metronidazole has been researched along with Cancer of Prostate in 13 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the effectiveness of metronidazole in combination with corticosteroids in enema and mesalazine (5-aminosalicylic acid) in comparison with the same protocol without metronidazole in the treatment of chronic radiation proctitis." | 9.09 | Metronidazole in the treatment of chronic radiation proctitis: clinical trial. ( Cavcić, J; Jelincić, Z; Martinac, P; Panijan-Pezerović, R; Turcić, J; Unusić, J; Zupancić, B, 2000) |
| "To evaluate the effectiveness of metronidazole in combination with corticosteroids in enema and mesalazine (5-aminosalicylic acid) in comparison with the same protocol without metronidazole in the treatment of chronic radiation proctitis." | 5.09 | Metronidazole in the treatment of chronic radiation proctitis: clinical trial. ( Cavcić, J; Jelincić, Z; Martinac, P; Panijan-Pezerović, R; Turcić, J; Unusić, J; Zupancić, B, 2000) |
| "After antibiotic prophylaxis with metronidazole and levofloxacin, a transrectal sextant biopsy was performed under the guide of transrectal ultrasonography (TRUS) for a 75-year-old suspicious patient with prostate adenocarcinoma." | 3.73 | Life-threatening meningitis resulting from transrectal prostate biopsy. ( Chen, SW; Shen, ZJ; Wang, H; Zhao, JP; Zhou, XL, 2005) |
| " sordellii ischio-rectal abscess with rapidly fatal septicaemia is described which complicated ultrasound-guided transrectal biopsy of the prostate, despite ciprofloxacin prophylaxis." | 3.70 | Fatal Clostridium sordellii ischio-rectal abscess with septicaemia complicating ultrasound-guided transrectal prostate biopsy. ( Borer, A; Buskila, D; Gilad, J; Riesenberg, K; Schlaeffer, F; Sikuler, E, 1999) |
| "Prostate cancer is the most common form of cancer in Danish men, and the incidence is rising." | 1.40 | Prophylactic antibiotics reduce sepsis after biopsy of the prostate. ( Hayatzaki, K; Menne, S; Nielsen, K, 2014) |
| "Four patients had had cervical cancer, five had uterine cancer, one had prostatic cancer, one had vesical cancer and one had vaginal cancer." | 1.37 | A novel treatment for haemorrhagic radiation proctitis using colonic irrigation and oral antibiotic administration. ( Atittharnsakul, P; Patiwongpaisarn, A; Rojanasakul, A; Sahakitrungruang, C; Thum-Umnuaysuk, S, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (15.38) | 18.7374 |
| 1990's | 4 (30.77) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 5 (38.46) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Heidari Bateni, Z | 1 |
| Shahrokh, H | 1 |
| Salimi, H | 1 |
| Safari, H | 1 |
| Tabatabai, M | 1 |
| Saedi, D | 1 |
| Agbugui, JO | 1 |
| Obarisiagbon, EO | 1 |
| Osaigbovo, EO | 1 |
| Osime, CO | 1 |
| Akumabor, PN | 1 |
| Hayatzaki, K | 1 |
| Menne, S | 1 |
| Nielsen, K | 1 |
| Aebischer, B | 1 |
| Elsig, S | 1 |
| Taeymans, J | 1 |
| Pomp, S | 1 |
| Kuhness, D | 1 |
| Barcaro, G | 1 |
| Sementa, L | 1 |
| Mankad, V | 1 |
| Fortunelli, A | 1 |
| Sterrer, M | 1 |
| Netzer, FP | 1 |
| Surnev, S | 1 |
| Schmieder, AH | 1 |
| Caruthers, SD | 1 |
| Keupp, J | 1 |
| Wickline, SA | 1 |
| Lanza, GM | 1 |
| Lowe, J | 1 |
| Wodarcyk, AJ | 1 |
| Floyd, KT | 1 |
| Rastogi, N | 1 |
| Schultz, EJ | 1 |
| Swager, SA | 1 |
| Chadwick, JA | 1 |
| Tran, T | 1 |
| Raman, SV | 1 |
| Janssen, PM | 1 |
| Rafael-Fortney, JA | 1 |
| Alcalay, RN | 1 |
| Levy, OA | 1 |
| Wolf, P | 1 |
| Oliva, P | 1 |
| Zhang, XK | 1 |
| Waters, CH | 1 |
| Fahn, S | 1 |
| Kang, U | 1 |
| Liong, C | 1 |
| Ford, B | 1 |
| Mazzoni, P | 1 |
| Kuo, S | 1 |
| Johnson, A | 1 |
| Xiong, L | 1 |
| Rouleau, GA | 1 |
| Chung, W | 1 |
