against Hansenula polymorpha CD3 with ade1 leu2 cds3 genotype by agar dilution method2008European journal of medicinal chemistry, Oct, Volume: 43, Issue:10
Antifungal activity of chalcones: a mechanistic study using various yeast strains.
AID386979Antifungal activity against haploid Saccharomyces cerevisiae 1169 by agar dilution method2008European journal of medicinal chemistry, Oct, Volume: 43, Issue:10
Antifungal activity of chalcones: a mechanistic study using various yeast strains.
AID386991Antifungal activity against Hansenula polymorpha CD1 with ade1 leu2 cds1 genotype by agar dilution method2008European journal of medicinal chemistry, Oct, Volume: 43, Issue:10
Antifungal activity of chalcones: a mechanistic study using various yeast strains.
AID387004Antifungal activity against Hansenula polymorpha R3 with rgh3 genotype by agar dilution method2008European journal of medicinal chemistry, Oct, Volume: 43, Issue:10
Antifungal activity of chalcones: a mechanistic study using various yeast strains.
AID386990Antifungal activity against Hansenula polymorpha WT2 with ade1 met6 genotype by agar dilution method2008European journal of medicinal chemistry, Oct, Volume: 43, Issue:10
Antifungal activity of chalcones: a mechanistic study using various yeast strains.
AID666994Cytotoxicity against human HepG2 cells assessed as cell viability at 25 uM after 48 hrs by MTT assay2012European journal of medicinal chemistry, Aug, Volume: 54Synthesis and in vitro evaluation of novel tetrazole embedded 1,3,5-trisubstituted pyrazoline derivatives as Entamoeba histolytica growth inhibitors.
AID1272515Antiplasmodial activity against chloroquine, quinine and pyrimethamine-resistant Plasmodium falciparum W2 assessed as inhibition of [3H]-hypoxanthine uptake after 48 hrs by liquid scintillation counting analysis2016Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3
In vitro efficacy of 2,N-bisarylated 2-ethoxyacetamides against Plasmodium falciparum.
AID386999Antifungal activity against Hansenula polymorpha MC1 with met2 cys1 genotype by agar dilution method2008European journal of medicinal chemistry, Oct, Volume: 43, Issue:10
Antifungal activity of chalcones: a mechanistic study using various yeast strains.
AID386987Antifungal activity against haploid Saccharomyces cerevisiae YSH1170 by agar dilution method2008European journal of medicinal chemistry, Oct, Volume: 43, Issue:10
Antifungal activity of chalcones: a mechanistic study using various yeast strains.
AID386985Antifungal activity against haploid Saccharomyces cerevisiae FY4 by agar dilution method2008European journal of medicinal chemistry, Oct, Volume: 43, Issue:10
Antifungal activity of chalcones: a mechanistic study using various yeast strains.
AID387000Antifungal activity against Hansenula polymorpha AS1 with arg1 gsh2delta genotype by agar dilution method2008European journal of medicinal chemistry, Oct, Volume: 43, Issue:10
Antifungal activity of chalcones: a mechanistic study using various yeast strains.
AID666992Selectivity index, ratio of IC50 for human HepG2 cells to IC50 for Entamoeba histolytica HM1:IMSS2012European journal of medicinal chemistry, Aug, Volume: 54Synthesis and in vitro evaluation of novel tetrazole embedded 1,3,5-trisubstituted pyrazoline derivatives as Entamoeba histolytica growth inhibitors.
AID386997Antifungal activity against Hansenula polymorpha D22 with arg1/arg1 ade1/ADE1 leu2/leu2 URA3/ura3 CYS1/cys1 genotype by agar dilution method2008European journal of medicinal chemistry, Oct, Volume: 43, Issue:10
Antifungal activity of chalcones: a mechanistic study using various yeast strains.
AID387002Antifungal activity against Hansenula polymorpha AU05 with ade3 ura3 genotype by agar dilution method2008European journal of medicinal chemistry, Oct, Volume: 43, Issue:10
Antifungal activity of chalcones: a mechanistic study using various yeast strains.
AID387003Antifungal activity against Hansenula polymorpha CTA1 with leu2 cat1 genotype by agar dilution method2008European journal of medicinal chemistry, Oct, Volume: 43, Issue:10
Antifungal activity of chalcones: a mechanistic study using various yeast strains.
AID386988Antifungal activity against haploid Saccharomyces cerevisiae YSH1171 by agar dilution method2008European journal of medicinal chemistry, Oct, Volume: 43, Issue:10
Antifungal activity of chalcones: a mechanistic study using various yeast strains.
