metronidazole has been researched along with Adverse Drug Event in 18 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metronidazole is frequently used off-label in infants with complicated intra-abdominal infections (cIAI) to provide coverage against anaerobic organisms, but its safety and efficacy in this indication are unknown." | 9.34 | Safety of Metronidazole in Late Pre-term and Term Infants with Complicated Intra-abdominal Infections. ( Benjamin, D; Bumpass, TG; Cohen-Wolkowiez, M; Commander, SJ; Courtney, SE; Debski, J; Delmore, P; Erinjeri, J; Gao, J; Heresi, G; Hornik, CP; Lavery, AP; Moya, F; Sharma, G; Smith, PB; Sokol, GM; Tracy, ET; Zinkhan, EK, 2020) |
| "Avibactam, a novel non-β-lactam β-lactamase inhibitor, restores the in vitro activity of ceftazidime against class A, C and some class D β-lactamase-producing pathogens, including those commonly associated with complicated intra-abdominal infections (cIAIs)." | 9.17 | Comparative study of the efficacy and safety of ceftazidime/avibactam plus metronidazole versus meropenem in the treatment of complicated intra-abdominal infections in hospitalized adults: results of a randomized, double-blind, Phase II trial. ( Lipka, J; Lucasti, C; Popescu, I; Ramesh, MK; Sable, C, 2013) |
| "Metronidazole is frequently used off-label in infants with complicated intra-abdominal infections (cIAI) to provide coverage against anaerobic organisms, but its safety and efficacy in this indication are unknown." | 5.34 | Safety of Metronidazole in Late Pre-term and Term Infants with Complicated Intra-abdominal Infections. ( Benjamin, D; Bumpass, TG; Cohen-Wolkowiez, M; Commander, SJ; Courtney, SE; Debski, J; Delmore, P; Erinjeri, J; Gao, J; Heresi, G; Hornik, CP; Lavery, AP; Moya, F; Sharma, G; Smith, PB; Sokol, GM; Tracy, ET; Zinkhan, EK, 2020) |
| "Avibactam, a novel non-β-lactam β-lactamase inhibitor, restores the in vitro activity of ceftazidime against class A, C and some class D β-lactamase-producing pathogens, including those commonly associated with complicated intra-abdominal infections (cIAIs)." | 5.17 | Comparative study of the efficacy and safety of ceftazidime/avibactam plus metronidazole versus meropenem in the treatment of complicated intra-abdominal infections in hospitalized adults: results of a randomized, double-blind, Phase II trial. ( Lipka, J; Lucasti, C; Popescu, I; Ramesh, MK; Sable, C, 2013) |
| "Lactic acid gel was associated with fewer reported side effects." | 3.30 | Intravaginal lactic acid gel versus oral metronidazole for treating women with recurrent bacterial vaginosis: the VITA randomised controlled trial. ( Abdali, Z; Anstey Watkins, J; Armstrong-Buisseret, LK; Brittain, C; Daniels, J; David, M; Dean, G; Griffiths, F; Hepburn, TM; Jackson, L; Kai, J; Manley, A; Montgomery, A; Ozolins, M; Ross, JDC, 2023) |
| "Giardiasis is one of the most common causes of diarrheal disease worldwide and 5-nitroimidazoles (5-NI) are the most commonly prescribed drugs for the treatment of giardiasis." | 2.50 | Efficacy of 5-nitroimidazoles for the treatment of giardiasis: a systematic review of randomized controlled trials. ( Deshpande, A; Escobedo, AA; Hernandez, AV; Pasupuleti, V; Roman, Y; Thota, P, 2014) |
