metronidazole has been researched along with Syndrome in 33 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Syndrome: A characteristic symptom complex.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A randomized controlled effectiveness trial compared single-dose tinidazole plus fluconazole (TF) with treatment for 7 days with metronidazole plus 3 days of treatment with vaginal clotrimazole (MC) among 1570 women presenting with vaginal discharge at primary health care institutions in Ghana, Guinea, Mali and Togo." | 5.12 | The syndromic management of vaginal discharge using single-dose treatments: a randomized controlled trial in West Africa. ( Agyarko-Poku, T; Asamoah-Adu, C; Deslandes, S; Diakité, S; Frost, E; Khonde, N; Labbé, AC; Pépin, J; Sobela, F; Sylla, M, 2006) |
| "In areas with a high prevalence of trichomoniasis, the addition of metronidazole to the syndromic management of male urethritis can eliminate infection with T vaginalis and may help to reduce the transmission of HIV." | 5.10 | Addition of treatment for trichomoniasis to syndromic management of urethritis in Malawi: a randomized clinical trial. ( Chilongozi, D; Cohen, MS; Hobbs, MM; Hoffman, IF; Kaydos-Daniels, SC; Kazembe, P; Kip, E; Martinson, F; Miller, WC; Msowoya, E; Price, MA; Zimba, D, 2003) |
| "In this case of painful legs and moving toes the essential characteristics were to be secondary to a neuropathy due to vincristine and metronidazole." | 3.67 | [Painful legs and moving toes. A drug-induced case]. ( Gastaut, JL, 1986) |
| "Lemierre's syndrome is characterized by acute oropharyngeal infection complicated by internal jugular venous thrombosis secondary to septic thrombophlebitis, and metastatic abscesses." | 2.43 | Lemierre's syndrome presenting with peritonsillar abscess and VIth cranial nerve palsy. ( Jones, C; O'Reilly, BJ; Seymour, FK; Siva, TM, 2006) |
| "Lemierre's syndrome is a rare disease in young otherwise healthy people showing septic embolism in the lungs and peripheral vessels." | 1.36 | [Phlegmon of the palm of the hand as initial manifestation of the Lemierre syndrome]. ( Braunbeck, A; Daecke, W; Fiebig, C; Geiger, EV; Maier, M; Marzi, I; Weber, R, 2010) |
| "Lemierre syndrome is a disease that every pediatrician must know." | 1.35 | [Lemierre syndrome: a complication of an oropharyngeal infection]. ( Bailly, C; Berlioz, M; Boutté, P; Passalidou, P, 2008) |
| "Lemierre's syndrome is a rare but potentially life-threatening entity that follows an oropharyngeal infection." | 1.32 | A case of Lemierre's syndrome. ( Jauch, EC; Johnson, MC; Ma, M, 2003) |
| "24 days after the onset of infectious mononucleosis, clinically and serologically confirmed, an otherwise healthy 18-year-old schoolboy developed a fulminant septicaemia with acute meningitis and loss of consciousness, consumptive coagulopathy and acute renal failure." | 1.29 | [Lemierre's post-tonsillitis sepsis with meningitis and intravascular consumption coagulopathy as complication of infectious mononucleosis with pansinusitis]. ( Busch, N; Haase, G; Kierdorf, H; Marschall, HU; Matern, S; Mertens, PR; Nguyen, H; Schönfelder, T; Sieberth, HG; Urhahn, R, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (24.24) | 18.7374 |
| 1990's | 8 (24.24) | 18.2507 |
