metronidazole has been researched along with Dysesthesia in 8 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Generalised convulsive seizures occurred on four occasions, associated with paresthesia of the four limbs, but without loss of motor or reflex activity, though some distal hypoesthesia was detected." | 5.26 | [Convulsive seizures and polyneuritis in a patient with lupus treated with metronidazole (author's transl)]. ( Betous, F; Herreman, G; Krainik, F; Mundler, B; Nicolas, MO, 1981) |
| "Fifty-three patients with Crohn's disease were chosen for this study." | 1.28 | Neurophysiologic studies of patients with Crohn's disease on long-term treatment with metronidazole. ( Bárány, F; Einarsson, K; Elmqvist, D; Persson, A; Ståhlberg, D; Ursing, B, 1991) |
| " Dosage reduction was associated with exacerbation of disease activity in all patients, but in all, the perineal manifestations of disease healed promptly when the full dosage of metronidazole was reinstituted." | 1.26 | Metronidazole therapy for perineal Crohn's disease: a follow-up study. ( Bernstein, LH; Boley, SJ; Brandt, LJ; Frank, MS, 1982) |
| "Generalised convulsive seizures occurred on four occasions, associated with paresthesia of the four limbs, but without loss of motor or reflex activity, though some distal hypoesthesia was detected." | 1.26 | [Convulsive seizures and polyneuritis in a patient with lupus treated with metronidazole (author's transl)]. ( Betous, F; Herreman, G; Krainik, F; Mundler, B; Nicolas, MO, 1981) |
| "Five patients with Crohn's disease for 4 months to 12 years were treated with metronidazole." | 1.25 | Metronidazole for Crohn's disease. ( Kamme, C; Ursing, B, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (87.50) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brandt, LJ | 1 |
| Bernstein, LH | 1 |
| Boley, SJ | 1 |
| Frank, MS | 1 |
| Herreman, G | 1 |
| Krainik, F | 1 |
| Betous, F | 1 |
| Nicolas, MO | 1 |
| Mundler, B | 1 |
| Kusumi, RK | 1 |
| Plouffe, JF | 1 |
| Wyatt, RH | 1 |
| Fass, RJ | 1 |
| Ambroise-Thomas, P | 1 |
| Meyer, HA | 1 |
| Ursing, B | 2 |
| Kamme, C | 1 |
| Coxon, A | 1 |
| Pallis, CA | 1 |
| Ståhlberg, D | 1 |
| Bárány, F | 1 |
| Einarsson, K | 1 |
| Elmqvist, D | 1 |
| Persson, A | 1 |
| Chari, MV | 1 |
| Gadiyar, BN | 1 |
8 other studies available for metronidazole and Dysesthesia
| Article | Year |
|---|---|
Metronidazole therapy for perineal Crohn's disease: a follow-up study.
Topics: Adult; Aged; Chromosome Aberrations; Crohn Disease; Drug Evaluation; Female; Follow-Up Studies; Huma | 1982 |
[Convulsive seizures and polyneuritis in a patient with lupus treated with metronidazole (author's transl)].
Topics: Abscess; Adult; Biopsy; Female; Humans; Lupus Erythematosus, Discoid; Male; Metronidazole; Middle Ag | 1981 |
Central nervous system toxicity associated with metronidazole therapy.
Topics: Blood-Brain Barrier; Brain Diseases; Cerebellar Ataxia; Female; Humans; Metronidazole; Middle Aged; | 1980 |
[Hepatic amebiasis in the Kilimanjaro region. Serodiagnosis on micro-specimens of dried blood and attempts at treatment with tinidazole (fasigyn)].
Topics: Adult; Aged; Alkaline Phosphatase; Emetine; Female; Fluorescent Antibody Technique; Hand; Humans; Li | 1975 |
Metronidazole for Crohn's disease.
Topics: Adult; Child; Crohn Disease; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Hu | 1975 |
Metronidazole neuropathy.
Topics: Adult; Crohn Disease; Diagnosis, Differential; Electrodiagnosis; Female; Humans; Male; Metronidazole | 1976 |
Neurophysiologic studies of patients with Crohn's disease on long-term treatment with metronidazole.
Topics: Adult; Aged; Crohn Disease; Evoked Potentials; Female; Humans; Male; Metronidazole; Middle Aged; Neu | 1991 |
A new drug (MK-910) in the therapy of intestinal and hepatic amebiasis. First results of clinical trial.
Topics: Adult; Aged; Amebicides; Dysentery, Amebic; Entamoeba histolytica; Female; Humans; Leg; Liver Absces | 1970 |