AID283847Antifungal activity against Candida albicans Berhaut 62I after 24 hrs2007European journal of medicinal chemistry, Jan, Volume: 42, Issue:1
Study on the substituents' effects of a series of synthetic chalcones against the yeast Candida albicans.
AID372906Antibacterial activity against Escherichia coli WF+2009European journal of medicinal chemistry, May, Volume: 44, Issue:5
Examination of growth inhibitory properties of synthetic chalcones for which antibacterial activity was predicted.
AID386976Antifungal activity against haploid Saccharomyces cerevisiae 1S by agar dilution method2008European journal of medicinal chemistry, Oct, Volume: 43, Issue:10
Antifungal activity of chalcones: a mechanistic study using various yeast strains.
AID386986Antifungal activity against haploid Saccharomyces cerevisiae 10560-6B by agar dilution method2008European journal of medicinal chemistry, Oct, Volume: 43, Issue:10
Antifungal activity of chalcones: a mechanistic study using various yeast strains.
AID538324Inhibition of Plasmodium falciparum-mediated human hemoglobin degradation at 100 uM2010European journal of medicinal chemistry, Nov, Volume: 45, Issue:11
Reinvestigation of structure-activity relationship of methoxylated chalcones as antimalarials: synthesis and evaluation of 2,4,5-trimethoxy substituted patterns as lead candidates derived from abundantly available natural β-asarone.
AID283848Growth inhibition of Candida albicans Berhaut 62I by agar cup method2007European journal of medicinal chemistry, Jan, Volume: 42, Issue:1
Study on the substituents' effects of a series of synthetic chalcones against the yeast Candida albicans.
AID387006Antifungal activity against Kluyveromyces lactis 2-18B with MATalpha metA1 ura3 leu2 genotype by agar dilution method2008European journal of medicinal chemistry, Oct, Volume: 43, Issue:10
Antifungal activity of chalcones: a mechanistic study using various yeast strains.
AID666995Cytotoxicity against human HepG2 cells assessed as cell viability at 50 to 100 uM after 48 hrs by MTT assay2012European journal of medicinal chemistry, Aug, Volume: 54Synthesis and in vitro evaluation of novel tetrazole embedded 1,3,5-trisubstituted pyrazoline derivatives as Entamoeba histolytica growth inhibitors.
AID538331Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O+ erythrocytes after 72 hrs by SYBR Green-1 fluorescence based assay2010European journal of medicinal chemistry, Nov, Volume: 45, Issue:11
Reinvestigation of structure-activity relationship of methoxylated chalcones as antimalarials: synthesis and evaluation of 2,4,5-trimethoxy substituted patterns as lead candidates derived from abundantly available natural β-asarone.
AID386998Antifungal activity against Hansenula polymorpha M2 with met2 genotype by agar dilution method2008European journal of medicinal chemistry, Oct, Volume: 43, Issue:10
Antifungal activity of chalcones: a mechanistic study using various yeast strains.
AID386996Antifungal activity against Hansenula polymorpha 2b with arg1 ade1 leu2 genotype by agar dilution method2008European journal of medicinal chemistry, Oct, Volume: 43, Issue:10
Antifungal activity of chalcones: a mechanistic study using various yeast strains.
AID1272514Antiplasmodial activity against mefloquine-resistant Plasmodium falciparum D6 assessed as inhibition of [3H]-hypoxanthine uptake after 48 hrs by liquid scintillation counting analysis2016Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3
In vitro efficacy of 2,N-bisarylated 2-ethoxyacetamides against Plasmodium falciparum.
AID387008Antifungal activity against Kluyveromyces lactis 2-19B with MATalpha ura lys arg genotype by agar dilution method2008European journal of medicinal chemistry, Oct, Volume: 43, Issue:10
Antifungal activity of chalcones: a mechanistic study using various yeast strains.
AID386989Antifungal activity against Hansenula polymorpha WT1 with ade1 ura3 genotype by agar dilution method2008European journal of medicinal chemistry, Oct, Volume: 43, Issue:10
Antifungal activity of chalcones: a mechanistic study using various yeast strains.
AID386980Antifungal activity against haploid Saccharomyces cerevisiae 2180 by agar dilution method2008European journal of medicinal chemistry, Oct, Volume: 43, Issue:10
Antifungal activity of chalcones: a mechanistic study using various yeast strains.
AID386992Antifungal activity against Hansenula polymorpha CD2 with ade1 leu2 cds2 genotype by agar dilution method2008European journal of medicinal chemistry, Oct, Volume: 43, Issue:10
Antifungal activity of chalcones: a mechanistic study using various yeast strains.