| 2000's | 14 (42.42) | 29.6817 |
| 2010's | 3 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhao, Z | 1 |
| Bao, L | 1 |
| Yu, X | 1 |
| Zhu, C | 1 |
| Xu, J | 1 |
| Wang, Y | 1 |
| Yin, M | 1 |
| Li, Y | 1 |
| Li, W | 1 |
| Passalidou, P | 1 |
| Berlioz, M | 1 |
| Bailly, C | 1 |
| Boutté, P | 1 |
| Braunbeck, A | 1 |
| Geiger, EV | 1 |
| Weber, R | 1 |
| Maier, M | 1 |
| Daecke, W | 1 |
| Fiebig, C | 1 |
| Marzi, I | 1 |
| Khan, SA | 1 |
| Dutta, P | 1 |
| Chowdhury, P | 1 |
| Borah, J | 1 |
| Topno, R | 1 |
| Mahanta, J | 1 |
| Zätterstrøm, UK | 1 |
| Hokland, BM | 1 |
| Walberg, M | 1 |
| Stubhaug, A | 1 |
| Aaløkken, TM | 1 |
| Frøland, SS | 1 |
| Gregg, CR | 1 |
| Tan, NC | 1 |
| Tan, DY | 1 |
| Tan, LC | 1 |
| Price, MA | 1 |
| Zimba, D | 1 |
| Hoffman, IF | 1 |
| Kaydos-Daniels, SC | 1 |
| Miller, WC | 1 |
| Martinson, F | 1 |
| Chilongozi, D | 1 |
| Kip, E | 1 |
| Msowoya, E | 1 |
| Hobbs, MM | 1 |
| Kazembe, P | 1 |
| Cohen, MS | 1 |
| Ma, M | 1 |
| Jauch, EC | 1 |
| Johnson, MC | 1 |
| Barbato, A | 1 |
| Panizzolo, C | 1 |
| Landi, L | 1 |
| Semenzato, R | 1 |
| Rugge, M | 1 |
| Valla, F | 1 |
| Berchiche, C | 1 |
| Floret, D | 1 |
| Spitzer, C | 1 |
| Foltys, H | 1 |
| Lemmen, SW | 1 |
| Block, F | 1 |
| Utikal, J | 1 |
| Poenitz, N | 1 |
| Kurzen, H | 1 |
| Goerdt, S | 1 |
| Repanos, C | 1 |
| Chadha, NK | 1 |
| Griffiths, MV | 1 |
| Jones, C | 1 |
| Siva, TM | 1 |
| Seymour, FK | 1 |
| O'Reilly, BJ | 1 |
| Pépin, J | 1 |
| Sobela, F | 1 |
| Khonde, N | 1 |
| Agyarko-Poku, T | 1 |
| Diakité, S | 1 |
| Deslandes, S | 1 |
| Labbé, AC | 1 |
| Sylla, M | 1 |
| Asamoah-Adu, C | 1 |
| Frost, E | 1 |
| Georgopoulos, S | 1 |
| Korres, S | 1 |
| Riga, M | 1 |
| Balatsouras, D | 1 |
| Kotsis, G | 1 |
| Ferekidis, E | 1 |
| Dubois, A | 1 |
| Raffanel, C | 1 |
| Pignodel, C | 1 |
| Janbon, C | 1 |
| Marty-Double, C | 1 |
| Balmes, P | 1 |
| Drenick, EJ | 1 |
| Bassett, LW | 1 |
| Stanley, TM | 1 |
| Balsdon, MJ | 1 |
| Dykhuizen, RS | 1 |
| Olson, ES | 1 |
| Clive, S | 1 |
| Douglas, JG | 1 |
| Carlson, ER | 1 |
| Bergamo, DF | 1 |
| Coccia, CT | 1 |
| Busch, N | 1 |
| Mertens, PR | 1 |
| Schönfelder, T | 1 |
| Nguyen, H | 1 |
| Marschall, HU | 1 |
| Kierdorf, H | 1 |
| Haase, G | 1 |
| Urhahn, R | 1 |
| Sieberth, HG | 1 |
| Matern, S | 1 |
| Stallworth, JR | 1 |
| Carroll, JM | 1 |
| Bouton, F | 1 |
| Cotils, M | 1 |
| Genard, M | 1 |
| Hubert, C | 1 |
| Haarala, M | 1 |
| Kiilholma, P | 1 |
| Lehtonen, OP | 1 |
| Geary, RJ | 1 |
| Long, LL | 1 |
| Mutasim, DF | 1 |
| Vaidya, AB | 1 |
| Doshi, JC | 1 |
| Gupta, KC | 1 |
| Paul, T | 1 |
| Sheth, UK | 1 |
| Tur, E | 1 |
| Ryatt, KS | 1 |
| Maibach, HI | 1 |
| Gastaut, JL | 1 |
| Su, WP | 1 |
| Liu, HN | 1 |
| Rudakov, NP | 1 |
| Kindzel'skiĭ, LP | 1 |
| Zlochevskaia, LL | 1 |
| Mitre, RJ | 1 |
| Rotheran, EB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomised Controlled Trial of Single Dose Tinidazole+Fluconazole Versus Longer Courses of Metronidazole+Clotrimazole in the Management of West African Women With Vaginal Discharge[NCT00313131] | Phase 3 | 1,524 participants | Interventional | 2004-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for metronidazole and Syndrome
| Article | Year |
|---|---|
Enteric bacterial flora and bacterial overgrowth syndrome.
