Compounds > cl 64855
Page last updated: 2024-12-06

cl 64855

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID29698
CHEMBL ID423172
SCHEMBL ID11696315
MeSH IDM0459779

Synonyms (35)

Synonym
nsc-265726
1,4-thiadiazole, 2-amino-5-(1-methyl-5-nitroimidazol-2-yl)-
1,4-thiadiazol-2-amine, 5-(1-methyl-5-nitro-1h-imidazol-2-yl)-
NCI60_002137
cl 64855
19622-55-0
1,3,4-thiadiazol-2-amine, 5-(1-methyl-5-nitro-1h-imidazol-2-yl)-
5-(1-methyl-5-nitro-imidazol-2-yl)-1,3,4-thiadiazol-2-amine
nitroimidazole thiadiazole
nsc265726
megazol
cl 64,855
1,3,4-thiadiazole, 2-amino-5-(1-methyl-5-nitroimidazol-2-yl)-
brn 0619299
nsc 265726
cl 64 855
ccris 2480
2-amino-5-(1-methyl-5-nitroimidazol-2-yl)-1,3,4-thiadiazole
2-amino-5-(1-methyl-5-nitro-2-imidazolyl)-1,3,4-thiadiazole
cl-64855
CHEMBL423172
5-(1-methyl-5-nitroimidazol-2-yl)-1,3,4-thiadiazol-2-amine
vq8uh664zj ,
unii-vq8uh664zj
2-(2-amino-1,3,4-thiadiazol-5-yl)-1-methyl-5-nitroimidazole
VDZZTXBMKRQEPO-UHFFFAOYSA-N
SCHEMBL11696315
DTXSID50173298
Q3304399
5-(1-METHYL-5-NITRO-1H-IMIDAZOL-2-YL)-1,3,4-THIADIAZOL-2-AMINE ,
CS-0068483
HY-119480
2-amino-5-(1-methyl-5-nitroimidazole-2-yl)-1,3,4-thiadiazole
1,3,4-thiadiazol, 2-amino-5-(1-methyl-5-nitro-2-imidazolyl)-
AKOS040748898

Research Excerpts

Overview

CL 64855 proved to be a potent mutagen to the frameshift indicator tester strains TA98 and TA102.

ExcerptReferenceRelevance
"CL 64855 proved to be a potent mutagen to the frameshift indicator tester strains TA98 and TA102."( Mutagenicity of CL 64855, a potent anti-Trypanosoma cruzi drug.
Ferreira, LC; Ferreira, RC, 1986)		1.34

Pharmacokinetics

ExcerptReferenceRelevance
"8 micrograms/ml for Cmax and 95547 micrograms."( Pharmacokinetics, metabolism and excretion of megazol, a new potent trypanocidal drug in animals.
Boudra, H; Bouteille, B; Chauvière, G; Dumas, M; Enanga, B; Houin, G; Labat, C, 1999)		0.3

Compound-Compound Interactions

ExcerptReferenceRelevance
" This megazol gel, when used in combination with melarsoprol (3."( Topical chemotherapy for experimental African trypanosomiasis with cerebral involvement: the use of melarsoprol combined with the 5-nitroimidazole, megazol.
Chauvière, G; Jennings, FW; Murray, M; Viode, C, 1996)		0.29

Dosage Studied

ExcerptRelevanceReference
" When unlabelled megazol was orally administered to rats with absence or presence of suramin, megazol recovered in urine and faeces 72 h dosing was: 55."( Pharmacokinetics, metabolism and excretion of megazol, a new potent trypanocidal drug in animals.
Boudra, H; Bouteille, B; Chauvière, G; Dumas, M; Enanga, B; Houin, G; Labat, C, 1999)		0.3
"2 microgram/ml and 46 micrograms/ml 24 h after dosing in all animals."( Pharmacokinetics, metabolism and excretion of megazol in a Trypanosoma brucei gambiense primate model of human African trypanosomiasis. Preliminary study.
Boudra, H; Bouteille, B; Chauvière, G; Debrauwer, L; Dubreuil, G; Dumas, M; Enanga, B; Houin, G; Labat, C; Ndong, JM; Périé, J, 2000)		0.31
" Results in rat and mouse fresh leukocytes showed a dose-response relation of drug-induced DNA damage."( Cytotoxic and genotoxic effects of megazol, an anti-Chagas' disease drug, assessed by different short-term tests.
Aline de Mello, M; Buschini, A; da Silva, S; Mortara, RA; Northfleet de Albuquerque, C; Poli, P; Rossi, C; Zucchi, TM, 2002)		0.31
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (62)