| "Traditionally, many of the chemotherapeutic agents used in tropical medicine have possessed limited efficacy and serious adverse effects." | 2.39 | Adverse effects of chemotherapeutic agents used in tropical medicine. ( Cook, GC, 1995) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| "Risk of breast cancer in women was assessed for eight pharmaceuticals that produce mammary tumors in experimental animals, using nested case-control analyses in two cohorts with prescription records in a comprehensive medical care program." | 1.35 | Pharmaceuticals that cause mammary gland tumors in animals: findings in women. ( Chan, J; Friedman, GD; Habel, LA; Jiang, SF; Quesenberry, CP; Udaltsova, N, 2009) |
| "5 million adverse drug reaction (ADR) reports for 8620 drugs/biologics that are listed for 1191 Coding Symbols for Thesaurus of Adverse Reaction (COSTAR) terms of adverse effects." | 1.32 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. ( Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.56) | 18.7374 |
| 1990's | 1 (5.56) | 18.2507 |
| 2000's | 4 (22.22) | 29.6817 |
| 2010's | 7 (38.89) | 24.3611 |
| 2020's | 5 (27.78) | 2.80 |
| Authors | Studies |
|---|---|
| Matthews, EJ | 1 |
| Kruhlak, NL | 1 |
| Weaver, JL | 1 |
| Benz, RD | 1 |
| Contrera, JF | 1 |
| Chen, M | 1 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 2 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Morgan, RE | 1 |
| van Staden, CJ | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Afshari, CA | 1 |
| Hamadeh, HK | 1 |
| Wallner, J | 1 |
| Rieder, M | 1 |
| Schwaiger, M | 1 |
| Pau, M | 1 |
| Zrnc, T | 1 |
| Zemann, W | 1 |
| Metzler, P | 1 |
| Correia, C | 1 |
| Almeida, N | 1 |
| Leal, C | 1 |
| Branquinho, D | 1 |
| Fernandes, A | 1 |
| Gravito-Soares, E | 1 |
| Calhau, C | 1 |
| Bastos, I | 1 |
| Vasconcelos, H | 1 |
| Figueiredo, P | 1 |
| Ross, JDC | 1 |
| Brittain, C | 1 |
| Anstey Watkins, J | 1 |
| Kai, J | 1 |
| David, M | 1 |
| Ozolins, M | 1 |
| Jackson, L | 1 |
| Abdali, Z | 1 |
| Hepburn, TM | 1 |
| Griffiths, F | 1 |
| Montgomery, A | 1 |
| Daniels, J | 1 |
| Manley, A | 1 |
| Dean, G | 1 |
| Armstrong-Buisseret, LK | 1 |
| Ayinde, O | 1 |
| Ross, JD | 1 |
| Commander, SJ | 1 |
| Gao, J | 1 |
| Zinkhan, EK | 1 |
| Heresi, G | 1 |
| Courtney, SE | 1 |
| Lavery, AP | 1 |
| Delmore, P | 1 |
| Sokol, GM | 1 |
| Moya, F | 1 |
| Benjamin, D | 1 |
| Bumpass, TG | 1 |
| Debski, J | 1 |
| Erinjeri, J | 1 |
| Sharma, G | 1 |
| Tracy, ET | 1 |
| Smith, PB | 1 |
| Cohen-Wolkowiez, M | 1 |
| Hornik, CP | 1 |
| Pasupuleti, V | 1 |
| Escobedo, AA | 1 |
| Deshpande, A | 1 |
| Thota, P | 1 |
| Roman, Y | 1 |
| Hernandez, AV | 1 |
| Hawke, KL | 1 |
| McGuire, TM | 1 |
| Ranmuthugala, G | 1 |
| van Driel, ML | 1 |
| Backus, KV | 1 |
| Muzny, CA | 1 |
| Beauchamps, LS | 1 |
| Friedman, GD | 1 |
| Jiang, SF | 1 |
| Udaltsova, N | 1 |
| Chan, J | 1 |
| Quesenberry, CP | 1 |
| Habel, LA | 1 |
| Lucasti, C | 1 |
| Popescu, I | 1 |
| Ramesh, MK | 1 |
| Lipka, J | 1 |
| Sable, C | 1 |
| Preskorn, SH | 1 |
| Hill, LM | 1 |
| Kleinberg, F | 1 |
| Cook, GC | 1 |
| Lyszkiewicz, DA | 1 |
| Gerichhausen, S | 1 |
| Björnsdóttir, I | 1 |
| Einarson, TR | 1 |
| Koren, G | 1 |
| Einarson, A | 1 |
3 reviews available for metronidazole and Adverse Drug Event
| Article | Year |
|---|---|
Efficacy of 5-nitroimidazoles for the treatment of giardiasis: a systematic review of randomized controlled trials.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antiprotozoal Agents; Child; Child, Preschool; Drug-Rela | 2014 |
Effects of drugs and chemicals on the fetus and newborn (2).