Topics: Aged; Aged, 80 and over; Anti-Infective Agents; Bacterial Infections; Diagnostic Techniques, Digesti | 2002 |
[Bacterial meningitis as a complication of Fusobacterium necroforum infection in adults].
Topics: Adult; Anti-Bacterial Agents; Blood Glucose; Cerebrospinal Fluid Proteins; Diagnosis, Differential; | 2003 |
Lemierre's syndrome presenting with peritonsillar abscess and VIth cranial nerve palsy.
Topics: Abducens Nerve Diseases; Adolescent; Anti-Bacterial Agents; Cefotaxime; Female; Follow-Up Studies; H | 2006 |
Gardnerella vaginalis and its clinical syndrome.
Topics: Amoxicillin; Ampicillin; Culture Media; Female; Gardnerella vaginalis; Gentian Violet; Haemophilus; | 1982 |
[Septic thrombophlebitis of the internal jugular vein and Lemierre syndrome].
Topics: Abscess; Acute Disease; Aged; Amoxicillin-Potassium Clavulanate Combination; Angina Pectoris; Anti-B | 1998 |
2 trials available for metronidazole and Syndrome
| Article | Year |
|---|---|
Addition of treatment for trichomoniasis to syndromic management of urethritis in Malawi: a randomized clinical trial.
Topics: Administration, Oral; Adult; Animals; Doxycycline; Drug Therapy, Combination; Gentamicins; HIV; HIV | 2003 |
The syndromic management of vaginal discharge using single-dose treatments: a randomized controlled trial in West Africa.
Topics: Adolescent; Adult; Africa, Western; Animals; Anti-Infective Agents; Antifungal Agents; Antitrichomon | 2006 |
26 other studies available for metronidazole and Syndrome
| Article | Year |
|---|---|
Acute vanishing bile duct syndrome after therapy with cephalosporin, metronidazole, and clotrimazole: A case report.
Topics: Adult; Anti-Bacterial Agents; Bile Duct Diseases; Bile Ducts, Intrahepatic; Cephalosporins; Clotrima | 2017 |
[Lemierre syndrome: a complication of an oropharyngeal infection].
Topics: Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Anti-Infective Agents; Cefotax | 2008 |
[Phlegmon of the palm of the hand as initial manifestation of the Lemierre syndrome].
Topics: Abscess; Acromioclavicular Joint; Anti-Bacterial Agents; Cellulitis; Combined Modality Therapy; Diag | 2010 |
Co-infection of arboviruses presenting as Acute Encephalitis Syndrome.
Topics: Acute Disease; Adult; Anti-Infective Agents; Brain; Consciousness; Encephalitis; Encephalitis Virus, | 2011 |
[A throat infection with rapid deterioration].
Topics: Abscess; Anti-Bacterial Agents; Diagnosis, Differential; Disease Progression; Drug Therapy, Combinat | 2002 |
An Unusual Headache: Lemierre's Syndrome.
Topics: Aged; Female; Fusobacterium Infections; Headache; Humans; Metronidazole; Neck; Penicillins; Syndrome | 2003 |
A case of Lemierre's syndrome.
Topics: Adolescent; Anti-Bacterial Agents; Clindamycin; Drug Therapy, Combination; Female; Fusobacterium Inf | 2003 |
Asthma-like syndrome in a teenager.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adolescent; Albuterol; Amoxicillin; Androstadienes; Anti-Ba | 2003 |
[Necrobacillosis and Lemierre's syndrome: case report].
