metronidazole has been researched along with Sarcoma in 4 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Sarcoma: A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (75.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, Z | 1 |
| Lin, X | 1 |
| Zhang, J | 1 |
| Wang, X | 1 |
| Jin, Z | 1 |
| Zhang, W | 1 |
| Zhang, Y | 1 |
| Munzenrider, JE | 1 |
| Rauth, AM | 1 |
| Paciga, JE | 1 |
| Hofer, KG | 1 |
| Hofer, MG | 1 |
| Ieracitano, J | 1 |
| McLaughlin, WH | 1 |
1 review available for metronidazole and Sarcoma
| Article | Year |
|---|---|
Recent advances in radiotherapy.
Topics: Breast Neoplasms; Bromodeoxyuridine; Carcinoid Tumor; Elementary Particles; Fast Neutrons; Hot Tempe | 1977 |
3 other studies available for metronidazole and Sarcoma
| Article | Year |
|---|---|
Kit formulation for preparation and biological evaluation of a novel (99m)Tc-oxo complex with metronidazole xanthate for imaging tumor hypoxia.
Topics: Animals; Cell Hypoxia; Cell Line, Tumor; Chemistry, Pharmaceutical; Drug Compounding; Metronidazole; | 2016 |
Effects of dimethyl sulfoxide and hypoxic cell radiosensitizers on the radiation response of the KHT murine tumor in vivo.
Topics: Animals; Cell Survival; Dimethyl Sulfoxide; Male; Metronidazole; Mice; Mice, Inbred C3H; Neoplasms, | 1977 |
Radiosensitization of hypoxic tumor cells by simultaneous administration of hyperthermia and nitroimidazoles.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Survival; Deoxyuridine; Female; Hyperthermia, Induced; Hypox | 1977 |