Assay IDTitleYearJournalArticle
AID214136In vitro percent inhibition against mouse peritoneal macrophages infected with Trypanosoma cruzi at 12.5 uM concentration2003Journal of medicinal chemistry, Jan-30, Volume: 46, Issue:3
Synthesis and biological activity of nitro heterocycles analogous to megazol, a trypanocidal lead.
AID248172Ability to cause lysis of trypomastigote form of Trypanosoma cruzi was determined2004Bioorganic & medicinal chemistry letters, Dec-20, Volume: 14, Issue:24
Synthesis and antitrypanosomal profile of new functionalized 1,3,4-thiadiazole-2-arylhydrazone derivatives, designed as non-mutagenic megazol analogues.
AID313195Trypanocidal activity against Trypanosoma cruzi Y trypomastigotes assessed as parasite lysis2008Bioorganic & medicinal chemistry, Jan-01, Volume: 16, Issue:1
Studies toward the structural optimization of new brazilizone-related trypanocidal 1,3,4-thiadiazole-2-arylhydrazone derivatives.
AID692982Cytotoxicity against in rat L6 cells assessed as reduction in cell viability after 70 hrs by alamar blue assay2011European journal of medicinal chemistry, May, Volume: 46, Issue:5
1-Aryl-4-nitro-1H-imidazoles, a new promising series for the treatment of human African trypanosomiasis.
AID523198Antitrypanosomal activity against Trypanosoma cruzi amastigotes infected in mouse embryo heart muscle cells assessed as inhibition of infection2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
In vitro and in vivo activities of 1,3,4-thiadiazole-2-arylhydrazone derivatives of megazol against Trypanosoma cruzi.
AID224388Concentration that cause cytotoxicity at 12.5 uM concentration2003Journal of medicinal chemistry, Jan-30, Volume: 46, Issue:3
Synthesis and biological activity of nitro heterocycles analogous to megazol, a trypanocidal lead.
AID253512Inhibitory concentration against wild-type (427) Trypanosoma brucei2005Journal of medicinal chemistry, Aug-25, Volume: 48, Issue:17
Design and synthesis of a series of melamine-based nitroheterocycles with activity against Trypanosomatid parasites.
AID523192Antitrypanosomal activity against Trypanosoma cruzi amastigotes infected in mouse peritoneal macrophages assessed as endocytic index after 2 day2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
In vitro and in vivo activities of 1,3,4-thiadiazole-2-arylhydrazone derivatives of megazol against Trypanosoma cruzi.
AID523202Cytotoxicity against swiss mouse HMC after 48 hrs by MTT assay2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
In vitro and in vivo activities of 1,3,4-thiadiazole-2-arylhydrazone derivatives of megazol against Trypanosoma cruzi.
AID214135Effective dose against Trypanosoma cruzi compared to sodium stibogluconate2003Journal of medicinal chemistry, Jan-30, Volume: 46, Issue:3
Synthesis and biological activity of nitro heterocycles analogous to megazol, a trypanocidal lead.
AID523206Toxicity in mouse assessed as GOT level in blood at 400 mg/kg, po after 4 days2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
In vitro and in vivo activities of 1,3,4-thiadiazole-2-arylhydrazone derivatives of megazol against Trypanosoma cruzi.
AID99730Percent inhibition in vitro against intracellular form of Leishmania donovani at 30 uM concentration2003Journal of medicinal chemistry, Jan-30, Volume: 46, Issue:3
Synthesis and biological activity of nitro heterocycles analogous to megazol, a trypanocidal lead.
AID523190Antitrypanosomal activity against Trypanosoma cruzi amastigotes infected in mouse peritoneal macrophages assessed as inhibition of infection after 4 day2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
In vitro and in vivo activities of 1,3,4-thiadiazole-2-arylhydrazone derivatives of megazol against Trypanosoma cruzi.
AID523203Selectivity index, ratio of LC50 for mouse peritoneal macrophages to IC50 for inhibition of Trypanosoma cruzi amastigotes2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
In vitro and in vivo activities of 1,3,4-thiadiazole-2-arylhydrazone derivatives of megazol against Trypanosoma cruzi.
AID523194Antitrypanosomal activity against Trypanosoma cruzi amastigotes infected in mouse peritoneal macrophages assessed as endocytic index after 4 day2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
In vitro and in vivo activities of 1,3,4-thiadiazole-2-arylhydrazone derivatives of megazol against Trypanosoma cruzi.
AID214137In vitro percent inhibition against mouse peritoneal macrophages infected with Trypanosoma cruzi at 25 uM concentration2003Journal of medicinal chemistry, Jan-30, Volume: 46, Issue:3
Synthesis and biological activity of nitro heterocycles analogous to megazol, a trypanocidal lead.
