metronidazole has been researched along with Gangrene in 19 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Gangrene: Death and putrefaction of tissue usually due to a loss of blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To demonstrate the efficacy of oral metronidazole (OM) in simple or complicated appendicitis with localized peritonitis, a randomized prospective study was carried out in 1083 patients, ranging in age from 4 to 50 years (mean age, 21." | 9.09 | Can oral metronidazole substitute parenteral drug therapy in acute appendicitis? A new policy in the management of simple or complicated appendicitis with localized peritonitis: a randomized controlled clinical trial. ( Banani, SA; Talei, A, 1999) |
| "59 children with gangrenous (n = 11) or perforated (n = 48) appendicitis underwent a prospective, randomized trial and received cefazolin or cefazolin plus metronidazole." | 9.05 | Metronidazole plus cefazolin versus cefazolin in gangrenous and perforated appendicitis in childhood--a prospective randomised trial. ( Miholić, J; Riezinger, F; Wurnig, P, 1983) |
| "A study comparing the effectiveness of metronidazole and ampicillin in preventing wound infection in gangrenous or perforated appendicitis without general peritonitis was performed." | 7.66 | Effect of metronidazole and ampicillin on patients with gangrenous or perforated appendicitis. A comparative study. ( Bergan, T; Jakobsen, A; Liavåg, I; Roland, M, 1981) |
| "To demonstrate the efficacy of oral metronidazole (OM) in simple or complicated appendicitis with localized peritonitis, a randomized prospective study was carried out in 1083 patients, ranging in age from 4 to 50 years (mean age, 21." | 5.09 | Can oral metronidazole substitute parenteral drug therapy in acute appendicitis? A new policy in the management of simple or complicated appendicitis with localized peritonitis: a randomized controlled clinical trial. ( Banani, SA; Talei, A, 1999) |
| "59 children with gangrenous (n = 11) or perforated (n = 48) appendicitis underwent a prospective, randomized trial and received cefazolin or cefazolin plus metronidazole." | 5.05 | Metronidazole plus cefazolin versus cefazolin in gangrenous and perforated appendicitis in childhood--a prospective randomised trial. ( Miholić, J; Riezinger, F; Wurnig, P, 1983) |
| "A study comparing the effectiveness of metronidazole and ampicillin in preventing wound infection in gangrenous or perforated appendicitis without general peritonitis was performed." | 3.66 | Effect of metronidazole and ampicillin on patients with gangrenous or perforated appendicitis. A comparative study. ( Bergan, T; Jakobsen, A; Liavåg, I; Roland, M, 1981) |
| "Cefepime is a new extended-spectrum cephalosporin with gram-positive and gram-negative coverage including Staphylococcus aureus and Pseudomonas aeruginosa." | 2.67 | Analysis of cefepime tissue penetration into human appendix. ( Appleman, MD; Berne, TV; Chin, A; Gill, MA; Heseltine, PN; Knupp, CA; Okamoto, MP; Sclar, DA; Yellin, AE, 1991) |
| "Abdominal pain is common feature of Henoch-Schonlein purpura, which may mimic appendicitis, leading to unnecessary laparotomy." | 1.35 | Gangrenous appendicitis in a child with Henoch-Schonlein purpura. ( Amouzeshi, A; Jalali, AN; Jangjoo, A, 2008) |
| "Necrotising fasciitis of the genitalia still carries a high risk of mortality and morbidity, frequently necessitating long periods of hospitalisation and repeated surgical procedures." | 1.27 | Fournier's gangrene: necrotising fasciitis of the male genitalia. ( Arndt, TC; Bahlmann, JC; Fourie, IJ, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (52.63) | 18.7374 |
| 1990's | 5 (26.32) | 18.2507 |
| 2000's | 2 (10.53) | 29.6817 |
| 2010's | 2 (10.53) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Feruzi, MK | 1 |
| Milindi, CS | 1 |
| Zabibu, MK | 1 |
| Mulefu, JP | 1 |
| Katombe, FT | 1 |
| Jangjoo, A | 1 |
| Amouzeshi, A | 1 |
| Jalali, AN | 1 |
| Le Falher, G | 1 |
| Makinson, A | 1 |
| Eden, A | 1 |
| Lesnik, A | 1 |
| Le Moing, V | 1 |
| Reynes, J | 1 |
| Miholić, J | 1 |
| Riezinger, F | 1 |
| Wurnig, P | 1 |
| Melekos, M | 1 |
| Asbach, HW | 1 |
| Al-Shurbaji, M | 1 |
| Kösters, S | 1 |
| Bahlmann, JC | 1 |
| Fourie, IJ | 1 |
| Arndt, TC | 1 |
| Bruce, M | 1 |
| Roland, M | 1 |
| Bergan, T | 1 |
| Jakobsen, A | 1 |
| Liavåg, I | 1 |
| Pinto, DJ | 1 |
| Sanderson, PJ | 1 |
| Stewart, D | 1 |
| Gospodarek, E | 1 |
| Tyloch, F | 1 |
| Tyloch, J | 1 |
| Bharani, A | 1 |
| Chattopadhyay, BP | 1 |
| Dani, P | 1 |
| Bhargava, KD | 1 |
| Söderquist-Elinder, C | 1 |
| Hirsch, K | 1 |
| Bergdahl, S | 1 |
| Rutqvist, J | 1 |
| Frenckner, B | 1 |
| Banani, SA | 1 |
| Talei, A | 1 |
| Maros, E | 1 |
| Bartha, K | 1 |
| Okamoto, MP | 1 |
| Chin, A | 1 |
| Gill, MA | 1 |
| Yellin, AE | 1 |
| Berne, TV | 1 |
| Heseltine, PN | 1 |
| Appleman, MD | 1 |
| Knupp, CA | 1 |
| Sclar, DA | 1 |
| Kjersgaard, P | 1 |
| Sweeney, JL | 1 |
| Hewett, P | 1 |
| Riddell, P | 1 |
| Hoffmann, DC | 1 |
| Finegold, SM | 1 |
| Rosenblatt, JE | 1 |
1 review available for metronidazole and Gangrene
| Article | Year |
|---|---|
[Endodontic treatment of gangrenous teeth--literature review].
