metronidazole has been researched along with Adenomatous Polyposis Coli, Familial in 8 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The medical treatment of acute pouchitis was usually oral metronidazole (250 mg twice daily) for 2 weeks or oral ciprofloxacin (200 mg thrice daily) in patients who could not tolerate metronidazole." | 1.32 | Incidence and therapeutic outcome of pouchitis for ulcerative colitis in Japanese patients. ( Ikeuchi, H; Nakamura, M; Nakano, H; Noda, M; Uchino, M; Yamamura, T; Yanagi, H, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (75.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Manninen, I | 1 |
| Ikeuchi, H | 1 |
| Nakano, H | 1 |
| Uchino, M | 1 |
| Nakamura, M | 1 |
| Yanagi, H | 1 |
| Noda, M | 1 |
| Yamamura, T | 1 |
| Nygaard, K | 1 |
| Bergan, T | 1 |
| Bjørneklett, A | 1 |
| Høverstad, T | 1 |
| Lassen, J | 1 |
| Aase, S | 1 |
| Chaussade, S | 1 |
| Hurst, RD | 1 |
| Molinari, M | 1 |
| Chung, TP | 1 |
| Rubin, M | 1 |
| Michelassi, F | 1 |
| Scates, DK | 1 |
| Spigelman, AD | 1 |
| Phillips, RK | 1 |
| Venitt, S | 1 |
| Rauh, SM | 1 |
| Schoetz, DJ | 1 |
| Roberts, PL | 1 |
| Murray, JJ | 1 |
| Coller, JA | 1 |
| Veidenheimer, MC | 1 |
| Dubé, S | 1 |
| Heyen, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Study of the Safety and Efficacy of AST-120 in the Treatment of Antibiotic-Refractory Pouchitis[NCT00583531] | Phase 2 | 2 participants (Actual) | Interventional | 2007-03-31 | Terminated (stopped due to Lack of enrollment) | ||
| "A Phase 1b/2 Study to Demonstrate the Safety and Efficacy of EXE-346 Live Biotherapeutic to Reduce High Bowel Movement Frequency in Subjects With an Ileal Pouch-Anal Anastomosis (PROF). The PROF Study."[NCT05938465] | Phase 1/Phase 2 | 50 participants (Anticipated) | Interventional | 2023-10-11 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for metronidazole and Adenomatous Polyposis Coli, Familial
| Article | Year |
|---|---|
[Ileoanal anastomosis with pouch: a rigorous surgical technique is necessary, but the most frequent long-term postoperative complication remains inflammation of the pouch].
Topics: Adenomatous Polyposis Coli; Adrenal Cortex Hormones; Colitis, Ulcerative; Diarrhea; Female; Humans; | 1993 |
1 trial available for metronidazole and Adenomatous Polyposis Coli, Familial
| Article | Year |
|---|---|
Topical metronidazole treatment in pouchitis.
Topics: Adenomatous Polyposis Coli; Administration, Topical; Adolescent; Adult; Colitis, Ulcerative; Fatty A | 1994 |
6 other studies available for metronidazole and Adenomatous Polyposis Coli, Familial
| Article | Year |
|---|---|
[The mystery of missing flatulence].
Topics: Abdominal Pain; Adenomatous Polyposis Coli; Adult; Anti-Infective Agents; Colon; Colonic Neoplasms; | 2001 |
Incidence and therapeutic outcome of pouchitis for ulcerative colitis in Japanese patients.
Topics: Adenomatous Polyposis Coli; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female | 2004 |
Prospective study of the incidence, timing and treatment of pouchitis in 104 consecutive patients after restorative proctocolectomy.
Topics: Adenomatous Polyposis Coli; Adolescent; Adult; Aged; Anti-Infective Agents; Ciprofloxacin; Colitis, | 1996 |
Prospective study of the incidence, timing and treatment of pouchitis in 104 consecutive patients after restorative proctocolectomy.
Topics: Adenomatous Polyposis Coli; Adolescent; Adult; Aged; Anti-Infective Agents; Ciprofloxacin; Colitis, | 1996 |
Prospective study of the incidence, timing and treatment of pouchitis in 104 consecutive patients after restorative proctocolectomy.
Topics: Adenomatous Polyposis Coli; Adolescent; Adult; Aged; Anti-Infective Agents; Ciprofloxacin; Colitis, | 1996 |
Prospective study of the incidence, timing and treatment of pouchitis in 104 consecutive patients after restorative proctocolectomy.
Topics: Adenomatous Polyposis Coli; Adolescent; Adult; Aged; Anti-Infective Agents; Ciprofloxacin; Colitis, | 1996 |
DNA adducts detected by 32P-postlabelling, in the intestine of rats given bile from patients with familial adenomatous polyposis and from unaffected controls.
Topics: Adenomatous Polyposis Coli; Adolescent; Adult; Aged; Animals; Bile; DNA; Female; Humans; Intestines; | 1992 |
Pouchitis--is it a wastebasket diagnosis?
Topics: Adenomatous Polyposis Coli; Anal Canal; Anastomosis, Surgical; Anti-Inflammatory Agents; Anti-Inflam | 1991 |
Pouchitis and gastric hyposecretion: cause or effect?
Topics: Adenomatous Polyposis Coli; Adult; Anal Canal; Anastomosis, Surgical; Cimetidine; Colitis, Ulcerativ | 1990 |