AID99731Percent inhibition in vitro against intracellular form of Leishmania donovani at 90 uM concentration2003Journal of medicinal chemistry, Jan-30, Volume: 46, Issue:3
Synthesis and biological activity of nitro heterocycles analogous to megazol, a trypanocidal lead.
AID523062Antitrypanosomal activity against Trypanosoma cruzi trypomastigotes assessed as mitochondrial swelling with scarcity of matrix and cristae at 9.9 uM after 24 hrs by Transmission electron microscopy2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
In vitro and in vivo activities of 1,3,4-thiadiazole-2-arylhydrazone derivatives of megazol against Trypanosoma cruzi.
AID224394Concentration that cause cytotoxicity at 6.2 uM concentration2003Journal of medicinal chemistry, Jan-30, Volume: 46, Issue:3
Synthesis and biological activity of nitro heterocycles analogous to megazol, a trypanocidal lead.
AID1510718Antibacterial activity against drug-sensitive Helicobacter pylori assessed as zone of inhibition at 8 ug/disc2019European journal of medicinal chemistry, Oct-01, Volume: 179Nitroimidazole-containing compounds and their antibacterial and antitubercular activities.
AID100898In vitro percent inhibition against mouse peritoneal macrophages infected with Leishmania infantum at 25 uM concentration2003Journal of medicinal chemistry, Jan-30, Volume: 46, Issue:3
Synthesis and biological activity of nitro heterocycles analogous to megazol, a trypanocidal lead.
AID523197Antitrypanosomal activity against Trypanosoma cruzi amastigotes infected in mouse embryo heart muscle cells assessed as inhibition of infection after 24 hrs2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
In vitro and in vivo activities of 1,3,4-thiadiazole-2-arylhydrazone derivatives of megazol against Trypanosoma cruzi.
AID100900In vitro percent inhibition against mouse peritoneal macrophages infected with Leishmania infantum at 6.2 uM concentration2003Journal of medicinal chemistry, Jan-30, Volume: 46, Issue:3
Synthesis and biological activity of nitro heterocycles analogous to megazol, a trypanocidal lead.
AID215324Effective concentration in vitro against the bloodstream trypomastigote form of Trypanosoma brucei2003Journal of medicinal chemistry, Jan-30, Volume: 46, Issue:3
Synthesis and biological activity of nitro heterocycles analogous to megazol, a trypanocidal lead.
AID100897In vitro percent inhibition against mouse peritoneal macrophages infected with Leishmania infantum at 12.5 uM concentration2003Journal of medicinal chemistry, Jan-30, Volume: 46, Issue:3
Synthesis and biological activity of nitro heterocycles analogous to megazol, a trypanocidal lead.
AID214139In vitro percent inhibition against mouse peritoneal macrophages infected with Trypanosoma cruzi at 6.2 uM concentration2003Journal of medicinal chemistry, Jan-30, Volume: 46, Issue:3
Synthesis and biological activity of nitro heterocycles analogous to megazol, a trypanocidal lead.
AID99729Percent inhibition in vitro against intracellular form of Leishmania donovani at 10 uM concentration2003Journal of medicinal chemistry, Jan-30, Volume: 46, Issue:3
Synthesis and biological activity of nitro heterocycles analogous to megazol, a trypanocidal lead.
AID215700In vitro percent inhibition against mouse peritoneal macrophages infected with Trypanosoma brucei at 6.2 uM concentration2003Journal of medicinal chemistry, Jan-30, Volume: 46, Issue:3
Synthesis and biological activity of nitro heterocycles analogous to megazol, a trypanocidal lead.
AID1510716Antibacterial activity against Helicobacter pylori clinical isolate assessed as zone of inhibition at 8 ug/disc2019European journal of medicinal chemistry, Oct-01, Volume: 179Nitroimidazole-containing compounds and their antibacterial and antitubercular activities.
AID224390Concentration that cause cytotoxicity at 25 uM concentration2003Journal of medicinal chemistry, Jan-30, Volume: 46, Issue:3
Synthesis and biological activity of nitro heterocycles analogous to megazol, a trypanocidal lead.
AID523193Antitrypanosomal activity against Trypanosoma cruzi amastigotes infected in mouse peritoneal macrophages assessed as endocytic index after 3 day2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
In vitro and in vivo activities of 1,3,4-thiadiazole-2-arylhydrazone derivatives of megazol against Trypanosoma cruzi.
AID215699In vitro percent inhibition against mouse peritoneal macrophages infected with Trypanosoma brucei at 3.1 uM concentration2003Journal of medicinal chemistry, Jan-30, Volume: 46, Issue:3
Synthesis and biological activity of nitro heterocycles analogous to megazol, a trypanocidal lead.