Topics: Amoxicillin; Anti-Infective Agents; Brain Diseases; Child, Preschool; Female; Fusobacterium Infectio | 2003 |
[Persistent facial erythema and edema].
Topics: Administration, Topical; Anti-Bacterial Agents; Anti-Infective Agents; Diagnosis, Differential; Edem | 2005 |
Sigmoid sinus thrombosis secondary to Lemierre's syndrome.
Topics: Adult; Anticoagulants; Cefuroxime; Drainage; Humans; Jugular Veins; Magnetic Resonance Imaging; Male | 2006 |
Lemierre's syndrome associated with consumption coagulopathy and acute renal failure: a case report.
Topics: Acute Kidney Injury; Adult; Anti-Bacterial Agents; Disseminated Intravascular Coagulation; Drug Ther | 2008 |
[Acute cerebellar syndrome associated with sensitive neuropathy in a patient treated with metronidazole].
Topics: Cerebellar Diseases; Humans; Male; Metronidazole; Middle Aged; Nervous System Diseases; Sensation; S | 1983 |
Rheumatoid arthritis associated with jejunoileal bypass.
Topics: Adult; Arthritis, Rheumatoid; Diagnosis, Differential; Female; Humans; Ileum; Jejunum; Metronidazole | 1984 |
Necrobacillosis (Lemmiere's syndrome): a rare cause of necrotizing pneumonia.
Topics: Adolescent; Adult; Diagnosis, Differential; Female; Fusobacterium Infections; Fusobacterium necropho | 1994 |
Lemierre's syndrome: two cases of a forgotten disease.
Topics: Adolescent; Arthritis, Infectious; Bacteremia; Cefoxitin; Clindamycin; Fusobacterium Infections; Fus | 1994 |
[Lemierre's post-tonsillitis sepsis with meningitis and intravascular consumption coagulopathy as complication of infectious mononucleosis with pansinusitis].
Topics: Acute Kidney Injury; Adolescent; Anti-Bacterial Agents; Bacteremia; Chloramphenicol; Disseminated In | 1996 |
Lemierre's syndrome: new insights into an old disease.
Topics: Adolescent; Anti-Bacterial Agents; Ceftriaxone; Cephalosporins; Drug Therapy, Combination; Female; F | 1997 |
Urinary bacterial flora of women with urethral syndrome and interstitial cystitis.
Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Bacteria, Aerobic; Bacteria, Anaerobic; Bacteroides | 1999 |
Bowel bypass syndrome without bowel bypass.
Topics: Adult; Anti-Infective Agents; Anti-Inflammatory Agents; Biopsy; Ciprofloxacin; Erythema Nodosum; Fem | 1999 |
Metronidazole in tropical eosinophillia: a phase II trial.
Topics: Adolescent; Adult; Eosinophilia; Female; Filariasis; Humans; Lung Diseases, Parasitic; Male; Metroni | 1976 |
Idiopathic recalcitrant facial flushing syndrome.
Topics: Facial Dermatoses; Female; Flushing; Humans; Male; Metronidazole; Middle Aged; Rosacea; Syndrome; Te | 1990 |
[Painful legs and moving toes. A drug-induced case].
Topics: Adult; Drug Interactions; Humans; Leg; Male; Metronidazole; Movement Disorders; Pain; Peripheral Ner | 1986 |
Diagnostic criteria for Sweet's syndrome.
Topics: Administration, Oral; Aged; Female; Fluorescent Antibody Technique; Humans; Male; Metronidazole; Mid | 1986 |
[Effect of metronidazole on the radiosensitivity of Guerin's carcinoma during its growth].
Topics: Animals; Carcinoma, Squamous Cell; Combined Modality Therapy; Metronidazole; Neoplasm Transplantatio | 1985 |
Anaerobic septicemia from thrombophlebitis of the internal jugular vein. Successful treatment with metronidazole.
Topics: Adult; Anaerobiosis; Bacteria; Drug Evaluation; Drug Resistance, Microbial; Focal Infection, Dental; | 1974 |