| Marder, KS | 1 |
| Gan-Or, Z | 1 |
| Kamei, K | 1 |
| Terao, T | 1 |
| Katayama, Y | 1 |
| Hatano, K | 1 |
| Kodama, K | 1 |
| Shirahama, M | 1 |
| Sakai, A | 1 |
| Hirakawa, H | 1 |
| Mizokami, Y | 1 |
| Shiotsuki, I | 1 |
| Ishii, N | 1 |
| Inoue, Y | 1 |
| Akboga, MK | 1 |
| Yayla, C | 1 |
| Balci, KG | 1 |
| Ozeke, O | 1 |
| Maden, O | 1 |
| Kisacik, H | 1 |
| Temizhan, A | 1 |
| Aydogdu, S | 1 |
| Zhu, J | 2 |
| Ying, SH | 1 |
| Feng, MG | 1 |
| Zhang, XG | 1 |
| Li, H | 1 |
| Wang, L | 1 |
| Hao, YY | 1 |
| Liang, GD | 1 |
| Ma, YH | 1 |
| Yang, GS | 1 |
| Hu, JH | 1 |
| Pfeifer, L | 1 |
| Goertz, RS | 1 |
| Neurath, MF | 1 |
| Strobel, D | 1 |
| Wildner, D | 1 |
| Lin, JT | 1 |
| Yang, XN | 1 |
| Zhong, WZ | 1 |
| Liao, RQ | 1 |
| Dong, S | 1 |
| Nie, Q | 1 |
| Weng, SX | 1 |
| Fang, XJ | 1 |
| Zheng, JY | 1 |
| Wu, YL | 1 |
| Řezanka, T | 1 |
| Kaineder, K | 1 |
| Mezricky, D | 1 |
| Řezanka, M | 1 |
| Bišová, K | 1 |
| Zachleder, V | 1 |
| Vítová, M | 1 |
| Rinker, JA | 1 |
| Marshall, SA | 1 |
| Mazzone, CM | 1 |
| Lowery-Gionta, EG | 1 |
| Gulati, V | 1 |
| Pleil, KE | 1 |
| Kash, TL | 1 |
| Navarro, M | 1 |
| Thiele, TE | 1 |
| Zhang, Y | 1 |
| Huang, Y | 1 |
| Jin, Z | 1 |
| Li, X | 1 |
| Li, B | 1 |
| Xu, P | 1 |
| Huang, P | 1 |
| Liu, C | 1 |
| Fokdal, L | 1 |
| Sturdza, A | 1 |
| Mazeron, R | 1 |
| Haie-Meder, C | 1 |
| Tan, LT | 1 |
| Gillham, C | 1 |
| Šegedin, B | 1 |
| Jürgenliemk-Schultz, I | 1 |
| Kirisits, C | 1 |
| Hoskin, P | 1 |
| Pötter, R | 1 |
| Lindegaard, JC | 1 |
| Tanderup, K | 1 |
| Levin, DE | 1 |
| Schmitz, AJ | 1 |
| Hines, SM | 1 |
| Hines, KJ | 1 |
| Tucker, MJ | 1 |
| Brewer, SH | 1 |
| Fenlon, EE | 1 |
| Álvarez-Pérez, S | 1 |
| Blanco, JL | 1 |
| Peláez, T | 1 |
| Martínez-Nevado, E | 1 |
| García, ME | 1 |
| Puckerin, AA | 1 |
| Chang, DD | 1 |
| Subramanyam, P | 1 |
| Colecraft, HM | 1 |
| Dogan, H | 1 |
| Coteli, E | 1 |
| Karatas, F | 1 |
| Ceylan, O | 1 |
| Sahin, MD | 1 |
| Akdamar, G | 1 |
| Kryczyk, A | 1 |
| Żmudzki, P | 1 |
| Hubicka, U | 1 |
| Giovannelli, D | 1 |
| Chung, M | 1 |
| Staley, J | 1 |
| Starovoytov, V | 1 |
| Le Bris, N | 1 |
| Vetriani, C | 1 |
| Chen, W | 1 |
| Wu, L | 1 |
| Liu, X | 1 |
| Shen, Y | 1 |
| Liang, Y | 1 |
| Tan, H | 1 |
| Yang, Y | 1 |
| Liu, Q | 1 |
| Wang, M | 1 |
| Liu, L | 1 |
| Wang, X | 1 |
| Liu, B | 1 |
| Liu, GH | 1 |
| Zhu, YJ | 1 |
| Wang, JP | 1 |
| Che, JM | 1 |
| Chen, QQ | 1 |
| Chen, Z | 1 |
| Maucksch, U | 1 |
| Runge, R | 1 |
| Wunderlich, G | 1 |
| Freudenberg, R | 1 |
| Naumann, A | 1 |
| Kotzerke, J | 1 |
| Sahakitrungruang, C | 1 |
| Thum-Umnuaysuk, S | 1 |
| Patiwongpaisarn, A | 1 |
| Atittharnsakul, P | 1 |
| Rojanasakul, A | 1 |
| Shen, ZJ | 1 |
| Chen, SW | 1 |
| Wang, H | 1 |
| Zhou, XL | 1 |
| Zhao, JP | 1 |
| Bilgrami, S | 1 |
| Pesanti, EL | 1 |
| Singh, NT | 1 |
| Cobb, RJ | 1 |
| Chen, LL | 1 |
| Synnott, V | 1 |
| Cipolla, B | 1 |
| Blanchard, Y | 1 |
| Chamaillard, L | 1 |
| Quemener, V | 1 |
| Guillé, F | 1 |
| Havouis, R | 1 |
| Moulinoux, JP | 1 |
| Baur, H | 1 |
| Frimberger, M | 1 |
| Altwein, JE | 1 |
| Borer, A | 1 |
| Gilad, J | 1 |
| Sikuler, E | 1 |
| Riesenberg, K | 1 |
| Schlaeffer, F | 1 |
| Buskila, D | 1 |
| Cavcić, J | 1 |
| Turcić, J | 1 |
| Martinac, P | 1 |
| Jelincić, Z | 1 |
| Zupancić, B | 1 |
| Panijan-Pezerović, R | 1 |
| Unusić, J | 1 |
| Munzenrider, JE | 1 |
| Ashby, EC | 1 |
| Rees, M | 1 |
| Dowding, CH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Postoperative or Salvage Radiotherapy for Node Negative Prostate Cancer Following Radical Prostatectomy[NCT00969111] | 70 participants (Anticipated) | Interventional | 2009-08-31 | Recruiting | |||