AID523051Antitrypanosomal activity against Trypanosoma cruzi Y infected in mouse assessed as decrease in parasitemia in blood at 200 mg/kg, po upto 40 days post infection2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
In vitro and in vivo activities of 1,3,4-thiadiazole-2-arylhydrazone derivatives of megazol against Trypanosoma cruzi.
AID523187Antitrypanosomal activity against Trypanosoma cruzi amastigotes infected in mouse peritoneal macrophages assessed as inhibition of infection after 1 day2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
In vitro and in vivo activities of 1,3,4-thiadiazole-2-arylhydrazone derivatives of megazol against Trypanosoma cruzi.
AID214147Percent inhibition in vitro against intracellular form of Trypanosoma cruzi at 10 uM concentration2003Journal of medicinal chemistry, Jan-30, Volume: 46, Issue:3
Synthesis and biological activity of nitro heterocycles analogous to megazol, a trypanocidal lead.
AID214149Percent inhibition in vitro against intracellular form of Trypanosoma cruzi at 30 uM concentration2003Journal of medicinal chemistry, Jan-30, Volume: 46, Issue:3
Synthesis and biological activity of nitro heterocycles analogous to megazol, a trypanocidal lead.
AID523207Toxicity in mouse assessed as GPT level in blood at 400 mg/kg, po after 4 days2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
In vitro and in vivo activities of 1,3,4-thiadiazole-2-arylhydrazone derivatives of megazol against Trypanosoma cruzi.
AID100899In vitro percent inhibition against mouse peritoneal macrophages infected with Leishmania infantum at 3.1 uM concentration2003Journal of medicinal chemistry, Jan-30, Volume: 46, Issue:3
Synthesis and biological activity of nitro heterocycles analogous to megazol, a trypanocidal lead.
AID523064Antitrypanosomal activity against Trypanosoma cruzi trypomastigotes assessed as intense cytoplasmic vacuolization at 9.9 uM after 24 hrs by Transmission electron microscopy2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
In vitro and in vivo activities of 1,3,4-thiadiazole-2-arylhydrazone derivatives of megazol against Trypanosoma cruzi.
AID214138In vitro percent inhibition against mouse peritoneal macrophages infected with Trypanosoma cruzi at 3.1 uM concentration2003Journal of medicinal chemistry, Jan-30, Volume: 46, Issue:3
Synthesis and biological activity of nitro heterocycles analogous to megazol, a trypanocidal lead.
AID523188Antitrypanosomal activity against Trypanosoma cruzi amastigotes infected in mouse peritoneal macrophages assessed as inhibition of infection after 2 day2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
In vitro and in vivo activities of 1,3,4-thiadiazole-2-arylhydrazone derivatives of megazol against Trypanosoma cruzi.
AID523063Antitrypanosomal activity against Trypanosoma cruzi trypomastigotes assessed as disruption of kDNA network at 9.9 uM after 24 hrs by Transmission electron microscopy2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
In vitro and in vivo activities of 1,3,4-thiadiazole-2-arylhydrazone derivatives of megazol against Trypanosoma cruzi.
AID523186Antitrypanosomal activity against Trypanosoma cruzi trypomastigotes assessed as shortening of flagellum at 9.9 uM after 24 hrs by scanning electron microscopy2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
In vitro and in vivo activities of 1,3,4-thiadiazole-2-arylhydrazone derivatives of megazol against Trypanosoma cruzi.
AID215514Minimum effective concentration in vitro against the bloodstream trypomastigote form of Trypanosoma brucei2003Journal of medicinal chemistry, Jan-30, Volume: 46, Issue:3
Synthesis and biological activity of nitro heterocycles analogous to megazol, a trypanocidal lead.
AID523208Toxicity in mouse assessed as urea level in blood at 400 mg/kg, po after 4 days2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
In vitro and in vivo activities of 1,3,4-thiadiazole-2-arylhydrazone derivatives of megazol against Trypanosoma cruzi.
AID214150Percent inhibition in vitro against intracellular form of Trypanosoma cruzi at 90 uM concentration2003Journal of medicinal chemistry, Jan-30, Volume: 46, Issue:3
Synthesis and biological activity of nitro heterocycles analogous to megazol, a trypanocidal lead.
AID523189Antitrypanosomal activity against Trypanosoma cruzi amastigotes infected in mouse peritoneal macrophages assessed as inhibition of infection after 3 day2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
In vitro and in vivo activities of 1,3,4-thiadiazole-2-arylhydrazone derivatives of megazol against Trypanosoma cruzi.
