metronidazole has been researched along with Experimental Radiation Injuries in 6 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Excerpt | Relevance | Reference |
---|---|---|
" It was observed that the bioavailability of metronidazole was significantly reduced in irradiated animals the reduction being dependent on the dose of radiation." | 1.27 | Oral absorption of metronidazole in rabbits irradiated with cobalt-60 gamma radiation. ( Bhatt, PP; Nimbkar, AY, 1988) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 5 (83.33) | 18.7374 |
1990's | 1 (16.67) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Vinskaia, NP | 1 |
Voloshina, EA | 1 |
Vygodskaia, AL | 1 |
Iarmonenko, SP | 1 |
Magdon, E | 1 |
Schröder, E | 1 |
Chekalina, SI | 2 |
Guseva, LI | 1 |
Tokarev, OIu | 2 |
Karpitskaia, VS | 1 |
Bhatt, PP | 1 |
Nimbkar, AY | 1 |
Kurpeshev, OK | 1 |
6 other studies available for metronidazole and Experimental Radiation Injuries
Article | Year |
---|---|
[Enhancement of the antitumor effect of ionizing radiations in the combined use of metronidazole and induced hyperglycemia].
Topics: Animals; Carcinoma, Ehrlich Tumor; Combined Modality Therapy; Glucose; Metronidazole; Mice; Oxygen C | 1984 |
[The effect of metronidazol on the survival rate of whole-body irradiated mice and DNA repair synthesis of lymphocytes].
Topics: Animals; Cells, Cultured; DNA; DNA Repair; Hypoxia; Lymphocytes; Metronidazole; Mice; Mice, Inbred C | 1978 |
[The prevention of radiation complications by using metronidazole experimentally and in the oncology clinic].
Topics: Animals; Combined Modality Therapy; Drug Evaluation; Drug Evaluation, Preclinical; Female; Male; Met | 1991 |
[Prevention of local radiation injuries using metronidazole].
Topics: Animals; Male; Metronidazole; Radiation Injuries, Experimental; Radiation-Protective Agents; Rats; R | 1989 |
Oral absorption of metronidazole in rabbits irradiated with cobalt-60 gamma radiation.
Topics: Animals; Biological Availability; Colorimetry; Female; Gamma Rays; Male; Metronidazole; Rabbits; Rad | 1988 |
[Modification of separate and combined effects of hyperthermia and ionizing radiation on normal tissues].
Topics: Animals; Cycloheximide; Dactinomycin; Ethanol; Fluorouracil; Glucose; Hot Temperature; Metronidazole | 1986 |