AID386982Antifungal activity against diploid Saccharomyces cerevisiae 29a by agar dilution method2008European journal of medicinal chemistry, Oct, Volume: 43, Issue:10
Antifungal activity of chalcones: a mechanistic study using various yeast strains.
AID386994Antifungal activity against Hansenula polymorpha WA1 with ade1 leu2 gsh1 genotype by agar dilution method2008European journal of medicinal chemistry, Oct, Volume: 43, Issue:10
Antifungal activity of chalcones: a mechanistic study using various yeast strains.
AID1272517Bio-transformation in human liver microsomes at 25 uM after 30 mins by LC-MS analysis2016Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3
In vitro efficacy of 2,N-bisarylated 2-ethoxyacetamides against Plasmodium falciparum.
AID1272516Resistant index, ratio of IC50 for chloroquine, quinine and pyrimethamine-resistant Plasmodium falciparum W2 to IC50 for mefloquine-resistant Plasmodium falciparum D62016Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3
In vitro efficacy of 2,N-bisarylated 2-ethoxyacetamides against Plasmodium falciparum.
AID283849Antifungal activity against Candida albicans Berhaut 62I in meat-pepton broth2007European journal of medicinal chemistry, Jan, Volume: 42, Issue:1
Study on the substituents' effects of a series of synthetic chalcones against the yeast Candida albicans.
AID387005Antifungal activity against Hansenula polymorpha CRD2 with leu2 CDR2 genotype by agar dilution method2008European journal of medicinal chemistry, Oct, Volume: 43, Issue:10
Antifungal activity of chalcones: a mechanistic study using various yeast strains.
AID666990Antiamnesic activity against Entamoeba histolytica HM1:IMSS after 72 hrs by microdilution method2012European journal of medicinal chemistry, Aug, Volume: 54Synthesis and in vitro evaluation of novel tetrazole embedded 1,3,5-trisubstituted pyrazoline derivatives as Entamoeba histolytica growth inhibitors.
AID387001Antifungal activity against Hansenula polymorpha M4 with met4 genotype by agar dilution method2008European journal of medicinal chemistry, Oct, Volume: 43, Issue:10
Antifungal activity of chalcones: a mechanistic study using various yeast strains.
AID387007Antifungal activity against Kluyveromyces lactis 1-6A with MATalpha uraA lys arg genotype by agar dilution method2008European journal of medicinal chemistry, Oct, Volume: 43, Issue:10
Antifungal activity of chalcones: a mechanistic study using various yeast strains.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (62.50)29.6817
2010's3 (37.50)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.13

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.13 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.13)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
chloroquine
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.		2.4920aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug
metronidazole
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.. metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.		2.0710C-nitro compound;
imidazoles;
primary alcohol		antiamoebic agent;
antibacterial drug;
antimicrobial agent;
antiparasitic agent;
antitrichomonal drug;
environmental contaminant;
prodrug;
radiosensitizing agent;
xenobiotic
thiazoles
[no description available]		2.01101,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
thiazolidines
Thiazolidines: Reduced (protonated) form of THIAZOLES. They can be oxidized to THIAZOLIDINEDIONES.		2.0110thiazolidine
chalcone
trans-chalcone : The trans-isomer of chalcone.		3.1450chalconeEC 3.2.1.1 (alpha-amylase) inhibitor
dibenzylidene acetone
dibenzylidene acetone: structure in first source		2.0310
4-hydroxychalcone
4-hydroxychalcone: structure in first source. 4-hydroxychalcone : A member of the class of chalcones that is trans-chalcone substituted by a hydroxy group at position 4.		2.7330chalcones;
phenols		antihypertensive agent;
plant metabolite
licochalcone a
licochalcone A: has both anti-inflammatory and antineoplastic activities; structure given in first source; isolated from root of Glycyrrhiza inflata; RN given refers to (E)-isomer		2.0510chalcones
4-chlorochalcone
4-chlorochalcone : A member of the class of chalcones that is trans-chalcone substituted by a chloro group at position 4.		2.7430chalcones;
monochlorobenzenes
dimethylaminochalcone
4-dimethylaminochalcone: a fluorescent probe; structure in first source		2.4420
phenyl-3-methoxy-4-hydroxystyryl ketone
phenyl-3-methoxy-4-hydroxystyryl ketone: structure given in first source		2.0510
3-hydroxy-4,3',4',5'-tetramethoxychalcone
3-hydroxy-4,3',4',5'-tetramethoxychalcone: structure in first source		2.0510
ConditionIndicatedRelationship StrengthStudiesTrials
Hyperlipemia
[description not available]		02.0310
Hyperlipidemias
Conditions with excess LIPIDS in the blood.		02.0310