AID523185Antitrypanosomal activity against Trypanosoma cruzi trypomastigotes assessed as torsion and rounding of parasite body at 9.9 uM after 24 hrs by scanning electron microscopy2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
In vitro and in vivo activities of 1,3,4-thiadiazole-2-arylhydrazone derivatives of megazol against Trypanosoma cruzi.
AID439771Antitrypanosomal activity against Trypanosoma cruzi trypomastigotes after 24 hrs by whole-parasite-based assay2009Journal of medicinal chemistry, Dec-10, Volume: 52, Issue:23
Neglected tropical diseases: multi-target-directed ligands in the search for novel lead candidates against Trypanosoma and Leishmania.
AID214148Percent inhibition in vitro against intracellular form of Trypanosoma cruzi at 3 uM concentration2003Journal of medicinal chemistry, Jan-30, Volume: 46, Issue:3
Synthesis and biological activity of nitro heterocycles analogous to megazol, a trypanocidal lead.
AID523056Antitrypanosomal activity against Trypanosoma cruzi Y infected in mouse assessed as mouse survival at 200 mg/kg, po upto 40 days post infection2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
In vitro and in vivo activities of 1,3,4-thiadiazole-2-arylhydrazone derivatives of megazol against Trypanosoma cruzi.
AID523199Antitrypanosomal activity against Trypanosoma cruzi amastigotes infected in mouse embryo heart muscle cells assessed as endocytic index2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
In vitro and in vivo activities of 1,3,4-thiadiazole-2-arylhydrazone derivatives of megazol against Trypanosoma cruzi.
AID693076Redox potential of the compound assessed as one electron redox potential by pulse radiolysis method2011European journal of medicinal chemistry, May, Volume: 46, Issue:5
1-Aryl-4-nitro-1H-imidazoles, a new promising series for the treatment of human African trypanosomiasis.
AID692981Antiparasitic activity against Trypanosoma brucei rhodesiense STIB900 bloodstream forms assessed as reduction in cell viability after 70 hrs by alamar blue assay2011European journal of medicinal chemistry, May, Volume: 46, Issue:5
1-Aryl-4-nitro-1H-imidazoles, a new promising series for the treatment of human African trypanosomiasis.
AID523205Toxicity in mouse assessed as body weight at 400 mg/kg, po after 4 days2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
In vitro and in vivo activities of 1,3,4-thiadiazole-2-arylhydrazone derivatives of megazol against Trypanosoma cruzi.
AID523191Antitrypanosomal activity against Trypanosoma cruzi amastigotes infected in mouse peritoneal macrophages assessed as endocytic index after 1 day2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
In vitro and in vivo activities of 1,3,4-thiadiazole-2-arylhydrazone derivatives of megazol against Trypanosoma cruzi.
AID215698In vitro percent inhibition against mouse peritoneal macrophages infected with Trypanosoma brucei at 1.5 uM concentration2003Journal of medicinal chemistry, Jan-30, Volume: 46, Issue:3
Synthesis and biological activity of nitro heterocycles analogous to megazol, a trypanocidal lead.
AID523204Selectivity index, ratio of LC50 for mouse HMC to IC50 for inhibition of Trypanosoma cruzi amastigotes2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
In vitro and in vivo activities of 1,3,4-thiadiazole-2-arylhydrazone derivatives of megazol against Trypanosoma cruzi.
AID523201Cytotoxicity against Swiss mouse peritoneal macrophages after 48 hrs by MTT assay2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
In vitro and in vivo activities of 1,3,4-thiadiazole-2-arylhydrazone derivatives of megazol against Trypanosoma cruzi.
AID1510717Antibacterial activity against drug-resistant Helicobacter pylori assessed as zone of inhibition at 8 ug/disc2019European journal of medicinal chemistry, Oct-01, Volume: 179Nitroimidazole-containing compounds and their antibacterial and antitubercular activities.
AID214133Effective dose against Trypanosoma cruzi2003Journal of medicinal chemistry, Jan-30, Volume: 46, Issue:3
Synthesis and biological activity of nitro heterocycles analogous to megazol, a trypanocidal lead.
AID253513Inhibitory concentration against wild-type (427) with NAC Trypanosoma brucei2005Journal of medicinal chemistry, Aug-25, Volume: 48, Issue:17
Design and synthesis of a series of melamine-based nitroheterocycles with activity against Trypanosomatid parasites.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (39)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (7.69)18.7374
1990's9 (23.08)18.2507
2000's21 (53.85)29.6817
2010's6 (15.38)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.16

