metronidazole has been researched along with Pachymeningitis in 29 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 69-year-old man developed meningitis due to Bacteroides fragilis and Streptococcus MG-intermedius, which progressed during chloramphenicol and nafcillin therapy to the extent that he seemed near death, with frank pus covering the spinal cord at surgery." | 7.66 | Intravenous metronidazole therapy for Bacteroides fragilis meningitis. ( Bryan, CS; Del Bene, VE; Huffman, LJ; Sanders, CV; Scalcini, MC, 1979) |
| "Four patients with Bacteroides fragilis bacteremia, one patient with a brain abscess due to Bacteroides species, Fusobacterium naviforme, and Peptostreptococcus species, and an infant with Bacteroides species ventriculitis and meningitis were treated with metronidazole." | 7.66 | Metronidazole therapy of anaerobic bacteremia, meningitis, and brain abscess. ( Cordero, L; Perkins, RL; Warner, JF, 1979) |
| "After antibiotic prophylaxis with metronidazole and levofloxacin, a transrectal sextant biopsy was performed under the guide of transrectal ultrasonography (TRUS) for a 75-year-old suspicious patient with prostate adenocarcinoma." | 3.73 | Life-threatening meningitis resulting from transrectal prostate biopsy. ( Chen, SW; Shen, ZJ; Wang, H; Zhao, JP; Zhou, XL, 2005) |
| "We successfully treated a serious case of Entamoeba histolytica infection showing brain abscess, meningitis, and liver abscess by oral administration of metronidazole, intramuscular injection of dehydroemetine, and drainage of the brain abscess." | 3.69 | Brain abscess due to infection with Entamoeba histolytica. ( Kojima, H; Murata, M; Ohnishi, K; Tachibana, H; Takemura, N; Tsuchida, T, 1994) |
| "A 69-year-old man developed meningitis due to Bacteroides fragilis and Streptococcus MG-intermedius, which progressed during chloramphenicol and nafcillin therapy to the extent that he seemed near death, with frank pus covering the spinal cord at surgery." | 3.66 | Intravenous metronidazole therapy for Bacteroides fragilis meningitis. ( Bryan, CS; Del Bene, VE; Huffman, LJ; Sanders, CV; Scalcini, MC, 1979) |
| "Four patients with Bacteroides fragilis bacteremia, one patient with a brain abscess due to Bacteroides species, Fusobacterium naviforme, and Peptostreptococcus species, and an infant with Bacteroides species ventriculitis and meningitis were treated with metronidazole." | 3.66 | Metronidazole therapy of anaerobic bacteremia, meningitis, and brain abscess. ( Cordero, L; Perkins, RL; Warner, JF, 1979) |
| "In many neurosurgery-associated infections, intrathecal or intraventricular antibiotics may be required to supplement parenteral treatment and/or surgical intervention." | 2.36 | Antimicrobial agents and the central nervous system. ( Everett, ED; Strausbaugh, LJ, 1980) |
| "Intracranial dermoid cysts are rare, but can cause recurrent bacterial or aseptic meningitis, abscesses or mass effect." | 1.35 | Posterior fossa dermoid cyst with sinus tract and meningitis in a toddler. ( Abbott, IR; Douvoyiannis, M; Goldman, DL; Litman, N, 2008) |
| "Neurocysticercosis is the commonest CNS parasitic disease worldwide but cysticercal meningitis and intraventricular lesions are relatively rare, especially in Indian patients." | 1.35 | Intraventricular neurocysticercosis. ( Garg, A; Kalra, V; Mishra, D; Seth, R; Suri, A, 2009) |
| "Sinusitis was suspected as the cause in only one patient initially." | 1.31 | Suppurative intracranial complications of sinusitis in children. ( Ong, YK; Tan, HK, 2002) |
| "24 days after the onset of infectious mononucleosis, clinically and serologically confirmed, an otherwise healthy 18-year-old schoolboy developed a fulminant septicaemia with acute meningitis and loss of consciousness, consumptive coagulopathy and acute renal failure." | 1.29 | [Lemierre's post-tonsillitis sepsis with meningitis and intravascular consumption coagulopathy as complication of infectious mononucleosis with pansinusitis]. ( Busch, N; Haase, G; Kierdorf, H; Marschall, HU; Matern, S; Mertens, PR; Nguyen, H; Schönfelder, T; Sieberth, HG; Urhahn, R, 1996) |