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Anti-Infective Agents; Calcium Hydroxide; Chloramphe | 2001 |
6 trials available for metronidazole and Gangrene
| Article | Year |
|---|---|
Metronidazole plus cefazolin versus cefazolin in gangrenous and perforated appendicitis in childhood--a prospective randomised trial.
Topics: Appendicitis; Appendix; Cefazolin; Child; Clinical Trials as Topic; Drug Therapy, Combination; Gangr | 1983 |
Rational use of antibiotic therapy after appendicectomy.
Topics: Adolescent; Adult; Aged; Ampicillin; Appendectomy; Appendicitis; Child; Child, Preschool; Female; Ga | 1980 |
Prophylactic antibiotics in uncomplicated appendicitis during childhood--a prospective randomised study.
Topics: Adolescent; Anti-Bacterial Agents; Antibiotic Prophylaxis; Appendicitis; Appendix; Bacterial Infecti | 1995 |
Can oral metronidazole substitute parenteral drug therapy in acute appendicitis? A new policy in the management of simple or complicated appendicitis with localized peritonitis: a randomized controlled clinical trial.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Anti-Infective Agents; Appendicitis; Ceftizo | 1999 |
Analysis of cefepime tissue penetration into human appendix.
Topics: Adolescent; Adult; Appendectomy; Appendicitis; Appendix; Ascitic Fluid; Cefepime; Cephalosporins; Cl | 1991 |
[Gangrenous appendicitis. Local application of ampicillin in the incision versus intravenous administration of metronidazole used peroperatively].
Topics: Administration, Topical; Adolescent; Adult; Aged; Ampicillin; Appendicitis; Appendix; Child; Child, | 1987 |
12 other studies available for metronidazole and Gangrene
| Article | Year |
|---|---|
[Amputation of all four limbs].
Topics: Adult; Amputation Stumps; Amputation, Surgical; Amputation, Traumatic; Anti-Bacterial Agents; Arm; C | 2014 |
Gangrenous appendicitis in a child with Henoch-Schonlein purpura.
Topics: Abdominal Pain; Adolescent; Anti-Bacterial Agents; Appendectomy; Appendicitis; Arthralgia; Ceftriaxo | 2008 |
[Two cases of pulmonary gangrene in HIV-infected patients: favorable outcome without surgery].
Topics: Acetamides; Adult; Alcoholism; Amoxicillin; Anti-Bacterial Agents; Drug Therapy, Combination; Gangre | 2011 |
Idiopathic gangrene (Fournier) of the male external genitalia, with report of a case and review of the literature.
Topics: Adult; Bacterial Infections; Bacteroides Infections; Gangrene; Humans; Male; Metronidazole; Penicill | 1983 |
Fournier's gangrene: necrotising fasciitis of the male genitalia.
Topics: Adult; Aged; Chloramphenicol; Fasciitis; Gangrene; Genital Diseases, Male; Humans; Male; Metronidazo | 1983 |
A case of Fournier's gangrene.
Topics: Gangrene; Genital Diseases, Male; Gentamicins; Humans; Male; Metronidazole; Middle Aged; Penicillin | 1980 |
Effect of metronidazole and ampicillin on patients with gangrenous or perforated appendicitis. A comparative study.
Topics: Adolescent; Adult; Aerobiosis; Aged; Ampicillin; Anaerobiosis; Appendicitis; Bacteria; Female; Gangr | 1981 |
Antibiotic treatment for gangrenous and perforated appendix.
Topics: Appendicitis; Gangrene; Humans; Intestinal Perforation; Metronidazole; Surgical Wound Infection | 1980 |
[Bacteroides melaninogenicus, during Fournier's gangrene].
Topics: Bacteroidaceae Infections; Combined Modality Therapy; Fasciitis; Gangrene; Humans; Male; Metronidazo | 1994 |
Metronidazole extravasation causing digital gangrene.
Topics: Antitrichomonal Agents; Capillary Permeability; Diarrhea; Extravasation of Diagnostic and Therapeuti | 1995 |
Rectal gangrene: a complication of phosphate enema.
Topics: Aged; Constipation; Debridement; Drug Therapy, Combination; Enema; Female; Gangrene; Gentamicins; He | 1986 |
Practical aspects of anaerobic sepsis.
Topics: Abscess; Anaerobiosis; Arthritis, Infectious; Bacterial Infections; Bacteroides; Bone Diseases; Brai | 1973 |