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.16 (24.57)
Research Supply Index3.71 (2.92)
Research Growth Index4.88 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.16)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews7 (17.50%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other33 (82.50%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
dimethyl sulfoxide
Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.. dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.		1.9910sulfoxide;
volatile organic compound		alkylating agent;
antidote;
Escherichia coli metabolite;
geroprotector;
MRI contrast agent;
non-narcotic analgesic;
polar aprotic solvent;
radical scavenger
propylene glycol
Propylene Glycol: A clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations.. propane-1,2-diol : The simplest member of the class of propane-1,2-diols, consisting of propane in which a hydrogen at position 1 and a hydrogen at position 2 are substituted by hydroxy groups. A colourless, viscous, hygroscopic, low-melting (-59degreeC) and high-boiling (188degreeC) liquid with low toxicity, it is used as a solvent, emulsifying agent, and antifreeze.		1.9910glycol;
propane-1,2-diols		allergen;
human xenobiotic metabolite;
mouse metabolite;
protic solvent
spermidine
[no description available]		210polyazaalkane;
triamine		autophagy inducer;
fundamental metabolite;
geroprotector
uracil
2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder		1.9910pyrimidine nucleobase;
pyrimidone		allergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
prodrug;
Saccharomyces cerevisiae metabolite
urea
pseudourea: clinical use; structure. isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.		2.0510isourea;
monocarboxylic acid amide;
one-carbon compound		Daphnia magna metabolite;
Escherichia coli metabolite;
fertilizer;
flour treatment agent;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
berberine
[no description available]		3.3110alkaloid antibiotic;
berberine alkaloid;
botanical anti-fungal agent;
organic heteropentacyclic compound		antilipemic drug;
antineoplastic agent;
antioxidant;
EC 1.1.1.141 [15-hydroxyprostaglandin dehydrogenase (NAD(+))] inhibitor;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
EC 1.13.11.52 (indoleamine 2,3-dioxygenase) inhibitor;
EC 1.21.3.3 (reticuline oxidase) inhibitor;
EC 2.1.1.116 [3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase] inhibitor;
EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor;
EC 2.7.11.10 (IkappaB kinase) inhibitor;
EC 3.1.1.4 (phospholipase A2) inhibitor;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor;
EC 3.4.14.5 (dipeptidyl-peptidase IV) inhibitor;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
geroprotector;
hypoglycemic agent;
metabolite;
potassium channel blocker
ciprofloxacin
Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.. ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.		3.3110aminoquinoline;
cyclopropanes;
fluoroquinolone antibiotic;
N-arylpiperazine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone;
zwitterion		antibacterial drug;
antiinfective agent;
antimicrobial agent;
DNA synthesis inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
environmental contaminant;
topoisomerase IV inhibitor;
xenobiotic
eflornithine
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.. eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.		4.4520alpha-amino acid;
fluoroamino acid		trypanocidal drug
enoxacin
Enoxacin: A broad-spectrum 6-fluoronaphthyridinone antibacterial agent that is structurally related to NALIDIXIC ACID.. enoxacin : A 1,8-naphthyridine derivative that is 1,4-dihydro-1,8-naphthyridine with an ethyl group at the 1 position, a carboxy group at the 3-position, an oxo sustituent at the 4-position, a fluoro substituent at the 5-position and a piperazin-1-yl group at the 7 position. An antibacterial, it is used in the treatment of urinary-tract infections and gonorrhoea.		3.31101,8-naphthyridine derivative;
amino acid;
fluoroquinolone antibiotic;
monocarboxylic acid;
N-arylpiperazine;
quinolone antibiotic		antibacterial drug;
DNA synthesis inhibitor
fluconazole
Fluconazole: Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.. fluconazole : A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis.		3.3110conazole antifungal drug;
difluorobenzene;
tertiary alcohol;
triazole antifungal drug		environmental contaminant;