| An Expanded Phase II Study of Hypofractionated Dose Intense Image Guided Proton Radiation Therapy for Low and Intermediate Risk Adenocarcinoma of the Prostate[NCT01368055] | 361 participants (Actual) | Interventional | 2011-09-30 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for metronidazole and Cancer of Prostate
| Article | Year |
|---|---|
Topics: AC133 Antigen; Acenaphthenes; Acer; Acrosome Reaction; Adult; Agaricales; Aged; Aged, 80 and over; A | 2016 |
Recent advances in radiotherapy.
Topics: Breast Neoplasms; Bromodeoxyuridine; Carcinoid Tumor; Elementary Particles; Fast Neutrons; Hot Tempe | 1977 |
3 trials available for metronidazole and Cancer of Prostate
| Article | Year |
|---|---|
Single-dose versus multiple-dose ciprofloxacin plus metronidazole prophylaxis in transrectal ultrasound-guided biopsy of the prostate: a randomized controlled trial.
Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Antibiotic Prophylaxis; Bacteremia; Bacterial | 2014 |
Antibiotic prophylaxis for transrectal prostate biopsy: a comparison of one-day and five-day regimen.
Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Antibiotic Prophylaxis; Biopsy, Needle; Cipro | 2014 |
Metronidazole in the treatment of chronic radiation proctitis: clinical trial.
Topics: Aged; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Beta | 2000 |
Metronidazole in the treatment of chronic radiation proctitis: clinical trial.
Topics: Aged; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Beta | 2000 |
Metronidazole in the treatment of chronic radiation proctitis: clinical trial.
Topics: Aged; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Beta | 2000 |
Metronidazole in the treatment of chronic radiation proctitis: clinical trial.
Topics: Aged; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Beta | 2000 |
8 other studies available for metronidazole and Cancer of Prostate
| Article | Year |
|---|---|
Prophylactic antibiotics reduce sepsis after biopsy of the prostate.
Topics: Aged; Antibiotic Prophylaxis; Biopsy, Needle; Ciprofloxacin; Denmark; Drug Resistance, Bacterial; Hu | 2014 |
A novel treatment for haemorrhagic radiation proctitis using colonic irrigation and oral antibiotic administration.
Topics: Aged; Aged, 80 and over; Anti-Infective Agents; Ciprofloxacin; Combined Modality Therapy; Female; Ga | 2011 |
Life-threatening meningitis resulting from transrectal prostate biopsy.
Topics: Adenocarcinoma; Aged; Anti-Infective Agents; Anti-Infective Agents, Urinary; Biopsy; Escherichia col | 2005 |
Spinal cord compression due to anaerobic vertebral osteomyelitis in a patient with metastatic prostate cancer.
Topics: Aged; Anti-Bacterial Agents; Bacteremia; Bacteroides fragilis; Bacteroides Infections; Humans; Lumba | 1995 |
In vivo, synergestic inhibition of MAT-LyLu rat prostatic adenocarcinoma growth by polyamine deprivation and low-dose cyclophosphamide.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Co | 1996 |
Simultaneous radical prostatectomy and partial rectum resection without colostomy.
Topics: Anastomosis, Surgical; Antitrichomonal Agents; Cefotaxime; Cephalosporins; Humans; Male; Metronidazo | 1997 |
Fatal Clostridium sordellii ischio-rectal abscess with septicaemia complicating ultrasound-guided transrectal prostate biopsy.
Topics: Abscess; Adenocarcinoma; Aged; Ampicillin; Anti-Infective Agents; Bacteremia; Biopsy; Ciprofloxacin; | 1999 |
Prophylaxis against systemic infection after transrectal biopsy for suspected prostatic carcinoma.
Topics: Ampicillin; Anti-Bacterial Agents; Biopsy; Humans; Male; Metronidazole; Prostatic Neoplasms; Rectum; | 1978 |