metronidazole has been researched along with Hypotension in 2 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Hypotension: Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.
Excerpt | Relevance | Reference |
---|---|---|
"Metronidazole was introduced (500mg X 3 by day)." | 1.72 | ( Boukobza, M; Duval, X; Laissy, JP; Raffoul, R, 2022) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 1 (50.00) | 24.3611 |
2020's | 1 (50.00) | 2.80 |
Authors | Studies |
---|---|
Boukobza, M | 1 |
Raffoul, R | 1 |
Duval, X | 1 |
Laissy, JP | 1 |
Manek, K | 1 |
Williams, V | 1 |
Callery, S | 1 |
Daneman, N | 1 |
2 other studies available for metronidazole and Hypotension
Article | Year |
---|---|
Topics: Abscess; Adult; Anti-Bacterial Agents; Aortic Valve; Cefotaxime; Endocarditis; Endocarditis, Bacteri | 2022 |
Reducing the risk of severe complications among patients with Clostridium difficile infection.
Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Antiprotozoal Agents; Comorbidity; Confusion; Entero | 2011 |