P450 inhibitor;
xenobiotic
metronidazole
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.. metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.		4.5640C-nitro compound;
imidazoles;
primary alcohol		antiamoebic agent;
antibacterial drug;
antimicrobial agent;
antiparasitic agent;
antitrichomonal drug;
environmental contaminant;
prodrug;
radiosensitizing agent;
xenobiotic
norfloxacin
Norfloxacin: A synthetic fluoroquinolone (FLUOROQUINOLONES) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA GYRASE.. norfloxacin : A quinolinemonocarboxylic acid with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase.		3.3110fluoroquinolone antibiotic;
N-arylpiperazine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone		antibacterial drug;
DNA synthesis inhibitor;
environmental contaminant;
xenobiotic
pentamidine
Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.. pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.		2.4220aromatic ether;
carboxamidine;
diether		anti-inflammatory agent;
antifungal agent;
calmodulin antagonist;
chemokine receptor 5 antagonist;
EC 2.3.1.48 (histone acetyltransferase) inhibitor;
NMDA receptor antagonist;
S100 calcium-binding protein B inhibitor;
trypanocidal drug;
xenobiotic
suramin
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.. suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.		2.9240naphthalenesulfonic acid;
phenylureas;
secondary carboxamide		angiogenesis inhibitor;
antinematodal drug;
antineoplastic agent;
apoptosis inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
GABA antagonist;
GABA-gated chloride channel antagonist;
purinergic receptor P2 antagonist;
ryanodine receptor agonist;
trypanocidal drug
gatifloxacin
Gatifloxacin: A fluoroquinolone antibacterial agent and DNA TOPOISOMERASE II inhibitor that is used as an ophthalmic solution for the treatment of BACTERIAL CONJUNCTIVITIS.. gatifloxacin : A monocarboxylic acid that is 4-oxo-1,4-dihydroquinoline-3-carboxylic acid which is substituted on the nitrogen by a cyclopropyl group and at positions 6, 7, and 8 by fluoro, 3-methylpiperazin-1-yl, and methoxy groups, respectively. Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial topoisomerase type-II enzymes.		3.3110N-arylpiperazine;
organofluorine compound;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone		antiinfective agent;
antimicrobial agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor
mitomycin
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.. mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.		2.0610mitomycinalkylating agent;
antineoplastic agent
4-nitroquinoline-1-oxide
4-nitroquinoline N-oxide : A quinoline N-oxide carrying a nitro substituent at position 4.		2.0610C-nitro compound;
quinoline N-oxide		carcinogenic agent
chloramphenicol
Amphenicol: Chloramphenicol and its derivatives.		3.3110C-nitro compound;
carboxamide;
diol;
organochlorine compound		antibacterial drug;
antimicrobial agent;
Escherichia coli metabolite;
geroprotector;
Mycoplasma genitalium metabolite;
protein synthesis inhibitor
kanamycin a
Kanamycin: Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major component, and kanamycins B and C, the minor components.. kanamycin : Kanamycin is a naturally occurring antibiotic complex from Streptomyces kanamyceticus that consists of several components: kanamycin A, the major component (also usually designated as kanamycin), and kanamycins B, C, D and X the minor components.		3.3110kanamycinsbacterial metabolite
1,2,4-triazole
1,2,4-triazole: RN given refers to 1H-1,2,4-triazole		2.1101,2,4-triazole
melarsoprol
Melarsoprol: Arsenical used in trypanosomiases. It may cause fatal encephalopathy and other undesirable side effects.		5.7960triazines
azomycin
azomycin: RN given refers to parent cpd with specified locant; structure		5.2190C-nitro compound;
imidazoles		antitubercular agent
myristic acid
Myristic Acid: A saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils. It is used to synthesize flavor and as an ingredient in soaps and cosmetics. (From Dorland, 28th ed). tetradecanoic acid : A straight-chain, fourteen-carbon, long-chain saturated fatty acid mostly found in milk fat.. tetradecanoate : A long-chain fatty acid anion that is the conjugate base of myristic acid; major species at pH 7.3.		3.1110long-chain fatty acid;
straight-chain saturated fatty acid		algal metabolite;
