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metronidazole and Experimental Radiation Injuries

metronidazole has been researched along with Experimental Radiation Injuries in 6 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Research Excerpts

ExcerptRelevanceReference
" It was observed that the bioavailability of metronidazole was significantly reduced in irradiated animals the reduction being dependent on the dose of radiation."1.27Oral absorption of metronidazole in rabbits irradiated with cobalt-60 gamma radiation. ( Bhatt, PP; Nimbkar, AY, 1988)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19905 (83.33)18.7374
1990's1 (16.67)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Vinskaia, NP1
Voloshina, EA1
Vygodskaia, AL1
Iarmonenko, SP1
Magdon, E1
Schröder, E1
Chekalina, SI2
Guseva, LI1
Tokarev, OIu2
Karpitskaia, VS1
Bhatt, PP1
Nimbkar, AY1
Kurpeshev, OK1

Other Studies

6 other studies available for metronidazole and Experimental Radiation Injuries

ArticleYear
[Enhancement of the antitumor effect of ionizing radiations in the combined use of metronidazole and induced hyperglycemia].
    Meditsinskaia radiologiia, 1984, Volume: 29, Issue:12

    Topics: Animals; Carcinoma, Ehrlich Tumor; Combined Modality Therapy; Glucose; Metronidazole; Mice; Oxygen C

1984
[The effect of metronidazol on the survival rate of whole-body irradiated mice and DNA repair synthesis of lymphocytes].
    Radiobiologia, radiotherapia, 1978, Volume: 19, Issue:4

    Topics: Animals; Cells, Cultured; DNA; DNA Repair; Hypoxia; Lymphocytes; Metronidazole; Mice; Mice, Inbred C

1978
[The prevention of radiation complications by using metronidazole experimentally and in the oncology clinic].
    Voprosy onkologii, 1991, Volume: 37, Issue:11-12

    Topics: Animals; Combined Modality Therapy; Drug Evaluation; Drug Evaluation, Preclinical; Female; Male; Met

1991
[Prevention of local radiation injuries using metronidazole].
    Meditsinskaia radiologiia, 1989, Volume: 34, Issue:6

    Topics: Animals; Male; Metronidazole; Radiation Injuries, Experimental; Radiation-Protective Agents; Rats; R

1989
Oral absorption of metronidazole in rabbits irradiated with cobalt-60 gamma radiation.
    The Journal of pharmacy and pharmacology, 1988, Volume: 40, Issue:4

    Topics: Animals; Biological Availability; Colorimetry; Female; Gamma Rays; Male; Metronidazole; Rabbits; Rad

1988
[Modification of separate and combined effects of hyperthermia and ionizing radiation on normal tissues].
    Meditsinskaia radiologiia, 1986, Volume: 31, Issue:12

    Topics: Animals; Cycloheximide; Dactinomycin; Ethanol; Fluorouracil; Glucose; Hot Temperature; Metronidazole

1986