| "Bacterial meningitis is not considered a separate disease entity but a complication of bacteremia and sepsis." | 1.27 | [Chemotherapy of severe bacterial infections in pediatrics]. ( Guggenbichler, JP, 1983) |
| "The meningitis was refractory to chloramphenicol and penicillin but responded to oral metronidazole." | 1.26 | Meningorectal fistula as a cause of polymicrobial anaerobic meningitis. ( Berelowitz, BA; Breyer, MD; Malinoff, H; Walsh, TJ; Weinstein, RA, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (65.52) | 18.7374 |
| 1990's | 4 (13.79) | 18.2507 |
| 2000's | 4 (13.79) | 29.6817 |
| 2010's | 1 (3.45) | 24.3611 |
| 2020's | 1 (3.45) | 2.80 |
| Authors | Studies |
|---|---|
| Diouf, MS | 1 |
| Tall, A | 1 |
| Ndiaye, C | 1 |
| Thiam, A | 1 |
| Deguenonvo, R | 1 |
| Ndiaye, M | 1 |
| Thomas, J | 1 |
| Fayad, M | 1 |
| Tong, D | 1 |
| Richards, BF | 1 |
| Douvoyiannis, M | 1 |
| Goldman, DL | 1 |
| Abbott, IR | 1 |
| Litman, N | 1 |
| Kalra, V | 1 |
| Mishra, D | 1 |
| Suri, A | 1 |
| Seth, R | 1 |
| Garg, A | 1 |
| Ong, YK | 1 |
| Tan, HK | 1 |
| Shen, ZJ | 1 |
| Chen, SW | 1 |
| Wang, H | 1 |
| Zhou, XL | 1 |
| Zhao, JP | 1 |
| Everett, ED | 1 |
| Strausbaugh, LJ | 1 |
| Guggenbichler, JP | 1 |
| Sundström, O | 1 |
| Svedberg, LE | 1 |
| Carling, L | 1 |
| Hoffmann, HG | 1 |
| Förster, D | 1 |
| Muirhead, B | 1 |
| Strong, AJ | 1 |
| Ingham, HR | 1 |
| Vogel, F | 1 |
| Baines, EJ | 1 |
| McFadzean, JA | 1 |
| Walsh, TJ | 1 |
| Weinstein, RA | 1 |
| Malinoff, H | 1 |
| Breyer, MD | 1 |
| Berelowitz, BA | 1 |
| Chandramuki, A | 1 |
| Rama Devi, MG | 1 |
| Siegler, D | 1 |
| Faiers, MC | 1 |
| Willis, AT | 1 |
| Law, BJ | 1 |
| Marks, MI | 1 |
| Ohnishi, K | 1 |
| Murata, M | 1 |
| Kojima, H | 1 |
| Takemura, N | 1 |
| Tsuchida, T | 1 |
| Tachibana, H | 1 |
| Busch, N | 1 |
| Mertens, PR | 1 |
| Schönfelder, T | 1 |
| Nguyen, H | 1 |
| Marschall, HU | 1 |
| Kierdorf, H | 1 |
| Haase, G | 1 |
| Urhahn, R | 1 |
| Sieberth, HG | 1 |
| Matern, S | 1 |
| Peterson, DI | 1 |
| Voorhees, EG | 1 |
| Elder, HA | 1 |
| Bryan, CS | 1 |
| Huffman, LJ | 1 |
| Del Bene, VE | 1 |
| Sanders, CV | 1 |
| Scalcini, MC | 1 |
| Warner, JF | 1 |
| Perkins, RL | 1 |
| Cordero, L | 1 |
| Berman, BW | 1 |
| King, FH | 1 |
| Rubenstein, DS | 1 |
| Long, SS | 1 |
| O'Grady, LR | 1 |
| Ralph, ED | 1 |
| Feldman, WE | 1 |
| Pace-Balzan, A | 1 |
| Keith, AO | 1 |
| Curley, JW | 1 |
| Ramsden, RT | 1 |
| Lewis, H | 1 |
| Jones, TH | 1 |
| Bergvall, V | 1 |
| Bradshaw, JP | 1 |
| Webber, SA | 1 |
| Tuohy, P | 1 |
| Soriano, F | 1 |
| Aguado, JM | 1 |
| Tornero, J | 1 |
| Fernandez-Guerrero, ML | 1 |
| Gómez-Garcés, JL | 1 |
2 reviews available for metronidazole and Pachymeningitis
| Article | Year |
|---|---|
Antimicrobial agents and the central nervous system.
Topics: Abscess; Anti-Bacterial Agents; Anti-Infective Agents; Central Nervous System Diseases; Cephalospori | 1980 |
The action of metronidazole on anaerobic bacilli and similar organisms.
Topics: Administration, Oral; Anaerobiosis; Animals; Bacteria; Bacterial Infections; Bacteroides Infections; | 1981 |
27 other studies available for metronidazole and Pachymeningitis
| Article | Year |
|---|---|
Complications of sinusitis: An 80-case series from the ENT and neurosurgery departments of the Fann university hospital center of Dakar, Senegal.
Topics: Acute Disease; Adolescent; Adult; Anti-Bacterial Agents; Brain Abscess; Child; Child, Preschool; Cla | 2020 |
Use of ventriculostomy in the treatment of septic cavernous sinus thrombosis (SCST).
Topics: Administration, Intravenous; Aftercare; Aged; Angiography; Anti-Bacterial Agents; Cavernous Sinus; C | 2019 |
Posterior fossa dermoid cyst with sinus tract and meningitis in a toddler.
Topics: Anti-Bacterial Agents; Bacteria, Anaerobic; Cranial Sinuses; Dermoid Cyst; Humans; Infant; Infratent | 2008 |
Intraventricular neurocysticercosis.
Topics: Anti-Bacterial Agents; Antifungal Agents; Ceftriaxone; Cerebral Ventricles; Child; Female; Humans; M | 2009 |
Suppurative intracranial complications of sinusitis in children.