Daphnia magna metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
human metabolite
vinblastine
[no description available]		2.0610
benzonidazole
benzonidazole: used in treatment of Chagas' disease. benznidazole : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2-nitroimidazol-1-yl)acetic acid with the aromatic amino group of benzylamine. Used for treatment of Chagas disease.		4.3560C-nitro compound;
imidazoles;
monocarboxylic acid amide		antiprotozoal drug
clinafloxacin
clinafloxacin: structure given in first source; RN given is for monoHCl		3.3110quinolines
2-Amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole
[no description available]		2.0110C-nitro compound;
furans
triazoles
Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.		2.49201,2,3-triazole
fexinidazole
fexinidazole: structure given in first source		3.830
combretastatin
combretastatin: cytotoxic principle from South African tree COMBRETUM caffrum; structure given in first source; acts at COLCHICINE site of TUBULIN		2.0510
trypanothione
trypanothione disulfide : An organic disulfide resulting from the formal oxidative coupling of the thiol groups of N(1),N(8)-bis(glutathionyl)-spermidine from the insect-parasitic trypanosomatid Crithidia fasciculata.		210organic disulfide
mk 436
MK 436: structure		1.9910
1,3,4-thiadiazole
1,3,4-thiadiazole: structure given in first source		2.4420thiadiazole
ro 15-0216
[no description available]		3.520
bekanamycin
bekanamycin: kanendomycin is the sulfate of bekanamycin; RN given refers to parent cpd; structure		3.3110kanamycins
nitrofurazone
Nitrofurazone: A topical anti-infective agent effective against gram-negative and gram-positive bacteria. It is used for superficial WOUNDS AND INJURIES and skin infections. Nitrofurazone has also been administered orally in the treatment of TRYPANOSOMIASIS.. nitrofurazone : A semicarbazone resulting from the formal condensation of semicarbazide with 5-nitrofuraldehyde. A broad spectrum antibacterial drug, although with little activity against Pseudomonas species, it is used as a local application for burns, ulcers, wounds and skin infections.		3.830
pafuramidine
pafuramidine: a prodrug of furamidine		4.0210
nifuroxime
5-nitro-2-furaldehyde oxime: structure in first source		2.0210
nifurtimox
Nifurtimox: A nitrofuran thiazine that has been used against TRYPANOSOMIASIS.		5.9270nitrofuran antibiotic
oxadiazoles
Oxadiazoles: Compounds containing five-membered heteroaromatic rings containing two carbons, two nitrogens, and one oxygen atom which exist in various regioisomeric forms.		2.0110
ConditionIndicatedRelationship StrengthStudiesTrials
Trypanosomiasis
Infection with protozoa of the genus TRYPANOSOMA.		03.6230
African Sleeping Sickness
[description not available]		07.06170
Trypanosomiasis, African
A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces African sleeping sickness. Nagana is a rapidly fatal trypanosomiasis of horses and other animals.		07.06170
Orphan Diseases
Rare diseases that have not been well studied.		02.9610
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		02.9340
Parasitemia
The presence of parasites (especially malarial parasites) in the blood. (Dorland, 27th ed)		02.7230
American Trypanosomiasis
[description not available]		03.2560
Chagas Disease
Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.		03.2560
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		03.8340
Bacterial Disease
[description not available]		03.1210
Bacterial Infections
Infections by bacteria, general or unspecified.		03.1210
Chromosome-Defective Micronuclei
[description not available]		02.0810
Cerebromeningitis
[description not available]		02.0210
Anemia
A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.		02.0210
Ovine Diseases
[description not available]		02.0210
Abnormalities, Autosome
[description not available]		02.0210
Brain Disorders
[description not available]		01.9910
Brain Diseases
Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.		01.9910
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		01.9910
Recrudescence
[description not available]		01.9910
Central Nervous System Disease
[description not available]		01.9910
Central Nervous System Diseases
Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord.		01.9910
Communicable Diseases, Emerging
Infectious diseases that are novel in their outbreak ranges (geographic and host) or transmission mode.		02.9210