Topics: Abnormalities, Drug-Induced; Anticoagulants; Anticonvulsants; Diazepam; Drug-Related Side Effects an | 1984 |
Adverse effects of chemotherapeutic agents used in tropical medicine.
Topics: Anthelmintics; Antimalarials; Drug-Related Side Effects and Adverse Reactions; Humans; Leprosy; Metr | 1995 |
4 trials available for metronidazole and Adverse Drug Event
| Article | Year |
|---|---|
Intravaginal lactic acid gel versus oral metronidazole for treating women with recurrent bacterial vaginosis: the VITA randomised controlled trial.
Topics: Ambulatory Care Facilities; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Lactic | 2023 |
The frequency and duration of side-effects associated with the use of oral metronidazole; A prospective study of VITA trial participants.
Topics: Administration, Intravaginal; Anti-Bacterial Agents; Drug-Related Side Effects and Adverse Reactions | 2023 |
Safety of Metronidazole in Late Pre-term and Term Infants with Complicated Intra-abdominal Infections.
Topics: Anti-Bacterial Agents; Cohort Studies; Drug Therapy, Combination; Drug-Related Side Effects and Adve | 2020 |
Comparative study of the efficacy and safety of ceftazidime/avibactam plus metronidazole versus meropenem in the treatment of complicated intra-abdominal infections in hospitalized adults: results of a randomized, double-blind, Phase II trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Azabicyclo Compounds; Ceftazidime | 2013 |
11 other studies available for metronidazole and Adverse Drug Event
| Article | Year |
|---|---|
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Dru | 2004 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
[Metronidazole - spectrum of activity, use and side effects].
Topics: Adult; Anti-Bacterial Agents; Bacterial Infections; Child; Drug-Related Side Effects and Adverse Rea | 2022 |
Single-capsule bismuth-based quadruple therapy as a rescue therapy for
Topics: Amoxicillin; Anti-Bacterial Agents; Bismuth; Drug Therapy, Combination; Drug-Related Side Effects an | 2023 |
What do consumers want to know about antibiotics? Analysis of a medicines call centre database.
Topics: Adolescent; Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Australia; Child; Child, Preschool; Cip | 2016 |
Trichomonas vaginalis Treated With Boric Acid in a Metronidazole Allergic Female.
Topics: Aged; Antiprotozoal Agents; Boric Acids; Drug Hypersensitivity; Drug-Related Side Effects and Advers | 2017 |
Pharmaceuticals that cause mammary gland tumors in animals: findings in women.
Topics: Adult; Aged; Antifungal Agents; Antiprotozoal Agents; Breast Neoplasms; Case-Control Studies; Diuret | 2009 |
Drug-drug interactions: proof of relevance (part I).
Topics: Anti-Bacterial Agents; Antifungal Agents; Antipsychotic Agents; Cyclophilins; Drug Interactions; Dru | 2005 |
Evidence based information on drug use during pregnancy: a survey of community pharmacists in three countries.
Topics: Adult; Anticonvulsants; Antidepressive Agents, Second-Generation; Antitrichomonal Agents; Canada; Ca | 2001 |