Topics: Adolescent; Anti-Bacterial Agents; Ceftriaxone; Child; Empyema, Subdural; Humans; Male; Meningitis; | 2002 |
Life-threatening meningitis resulting from transrectal prostate biopsy.
Topics: Adenocarcinoma; Aged; Anti-Infective Agents; Anti-Infective Agents, Urinary; Biopsy; Escherichia col | 2005 |
[Chemotherapy of severe bacterial infections in pediatrics].
Topics: Aminoglycosides; Anti-Bacterial Agents; Bacterial Infections; Cefotaxime; Cephalosporins; Clindamyci | 1983 |
[Meningitis caused by metronidazole].
Topics: Adult; Female; Humans; Meningitis; Metronidazole | 1984 |
[Metronidazole concentration of the cerebrospinal fluid from slightly inflamed meninges].
Topics: Adolescent; Adult; Female; Humans; Male; Meningitis; Metronidazole; Middle Aged | 1984 |
Brain abscess.
Topics: Adrenal Cortex Hormones; Brain Abscess; Diagnosis, Differential; Humans; Meningitis; Metronidazole; | 1983 |
[Antibiotic therapy in severe infections].
Topics: Aminoglycosides; Anti-Bacterial Agents; Bacterial Infections; Cephalosporins; Humans; Infections; Me | 1983 |
Meningorectal fistula as a cause of polymicrobial anaerobic meningitis.
Topics: Female; Fistula; Humans; Meninges; Meningitis; Metronidazole; Middle Aged; Radiotherapy; Rectal Fist | 1982 |
Anaerobic meningitis.
Topics: Adult; Child; Child, Preschool; Female; Gram-Negative Anaerobic Bacteria; Humans; Male; Meningitis; | 1982 |
Bacteroides meningitis complicating chronic mastoiditis.
Topics: Aged; Bacteroides Infections; Chronic Disease; Humans; Male; Mastoiditis; Meningitis; Metronidazole | 1982 |
Excellent outcome of Bacteroides meningitis in a newborn treated with metronidazole.
Topics: Bacteroides fragilis; Bacteroides Infections; Humans; Infant, Newborn; Infant, Newborn, Diseases; Ma | 1980 |
Brain abscess due to infection with Entamoeba histolytica.
Topics: Administration, Oral; Animals; Antibodies, Protozoan; Brain Abscess; DNA, Protozoan; Drainage; Emeti | 1994 |
[Lemierre's post-tonsillitis sepsis with meningitis and intravascular consumption coagulopathy as complication of infectious mononucleosis with pansinusitis].
Topics: Acute Kidney Injury; Adolescent; Anti-Bacterial Agents; Bacteremia; Chloramphenicol; Disseminated In | 1996 |
Bacteroides meningitis successfully treated with metronidazole.
Topics: Aged; Bacteroides Infections; Chloramphenicol; Humans; Male; Meningitis; Metronidazole; Penicillin R | 1979 |
Intravenous metronidazole therapy for Bacteroides fragilis meningitis.
Topics: Adult; Aged; Bacteroides fragilis; Bacteroides Infections; Chloramphenicol; Drug Therapy, Combinatio | 1979 |
Metronidazole therapy of anaerobic bacteremia, meningitis, and brain abscess.
Topics: Adult; Anaerobiosis; Bacterial Infections; Bacteroides fragilis; Bacteroides Infections; Brain Absce | 1979 |
Bacteroides fragilis meningitis in a neonate successfully treated with metronidazole.
Topics: Bacteroides fragilis; Bacteroides Infections; Female; Humans; Infant, Newborn; Infant, Newborn, Dise | 1978 |
Anaerobic meningitis and bacteremia caused by Fusobacterium species.
Topics: Adolescent; Child, Preschool; Chloramphenicol; Diagnosis, Differential; Female; Fusobacterium; Human | 1976 |
Bacteroides fragilis ventriculitis and meningitis. Report of two cases.
Topics: Ampicillin; Bacteroides fragilis; Bacteroides Infections; Cerebrospinal Fluid Shunts; Chloramphenico | 1976 |
Otogenic Fusobacterium necrophorum meningitis.
Topics: Acute Disease; Child, Preschool; Chloramphenicol; Drug Therapy, Combination; Female; Fusobacterium I | 1991 |
Carotid artery stenoses and thrombosis secondary to cavernous sinus thromboses in Fusobacterium necrophorum meningitis.
Topics: Adult; Arterial Occlusive Diseases; Carotid Artery Diseases; Carotid Artery Thrombosis; Cavernous Si | 1990 |
Bacteroides fragilis meningitis in a premature infant successfully treated with metronidazole.
Topics: Bacteroides fragilis; Bacteroides Infections; Cefotaxime; Drug Therapy, Combination; Female; Humans; | 1988 |
Bacteroides fragilis meningitis successfully treated with metronidazole after a previous failure with thiamphenicol.
Topics: Aged; Bacteroides fragilis; Bacteroides Infections; Female; Humans; Meningitis; Metronidazole; Micro | 1986 |