metronidazole has been researched along with Teeth, Impacted in 9 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Incidence of dry socket in amoxicillin group was 3 (5." | 3.01 | Prevention of dry socket in mandibular 3rd molars with single preoperative oral dose of metronidazole and amoxicillin compared to conventional therapy. ( Hassan, SU; Khooharo, TS; Shaikh, AH, 2021) |
| "Of the 89 patients, 5 had surgical wound infection (3 [10." | 2.76 | Antibiotic prophylaxis in third molar surgery. ( Alexander, M; Pasupathy, S, 2011) |
| "Metronidazole was more effective in pain control than Arnica (p less than 0." | 2.65 | Metronidazole (Flagyl) and Arnica Montana in the prevention of post-surgical complications, a comparative placebo controlled clinical trial. ( Kaziro, GS, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (22.22) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Khooharo, TS | 1 |
| Hassan, SU | 1 |
| Shaikh, AH | 1 |
| Rabi, A | 1 |
| Maheshwari, R | 1 |
| Srinivasan, B | 1 |
| Warad, LP | 1 |
| Suvarna, CC | 1 |
| Tank, KS | 1 |
| Pasupathy, S | 1 |
| Alexander, M | 1 |
| Bergdahl, M | 1 |
| Hedström, L | 2 |
| Kaziro, GS | 1 |
| Ritzau, M | 1 |
| Hillerup, S | 1 |
| Branebjerg, PE | 1 |
| Ersbøl, BK | 1 |
| Lyall, JB | 1 |
| Barclay, JK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Does a Single Dose of Systemic Antibiotics Prevent Postoperative Inflammatory Complications After Lower Third Molar Surgery? A Randomized Controlled Trial[NCT03130933] | Phase 1/Phase 2 | 400 participants (Actual) | Interventional | 2010-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 trials available for metronidazole and Teeth, Impacted
| Article | Year |
|---|---|
Prevention of dry socket in mandibular 3rd molars with single preoperative oral dose of metronidazole and amoxicillin compared to conventional therapy.
Topics: Amoxicillin; Dry Socket; Female; Humans; Male; Metronidazole; Molar; Molar, Third; Tooth Extraction; | 2021 |
Effectiveness of Antimicrobial Therapy after Extraction of Impacted Mandibular Third Molar: A Randomized Clinical Trial.
Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Anti-Infective Agents; beta-Lactamase Inhibito | 2018 |
Antibiotic prophylaxis in third molar surgery.
Topics: Adolescent; Adult; Amoxicillin; Analysis of Variance; Antibiotic Prophylaxis; Chi-Square Distributio | 2011 |
Metronidazole for the prevention of dry socket after removal of partially impacted mandibular third molar: a randomised controlled trial.
Topics: Administration, Oral; Adolescent; Adult; Anti-Infective Agents; Chi-Square Distribution; Contracepti | 2004 |
Metronidazole (Flagyl) and Arnica Montana in the prevention of post-surgical complications, a comparative placebo controlled clinical trial.
Topics: Clinical Trials as Topic; Humans; Metronidazole; Molar, Third; Pain, Postoperative; Placebos; Plants | 1984 |
Does metronidazole prevent alveolitis sicca dolorosa? A double-blind, placebo-controlled clinical study.
Topics: Adult; Double-Blind Method; Dry Socket; Female; Humans; Male; Metronidazole; Molar, Third; Placebos; | 1992 |
Third molar surgery: the effect of primary closure, wound dressing and metronidazole on postoperative recovery.
Topics: Acetaminophen; Adult; Analgesics; Bandages; Bismuth; Caffeine; Codeine; Drug Combinations; Female; H | 1991 |
2 other studies available for metronidazole and Teeth, Impacted
| Article | Year |
|---|---|
[Effect of metronidazole on development of dry socket following removal of lower third molars].
Topics: Adolescent; Adult; Double-Blind Method; Dry Socket; Female; Humans; Male; Metronidazole; Molar, Thir | 1990 |
Metronidazole and dry socket: prophylactic use in mandibular third molar removal complicated by non-acute pericoronitis.
Topics: Adolescent; Adult; Dry Socket; Female; Humans; Male; Metronidazole; Middle Aged; Molar, Third; Peric | 1987 |