metronidazole has been researched along with Peritoneal Diseases in 6 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Peritoneal Diseases: Pathological processes involving the PERITONEUM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mice were treated with broad-spectrum antibiotics or metronidazole, subjected to surgically-induced endometriosis and assayed after 21 days." | 7.91 | Antibiotic therapy with metronidazole reduces endometriosis disease progression in mice: a potential role for gut microbiota. ( Chadchan, SB; Cheng, M; Kommagani, R; Mysorekar, IU; Parnell, LA; Schriefer, A; Yin, Y, 2019) |
| "Mice were treated with broad-spectrum antibiotics or metronidazole, subjected to surgically-induced endometriosis and assayed after 21 days." | 3.91 | Antibiotic therapy with metronidazole reduces endometriosis disease progression in mice: a potential role for gut microbiota. ( Chadchan, SB; Cheng, M; Kommagani, R; Mysorekar, IU; Parnell, LA; Schriefer, A; Yin, Y, 2019) |
| "The efficacy of rifampicin in treating a Bacteroides fragilis infection was investigated and compared to clindamycin and metronidazole in an experimental model of intra-abdominal abscess in mice." | 3.67 | Therapeutic efficacy and pharmacokinetic properties of rifampicin in a Bacteroides fragilis intra-abdominal abscess. ( Fu, KP; Kimble, EF; Konopka, EA; Lasinski, ER; Zoganas, HC, 1984) |
| "A patient had Crohn's disease in relapse with multiple small bowel fistulae and mesenteric abscesses." | 1.30 | Relative sensitivity of Tc-99m WBC versus In-111 WBC in a patient with Crohn's disease on steroids. ( Broekelschen, P; Challa, S; Lyons, KP; Milne, N, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (33.33) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chadchan, SB | 1 |
| Cheng, M | 1 |
| Parnell, LA | 1 |
| Yin, Y | 1 |
| Schriefer, A | 1 |
| Mysorekar, IU | 1 |
| Kommagani, R | 1 |
| Fu, KP | 1 |
| Lasinski, ER | 1 |
| Zoganas, HC | 1 |
| Kimble, EF | 1 |
| Konopka, EA | 1 |
| Závadová, M | 1 |
| Tynková, S | 1 |
| Adensámová, J | 1 |
| Brezinová, L | 1 |
| Lyons, KP | 2 |
| Challa, S | 2 |
| Broekelschen, P | 2 |
| Milne, N | 2 |
| Oncel, M | 1 |
| Kurt, N | 1 |
| Remzi, FH | 1 |
| Sensu, SS | 1 |
| Vural, S | 1 |
| Gezen, CF | 1 |
| Cincin, TG | 1 |
| Olcay, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Use of Low Dose Metronidazole to Decrease Postoperative Pain After Endometriosis Surgery: A Prospective, Randomized, Placebo-Controlled Trial[NCT04554693] | Phase 4 | 90 participants (Anticipated) | Interventional | 2020-10-19 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 other studies available for metronidazole and Peritoneal Diseases
| Article | Year |
|---|---|
Antibiotic therapy with metronidazole reduces endometriosis disease progression in mice: a potential role for gut microbiota.
Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Disease Progression; Endometriosis; Endometr | 2019 |
Therapeutic efficacy and pharmacokinetic properties of rifampicin in a Bacteroides fragilis intra-abdominal abscess.
Topics: Abscess; Administration, Oral; Animals; Bacteroides fragilis; Bacteroides Infections; Clindamycin; F | 1984 |
Sensitivity of Bacteroides species to modern antimicrobial preparations.
Topics: Abscess; Bacteroides; Bacteroides Infections; beta-Lactamases; Cefamandole; Cefoxitin; Cephalosporin | 1983 |
Relative sensitivity of Tc-99m WBC versus In-111 WBC in a patient with Crohn's disease on steroids.
Topics: Abdominal Abscess; Adult; Ampicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inflammator | 1997 |
Relative sensitivity of Tc-99m WBC versus In-111 WBC in a patient with Crohn disease and steroid use.
Topics: Abdominal Abscess; Adult; Ampicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inflammator | 1997 |
The effectiveness of systemic antibiotics in preventing postoperative, intraabdominal adhesions in an animal model.
Topics: Animals; Anti-Infective Agents; Cefepime; Cephalosporins; Fibrosis; Injections, Intramuscular; Metro | 2001 |